Chemoprevention of cancer: Basic mechanisms and molecular targets

Carcinogenic and Anticarcinogenic Food Components

Volumn , Issue , 2005, Pages 177-196

  Baer Dubowska, Wanda ^a   Ignatowicz, Ewa ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

PATHOLOGY; TUMORS;

CANCER CHEMOPREVENTION; CARCINOGENIC AGENTS; CARCINOGENIC PROCESS; NEOPLASTIC PROCESS; REGULATORY PATHWAY; SYNTHETIC CHEMICALS; THERAPEUTIC MODALITY; TRADITIONAL APPROACHES;

DISEASES;

EID: 36649032699     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (91)

1. Ahsan, H., Parveen, N., Khan, N.U., and Hadi, S.M., Prooxidant, antioxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin, Chem. Biol. Interact., 121, 161, 1999.
2. Alexandrov, K., Cascorobi, I, Rojas, M., Bouvier, G., Kriek, E., and Bartsch, H., CYP1A1 and GSTM1 genotype affect benzo[a]pyrene DNA adducts in smokers’ lung: comparison with aromatic/hydrophobic adduct formation, Carcinogenesis, 23, 1969, 2002.
3. Baer-Dubowska, W., Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds, Xenobiotica, 28, 735, 1998.
4. Bair, W.B. III, Hart, N., Einspahr, J., Liu, G., Dong, Z., Alberts, D., and Bowden, G.T., Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis, Cancer Epidemiol. Biomarkers Prev., 11, 1645, 2002.
5. Barrett, J.C., Relationship between mutagenesis and carcinogenesis, in Origins of Human Cancer: A Comprehensive Review, Brugge, J., Curran, T., Harlow, E., and McCormick, F., Eds., Cold Spring Harbor Laboratory Press, Plainview, NJ, 1991, p. 101.
6. Barthelman, M., Bair, W.B. III, Kramer-Stickland, K., Chen, W., Timmermann, B.N., Valcic, S., Dong, Z., and Bowden, G.T., (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity, Carcinogenesis, 19, 2201, 1998.
7. Brady, J.F., Ishiziki, H., Ukuto, J.M., Lin, M.C., Fidel, A., Gapac, J.M., and Yang, C.S., Inhibition of cytochrome P-450IIE1 by diallyl sulfide and its metabolites, Chem. Res. Toxicol., 4, 642, 1991.
8. Buening, M.K., Chang, R.L., Huang, M-T., Fortner, J.G., Wood, A.W., and Conney, A.H., Activation and inhibition of benzo[a]pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids, Cancer Res., 41, 67, 1981.
9. Cai, Y., Baer-Dubowska, W., Ashwood-Smith, M.J., Ceska, O., Tachibana, S., and DiGiovanni, J., Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins, Chem. Res. Toxicol., 9, 729, 1996.
10. Cantley, L.C., Auger, K.R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S., Oncogenes and signal transduction, Cell, 64, 281, 1991.
11. Chun, K-S., Cha, H-H, Shin, J-W., Na, H-K., Park, K-K., Chung, W-Y., and Surh, Y-J., Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-κB, Carcinogenesis, 25, 445, 2004.
12. Chun, Y-J., Kim, S., Kim, D., Lee, S-K., and Guengerich, F.P., A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis, Cancer Res., 61, 8164, 2001.
13. Cobbs, C.S., Brenman, J.E., Aldape, K.D., Bredt, D.S., and Israel, M.A., Expression of nitric acid synthase in human central nervous system tumors, Cancer Res., 55, 727, 1995.
14. Conney, A.H., Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: The seventh DeWitt S. Goodman lecture, Cancer Res., 63, 7005, 2003.
15. Costello, J.F., Fruhwald, M.C., Smiraglia, D.J., Rush, L.J., Robertson, G.O., Gao, X., Wright, F.A., Feramisco, J.D., Peltomaki, P., Lang, J.C., Schuller, D.E., Yu. L., Bloomfield, C.D., Caligiuri, M.A., Yates, A., Nishikawa, R., Su Huang, H., Petrelli, N.J., Zhang, X., O’Dorisio, M.S., Held, W.A., Cavenee, W.K., and Plass, C., Aberrant CpG-island methylation has nonrandom and tumour-type-specific patterns, Nat. Genet., 25, 132, 2000.
