Dietary long-chain n-3 fatty acids modify blood and cardiac phospholipids and reduce protein kinase-C-δ and protein kinase-C-ε translocation

British Journal of Nutrition

Volumn 98, Issue 6, 2007, Pages 1143-1151

  Judé, Sébastien ^a,b,c   Martel, Eric ^a   Vincent, Fanny ^c   Besson, Pierre ^b,c   Couet, Charles ^b,c   Ogilvie, Gregory K ^b,c   Pinault, Michelle ^b,c   De Chalendar, Catherine ^a   Bougnoux, Philippe ^b,c   Richard, Serge ^a   Champeroux, Pascal ^a   Crozatier, Bertrand ^c   Le Guennec, Jean Yves ^b,c  

^a CERB   (France)

^b UNIVERSITÉ DE TOURS   (France)

^c INSERM   (France)

Author keywords

Cardiac membrane phospholipids; Fish oils; Long chain n 3 fatty acids; Protein kinase C

Indexed keywords

DIACYLGLYCEROL; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; ISOPROTEIN; OMEGA 3 FATTY ACID; PALM OIL; PHOSPHOLIPID; PROTEIN KINASE C EPSILON; PROTEIN KINASE C GAMMA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DIETARY INTAKE; DOG; HEART MUSCLE FIBER MEMBRANE; LIPID COMPOSITION; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; DIETARY FATS, UNSATURATED; DIETARY SUPPLEMENTS; DOGS; FATTY ACIDS, OMEGA-3; FISH OILS; MALE; MYOCARDIUM; PHOSPHOLIPIDS; PLANT OILS; PROTEIN KINASE C-DELTA; PROTEIN KINASE C-EPSILON; RANDOM ALLOCATION;

CANIS FAMILIARIS; MAMMALIA;

EID: 36649003474     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507798914     Document Type: Article

References (36)

1. Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9, 484-496.
2. Newton AC (2001) Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101, 2353-2364.
3. Puceat M, Hilal-Dandan R, Strulovici B, Brunton LL & Brown JH (1994) Differential regulation of protein Idnase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem 269, 16938-16944.
4. Rohde S, Sabri A, Kamasamudran R & Steinberg SF (2000) The α(1)-adrenoceptor subtype- and protein kinase C isoform-dependence of norepinephrine's actions in cardiomyocytes. J Mol Cell Cardiol 32, 1193-1209.
5. Wang L, Rolfe M & Proud CG (2003) Ca(2+)4ndependent protein kinase C activity is required for α1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. Biochem J 373, 603-611.
6. Korzick DH, Holiman DA, Boluyt MO, Laughlin MH & Lakatta, EG (2001) Diminished α1-adrenergic-mediated contraction and translocation of PKC in senescent rat heart. Am J Physiol Heart Circ Physiol 281, H581-H589.
7. Lanson M, Besson P & Bougnoux P (1997) Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. J Lipid Mediat Cell Signal 16, 189-197.
8. Seung Kim HF, Weeber EJ, Sweatt JD, Stoll AL & Marangell LB (2001) Inhibitory effects of ω-3 fatty acids on protein kinase, C activity in vitro. Mol Psychiatry 6, 246-248.
9. Madani S, Hicharni A, Legrand A, Belleville J & Khan NA (2001) Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J 15, 2595-2601.
10. Hichami A, Morin C, Rousseau E & Khan NA (2005) Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone. Am J Respir Cell Mol Biol 33, 378-386.
11. Fan YY, Ly LH, Barhoumi R, McMurray DN & Chapkin RS (2004) Dietary docosahexacnoic acid suppresses T cell protein kinase C θ lipid raft recruitment and IL-2 production. J Immunol 173, 6151-6160.
12. Denys A, Hichami A & Khan NA (2005) n-3 PUFAs modulate T-cell activation via protein kinase C-α and -ε and the NF-κB signaling pathway. J Lipid Res 46, 752-758.
13. Kurz T, Schneider I, Tolg R & Richardt G (1999) α 1-Adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart. Cardiovasc Res 42, 48-56.
14. Haan GJ, van der Heide S & Wolthers BG (1979) Analysis of fatty acids from human lipids by gas chromatography. J Chromatogr 162, 261-271.
15. Detmer A, Carter AM & Thomas CR (1992) The metabolism of free fatty acids and triacylglycerols by the fetal liver in a guinea pig model of intrauterine growth retardation. Pediatr Res 32, 441-446.
16. Rose HG & Oklander M (1965) Improved procedure for the extraction of lipids from human erythrocytes. J Lipid Res 6, 428-431.
17. Folch J, Lees M & Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497-509.
18. Rouet-Benzineb P, Mohammadi K, Perennec J, Poyard M, Bouanani Nel H & Crozatier B (1996) Protein kinase C isoform expression in normal and failing rabbit hearts. Circ Res 79, 153-161.
19. Hansen RA, Ogilvie GK, Davenport DJ, Gross KL, Walton JA, Richardson KL, Mallinckrodt CH, Hand MS & Fettman MJ (1998) Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. Am J Vet Res 59 864-868.
20. von Schacky C & Weber PC (1985) Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest 76, 2446-2450.
21. Murphy MG, Wright V, Ackman RG & Horackova M (1997) Diets enriched in menhaden fish oil, seal oil, or shark liver oil have distinct effects on the lipid and fatty-acid composition of guinea pig heart. Mol Cell Biochem 177, 257-269.
22. Rousseau D, Helies-Toussaint C, Moreau D, Raederstorff D & Grynberg A (2003) Dietary n-3 PUFAs affect the blood pressure rise and cardiac'impairments in a hyperinsulinemia rat model in vivo. Am J Physiol Heart Circ Physiol 285, H1294-HI302.
23. Peter-Riesch B, Fathi M, Schlegel W & Wollheim CB (1988) Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. J Clin Invest 81, 1154-1161.
24. Exton JH (1990) Signaling through phosphatidy1choline break-down. J Biol Chem 265, 1-4.
25. Berridge MJ (1987) Inositol trisphosphate and diacylglycerol: Two interacting second messengers. Annu Rev Biochem 56, 159-193.
26. Kiss Z & Anderson WB (1990) ATP stimulates the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells. Potentiating effects of guanosine triphosphates and sphingosine. J Biol Chem 265, 7345-7350.
27. Griendling KK, Rittenhouse SE, Brock TA, Ekstein LS, Gimbrone MA Jr & Alexander RW (1986) Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem 261, 5901-5906.
28. Wright TM, Rangan LA, Shin HS & Raben DM (1988) Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by α-thrombin and epidermal growth factor. J Biol Chem 263, 9374-9380.
29. Eskildsen-Helmond YE, Hahnel D, Reinhardt U, Dekkers DH, Engelmann B & Lamers JM (1998) Phospholipid source and molecular species composition of 1,2-diacylglycerol in agonist-stimulated rat cardiomyocytes. Cardiovasc Res 40, 182-190.
30. Lamers JM, De Jonge HW, Panagia V & Van Heugten HA (1993) Receptor-mediated signalling pathways acting through hydrolysis of membrane phospholipids in cardiomyocytes. Cardioscience 4, 121-131.
31. Gudbjamason S & Hallgrimsson J (1976) The role of myocardial membrane lipids in the development of cardiac necrosis. Acta Med Scand Suppl 587, 17-27.
32. Bougnoux P (1999) n-3 Polyunsaturated fatty acids and cancer. Curr Opin Clin Nutr Metab Care 2, 121-126.
33. Judé S, Roger S, Martel E, Besson P, Richard S, Bougnoux P, Champeroux P & Le Guennec JY (2006) Dietary long-chain ω-3 fatty acids of marine origin: A comparison of their protective effects on coronary heart disease and breast cancers. Prog Biophys Mol Biol 90, 299-325.
34. Debies MT & Welch DR (2001) Genetic basis of human breast cancer metastasis. J Mammary Gland Biol Neoplasia 6, 441-451.
35. Inagaki K, Hahn HS, Dorn GW II & Mochly-Rosen D (2003) Additive protection of the ischemic heart ex vivo by combined treatment with δ-protein kinase C inhibitor and ε-protein kinase C activator. Circulation 108, 869-875.
36. Chen L, Hahn H, Wu G, et al. (2001) Opposing cardioprotective actions and parallel hypertrophic effects of δ PKC and ε PKC. Proc Natl Acad Sci USA 98, 11114-11119.