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Volumn 24, Issue 2, 1999, Pages 151-159

Human T cell recognition of the Mycobacterium leprae LSR antigen: Epitopes and HLA restriction

Author keywords

LSR antigen; Major histocompatibility complex restriction; Mycobacterium leprae; T cell epitope

Indexed keywords

CD4 ANTIGEN; EPITOPE; HLA DR ANTIGEN;

EID: 0032940593     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(99)00018-8     Document Type: Article
Times cited : (10)

References (40)
  • 1
    • 0023039277 scopus 로고
    • Learning from leprosy: A perspective on immunity and the third world
    • Bloom, B.R. (1986) Learning from leprosy: A perspective on immunity and the third world. J. Immunol. 137, i-x.
    • (1986) J. Immunol. , vol.137
    • Bloom, B.R.1
  • 2
    • 0018196950 scopus 로고
    • Immunological aspects of leprosy - present status
    • Godal, T. (1978) Immunological aspects of leprosy - present status. Prog. Allergy 25, 211-216.
    • (1978) Prog. Allergy , vol.25 , pp. 211-216
    • Godal, T.1
  • 3
    • 0022066521 scopus 로고
    • Results of a World Health Organization-sponsored workshop on monoclonal antibodies to Mycobacterium leprae
    • Engers, H.D., Abe, M., Bloom, B.R. et al. (1985) Results of a World Health Organization-sponsored workshop on monoclonal antibodies to Mycobacterium leprae. Infect. Immun. 48, 603-607.
    • (1985) Infect. Immun. , vol.48 , pp. 603-607
    • Engers, H.D.1    Abe, M.2    Bloom, B.R.3
  • 4
    • 0022656049 scopus 로고
    • Results of a World Health Organization-sponsored workshop to characterize antigens recognized by mycobacteria specific monoclonal antibodies
    • Engers, H.D., Houba, V., Bennedsen, J. et al. (1986) Results of a World Health Organization-sponsored workshop to characterize antigens recognized by mycobacteria specific monoclonal antibodies. Infect. Immun. 51, 718-723.
    • (1986) Infect. Immun. , vol.51 , pp. 718-723
    • Engers, H.D.1    Houba, V.2    Bennedsen, J.3
  • 5
    • 0344866667 scopus 로고
    • Monoclonal antibodies against mycobacterial antigens
    • Engers, H.D., Bloom, B.R. and Godal, T. (1985) Monoclonal antibodies against mycobacterial antigens. Immunol. Today 6, 345-346.
    • (1985) Immunol. Today , vol.6 , pp. 345-346
    • Engers, H.D.1    Bloom, B.R.2    Godal, T.3
  • 8
    • 0023108068 scopus 로고
    • Human T-cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in E. coli
    • Oftung, F., Mustafa, A.S., Husson, R., Young, R.A. and Godal, T. (1987) Human T-cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in E. coli. J. Immunol. 138, 927-931.
    • (1987) J. Immunol. , vol.138 , pp. 927-931
    • Oftung, F.1    Mustafa, A.S.2    Husson, R.3    Young, R.A.4    Godal, T.5
  • 9
    • 0022548339 scopus 로고
    • A recombinant 64 kilodalton protein of Mycobacterium bovis Bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens
    • Emmerich, F., Thole, J., van Embden, J. and Kaufmann, S.H.E. (1986) A recombinant 64 kilodalton protein of Mycobacterium bovis Bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. J. Exp. Med. 163, 1024-1029.
    • (1986) J. Exp. Med. , vol.163 , pp. 1024-1029
    • Emmerich, F.1    Thole, J.2    Van Embden, J.3    Kaufmann, S.H.E.4
  • 10
    • 0023677559 scopus 로고
    • Identification of T-cell activating recombinant antigens shared among three candidate antileprosy vaccines, killed M. leprae, M. bovis BCG, and Mycobacterium w
    • Mustafa, A.S. (1988) Identification of T-cell activating recombinant antigens shared among three candidate antileprosy vaccines, killed M. leprae, M. bovis BCG, and Mycobacterium w. Int. J. Lepr. 50, 265-273.
