-
1
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
FENG, Z. et al. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. USA 102: 8204-8209.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8204-8209
-
-
FENG, Z.1
-
2
-
-
30044447244
-
Apoptosis evasion: The role of survival pathways in prostate cancer progression and therapeutic resistance
-
MCKENZIE, S. & N. KYPRIANOU. 2006. Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance. J. Cell. Biochem. 97: 18-32.
-
(2006)
J. Cell. Biochem
, vol.97
, pp. 18-32
-
-
MCKENZIE, S.1
KYPRIANOU, N.2
-
3
-
-
0036212767
-
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
-
SCHOEBERL, B. et al. 2002. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 20: 370-375.
-
(2002)
Nat. Biotechnol
, vol.20
, pp. 370-375
-
-
SCHOEBERL, B.1
-
4
-
-
0348049802
-
Systems biology markup language: Level 2 and beyond
-
FINNEY, A. & M. HUCKA. 2003. Systems biology markup language: level 2 and beyond. Biochem. Soc. Trans. 31: 1472-1473.
-
(2003)
Biochem. Soc. Trans
, vol.31
, pp. 1472-1473
-
-
FINNEY, A.1
HUCKA, M.2
-
5
-
-
28944444766
-
Representations of molecular pathways: An evaluation of SBML, PSI MI and BioPAX
-
STROMBACK, L. & P. LAMBRIX. 2005. Representations of molecular pathways: an evaluation of SBML, PSI MI and BioPAX. Bioinformatics 21: 4401-4407.
-
(2005)
Bioinformatics
, vol.21
, pp. 4401-4407
-
-
STROMBACK, L.1
LAMBRIX, P.2
-
6
-
-
0030787464
-
Heterogeneity of epidermal growth factor binding kinetics on individual cells
-
CHUNG, J.C., N. SCIAKY & D.J. GROSS. 1997. Heterogeneity of epidermal growth factor binding kinetics on individual cells. Biophys. J. 73: 1089-1102.
-
(1997)
Biophys. J
, vol.73
, pp. 1089-1102
-
-
CHUNG, J.C.1
SCIAKY, N.2
GROSS, D.J.3
-
7
-
-
0023677140
-
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system
-
WILEY, H.S. 1988. Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J. Cell. Biol. 107: 801-810.
-
(1988)
J. Cell. Biol
, vol.107
, pp. 801-810
-
-
WILEY, H.S.1
-
8
-
-
0033570090
-
Quantification of short term signaling by the epidermal growth factor receptor
-
KHOLODENKO, B.N. et al. 1999. Quantification of short term signaling by the epidermal growth factor receptor. J. Biol. Chem. 274: 30169-30181.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 30169-30181
-
-
KHOLODENKO, B.N.1
-
9
-
-
0026833077
-
Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses
-
STARBUCK, C. & D.A. LAUFFENBURGER. 1992. Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses. Biotechnol. Prog. 8: 132-143.
-
(1992)
Biotechnol. Prog
, vol.8
, pp. 132-143
-
-
STARBUCK, C.1
LAUFFENBURGER, D.A.2
-
10
-
-
0028969961
-
Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction
-
FRENCH, A.R. et al. 1995. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J. Biol. Chem. 270: 4334-4340.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 4334-4340
-
-
FRENCH, A.R.1
-
11
-
-
0032540268
-
The importance of two conserved arginine residues for catalysis by the ras GTPase-activating protein, neurofibromin
-
SERMON, B.A. et al. 1998. The importance of two conserved arginine residues for catalysis by the ras GTPase-activating protein, neurofibromin. J. Biol. Chem. 273: 9480-9485.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 9480-9485
-
-
SERMON, B.A.1
-
12
-
-
0032491205
-
Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex
-
SYDOR, J.R. et al. 1998. Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex. Biochemistry 37: 14292-14299.