16. Costello, J.F. and Plass, C., Methylation matters, J. Med. Genet., 38, 285, 2001.
17. Crowell, P.L. and Gould, M.N., Chemoprevention and therapy of cancer by D-limonene, Crit. Rev. Oncog., 5, 1, 1994.
18. DiGiovanni, J., Multistage skin carcinogenesis in mice, In Carcinogenesis, Waalkes, M.P. and Ward J.M., Eds., New York, Raven Press, 1994, p. 265.
19. DiGiovanni, J. and Fischer, S.M., Inhibition of tumor growth and progression, Cancer Bull., 47, 464, 1995.
20. Domann, F.E., Levy, J.P., Birrer, M.J., and Bowden, G.T., Stable expression of a c-Jun deletion mutant in two malignant epidermal cell lines blocks tumor formation in nude mice, Cell Growth Diff., 58, 9, 1994.
21. Dong, Z., Birrer, M.J., Watts, R.G., Matrisian, L.M., and Colburn, N.H., Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells, Proc. Natl. Acad. Sci. USA, 91, 609, 1994.
22. Eads, C.A., Lord, R.V., Wickramasinghe, K., Long, T.I., Kurumboor, S.K., Bernstein, L., Peters, J.H., DeMeester, S.R., DeMeester, T.R., Skinner, K.A., and Laird, P.W., Epigenetic patterns in the progression of esophageal adenocarcinoma, Cancer Res., 61, 3410, 2001.
23. Esteller, M., CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future, Oncogene, 21, 5427, 2002.
24. Esteller, M., Corn, P.G., Baylin, S.B., and Herman, J.G., A gene hypermethylation profile of human cancer, Cancer Res., 61, 3225, 2001.
25. Fahey, J.W., Zhang, Y., and Talalay, P., Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens, Proc. Natl. Acad. Sci. USA, 94, 10,367, 1997.
26. Fischer, S.M. and DiGiovanni, J., Mechanisms of tumor promotion: epigenetic changes in cell signaling, Cancer Bull., 47, 456, 1995.
27. Frenkel, K., Carcinogenesis: role of active oxygen species, in Encyclopedia of Cancer, Vol. 1, Bertino, J.R., Ed, Academic Press, Inc., San Diego, CA, 1997, p. 233.
28. Gescher, A.J., Sharma, R.A., and Steward, W.P., Cancer chemoprevention by dietary constituents: a tale of failure and promise, Lancet Oncol., 2, 371, 2001.
29. Gilmore, T.D., Koedood, M., Piffat, K.A., and White, D.W., Rel/NFκB proteins and cancer, Oncogene, 13, 1367, 1996.
30. Goffin, J. and Eisenhauer, E., DANN methyltransferase inhibitors-state of the art, Ann. Oncol., 13, 1699, 2002.
31. Guengerich, F.P. and Kim, D-H., In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by narigenin and other flavonoids, Carcinogenesis, 11, 2275, 1991.
32. Guengerich, F.P., Chun, Y.J., Kim, D., Gillam, E.M., and Shimada, T., Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies, Mutation Res., 523-524, 173, 2003.
33. Guinn, B.A. and Mills, K.I., p53 mutations, methylation, and genomic instability in the progression of chronic myeloid leukaemia, Leuk. Lymphoma, 26, 211, 1997.
34. Harris, C.C., p53 at the crossroads of molecular carcinogenesis and risk assessment, Science, 262, 1980, 1993.
35. Henderson, C.J., Smith, A.G., Ure, J., Brown, K., Bacon, E.J., and Wolf, C.R., Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases, Proc. Natl. Acad. Sci. USA, 95, 5275, 1998.
