Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Biochemical Journal

Volumn 377, Issue 3, 2004, Pages 701-708

  Mariette, Christophe ^a,b   Perrais, Michaël ^a   Leteurtre, Emmanuelle ^a,b   Jonckheere, Nicolas ^a   Hémon, Brigitte ^a   Pigny, Pascal ^a   Batra, Surinder ^c   Aubert, Jean Pierre ^a   Triboulet, Jean Pierre ^b   Van Seuningen, Isabelle ^a  

^a INSERM   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Bile acid; Mitogen activated protein kinase (MAPK); MUC4; Mucin; Oesophagus; Phosphatidylinositol 3 kinase (PI3K); Transcription

Indexed keywords

CARCINOGENS; ENZYMES; GENES; IMMUNOLOGY; TUMORS;

PHARMACOLOGICAL INHIBITORS;

BIOCHEMISTRY;

BILE ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GLYCOCHOLATE SODIUM; GLYCOCHOLIC ACID; ISOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MUCIN 4; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID;

ARTICLE; BIOPSY; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CONJUGATE; CONTROLLED STUDY; ENZYME ACTIVATION; ESOPHAGUS CARCINOMA; GENE CONTROL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 10744219516     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj20031132     Document Type: Article

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