-
(1998)
Biochemistry
, vol.37
, pp. 14292-14299
-
-
SYDOR, J.R.1
-
13
-
-
0029130717
-
Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors
-
OKADA, S., K. YAMAUCHI & J.E. PESSIN. 1995. Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors. J. Biol. Chem. 270: 20737-20741.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 20737-20741
-
-
OKADA, S.1
YAMAUCHI, K.2
PESSIN, J.E.3
-
14
-
-
0028040812
-
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
-
BATZER, A.G. et al. 1994. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 14: 5192-5201.
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 5192-5201
-
-
BATZER, A.G.1
-
15
-
-
0029790351
-
-
HUANG, C.Y. & J.E. FERRELL, JR. 1996. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 93: 10078-10083.
-
HUANG, C.Y. & J.E. FERRELL, JR. 1996. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 93: 10078-10083.
-
-
-
-
16
-
-
0037075690
-
Modeling and simulation: Tools for metabolic engineering
-
WIECHERT, W. 2002. Modeling and simulation: tools for metabolic engineering. J. Biotechnol. 94: 37-63.
-
(2002)
J. Biotechnol
, vol.94
, pp. 37-63
-
-
WIECHERT, W.1
-
17
-
-
13444259844
-
Reactome: A knowledgebase of biological pathways
-
JOSHI-TOPE, G. et al. 2005. Reactome: a knowledgebase of biological pathways. Nucleic Acids Res. 33: D428-432.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
JOSHI-TOPE, G.1
-
18
-
-
33644877164
-
BioModels Database: A free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems
-
LE NOVERE, N. et al. 2006. BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Res. 34: D689-691.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
LE NOVERE, N.1
-
19
-
-
13444278821
-
Reconstruction of cellular signalling networks and analysis of their properties
-
PAPIN, J.A. et al. 2005. Reconstruction of cellular signalling networks and analysis of their properties. Nat. Rev. Mol. Cell. Biol. 6: 99-111.
-
(2005)
Nat. Rev. Mol. Cell. Biol
, vol.6
, pp. 99-111
-
-
PAPIN, J.A.1
-
20
-
-
17644427718
-
Causal protein-signaling networks derived from multiparameter single-cell data
-
SACHS, K. et al. 2005. Causal protein-signaling networks derived from multiparameter single-cell data. Science 308: 523-529.
-
(2005)
Science
, vol.308
, pp. 523-529
-
-
SACHS, K.1
-
21
-
-
13444272070
-
The Biomolecular Interaction Network Database and related tools 2005 update
-
ALFARANO, C. et al. 2005. The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res. 33: D418-424.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
ALFARANO, C.1
-
22
-
-
33644873184
-
BioGRID: A general repository for interaction datasets
-
STARK, C. et al. 2006. BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 34: D535-539.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
STARK, C.1
-
23
-
-
0347755535
-
The Database of Interacting Proteins: 2004 update
-
SALWINSKI, L. et al. 2004. The Database of Interacting Proteins: 2004 update. Nucleic Acids Res. 32: D449-451.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
SALWINSKI, L.1
-
24
-
-
0034889729
-
Mathematical modeling of Escherichia coli inactivation under high-pressure carbon dioxide
-
ERKMEN, O. 2001. Mathematical modeling of Escherichia coli inactivation under high-pressure carbon dioxide. J. Biosci. Bioeng. 92: 39-43.
-
(2001)
J. Biosci. Bioeng
, vol.92
, pp. 39-43
-
-
ERKMEN, O.1
-
25
-
-
33747126481
-
Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors
-
TRUMMER, E. et al. 2006. Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors. Biotechnol. Bioeng. 94: 1033-1044.
-
(2006)
Biotechnol. Bioeng
, vol.94
, pp. 1033-1044
-
-
TRUMMER, E.1
-
26
-
-
0034977008
-
Effects of shifts up and down in osmotic pressure on production of tissue plasminogen activator by Chinese hamster ovary cells in suspension
-
TAKAGI, M., T. MORIYAMA & T. YOSHIDA. 2001. Effects of shifts up and down in osmotic pressure on production of tissue plasminogen activator by Chinese hamster ovary cells in suspension. J. Biosci. Bioeng. 91: 509-514.
