Modification of a reactive cysteine explains differences between rasburicase and Uricozyme®, a natural Aspergillus flavus uricase

Biotechnology and Applied Biochemistry

Volumn 36, Issue 1, 2002, Pages 21-31

  Bayol, Alain ^a   Capdevielle, Joël ^a   Malazzi, Pascal ^a   Buzy, Armelle ^a   Bonnet, Marie Claude ^a   Colloc'h, Nathalie ^a   Mornon, Jean Paul ^a   Loyaux, Denis ^a   Ferrara, Pascual ^a  

^a SANOFI   (France)

Author keywords

Cysteine adduct; Mass spectrometry; Reverse phase chromatography; Zymogram

Indexed keywords

CHEMOTHERAPY; CHROMATOGRAPHIC ANALYSIS; CRYSTAL STRUCTURE; ORGANIC ACIDS;

CYSTENE ADDUCT;

ENZYMES;

CYSTEINE; RASBURICASE; URATE OXIDASE; URICOZYME;

ARTICLE; ASPERGILLUS FLAVUS; CHROMATOGRAPHY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MODIFICATION; ENZYME PURIFICATION; GENE EXPRESSION; POLYACRYLAMIDE GEL ELECTROPHORESIS; SACCHAROMYCES CEREVISIAE; URIC ACID BLOOD LEVEL;

ASPERGILLUS FLAVUS; CYSTEINE; ENZYME ACTIVATION; QUALITY CONTROL; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; URATE OXIDASE;

ASPERGILLUS; ASPERGILLUS FLAVUS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036347379     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20010083     Document Type: Article

References (10)