-
2
-
-
0032170425
-
-
(b) Eisenreich, W.; Schwarz, M.; Cartayrade, A.; Arigoni, D.; Zenk, M. H.; Bacher, A. Chem. Biol. 1998, 5, R221-R233.
-
(1998)
Chem. Biol
, vol.5
-
-
Eisenreich, W.1
Schwarz, M.2
Cartayrade, A.3
Arigoni, D.4
Zenk, M.H.5
Bacher, A.6
-
3
-
-
0034620687
-
-
For mechanistic references on aristolochene and pentalenene synthases, respectively: a
-
For mechanistic references on aristolochene and pentalenene synthases, respectively: (a) Rising, K. A.; Starks, C. M.; Noel, J. P.; Chappell, J. J. Am. Chem. Soc. 2000, 122, 1861-1866.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 1861-1866
-
-
Rising, K.A.1
Starks, C.M.2
Noel, J.P.3
Chappell, J.4
-
5
-
-
0034678033
-
-
(a) Schreiber, S. L. Science 2000, 287, 1964-1969.
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
7
-
-
33644651861
-
-
For selected examples of catalyst/ligand-control of skeletal diversity, see: a
-
For selected examples of catalyst/ligand-control of skeletal diversity, see: (a) Vitale, M.; Lecourt, T.; Sheldon, C. G.; Aggarwal, V. K. J. Am. Chem. Soc. 2006, 128, 2524-2525.
-
(2006)
J. Am. Chem. Soc
, vol.128
, pp. 2524-2525
-
-
Vitale, M.1
Lecourt, T.2
Sheldon, C.G.3
Aggarwal, V.K.4
-
8
-
-
0141633653
-
-
(b) Ma, S.; Wang, G. Angew. Chem., Int. Ed. 2003, 42, 4215-4217.
-
(2003)
Angew. Chem., Int. Ed
, vol.42
, pp. 4215-4217
-
-
Ma, S.1
Wang, G.2
-
10
-
-
33645172584
-
-
(d) Ito, T.; Kawai, T.; Takami, Y. Tetrahedron Lett. 1972, 47, 4775-4778.
-
(1972)
Tetrahedron Lett
, vol.47
, pp. 4775-4778
-
-
Ito, T.1
Kawai, T.2
Takami, Y.3
-
11
-
-
3042799070
-
-
For examples of reagent-based approaches to skeletal diversity differentiating processes, see Burke, M. D, Schreiber, S. L. Angew. Chem, Int. Ed. 2004, 43, 46-58, and references therein
-
For examples of reagent-based approaches to skeletal diversity (differentiating processes), see Burke, M. D.; Schreiber, S. L. Angew. Chem., Int. Ed. 2004, 43, 46-58, and references therein.
-
-
-
-
12
-
-
15844377234
-
-
(a) Trost, B. M.; Fleitz, F. J.; Watkins, W. J. J. Am. Chem. Soc. 1996, 118, 5146-5147.
-
(1996)
J. Am. Chem. Soc
, vol.118
, pp. 5146-5147
-
-
Trost, B.M.1
Fleitz, F.J.2
Watkins, W.J.3
-
15
-
-
27644568017
-
-
(a) Taillemite, S.; Aubert, C.; Fichou, D.; Malacria, M. Tetrahedron Lett. 2005, 48, 8325-8328.
-
(2005)
Tetrahedron Lett
, vol.48
, pp. 8325-8328
-
-
Taillemite, S.1
Aubert, C.2
Fichou, D.3
Malacria, M.4
-
16
-
-
22244477110
-
-
(b) Groth, U.; Huhn, T.; Kesenheimer, C.; Kalogerakis, A. Synlett 2005, 11, 1758-1760.
-
(2005)
Synlett
, vol.11
, pp. 1758-1760
-
-
Groth, U.1
Huhn, T.2
Kesenheimer, C.3
Kalogerakis, A.4
-
18
-
-
2442551867
-
-
(d) Chouraqui, G.; Petit, M.; Aubert, C.; Malacria, M. Org. Lett. 2004, 6, 1519-1522.
-
(2004)
Org. Lett
, vol.6
, pp. 1519-1522
-
-
Chouraqui, G.1
Petit, M.2
Aubert, C.3
Malacria, M.4
-
21
-
-
0141854215
-
-
Petit, M.; Chouraqui, G.; Aubert, C.; Malacria, M. Org. Lett. 2003, 5, 2037-2040.