-
(2001)
J. Biosci. Bioeng
, vol.91
, pp. 509-514
-
-
TAKAGI, M.1
MORIYAMA, T.2
YOSHIDA, T.3
-
27
-
-
0000718899
-
The Map Method for Synthesis of Combinational Logic Circuits
-
KARNAUGH, M. 1953. The Map Method for Synthesis of Combinational Logic Circuits. Trans. AIEE Comm. Electron. 72: 593-599.
-
(1953)
Trans. AIEE Comm. Electron
, vol.72
, pp. 593-599
-
-
KARNAUGH, M.1
-
28
-
-
0031616241
-
Reveal, a general reverse engineering algorithm for inference of genetic network architectures
-
LIANG, S., S. FUHRMAN & R. SOMOGYI. 1998. Reveal, a general reverse engineering algorithm for inference of genetic network architectures. Pac. Symp. Biocomput. :18-29.
-
(1998)
Pac. Symp. Biocomput
, pp. 18-29
-
-
LIANG, S.1
FUHRMAN, S.2
SOMOGYI, R.3
-
29
-
-
36248971654
-
Alternative pathway approach for automating analysis and validation of cell perturbation networks and design of perturbation experiments
-
GONG, Y. & Z. ZHANG. 2007. Alternative pathway approach for automating analysis and validation of cell perturbation networks and design of perturbation experiments. Ann. N. Y. Acad. Sci. 1407: XX-XX.
-
(2007)
Ann. N. Y. Acad. Sci
, vol.1407
-
-
GONG, Y.1
ZHANG, Z.2
-
30
-
-
0030723263
-
Expression of retinoid-responsive genes occurs in colorectal carcinoma-derived cells irrespective of the presence of resistance to all-trans retinoic acid
-
WALISZEWSKI, P. et al. 1997. Expression of retinoid-responsive genes occurs in colorectal carcinoma-derived cells irrespective of the presence of resistance to all-trans retinoic acid. J. Surg. Oncol. 66: 156-167.
-
(1997)
J. Surg. Oncol
, vol.66
, pp. 156-167
-
-
WALISZEWSKI, P.1
-
31
-
-
0032508704
-
Differences in the migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620)
-
KUBENS, B.S. & K.S. ZANKER. 1998. Differences in the migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620). Cancer Lett. 131: 55-64.
-
(1998)
Cancer Lett
, vol.131
, pp. 55-64
-
-
KUBENS, B.S.1
ZANKER, K.S.2
-
32
-
-
0034193036
-
Differential role of Fas/Fas ligand interactions in cytolysis of primary and metastatic colon carcinoma cell lines by human antigen-specific CD8+ CTL
-
BERGMANN-LEITNER, E.S. & S.I. ABRAMS. 2000. Differential role of Fas/Fas ligand interactions in cytolysis of primary and metastatic colon carcinoma cell lines by human antigen-specific CD8+ CTL. J. Immunol. 164: 4941-454.
-
(2000)
J. Immunol
, vol.164
, pp. 4941-4454
-
-
BERGMANN-LEITNER, E.S.1
ABRAMS, S.I.2
-
33
-
-
33644669224
-
Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein
-
VOELKEL-JOHNSON, C., Y.A. HANNUN & A. EL-ZAWAHRY. 2005. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol. Cancer Ther. 4: 1320-1327.
-
(2005)
Mol. Cancer Ther
, vol.4
, pp. 1320-1327
-
-
VOELKEL-JOHNSON, C.1
HANNUN, Y.A.2
EL-ZAWAHRY, A.3
-
34
-
-
5744225755
-
A spectrum of models of signaling pathways
-
VAYTTADEN, S.J., S.M. AJAY & U.S. BHALLA. 2004. A spectrum of models of signaling pathways. Chembiochem 5: 1365-1374.
-
(2004)
Chembiochem
, vol.5
, pp. 1365-1374
-
-
VAYTTADEN, S.J.1
AJAY, S.M.2
BHALLA, U.S.3
-
35
-
-
0037433037
-
The Database of Quantitative Cellular Signaling: Management and analysis of chemical kinetic models of signaling networks
-
SIVAKUMARAN, S. et al. 2003. The Database of Quantitative Cellular Signaling: management and analysis of chemical kinetic models of signaling networks. Bioinformatics 19: 408-415.