    • (1988) Int. J. Lepr. , vol.50 , pp. 265-273
    • Mustafa, A.S.1
  • 11
    • 0025746629 scopus 로고
    • A systematic molecular analysis of the T-cell-stimulating antigens from Mycobacterium leprae with T-cell clones of leprosy patients. Identification of a novel M. leprae HSP70 fragment by M. leprae specific T-cells
    • Janson, A.A.M., Klatser, P.R., van der Zee, R., Cornelisse, Y.E., de Vries, R.R.P., Thole, J. and Ottenhoff, T.H.M. (1991) A systematic molecular analysis of the T-cell-stimulating antigens from Mycobacterium leprae with T-cell clones of leprosy patients. Identification of a novel M. leprae HSP70 fragment by M. leprae specific T-cells. J. Immunol. 147, 3530-3537.
    • (1991) J. Immunol. , vol.147 , pp. 3530-3537
    • Janson, A.A.M.1    Klatser, P.R.2    Van Der Zee, R.3    Cornelisse, Y.E.4    De Vries, R.R.P.5    Thole, J.6    Ottenhoff, T.H.M.7
  • 13
    • 0030682524 scopus 로고    scopus 로고
    • A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins
    • Oftung, F., Wiker, H.G., Deggerdal, A. and Mustafa, A.S. (1997) A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins. Scand. J. Immunol. 46, 445-451.
    • (1997) Scand. J. Immunol. , vol.46 , pp. 445-451
    • Oftung, F.1    Wiker, H.G.2    Deggerdal, A.3    Mustafa, A.S.4
  • 14
    • 0026100623 scopus 로고
    • Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T cell responses across the leprosy spectrum
    • Laal, S., Sharma, Y.D., Prasad, H.K., Murtaza, A., Singh, S., Tangri, S., Mishra, S. and Nath, I. (1991) Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T cell responses across the leprosy spectrum. Proc. Natl. Acad. Sci. USA 88, 1054-1058.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1054-1058
    • Laal, S.1    Sharma, Y.D.2    Prasad, H.K.3    Murtaza, A.4    Singh, S.5    Tangri, S.6    Mishra, S.7    Nath, I.8
  • 15
    • 0025988313 scopus 로고
    • Identification of Mycobacterium leprae antigens from a cosmid library: Characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients
    • Sela, S., Thole, J.E.R., Ottenhoff, T.H.M. and Clark-Curtiss, J.E. (1991) Identification of Mycobacterium leprae antigens from a cosmid library: Characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients. Infect. Immun. 59, 4117-4124.
    • (1991) Infect. Immun. , vol.59 , pp. 4117-4124
    • Sela, S.1    Thole, J.E.R.2    Ottenhoff, T.H.M.3    Clark-Curtiss, J.E.4
  • 16
    • 0028120801 scopus 로고
    • Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein
    • Singh, S., Shankar Narayan, N.P., Jenner, P.J., Ramu, G., Colston, M.J., Prasad, H.K. and Nath, I. (1994) Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein. Infect. Immun. 62, 86-90.
    • (1994) Infect. Immun. , vol.62 , pp. 86-90
    • Singh, S.1    Shankar Narayan, N.P.2    Jenner, P.J.3    Ramu, G.4    Colston, M.J.5    Prasad, H.K.6    Nath, I.7
  • 17
    • 0027960205 scopus 로고
    • Critical residues of the Mycobacterium leprae LSR recombinant protein discriminate clinical activity in erythema nodosum leprosum reactions
    • Singh, S., Jenner, P.J., Shankar Narayan, N.P., Ramu, G., Colston, M.J., Prasad, H.K. and Nath, I. (1994) Critical residues of the Mycobacterium leprae LSR recombinant protein discriminate clinical activity in erythema nodosum leprosum reactions. Infect. Immun. 62, 5702-5705.