-
(2003)
Org. Lett
, vol.5
, pp. 2037-2040
-
-
Petit, M.1
Chouraqui, G.2
Aubert, C.3
Malacria, M.4
-
24
-
-
0347983789
-
-
For similar examples of diyne cyclodimerization, see
-
(a) For similar examples of diyne cyclodimerization, see Kotha, S.; Brahmachary, E. J. Organomet. Chem. 2004, 689, 158-163.
-
(2004)
J. Organomet. Chem
, vol.689
, pp. 158-163
-
-
Kotha, S.1
Brahmachary, E.2
-
25
-
-
0037152562
-
-
(b) Shibata, T.; Yamashita, K.; Katayama, E.; Takagi, K. Tetrahedron 2002, 58, 8661-8668.
-
(2002)
Tetrahedron
, vol.58
, pp. 8661-8668
-
-
Shibata, T.1
Yamashita, K.2
Katayama, E.3
Takagi, K.4
-
26
-
-
0037134815
-
-
(c) Yamamoto, Y.; Takagishi, Y.; Hideyuki, T.; Itoh, K. J. Am. Chem. Soc. 2002, 124, 6844-6845.
-
(2002)
J. Am. Chem. Soc
, vol.124
, pp. 6844-6845
-
-
Yamamoto, Y.1
Takagishi, Y.2
Hideyuki, T.3
Itoh, K.4
-
27
-
-
0037149440
-
-
(d) Sugihara, T.; Wakabayashi, A.; Nagai, A.; Yasuku, N.; Takao, H.; Imagawa, H.; Nishizawa, M. Chem. Commun. 2002, 6, 576-577.
-
(2002)
Chem. Commun
, vol.6
, pp. 576-577
-
-
Sugihara, T.1
Wakabayashi, A.2
Nagai, A.3
Yasuku, N.4
Takao, H.5
Imagawa, H.6
Nishizawa, M.7
-
28
-
-
0000110406
-
-
(e) Yamamoto, Y.; Takaguchi, H.; Itoh, K. Org. Lett. 2001, 3, 2117-2120.
-
(2001)
Org. Lett
, vol.3
, pp. 2117-2120
-
-
Yamamoto, Y.1
Takaguchi, H.2
Itoh, K.3
-
29
-
-
0000199189
-
-
(f) Grigg, R.; Scott, R.; Stevenson, P. Tetrahedron Lett. 1982, 26, 2691-2692.
-
(1982)
Tetrahedron Lett
, vol.26
, pp. 2691-2692
-
-
Grigg, R.1
Scott, R.2
Stevenson, P.3
-
30
-
-
36649037489
-
-
a values stronger than AcOH resulted in cleavage of the silyl ether.
-
a values stronger than AcOH resulted in cleavage of the silyl ether.
-
-
-
-
31
-
-
0001342781
-
-
For early mechanistic studies consistent with Pd(II) as the active catalyst, see Trost, B. M.; Rise, F. J. Am. Chem. Soc. 1987, 109, 3161-3163.
-
For early mechanistic studies consistent with Pd(II) as the active catalyst, see Trost, B. M.; Rise, F. J. Am. Chem. Soc. 1987, 109, 3161-3163.
-
-
-
-
32
-
-
0028266112
-
-
A reductive cyclization-alkylation of 1,6-enynes where ring size is controlled by choice of ligand (dppp versus dmppp) has been described. Trost, B. M.; Zhi, L.; Imi, K. Tetrahedron Lett. 1994, 35, 1361-1364.
-
A reductive cyclization-alkylation of 1,6-enynes where ring size is controlled by choice of ligand (dppp versus dmppp) has been described. Trost, B. M.; Zhi, L.; Imi, K. Tetrahedron Lett. 1994, 35, 1361-1364.
-
-
-
-
34
-
-
0032481636
-
-
(b) Hayashi, T.; Kawatsura, M.; Uozumi, Y. J. Am. Chem. Soc. 1998, 120, 1681-1687.
-
(1998)
J. Am. Chem. Soc
, vol.120
, pp. 1681-1687
-
-
Hayashi, T.1
Kawatsura, M.2
Uozumi, Y.3
-
35
-
-
0001586814
-
-
In several reported cases, catalysts formed in the absence of phosphine ligands give optimal results. Ligandless conditions applied to the silyl ether substrates routinely gave complex product mixtures, suggesting a balance between catalyst stability and activity is necessary for this substrate class. See Trost, B. M.; Lee, D. C.; Rise, F. Tetrahedron Lett. 1989, 30, 651-654.
