Recent advances in molecular biology of leprosy

Indian Journal of Leprosy

Volumn 79, Issue 2-3, 2007, Pages 151-166

  Katoch, Vishwa Mohan ^a   Lavania, M ^b   Chauhan, D S ^b   Sharma, R ^b   Hirawati, ^b   Katoch, K ^b  

^a NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES   (India)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CLOFAZIMINE; DAPSONE; ETHAMBUTOL; ISONIAZID; OFLOXACIN; PYRAZINAMIDE; RIBOSOME RNA; RIFAMPICIN;

ANTIBACTERIAL ACTIVITY; BACTERIAL GENOME; BACTERIAL SURVIVAL; BACTERIAL TRANSMISSION; COMBINATION CHEMOTHERAPY; DRUG DNA BINDING; GENE AMPLIFICATION; GENE EXPRESSION; GENE PROBE; GENE SEQUENCE; GENE STRUCTURE; HUMAN; LEPROSY; MISSENSE MUTATION; MOLECULAR BIOLOGY; MOLECULAR EPIDEMIOLOGY; MOLECULAR GENETICS; MYCOBACTERIOSIS; MYCOBACTERIUM LEPRAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATIENT COMPLIANCE; POLYMERASE CHAIN REACTION; PREVALENCE; REVIEW; SKIN BIOPSY;

DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; HUMANS; LEPROSY; MYCOBACTERIUM LEPRAE; POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL;

EID: 36448965691     PISSN: 02549395     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (101)

1. Booth RJ, Harris DP, Love JM, Watson JE (1988). Antigenic proteins of M. leprae. Complete sequence of gene for 18 kDa protein. J Immunol 140: 597-601
2. Cambau E, Carthagena L, Chauffour A, et al (2006). Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy. Clin Infect Dis 42: 238-41
3. Cambau E, Sougakoff W, Jarlier V (1994). Amplification and nucleotide sequence of the quinolone resistance-determining region in the gyrA gene of mycobacteria. FEMS Microbiol Lett. 116: 49-54
4. Clark-Curtiss JE, Docherty MA (1989). A species specific sequence in Mycobacterium leprae DNA. J Infect Dis 159: 7-15
5. Clark-Curtiss JE, Jacobs WR, Docherty MA, et al (1985). Molecular analysis of DNA and construction of genomic libraries of Mycobacterium leprae. J Bacteriol 161: 1093-1102
6. Cole ST, Eiglmeier K, Parkhill J, et al (2001). Massive gene decay in the leprosy bacillus. Nature 409: 1007-11
7. Cole ST, Supply P, Honore N (2001). Repetitive sequences in Mycobacterium leprae and their impact on genome plasticity. Lepr Rev 72: 449-61
8. Cox RA, Kempsell K, Fairclough L, et al (1991) The 16S ribosomal RNA of Mycobacterium leprae contains a unique sequence which can be used for identification by polymerase chain reaction. J Gen Microbiol 30: 284-90
9. Dawes SS, Mizrahi V (2001). DNA metabolism in Mycobacterium leprae. Lepr Rev. 72: 408-14
10. Davey TF, Schenck RR (1964). The endocrines in leprosy. In R.G. Cochrane, T.F. Davey (ed.), Leprosy in theory and practice. Bristol: John Wright and Sons, Ltd. p. 198
11. Dhandayuthapani S, Mudd M, Deretic V (1997). Interactions of OxyR with promoter region of Oxy R and ahpC gene of Mycobacterium leprae and M. tuberculosis. J Bacteriol 179: 2401-9
12. Dharmendra (1994). Classifications of leprosy. In: Leprosy (Hastings RC, ed.). London, Churchill Livingstone. pp. 179-90
13. Dharmendra, Chaterjee SN (1978). Examination for Mycobacterium leprae. In: Dharmendra (Ed.). Leprosy. Vol. I. Bombay: Kothari Medical Publishing House. pp 258-62
14. Dockrell HM, Stocker NG, Lee SP, et al (1979). T-cell recognition of the 18 kilodalton mycobacterial antigen. Infect Immun 57: 1979-83
15. Donoghue HD, Holton J, Spigelman M (2001). PCR primers that can detect low levels of Mycobacterium leprae DNA. J Med Microbiol 50: 177-82
16. Draper P (1982). The anatomy of M. leprae. In: Ratledge C, Standford JL (Ed.) The biology of mycobacteria. Vol I. London: Academic Press. pp 9-52.