    • (1994) Infect. Immun. , vol.62 , pp. 5702-5705
    • Singh, S.1    Jenner, P.J.2    Shankar Narayan, N.P.3    Ramu, G.4    Colston, M.J.5    Prasad, H.K.6    Nath, I.7
  • 18
    • 0023115557 scopus 로고
    • The relationship between major Histocompatibility Complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides
    • Buus, S., Sette, A., Colon, S.M., Jenis, D.M. and Grey, H.M. (1987) The relationship between major Histocompatibility Complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides. Science 235, 1353-1357.
    • (1987) Science , vol.235 , pp. 1353-1357
    • Buus, S.1    Sette, A.2    Colon, S.M.3    Jenis, D.M.4    Grey, H.M.5
  • 19
    • 0021894971 scopus 로고
    • HLA class II immune response genes and products in leprosy
    • De Vries, R.R.P., van Eden, W. and Ottenhoff, T.H.M. (1985) HLA class II immune response genes and products in leprosy. Prog. Allergy 36, 95-98.
    • (1985) Prog. Allergy , vol.36 , pp. 95-98
    • De Vries, R.R.P.1    Van Eden, W.2    Ottenhoff, T.H.M.3
  • 20
    • 0024503129 scopus 로고
    • Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides
    • Van der Zee, R., van Eden, W., Meloen, R.H., Nordzij, A., van Embden, J.D.A. (1989) Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides. Eur. J. Immunol. 19, 43-48.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 43-48
    • Van Der Zee, R.1    Van Eden, W.2    Meloen, R.H.3    Nordzij, A.4    Van Embden, J.D.A.5
  • 21
    • 0022472141 scopus 로고
    • Induction of delayed hypersensitivity in human volunteers immunized with a candidate leprosy vaccine consisting of killed Mycobacterium leprae
    • Gill, H.K., Mustafa, A.S. and Godal, T. (1986) Induction of delayed hypersensitivity in human volunteers immunized with a candidate leprosy vaccine consisting of killed Mycobacterium leprae. Bull. WHO 64, 121-126.
    • (1986) Bull. WHO , vol.64 , pp. 121-126
    • Gill, H.K.1    Mustafa, A.S.2    Godal, T.3
  • 22
    • 0027165683 scopus 로고
    • Long lasting sensitization of T cells to M. leprae specific antigens and epitopes in volunteers immunized with killed M. leprae
    • Mustafa, A.S. and Oftung, F. (1993) Long lasting sensitization of T cells to M. leprae specific antigens and epitopes in volunteers immunized with killed M. leprae. Vaccine 11, 1108-1112.
    • (1993) Vaccine , vol.11 , pp. 1108-1112
    • Mustafa, A.S.1    Oftung, F.2
  • 23
    • 0022972673 scopus 로고
    • HLA class I and II typing using cells positively selected from blood by immunomagnetic isolation - A fast and reliable technique
    • Vartdal, F., Gaundernack, G., Funderud, S., Bratlie, A., Lea, T., Ugelstad, J. and Thorsby, E. (1986) HLA class I and II typing using cells positively selected from blood by immunomagnetic isolation - a fast and reliable technique. Tissue Antigens 28, 301-312.
    • (1986) Tissue Antigens , vol.28 , pp. 301-312
    • Vartdal, F.1    Gaundernack, G.2    Funderud, S.3    Bratlie, A.4    Lea, T.5    Ugelstad, J.6    Thorsby, E.7
  • 26
    • 0027482133 scopus 로고
    • Human T cell recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: Studies with healthy subjects vaccinated with M. bovis BCG and M. leprae
    • Mustafa, A.S., Lundin, K.E.A. and Oftung, F. (1993) Human T cell recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: Studies with healthy subjects vaccinated with M. bovis BCG and M. leprae. Infect. Immun. 61, 5294-5301.