-
In several reported cases, catalysts formed in the absence of phosphine ligands give optimal results. Ligandless conditions applied to the silyl ether substrates routinely gave complex product mixtures, suggesting a balance between catalyst stability and activity is necessary for this substrate class. See Trost, B. M.; Lee, D. C.; Rise, F. Tetrahedron Lett. 1989, 30, 651-654.
-
-
-
-
36
-
-
36649037286
-
-
Alkynes bearing electron-deficient substituents should be less reactive toward the key hydridopalladium carboxlate species
-
Alkynes bearing electron-deficient substituents should be less reactive toward the key hydridopalladium carboxlate species.
-
-
-
-
37
-
-
3543125474
-
-
For an example of cycloaddition starting from a 1-substituted oxasilacyclopentene, see
-
For an example of cycloaddition starting from a 1-substituted oxasilacyclopentene, see: Clark, T. B.; Woerpel, K. A. J. Am. Chem. Soc. 2004, 126, 9522-9523.
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 9522-9523
-
-
Clark, T.B.1
Woerpel, K.A.2
-
38
-
-
4644352301
-
-
For an example of an enyne metathesis sequence yielding a mixture of the exo and endo adducts, see reference 19e. Maifeld, S. V.; Miller, R. L.; Lee, D. J. Am. Chem. Soc. 2004, 126, 12228-12229.
-
(a) For an example of an enyne metathesis sequence yielding a mixture of the exo and endo adducts, see reference 19e. Maifeld, S. V.; Miller, R. L.; Lee, D. J. Am. Chem. Soc. 2004, 126, 12228-12229.
-
-
-
-
39
-
-
21644464686
-
-
(b) Park, S.; Kim, M.; Lee, D. J. Am. Chem. Soc. 2005, 127, 9410-9415.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 9410-9415
-
-
Park, S.1
Kim, M.2
Lee, D.3
-
40
-
-
4143150671
-
-
(c) Kim, M.; Park, S.; Maifeld, S. V.; Lee, D. J. Am. Chem. Soc. 2004, 126, 10242-10243.
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 10242-10243
-
-
Kim, M.1
Park, S.2
Maifeld, S.V.3
Lee, D.4
-
41
-
-
4143116942
-
-
(d) Miller, R. L.; Maifeld, S. V.; Lee, D. Org. Lett. 2004, 6, 2773-2776.
-
(2004)
Org. Lett
, vol.6
, pp. 2773-2776
-
-
Miller, R.L.1
Maifeld, S.V.2
Lee, D.3
-
43
-
-
0037529216
-
-
(f) Gierasch, T. M.; Shi, Z.; Verdine, G. L. Org. Lett. 2003, 5, 621-624.
-
(2003)
Org. Lett
, vol.5
, pp. 621-624
-
-
Gierasch, T.M.1
Shi, Z.2
Verdine, G.L.3
-
44
-
-
0037078848
-
-
(g) Van de Weghe, P.; Aoun, D.; Boiteau, J-G.; Eustache. J. Org. Lett. 2002, 4, 4105-4108.
-
(2002)
Org. Lett
, vol.4
, pp. 4105-4108
-
-
Van de Weghe, P.1
Aoun, D.2
Boiteau, J.-G.3
Eustache, J.4
-
46
-
-
36649033219
-
-
Tricyclic silacycles of type IX were found to be unstable to silica gel and were chromatographed through 20 micron powdered cellulose. Silacyclic dienes of type V were unreactive towards most dienophiles at temperatures that did not incur decomposition of the diene.
-
Tricyclic silacycles of type IX were found to be unstable to silica gel and were chromatographed through 20 micron powdered cellulose. Silacyclic dienes of type V were unreactive towards most dienophiles at temperatures that did not incur decomposition of the diene.
-
-
-
-
47
-
-
33846842437
-
-
(a) Franz, A. K.; Dreyfuss, P. D.; Schreiber, S. L. J. Am. Chem. Soc. 2007, 129, 1020-1021.
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 1020-1021
-
-
Franz, A.K.1
Dreyfuss, P.D.2
Schreiber, S.L.3
-
48
-
-
8844221233
-
-
(b) Kim, Y-K.; Arai, M. A.; Arai, T.; Lamenzo, J. O.; Dean, E. F., III; Patterson, N.; Clemons, P. A.; Schreiber, S. L. J. Am. Chem. Soc. 2004, 126, 14740-14745.
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 14740-14745
-
-
Kim, Y.-K.1
Arai, M.A.2
Arai, T.3
Lamenzo, J.O.4
Dean III, E.F.5
Patterson, N.6
Clemons, P.A.7
Schreiber, S.L.8
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