36. Horn, T.L., Reichert, M.A., Bliss, R.L., and Malejka-Giganti, D., Modulation of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol, Biochem. Pharmacol., 64, 393, 2002.
37. Hou, D-X., Kai, K., Li, J-J., Lin, S., Terahara, N., Wakamatsu, M., Fuji, M., Young, M.R., and Colburn, N., Anthocyanidins inhibit activator protein-1 activity and cell transformation: structure-activity relationship and molecular mechanisms, Carcinogenesis, 25, 29, 2004.
38. Hursting, S.D., Slaga, T.J., Fischer, S.M, DiGiovanni, J., and Phang, J.M., Mechanism-based cancer prevention approaches: targets, examples, and use of transgenic mice, J. Natl. Cancer Inst., 91, 215, 1999.
39. Ignatowicz, E., Balana B., Vulimiri, S.V., Szaefer, H., and Baer-Dubowska, W., The effect of plant phenolics on the formation of 7,12-dimethylbenz[a]anthracene-DNA adducts and TPA-stimulated polymorphonuclear neutrophils chemiluminescence in vitro, Toxicology, 189, 199, 2003.
40. Itri, L.M., Cancer chemoprevention, Cancer (Suppl.),72, 3374, 1993.
41. Irani, K., Xia, Y., Zweier, J.L., Sollott, S.J., Der, C.J., Fearon, E.R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P.J., Mitogenic signaling mediated by oxidants in rastransformed fibroblasts, Science, 275, 1649, 1997.
42. John, A. and Tuszynski, G., The role of matrix mettalloproteinases in tumor angiogenesis and tumor metastasis, Pathol. Oncol. Res., 7, 14, 2001.
43. Johnson, D.G., Richie, E.R., and Conti, C.J., The cell cycle and cancer, Cancer Bull., 47, 480, 1995.
44. Jones, P.A. and Baylin, S.B., The fundamental role of epigenetic events in cancer, Nat. Rev. Genet., 3, 415, 2002.
45. Kelloff, G.J., Perspectives on cancer chemoprevention research and drug development, Adv. Cancer Res., 78, 199, 2000.
46. Klein, C.B, Mure, K., Leszczynska, J., Matz, J., King, A., and Rossman, T.G., Can dietary antioxidants prevent deletion mutations? presented at The Second Annual AACR Int. Conf. Frontiers in Cancer Prevention Research, Phoenix, AZ, October 26-30, 2003, C172.
47. Kojima, M., Morisaki, T., Izuhara, K., Uchiyama, A., Matsunari, Y., Katano, M., and Tanaka, M., Lipopolysacharide increases cyclooxygenase-2 expression in a colon carcinoma cell line through nuclear factor-κB activation, Oncogene, 19, 1225, 2000.
48. Kong, A.N., Yu, R., Chen, C., Mandlekar, S., and Primiano, T., Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis, Arch. Pharm. Res., 23, 1, 2000.
49. Kong, A.N., Yu, R., Hebbar, V., Chen, C., Owuor, E., Hu, R., Ee, R., and Mandlekar, S., Signal transduction events elicited by cancer prevention compounds, Mutation Res., 480-481, 231, 2001.
50. Kopelovich, L., Crowell, J.A., and Fay, J.R., The epigenome as a target for cancer chemoprevention, J. Natl. Cancer Inst., 95, 1747, 2003.
51. Lamb, R.F., Henningan, R.T., Turnbull, K., Katsanakis, K.D., MacKenzie, E.D., Birnie, G.D., and Ozanne, B.W., AP-1 mediated invasion requires increased expression of the hyaluronan receptor CD44, Mol. Cell. Biol., 17, 965, 1997.
52. Li, J.J., Westergaard, C., Ghosh, P., and Colburn, N.H., Inhibitors of both nuclear factor-κB and activator protein-1 activation block the neoplastic transformation response, Cancer Res., 57, 3569, 1997.