17. Drlica K, Xu C, Wang JY, et al (1996). Fluoroquinolone action in mycobacteria: similarity with effects in Escherichia coli and detection by cell lysate viscosity. Antimicrob Agents Chemother 40: 1594-9
18. Ebenezer GJ, Norman G, Joseph GA, et al (2002). Drug resistant- Mycobacterium leprae - results of mouse footpad studies from a laboratory in south India. Indian J Lepr. 74: 301-12
19. Eiglmeier K, Parkhill J, Honore N, et al (2001). The decaying genome of Mycobacterium leprae. Lepr Rev 72: 387-98
20. Fsihi H, Cole ST (1995). The Mycobacterium leprae genome; systematic sequence analysis identifies key catabolic enzymes, ATP dependent transport system and a novel pol (A) locus associated with genomic variability. Mol Microbiol 16: 909-19
21. Fsihi H, De Rossi E, Salazar L, et al (1996). Gene arrangement and organisation in a 76kb fragment encompassing the oriC region of chromosome of Mycobacterium leprae. Microbiol 142: 3147-61
22. Groathouse NA, Rivoire B, Kim H, et al (2004). Multiple polymorphic loci for molecular typing of strains of Mycobacterium leprae. J Clin Microbiol 42: 1666-72
23. Grosset JH, Cole ST (2001). Genomics and the chemotherapy of leprosy. Lepr Rev 72: 429-40
24. Gupta UD, Katoch K, Sharma RK, et al (2001). Analysis of quantitative relationship between viability determination in leprosy by MFP, ATP bioluminescence and gene amplification assays. Int J Lepr and Other Mycobact Dis 69: 328-34
25. Gupta UD, Katoch VM (1997). Understanding the phenomenon of persistence in mycobacterial infections. Indian J Lepr 69: 385-93
26. Hackel C, Hourd S, Portaels F, et al (1990). Specific identification of Mycobacterium leprae by polymerase chain reaction. Mol Cell Probes 4: 205-210.
27. Hartskeerl RA, de Wit MYL, Klatser PR (1989). Polymerase chain reaction for the detection of Mycobacterium leprae. J Gen Microbiol 135: 2357-64
28. Honore N, Cole ST (1993). Molecular basis of rifampin resistance in Mycobacterium leprae. Antimicrob Agents Chemother 37: 414-8
29. Honore N, Cole ST (2001). A method for rapid detection of rifampicin-resistant isolates of Mycobacterium leprae. Lepr Rev 72: 441-8
30. Ilangumaran S, Shankaranarayna NP, Ramu G, et al (1994). Antibody responses to recombinant 65kDa, 70kDa and 18kDa mycobacterial antigens in leprosy patients and healthy contacts. Int J Lepr and Other Mycobact Dis 62: 245-55
31. Jadhav RS, Kamble RR, Shinde VS, et al (2005). Use of reverse transcription polymerase chain reaction for the detection of Mycobacterium leprae in the slit-skin smears of leprosy patients Indian J Lepr 77: 116-27
32. Ji B, Perani EG, Petinom C, et al (1994). Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy. Antimicrob Agents Chemother 38: 662-7
33. Ji B, Sow S, Perani E, et al (1998). Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients. Antimicrob Agents Chemother 42: 1115-20
34. Katoch VM (1997). Mechanisms of drug resistance in mycobacteria. In: Singhal RI, Sood OP (Ed). Drug resistance: mechanisms and management. Proc IV Annual Ranbaxy Symposium. New Delhi: Communicore: 1997. pp 41-7
35. Katoch VM (1998). New investigative techniques in leprosy. In: Dermatology Update Valia, RG Valia, AR (Ed). Mumbai (India): Bhalani Publishing House. pp. 165-74
36. Katoch VM (2002). Advances in the diagnosis and treatment of leprosy. Expert Rev Mol Med 22: 1-14
37. Katoch VM, Kanaujia GV, Shivannavar CT, et al (1994). Progress in developing ribosomal RNAS and rRNA gene(s) based probes for the diagnosis and epidemiology of infectious diseases including leprosy. In: Kumar S, Sen AK, Dutta GP, Sharma RN (Ed). Trop Dis Mol Biol Control Start. New Delhi: CSIR. pp: 581-7
