The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells

Biochemical and Biophysical Research Communications

Volumn 325, Issue 3, 2004, Pages 952-960

  Van Der Sluis, Maria ^a   Melis, Monique H M ^a   Jonckheere, Nicolas ^b   Ducourouble, Marie Paule ^b   Büller, Hans A ^a   Renes, Ingrid ^a   Einerhand, Alexandra W C ^a   Van Seuningen, Isabelle ^b  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b INSERM   (France)

Author keywords

Differentiation; GATA 4; Goblet cell; Intestine; Muc2; Mucin; Transcription

Indexed keywords

MUCIN 2; TRANSCRIPTION FACTOR GATA 4; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DELETION MUTANT; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE LOSS; GENE OVEREXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GOBLET CELL; INTESTINE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET CELL; TRANSACTIVATION; TRANSCRIPTION REGULATION; WILD TYPE; ZINC FINGER MOTIF;

ANIMALS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; INTESTINES; MICE; MUCINS; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZINC FINGERS;

MURINAE; VECTORS;

EID: 8444227379     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.10.108     Document Type: Article

References (33)

1. A.P. Corfield, D. Carroll, N. Myerscough, and C.S. Probert Mucins in the gastrointestinal tract in health and disease Front. Biosci. 6 2001 D1321 D1357
2. K.M. Tytgat, H.A. Buller, F.J. Opdam, Y.S. Kim, A.W. Einerhand, and J. Dekker Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin Gastroenterology 107 1994 1352 1363
3. B.J. van Klinken, A.W. Einerhand, L.A. Duits, M.K. Makkink, K.M. Tytgat, I.B. Renes, M. Verburg, H.A. Buller, and J. Dekker Gastrointestinal expression and partial cDNA cloning of murine Muc2 Am. J. Physiol. 276 1999 G115 G124
4. M.P. Buisine, L. Devisme, T.C. Savidge, C. Gespach, B. Gosselin, N. Porchet, and J.P. Aubert Mucin gene expression in human embryonic and fetal intestine Gut 43 1998 519 524
5. I. Van Seuningen, P. Pigny, M. Perrais, N. Porchet, and J.P. Aubert Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer? Front. Biosci. 6 2001 D1216 D1234
6. P. Mesquita, N. Jonckheere, R. Almeida, M.P. Ducourouble, J. Serpa, E. Silva, P. Pigny, F.S. Silva, C. Reis, D. Silberg, I. Van Seuningen, and L. David Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines J. Biol. Chem. 278 2003 51549 51556
7. D.G. Silberg, G.P. Swain, E.R. Suh, and P.G. Traber Cdx1 and cdx2 expression during intestinal development Gastroenterology 119 2000 961 971
8. J.D. Molkentin The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression J. Biol. Chem. 275 2000 38949 38952
9. E.E. Morrisey, H.S. Ip, M.M. Lu, and M.S. Parmacek GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm Dev. Biol. 177 1996 309 322
10. E.E. Morrisey, H.S. Ip, Z. Tang, M.M. Lu, and M.S. Parmacek GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development Dev. Biol. 183 1997 21 36
11. X. Gao, T. Sedgwick, Y.B. Shi, and T. Evans Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation Mol. Cell. Biol. 18 1998 2901 2911
12. R. Fang, L.C. Olds, N.A. Santiago, and E. Sibley GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells Am. J. Physiol. Gastrointest. Liver Physiol. 280 2001 G58 G67
13. H.M. Van Wering, T. Bosse, A. Musters, E. De Jong, N. De Jong, C.E. Hogen Esch, F. Boudreau, G.P. Swain, L.N. Dowling, R.K. Montgomery, R.J. Grand, and S.D. Krasinski Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4 Am. J. Physiol. Gastrointest. Liver Physiol. 287 2004 G899 G909
14. S.D. Krasinski, H.M. Van Wering, M.R. Tannemaat, and R.J. Grand Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha Am. J. Physiol. Gastrointest. Liver Physiol. 281 2001 G69 G84
15. F. Aslam, L. Palumbo, L.H. Augenlicht, and A. Velcich The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters Cancer Res. 61 2001 570 576
16. I.B. Renes, J.A. Boshuizen, D.J. Van Nispen, N.P. Bulsing, H.A. Buller, J. Dekker, and A.W. Einerhand Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis Am. J. Physiol. Gastrointest. Liver Physiol. 282 2002 G382 G389
17. I. Van Seuningen, M. Perrais, P. Pigny, N. Porchet, and J.P. Aubert Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells Biochem. J. 348 Pt. 3 2000 675 686
18. M. Perrais, P. Pigny, M.C. Copin, J.P. Aubert, and I. Van Seuningen Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1 J. Biol. Chem. 277 2002 32258 32267
19. N. Jonckheere, M. Van Der Sluis, A. Velghe, M.P. Buisine, M. Sutmuller, M.P. Ducourouble, P. Pigny, H.A. Buller, J.P. Aubert, A.W. Einerhand, and I. Van Seuningen Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1 Biochem. J. 377 2004 797 808
20. I. Van Seuningen, J. Ostrowski, X.R. Bustelo, P.R. Sleath, and K. Bomsztyk The K protein domain that recruits the interleukin 1-responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform J. Biol. Chem. 270 1995 26976 26985
21. K. Quandt, K. Frech, H. Karas, E. Wingender, and T. Werner MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data Nucleic Acids Res. 23 1995 4878 4884
22. J.P. Audié, A. Janin, N. Porchet, M.C. Copin, B. Gosselin, and J.P. Aubert Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization J. Histochem. Cytochem. 41 1993 1479 1485
23. P.G. Traber Epithelial cell growth and differentiation. V. Transcriptional regulation, development, and neoplasia of the intestinal epithelium Am. J. Physiol. 273 1997 G979 G981
24. A. Velcich, L. Palumbo, L. Selleri, G. Evans, and L. Augenlicht Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus J. Biol. Chem. 272 1997 7968 7976
25. L.M. Franks, and V.J. Hemmings A cell line from an induced carcinoma of mouse rectum J. Pathol. 124 1978 35 38
26. A. Quaroni, J. Wands, R.L. Trelstad, and K.J. Isselbacher Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria J. Cell Biol. 80 1979 248 265
27. J.R. Gum, J.W. Hicks, and Y.S. Kim Identification and characterization of the MUC2 (human intestinal mucin) gene 5′-flanking region: promoter activity in cultured cells Biochem. J. 325 Pt. 1 1997 259 267
28. K. Zaret Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins Dev. Biol. 209 1999 1 10
29. P.G. Traber, and D.G. Silberg Intestine-specific gene transcription Annu. Rev. Physiol. 58 1996 275 297
30. F. Boudreau, E.H. Rings, H.M. van Wering, R.K. Kim, G.P. Swain, S.D. Krasinski, J. Moffett, R.J. Grand, E.R. Suh, and P.G. Traber Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene J. Biol. Chem. 277 2002 31909 31917
31. H.M. van Wering, I.L. Huibregtse, S.M. vander Zwan, M.S. de Bie, L.N. Dowling, F. Boudreau, E.H. Rings, R.J. Grand, and S.D. Krasinski Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter J. Biol. Chem. 277 2002 27659 27667
32. S. Tamura, X.H. Wang, M. Maeda, and M. Futai Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes Proc. Natl. Acad. Sci. USA 90 1993 10876 10880
33. Y. Yuasa Control of gut differentiation and intestinal-type gastric carcinogenesis Nat. Rev. Cancer 3 2003 592 600