    • (1993) Infect. Immun. , vol.61 , pp. 5294-5301
    • Mustafa, A.S.1    Lundin, K.E.A.2    Oftung, F.3
  • 27
    • 0019417383 scopus 로고
    • Regulation of B cell differentiation by T cell subsets defined with monoclonal OKT4 and OKT8 antibodies in human cord blood
    • Yachie, A.T., Miyawaki, T., Nagaoki, T., Mukai, M., Uwadara, N. and Tanigichi, N. (1981) Regulation of B cell differentiation by T cell subsets defined with monoclonal OKT4 and OKT8 antibodies in human cord blood. J. Immunol. 127, 1314-1316.
    • (1981) J. Immunol. , vol.127 , pp. 1314-1316
    • Yachie, A.T.1    Miyawaki, T.2    Nagaoki, T.3    Mukai, M.4    Uwadara, N.5    Tanigichi, N.6
  • 28
    • 0029825307 scopus 로고    scopus 로고
    • Restoration of proliferative responses to M. leprae antigens in lepromatous T cells against candidate antileprosy vaccines
    • Mustafa, A.S. (1996) Restoration of proliferative responses to M. leprae antigens in lepromatous T cells against candidate antileprosy vaccines. Int. J. Lepr. 64, 257-267.
    • (1996) Int. J. Lepr. , vol.64 , pp. 257-267
    • Mustafa, A.S.1
  • 30
    • 0027987778 scopus 로고
    • An HLA-DRw53 restricted T cell epitope from a novel Mycobacterium leprae protein antigen important to the human memory T cell repertoire against M. leprae
    • Mustafa, A.S., Lundin, K.E.A., Meloen, R.H., Shinnick, T.M. and Oftung, F. (1994) An HLA-DRw53 restricted T cell epitope from a novel Mycobacterium leprae protein antigen important to the human memory T cell repertoire against M. leprae. J. Immunol. 62, 5595-5602.
    • (1994) J. Immunol. , vol.62 , pp. 5595-5602
    • Mustafa, A.S.1    Lundin, K.E.A.2    Meloen, R.H.3    Shinnick, T.M.4    Oftung, F.5
  • 31
    • 0027960195 scopus 로고
    • Mapping of multiple HLA class II restricted T cell epitopes of the mycobacterial 70 kD heat shock protein
    • Oftung, F., Geluk, A., Lundin, K.E.A., Meloen, R.H., Thole, J.E.R., Mustafa, A.S. and Ottenhoff, T.H.M. (1994) Mapping of multiple HLA class II restricted T cell epitopes of the mycobacterial 70 kD heat shock protein. J. Immunol. 62, 5411-5418.
    • (1994) J. Immunol. , vol.62 , pp. 5411-5418
    • Oftung, F.1    Geluk, A.2    Lundin, K.E.A.3    Meloen, R.H.4    Thole, J.E.R.5    Mustafa, A.S.6    Ottenhoff, T.H.M.7
  • 32
    • 0031955285 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis reactive T cell clones from naturally converted PPD-positive healthy subjects: recognition of the M. tuberculosis 16-kDa antigen
    • Oftung, F., Borka, E. and Mustafa, A.S. (1998) Mycobacterium tuberculosis reactive T cell clones from naturally converted PPD-positive healthy subjects: recognition of the M. tuberculosis 16-kDa antigen. FEMS Immunol. Med. Microbiol. 20, 319-325.
    • (1998) FEMS Immunol. Med. Microbiol. , vol.20 , pp. 319-325
    • Oftung, F.1    Borka, E.2    Mustafa, A.S.3
  • 33
    • 0022895320 scopus 로고
    • Characteristics of human T cell clones from BCG and killed M. leprae vaccinated subjects and tuberculosis patients
    • Mustafa, A.S., Oftung, F., Gill, H.K. and Natvig, I. (1986) Characteristics of human T cell clones from BCG and killed M. leprae vaccinated subjects and tuberculosis patients. Lepr. Rev. 57, 123-130.