38. Katoch VM, Kanaujia GV, Shivannavar CT, et al (1992). Ribosomal RNA gene(s) based probes for early diagnosis and epidemiology of leprosy. Quad Di Co-oper San N-12: 163-6
39. Katoch VM, Shivannavar CT, Datta AK (1989). Studies on ribosomal RNA genes of mycobacteria including M. leprae. Acta Leprol 7: 231-3
40. Khandekar PS, Munshi A, Sinha S, et al (1986). Construction of genomic libraries of mycobacterial origin; identification of recombinants encoding mycobacterial specific protein. Int J Lepr and Other Mycobact Dis 54: 416-21
41. Kim SK, Lee SB, Kang TJ, et al (2003). Detection of gene mutations related with drug resistance in Mycobacterium leprae from leprosy patients using Touch-Down (TD) PCR. FEMS Immunol Med Microbiol 36: 27-32
42. Kramme S, Bretzel G, Panning M, et al (2004). Detection and quantification of Mycobacterium leprae in tissue samples by real time PCR. Med Microbiol Immunol 193: 189-93
43. Kumar A, Girdhar A, Yadav VS, et al (2003). Epidemiology of leprosy in urban Agra, India. Lepr Rev 74: 31-4
44. Kulkarni VM, Seydel JK. (1983). Inhibitory activity and mode of action of diaminodiphenylsulfone in cell-free folate-synthesizing systems prepared from Mycobacterium lufu and Mycobacterium leprae: A comparison. Chemother 29: 58-67
45. Lamb FI, Kingston AE, Iris-Estrada G, et al (1988). Heterologous expression of the 65kDa antigen of Mycobacterium leprae and murine T-cell responses to the gene product. Infect Immun 56: 1237-41
46. Lamichhane G, Tyagi S, Bishai WR (2005). Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs. Infect Immun 73: 2533-40
47. Lavania M, Katoch VM, Singh HB, et al (2005). Genetic polymorphism among Mycobacterium leprae strains from Northern India using TTC repeats. Indian J Lepr 77: 60-5
48. Levy L, Shepard CC, Fasal P (1976). The bactericidal effect of rifampicin on M. leprae in man: (a) single doses of 600, 900 and 1200 mg; and (b) daily doses of 300 mg. Int J Lepr Other Mycobact Dis 44: 183-7
49. Martinez AN, Britto FPCC, Nery JAC, et al (2006). Evaluation of real time and conventional PCR targeting complex 85 genes for detection of Mycobacteium leprae DNA in skin biopsy samples from patients diagnosed with leprosy. J Clin Microbiol 44: 3154-9
50. Matsuoka M, Maeda S, Kai M, et al (2000). Mycobacterium leprae typing by genomic diversity and global distribution of genotypes. Int J Lepr Other Mycobact Dis 68: 121-8
51. Matsuoka M, Zhang L, Fafutis Morris M, et al (2005). Polymorphism in the rpoT gene in Mycobacterium leprae isolates obtained from Latin American countries and its possible correlation with the spread of leprosy. FEMS Microbiol Letts 243: 311-5
52. McFadden J, Kunze Z, Seechum P (1990). DNA probes for detection and identification. In: McFadden J (Ed.). Molecular biology of mycobacteria. Survey: Surrey University Press. pp 139-72
53. Mehra V, Sweetser D, Young R (1986). Efficient mapping of protein antigenic determinants. Proc Natl Acad Sci USA 83: 7013-7
54. Misra N, Ramesh V, Misra RS, et al (1995). Clinical activity of LSR/A 15 gene for Mycobacterium leprae detection in leprosy using polymerase chain reaction. Int J Lepr Other Mycobact Dis 63: 35-41
55. Monot M, Honore N, Garnier T, et al (2005). On the origin of leprosy. Science 308: 1040-2
56. Musser JM (1995). Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin Microbiol Rev 8: 496-514
57. Mustafa AS, Gill HK, Nerland A, et al (1986). Human T cells recognise a major M. leprae protein antigen expressed in E. coli. Nature 319: 63-6
58. Naafs B (2000). Viewpoint: leprosy after the year 2000. Trop Med Int Health 5: 400-3
59. Nakata N, Matsuoka M, Kashiwabara Y, et al (1997). Nucleotide sequence of the Mycobacterium leprae katG region. J Bacteriol 179: 3053-7
