Extensive sequence homology between the Mycobacterium leprae LSR (12 kDa) antigen and its Mycobacterium tuberculosis counterpart

FEMS Immunology and Medical Microbiology

Volumn 27, Issue 1, 2000, Pages 87-89

  Oftung, Fredrik ^a   Mustafa, Abu Salim ^b   Wiker, Harald G ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b KUWAIT UNIVERSITY   (Kuwait)

Author keywords

LSR antigen sequence; Mycobacterium tuberculosis

Indexed keywords

ANTIGEN; EPITOPE; MYCOBACTERIUM ANTIGEN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; DNA SEQUENCE; GENE; LEPROSY; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SHORT SURVEY; TUBERCULOSIS;

EID: 0033986842     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(99)00169-8     Document Type: Article

References (8)

1. Bloom B.R. Learning from leprosy: A perspective on immunity and the third world. J. Immunol. 137:1986;1-10.
2. Laal S., Sharma Y.D., Prasad H.K., Murtaza A., Singh S., Tangri S., Mishra S., Nath I. Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T cell responses across the leprosy spectrum. Proc. Natl. Acad. Sci. USA. 88:1991;1054-1058.
3. Sela S., Thole J.E.R., Ottenhoff T.H.M., Clark-Curtiss J.E. Identification of Mycobacterium leprae antigens from a cosmid library: Characterization of a 15- kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients. Infect. Immun. 59:1991;4117-4124.
4. Singh S., Shankar Narayan N.P., Jenner P.J., Ramu G., Colston M.J., Prasad H.K., Nath I. Sera of leprosy patients with type 2 reactions recognize selective sequences in Mycobacterium leprae recombinant LSR protein. Infect. Immun. 62:1994;86-90.
5. Singh S., Jenner P.J., Shankar Narayan N.P., Ramu G., Colston M.J., Prasad H.K., Nath I. Critical residues of the Mycobacterium leprae LSR recombinant protein discriminate clinical activity in erythema nodosum leprosum reactions. Infect. Immun. 62:1994;5702-5705.
6. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
7. Cole, S.T., Brosch, R., Parkhill, J., Garnier, Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, Jagels, K., Krogh, A., Mclean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M.A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J.E., Taylor, K., Whitehead, S. and Barrell, B.G. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
8. Oftung F., Lundin K.E.A., Meloen R., Mustafa A.S. Human T cell recognition of the Mycobacterium leprae LSR antigen: epitopes and HLA restriction. FEMS Immunol. Med. Microbiol. 24:1999;151-159.