    • (1986) Lepr. Rev. , vol.57 , pp. 123-130
    • Mustafa, A.S.1    Oftung, F.2    Gill, H.K.3    Natvig, I.4
  • 34
    • 0024413763 scopus 로고
    • HLA-DR restricted antigen-induced proliferation and cytotoxicity mediated by CD4+ T cell clones from subjects vaccinated with M. leprae
    • Mustafa, A.S. and Qvigstad, E. (1989) HLA-DR restricted antigen-induced proliferation and cytotoxicity mediated by CD4+ T cell clones from subjects vaccinated with M. leprae. Int. J. Lepr. 57, 1-11.
    • (1989) Int. J. Lepr. , vol.57 , pp. 1-11
    • Mustafa, A.S.1    Qvigstad, E.2
  • 35
    • 0023815246 scopus 로고
    • Gene isolation with human T lymphocyte probes. Isolation of a gene that expresses an epitope recognized by T cells specific for Mycobacterium bovis BCG and pathogenic mycobacteria
    • Mustafa, A.S., Oftung, F., Deggerdal, A., Gill, H.K., Young, R.A. and Godal, T. (1988) Gene isolation with human T lymphocyte probes. Isolation of a gene that expresses an epitope recognized by T cells specific for Mycobacterium bovis BCG and pathogenic mycobacteria. J. Immunol. 141, 2729-2733.
    • (1988) J. Immunol. , vol.141 , pp. 2729-2733
    • Mustafa, A.S.1    Oftung, F.2    Deggerdal, A.3    Gill, H.K.4    Young, R.A.5    Godal, T.6
  • 36
    • 0029947235 scopus 로고    scopus 로고
    • HLA-DR4 restricted T cell epitopes from the mycobacterial 60 kD heat shock protein (HSP60) do not map to the sequence homology regions with the human HSP60
    • Mustafa, A.S., Lundin, K.E.A., Meloen, R.H., Shinnick, T.M., Coulson, A.F.W. and Oftung, F. (1996) HLA-DR4 restricted T cell epitopes from the mycobacterial 60 kD heat shock protein (HSP60) do not map to the sequence homology regions with the human HSP60. Immunology 87, 421-427.
    • (1996) Immunology , vol.87 , pp. 421-427
    • Mustafa, A.S.1    Lundin, K.E.A.2    Meloen, R.H.3    Shinnick, T.M.4    Coulson, A.F.W.5    Oftung, F.6
  • 37
    • 0025117772 scopus 로고
    • Heterogeneity among human T cell clones recognizing an HLA-DR4, Dw4-restricted epitope from the 18-kD antigen of Mycobacterium leprae defined by synthetic peptides
    • Oftung, F., Schinnick, T.M., Mustafa, A.S., Lundin, K.E.A., Godal, T. and Nerland, A. (1990) Heterogeneity among human T cell clones recognizing an HLA-DR4, Dw4-restricted epitope from the 18-kD antigen of Mycobacterium leprae defined by synthetic peptides. J. Immunol. 144, 1478-1483.
    • (1990) J. Immunol. , vol.144 , pp. 1478-1483
    • Oftung, F.1    Schinnick, T.M.2    Mustafa, A.S.3    Lundin, K.E.A.4    Godal, T.5    Nerland, A.6
  • 40
    • 0343598740 scopus 로고
    • DRw53
    • (Aizawa, M., Ed.), Hokkaido University Press, Sapporo
    • Aizawa, M. (1986) DRw53. In: HLA in Asia-Oceania (Aizawa, M., Ed.), p. 175. Hokkaido University Press, Sapporo.
    • (1986) In: HLA in Asia-Oceania , pp. 175
    • Aizawa, M.1


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