53. MacMicking, J., Xie, Q.W., and Nathan, C., Nitric oxide and macrophage function, Annu. Rev. Immunol., 15, 323, 1997.
54. Manson, M.M., Gescher, A., Hudson, E.A., Plummer, S.M., Squires, M.S., and Prigent, S.A., Blocking and suppressing mechanisms of chemoprevention by dietary constituents, Toxicol. Lett., 112, 499, 2000.
55. Mikstacka, R., Gnojkowski, J., and Baer-Dubowska, W., Effect of natural phenols on the catalytic activity of cytochrome P450 2E1, Acta Bioch. Pol., 49, 917, 2002.
56. Naasani, I., Seimiya, H., and Tsuruo, T., Telomerase inhibition, telomerase shortening, and senescence of cancer cells by tea catechins, Biochim. Biophys. Res. Commun., 249, 391, 1998.
57. Nebert, D.W., Puga, A., and Vasilou, V., Role of the Ah receptor and dioxin-inducible [Ah] gene battery in toxicity, cancer and signal transduction, Ann. NY Acad. Sci., 685, 624, 1993.
58. Nebert, D.W., Transcription factors and cancer: an overview, Toxicology, 181-182, 131, 2002.
59. Ohshima, H. and Bartsch, H., Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis, Mutation Res., 305, 253, 1994.
60. Pahl, H.L., Activators and target genes of Rel/NFκB transcription factors, Oncogene, 18, 6853, 1999.
61. Paolini, M., Perocco, P., Canistro, D., Valgimigli, L., Pedulli, G.F., Iori, R., Croce, C.D., Cantelli-Forti G., Legator, M.S., and Abdel-Rahman, S.Z., Induction of cytochrome P450, generation of oxidative stress, and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli, Carcinogenesis, 25, 61, 2004.
62. Perchellet, J.P., Perchellet, E.M., Gali, H.U., and Gao, X.M., Oxidant stress and multistage carcinogenesis, In Skin Cancer: Mechanisms and Human Relevance, Mukhtar, H., Ed., CRC Press, Boca Raton, FL, 1995, p. 145.
63. Pinkus, R., Weiner, L.M., and Daniel, V., Role of oxidants and antioxidants in the induction of AP-1, NF-κB, and glutathione S-transferase gene expression, J. Biol. Chem., 271, 13,422, 1996.
64. Prescott, S.M. and Fitzpatrick, F.A., Cyclooxygenase-2 and carcinogenesis, Biochim. Biophys. Acta, 1470, M69, 2000.
65. Pryor, W.A. and Squadrito, G.L., The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide, Am. J. Physiol., 268, L699, 1995.
66. Puga, A., Marlowe, J., Barnes, S., Chang, C.Y., Maier, A., Tan, Z., Kerzee, J.I., Chang, X., Strobeck, M., and Knudsen, E.S., Role of the aryl hydrocarbon receptor in cell cycle regulation, Toxicology, 181-182, 171, 2002.
67. Rao, C.V., Kawamori, T., Hamid, R., and Reddy, B.S., Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor, Carcinogenesis, 20, 641, 1999.
68. Ripple, G.H., Gould, M.N., Arzoomanian, R.Z, Alberti, D., Feierabend, C., Simon, K., Binger, K., Tutsch, K.D., Pomplum, M., Wahamaki, A., Marnocha, R., Wilding, G., and Bailey, H.H., Phase I clinical and pharmaceutical study of perrillyl alcohol administered four times a day, Clin. Cancer Res., 6, 390, 2000.
69. Rosette, C. and Karin, M., Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors, Science, 274, 1194, 1996.
70. Rowinsky, E.K., Windle, J.J., and Von Hoff, D.D., Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development, J. Clin. Oncol., 17, 3631, 1999.
71. Saez, E., Rutberg, S.E., Mueller, E., Oppenheim, H., Smoluk, J., Yuspa, S., and Spiegelman, B.M., c-Fos is required for malignant progression of skin tumors, Cell, 82, 721, 1995.
72. Shishodia, S., Majumdar, S., Banerjee, S., and Aggarwal, B.B., Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1, Cancer Res., 63, 4375, 2003.