60. Natrajan M, Katoch K, Katoch VM, et al (2004). In situ hybridization in the histodiagnosis of early and clinically suspicious leprosy. Int J Lepr and Other Mycobact Dis 72: 296-305
61. Oftung F, Lundin KE, Meloen R, et al (1999). Human T-cell recognition of the Mycobacterium leprae LSR antigen: epitopes and HLA restriction. FEMS Immunol Med Microbiol. 24: 151-9
62. Oftung F, Mustafa AS, Wiker HG. (2000). Extensive sequence homology between the Mycobacterium leprae LSR (12kDa) antigen and its Mycobacterium tuberculosis counterpart. FEMS Immunol Med Microbiol 27: 87-9
63. Oskam L, Hartskeerl RA, Hermans CJ, et al (1995). A 46kDa integral membrane protein for Mycobacterium leprae resembles a number of bacterial and mammalian membrane target proteins. Microbiol 141: 1963-8
64. Pattyn SR, Uris D, Iven M, et al (1992). Polymerase chain reaction amplifying DNA coding for species specific rRNA of Mycobacterium leprae. Int J Lepr 60: 234-43
65. Pessolani MCV, Brennan PJ (1996). Molecular definition and identification of new proteins of Mycobacterium leprae. Infect Immun 64: 5425-7
66. Phetsuksiri B, Rudeeaneksin J, Supapkul P, et al (2006). A simplified reverse transcriptase PCR for rapid detection of Mycobacterium leprae in skin specimens. FEMS Immunol Med Microbiol 48: 319-28
67. Pitulle D, Witt D, Stackebrandt E, et al (1990). Further evidence for the exclusiveness of the Mycobacterium leprae specific probe. Int J Lepr and Other Mycobact. Dis 58: 130-3
68. Plikaytis BB, Gelber RH, Shinnick TM (1990). Rapid and sensitive detection of Mycobacterium leprae using nested primer gene amplification assay. J Clin Microbiol 28: 1913-7
69. Praputpittaya K, Ivanyi J (1987). Study of idiotypes expressed by monoclonal antibodies to the 35kD and 12 kD antigens of Mycobacterium leprae. Clin Exp Immun 70: 298-306
70. Rengarajan J, Bloom BR, Rubin EJ (2005). Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci USA 102: 8327-32
71. Ridley DS (1964). Bacterial indices. In: Cochrane RG, Davey TF (Ed.). Leprosy in theory and practice. Bristol: John Wright and Sons. pp: 620-2
72. Sharma RK, Katoch K, Sharma VD, et al (1995). Isolation and characterization of cultivable mycobacteria from leprosy skin. Indian J Lepr 67: 321-8
73. Sharma RK, Katoch K, Shivannavar CT, et al (1996). Detection of M. leprae by gene amplification-ethidium bromide staining and hybridization. Int J Lepr and Other Mycobact Dis 64: 409-16
74. Sharma RK, Katoch VM, Katoch K, et al (1996). Comparison of probes targeting ribosomal RNA vs DNA in leprosy cases. Indian J Med Microbiol 14: 99-104
75. Sharma RK, Shivannavar CT, Katoch K, et al (1997). Microdensitometric scanning procedure for quantitative assessment of hybridization of rRNA targeting probes in leprosy. Acta Leprol 10: 213-7
76. Shepard CC (1960) The experimental disease that follows the injection of human leprosy bacilli into foot pads of mice. J Exp Med 112: 445-54
77. Shin YC, Lee H, Lee H, et al (2000). Variable numbers of TTC repeats in Mycobacterium leprae DNA from leprosy patients and use in strain differentiation. J Clin Microbiol 38: 4535-8
78. Singh HB, Katoch VM, Natrajan M, et al (2004). Improved protocols for PCR detection of Mycobacterium leprae in buffered formalin fixed skin biopsies Int J Lepr and Other Mycobact Dis 72: 175-8
79. Singh S, Shankaranarayan NP, Jenner PJ, et al (1994). Sera of leprosy patients with type 2 reactions recognize sequences in Mycobacterium leprae recombinant LSR protein, Infect Immun 62: 86-90
80. Stackebrandt E, Smida J, Kazda J (1989). The primary structure of 16S rRNA of Mycobacterium leprae: its use in phylogeny and development of DNA probes. Acta Leprol 7: 222-5
