Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy

Clinical Infectious Diseases

Volumn 42, Issue 2, 2006, Pages 238-241

  Cambau, Emmanuelle ^a,b   Carthagena, Laetitia ^a   Chauffour, Aurélie ^a   Ji, Baohong ^a   Jarlier, Vincent ^a,c  

^a SORBONNE UNIVERSITÉ   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DAPSONE; DIHYDROPTEROATE SYNTHASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CLINICAL ARTICLE; FOLP1 GENE; GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; LEPROSY; MOUSE; MULTIBACILLARY LEPROSY; MULTIDRUG RESISTANCE; MYCOBACTERIUM LEPRAE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN BIOPSY; STRAIN DIFFERENCE;

ANIMALS; DAPSONE; DIHYDROPTEROATE SYNTHASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; HUMANS; LEPROSTATIC AGENTS; LEPROSY; MICE; MUTATION, MISSENSE; MYCOBACTERIUM LEPRAE; RECURRENCE;

EID: 30144432399     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/498506     Document Type: Article

References (31)

1. Vinnicombe H, Derrick J. Dihydropteroate synthase: an old drug target revisited. Biochem Soc Trans 1999; 27:1999-2004.
2. Ji B. Drug resistance in leprosy: a review. Lepr Rev 1985; 56:265-78.
3. Pearson J, Rees R, Waters M. Sulfone resistance in leprosy: a review of 100 proven clinical cases. Lancet 1976; 2:69-72.
4. Pettit J, Rees R. Sulphone resistance in leprosy: an experimental and clinical study. Lancet 1964; 2:673-4.
5. Shepard C, Tolentino J, McRae D. The therapeutic effect of 4-4′-di-acetyldiaminodiphenylsulfone (DADDS) in leprosy. Am J Trop Med Hyg 1968; 17:192-201.
6. Guelpa-Lauras C, Cartel J, Constant-Desportes M, et al. Primary and secondary dapsone resistance of M. leprae in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris between 1980 and 1985. Int J Lepr Other Mycobact Dis 1987; 55:672-9.
7. World Health Organization. Chemotherapy of leprosy for control programmes. Geneva: World Health Organization, 1982.
8. Roche P, Nupane K, Failbus S, Butlin C. Dapsone resistance in the MDT era. Int J Lepr Other Mycobact Dis 2000; 68:323-5.
9. Sekar B, Elangeswaran N, Jayarama E, et al. Drug susceptibility of Mycobacterium leprae: a retrospective analysis of mouse footpad inoculation results from 1983 to 1997. Lepr Rev 2002; 73:239-44.
10. Shepard C. The experimental disease that follows the injection of human leprosy bacillus into footpads of mice. J Exp Med 1960; 112: 445-54.
11. Ji B. Drug susceptibility testing of Mycobacterium leprae. Int J Lepr Other Mycobact Dis 1985; 55:830-5.
12. Cambau E, Perani E, Guillemin I, Jamet P, Ji B. Multidrug resistance to dapsone, rifampin and ofloxacin in Mycobacterium leprae. Lancet 1997; 349:103-4.
13. Grosset J, Guelpa-Lauras C, Bobin P. Study of 39 documented relapses of multibacillary leprosy after treatment with rifampin. Int J Lepr Other Mycobact Dis 1989;57:607-14.
14. Cambau E, Bonnafous P, Perani E, Sougakoff W, Ji B, Jarlier V. Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy. Clin Infect Dis 2002; 34: 39-45.
15. Matsuoka M, Kashiwabara Y, Namisato M. A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin, and sparfloxacin. Int J Lepr Other Mycobact Dis 2000;68:452-5.
16. Honore N, Cole S. Molecular basis of rifampin resistance in Mycobacterium leprae. Antimicrob Agents Chemother 1993; 37:414-8.
17. Kai M, Matsuoka M, Nakata N, et al. Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene. FEMS Microbiol Lett 1999; 177:231-5.
18. Maeda S, Matsuoka M, Nakata N, et al. Multidrug resistant Mycobacterium leprae from patients with leprosy. Antimicrob Agents Chemother 2001; 45:3635-9.
19. Williams D, Pittman T, Gillis T, Matsuoka M, Kashiwabara Y. Simultaneous detection of Mycobacterium leprae and its susceptibility to dapsone using heteroduplex analysis. J Clin Microbiol 2001; 39:2083-8.
20. Williams D, Spring L, Harris E, Roche P, Gillis T. Dihydropteroate synthase of Mycobacterium leprae and dapsone resistance. Antimicrob Agents Chemother 2000; 44:1530-7.
21. Ma L, Kovacs J, Cargnel A, Valerio A, Fantoni G, Atzori C. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. J Infect Dis 1999; 180:1969-78.
22. Baca A, Sirawaraporn R, Turley S, Sirawaraporn W, Hol W Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase I complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action. J Mol Biol 2000; 302:1193-1212.
23. Nopponpunth V, Sirawaraporn W, Greene P, Santi D. Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli. J Bacteriol 1999; 181: 6814-21.
24. Achari A, Somers D, Champness J, Bryand P, Rosemond J, Stammers D. Crystal structure of the antibacterial sulfonamide drug target dihydropteroate synthase. Nat Struct Biol 1997; 4:490-7.
25. Hampele I, D'Arcy A, Dale G, et al. Structure and function of the dihydropteroate synthase from Staphylococcus aureus. J Mol Biol 1997; 268:21-31.
26. Cole S, Eiglmeier K, Parkhill P, et al. Massive gene decay in the leprosy bacillus. Nature 2001; 409:1007-11.
27. Trias J, Jarlier V, Benz R. Porins in the cell wall of mycobacteria. Science 1992; 258:1479-81.
28. Niederweiss M. Mycobacterial porins-new channel proteins in unique outer membranes. Mol Microbiol 2003; 49:1167-77.
29. Li X-Z, Zhang L, Nikaido H. Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother 2004; 48:2415-23.
30. Ji B, Perani E, Petinon C, N'Deli L, Grosset J. Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy. Antimicrob Agents Chemother 1994; 38:662-7.
31. American Thoracic Society. Treatment of tuberculosis. Am J Respir Grit Care Med 2003; 167:603-62.