73. Smith, G., Stubbins, M.J., Harries, L.W., and Wolf, C.R., Molecular genetics of the human cytochrome P450 monooxygenase superfamily, Xenobiotica, 28, 1129, 1998.
74. Smith, M.L., Chen, I.T., Zhan, Q., O’Connor, P.M., and Fornace, A.J. Jr., Involvement of the the p53 tumor suppressor in repair of u.v.-type DNA damage, Oncogene, 10, 105, 1995.
75. Sporn, M.B. and Suh, N., Chemoprevention of cancer, Carcinogenesis, 21, 525, 2000.
76. Subbaramaiah, K., Zakim, D., Weksler, B.B., and Dannenberg, A.J., Inhibition of cyclooxygenase: a novel approach to cancer prevention, Proc. Soc. Exp. Biol. Med., 216, 201, 1997.
77. Szaefer, H., Cichocki, M., Brauze, D., and Baer-Dubowska W., Alteration in phase I and II enzymes activities and polycyclic aromatic hydrocarbons-DNA adduct formation by plant phenolics in mouse epidermis, Nutr. Cancer, 48, 70-77, 2004.
78. Talalay, P., Dinkova-Kostova, A.T., and Holtzclaw, W.D., Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis, Advan. Enzyme Regul., 43, 121, 2003.
79. Thomsen, L.L., Lawton, F.G., Knowles, R.G., Beesley, J.E., Riveros-Moreno, V., and Moncada, S., Nitric oxide synthase activity in human gynecological cancer, Cancer Res., 54, 1352, 1994.
80. Thomsen, L.L., Miles, D.W., Happerfield, L., Bobrow, L.G., Knowles, R.G., and Moncada, S., Nitric oxide synthase activity in human breast cancer, Br. J. Cancer, 72, 41, 1995.
81. Thomsen, L.L., Scott, J.M.J., Topley, P., Knowles, R.G., Keerie, A-J., and Frend, A.J., Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor, Cancer Res., 57, 3300, 1997.
82. Trent, J.C. and Ananthaswamy, H.N., Signal transduction by Ras and intervention by the Rap1A tumor suppressor gene, Cancer Bull., 47, 140, 1995.
83. Vang, O., Jensen, M.B., and Autrup, H., Induction of cytochrome P4501A1 in rat colon and liver by indole-3-carbinol and 5,6-benzoflavone, Carcinogenesis, 11, 1259, 1990.
84. Wattenberg, L.W., Chemoprophylaxis of carcinogenesis: a review, Cancer Res., 26, 1520, 1966.
85. Wattenberg, L.W., Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer: effect of diet on benzpyrene hydroxylase activity, Cancer, 28, 99, 1971.
86. Wei, H., Tye, L., Bresnick, E., and Birt, D.F., Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice, Cancer Res., 50, 499, 1990.
87. Weinstein, J.B., Carothers, A.M., Santella, R.M., and Perera, F.P., Molecular mechanisms of mutagenesis and multistage carcinogenesis, in The MolecularBasis of Cancer, Menselsohn, J., Howley, P.M, Israel, M.A., and Liotta, L.A., Eds., W.B. Saunders, Philadelphia 1995, p. 59.
88. Willis, D.B. and Colburn, N.H., Molecular targets for cancer prevention: a meeting review of the Third American Cancer Society-Schilling Research Conference, Cancer Epidemiol. Biomarkers Prev., 11, 972, 2002.
89. Yang, C.S., Brady, J.F., and Hong, J-Y., Dietary effects on cytochrome P450, xenobiotic metabolism, and toxicity, FASEB J., 6, 737, 1992.
90. Yang, C.S., Smith, T.J., and Hong, J-Y., Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations, Cancer Res. (Suppl.), 54, 1982, 1994.
91. Yuspa, S.H. and Shields, P.G., Etiology of cancer:chemical factors, In Cancer: Principles and Practice of Oncology, 5th ed., DeVita, V.T. Jr., Hellman, S.H., and Rosenberg, S.A., Eds., Lippincott-Raven, Philadelphia, 1997, p. 185.