81. Stewart-Tull DES (1982). Mycobacterium leprae, the bacteriologists enigma. In: Ratledge C, Stanford JL (Ed.). The biology of mycobacteria. Vol. I. London: Academic Press. pp: 273-307
82. Takiff HE, Salazar L, Guerrero C, et al (1994). Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrob Agents Chemother 38: 773-80
83. Telenti A, Imboden P, Marchesi F, et al (1993). Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 341: 647-50
84. Teske A, Walters J, Botter EC (1991). The 16S rRNA nucleotide sequence of Mycobacterium leprae: phylogenetic position and development of DNA probes. FEMS Microbiol Lett 64: 231-3
85. Thangaraj HS, Lamb FI, Davis EO, et al (1990). Identification, sequencing and expression of Mycobacterium leprae superoxide dismutase, a major antigen. Infect Immun 58: 1937-42
86. Thole JER, Stabel FEM, Suykerbuyk MEG, et al (1990). A major immunogenic 36,000 molecular weight antigen from Mycobacterium leprae contains an immunoreactive region of proline-rich repeats. Infect Immun 58: 80-7
87. Truman R, Fontes AB, de Miranda AB, et al (2004). Genotypic variation and stability of four variable-number tandem repeats and their suitability for discriminating strains of Mycobacterium leprae. J Clin Microbiol 42: 2558-65
88. Vega-Lopez F, Stoker NG, Lackniskar MF, et al (1988). Recognition of mycobacterial antigen by sera from patients with leprosy. J Clin Microbiol 26: 2474-9
89. Wheeler PR (2001). The microbial physiologist's guide to the leprosy genome. Lepr Rev 72: 399-407
90. WHO (2006). World Health Organization Representative to India. Leprosy Situation in India. www.whoindia.org/CDS/CD/Leprosy/Nov/Lep-Nov-05.htm (accessed on 14th Nov 2006).
91. Wieles B, Ottenhof THM, Steenwijk TM, et al (1997). Increased intracellular survival of Mycobacterium smegmatis containing Mycobacterium leprae thioredoxin reductase gene. Infect Immun 65: 2537-41
92. Wieles B, Spierings E, van Noort J, et al (1995). Molecular characterization and T cell stimulatory capacity of Mycobacterium leprae antigen T5. Infect Immun 63: 4682-5
93. Williams DL, Gillis TP, Portaels F (1990). Geographically distinct isolates of Mycobacterium leprae exhibit no genotypic diversity by restriction fragment-length polymorphism analysis. Mol Microbiol 4: 1653-9
94. Williams DL, Spring L, Harris E, et al (2000). Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance. Antimicrob Agents Chemother 44: 1530-7
95. Williams DL, Torrero M, Wheeler PR, et al (2004). Biological Implications of Mycobacterium leprae gene expression during infection. J Mol Microbiol Biotechnol 8: 58-72
96. Williams DL, Waguespack C, Eisenach K, et al (1994). Characterization of rifampin resistance in pathogenic mycobacteria. Antimicrob Agents Chemother 38: 2380-6
97. Woods SA, Cole ST (1989). A rapid method for detection of potentially viable Mycobacterium leprae in human biopsies: a novel application of PCR. FEMS Microbiol Lett 65: 305-10
98. Young DB, Gaebe T, Lathigra R, et al (1990). Protein antigens: structure, function and regulation. In: McFadden JJ (Ed.) Molecular biology of mycobacteria. Surrey: Surrey University Press. pp: 1-35
99. Young RA, Mehra V, Sweetser O, et al (1985). Genes for major protein antigens of leprosy parasite Mycobacterium leprae. Nature 316: 450-2
100. Young SK, Taylor GM, Jain S, et al (2004). Microsatellite mapping of Mycobacterium leprae populations in infected humans. J Clin Microbiol 42: 4931-6
101. Zhang L, Namisato M, Matsuoka M. (2004). A mutation at codon 516 in the rpoB gene of Mycobacterium leprae confers resistance to rifampin. Int J Lepr Other Mycobact Dis 72: 468-72