-
(2003)
Bioinformatics
, vol.19
, pp. 408-415
-
-
SIVAKUMARAN, S.1
-
36
-
-
0027388945
-
A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase
-
ITOH, T. et al. 1993. A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase. Proc. Natl. Acad. Sci. USA 90: 975-979.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 975-979
-
-
ITOH, T.1
-
37
-
-
0026647749
-
Raf-1 activates MAP kinase-kinase
-
KYRIAKIS, J.M. et al. 1992. Raf-1 activates MAP kinase-kinase. Nature 358: 417-421.
-
(1992)
Nature
, vol.358
, pp. 417-421
-
-
KYRIAKIS, J.M.1
-
38
-
-
0030746219
-
Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase
-
FERRELL, J.E., JR. & R.R. BHATT. 1997. Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J. Biol. Chem. 272: 19008-19016.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 19008-19016
-
-
FERRELL, J.E.J.1
BHATT, R.R.2
-
39
-
-
0030972112
-
The activating dual phosphorylation of MAPK by MEK is nonprocessive
-
BURACK, W.R. & T.W. STURGILL. 1997. The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry 36: 5929-5933.
-
(1997)
Biochemistry
, vol.36
, pp. 5929-5933
-
-
BURACK, W.R.1
STURGILL, T.W.2
-
40
-
-
0032496358
-
The biochemical basis of an all-ornone cell fate switch in Xenopus oocytes
-
FERRELL, J.E., JR. & E.M. MACHLEDER. 1998. The biochemical basis of an all-ornone cell fate switch in Xenopus oocytes. Science 280: 895-898.
-
(1998)
Science
, vol.280
, pp. 895-898
-
-
FERRELL, J.E.J.1
MACHLEDER, E.M.2
-
41
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
BHALLA, U.S. & R. IYENGAR. 1999. Emergent properties of networks of biological signaling pathways. Science 283: 381-387.
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
BHALLA, U.S.1
IYENGAR, R.2
-
42
-
-
0034019315
-
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
-
KHOLODENKO, B.N. 2000. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur. J. Biochem. 267: 1583-1588.
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 1583-1588
-
-
KHOLODENKO, B.N.1
-
43
-
-
0034705227
-
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
-
LEVCHENKO, A., J. BRUCK & P.W. STERNBERG. 2000. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci. USA 97: 5818-5823.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5818-5823
-
-
LEVCHENKO, A.1
BRUCK, J.2
STERNBERG, P.W.3
-
44
-
-
0034914737
-
A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model
-
ASTHAGIRI, A.R. & D.A. LAUFFENBURGER. 2001. A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotechnol. Prog. 17: 227-239.
-
(2001)
Biotechnol. Prog
, vol.17
, pp. 227-239
-
-
ASTHAGIRI, A.R.1
LAUFFENBURGER, D.A.2
-
45
-
-
0034613112
-
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells
-
BRIGHTMAN, F.A. & D.A. FELL. 2000. Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Lett. 482: 169-174.
-
(2000)
FEBS Lett
, vol.482
, pp. 169-174
-
-
BRIGHTMAN, F.A.1
FELL, D.A.2
-
46
-
-
0036109556
-
The role of proofreading in signal transduction specificity
-
SWAIN, P.S. & E.D. SIGGIA. 2002. The role of proofreading in signal transduction specificity. Biophys. J. 82: 2928-2933.
-
(2002)
Biophys. J
, vol.82
, pp. 2928-2933
-
-
SWAIN, P.S.1
SIGGIA, E.D.2
-
47
-
-
0036402315
-
Selectivity in overlapping MAP kinase cascades
-
SOMSEN, O.J. et al. 2002. Selectivity in overlapping MAP kinase cascades. J. Theor. Biol. 218: 343-354.
-
(2002)
J. Theor. Biol
, vol.218
, pp. 343-354
-
-
SOMSEN, O.J.1
-
48
-
-
0345359924
-
-
XIONG, W. & J.E. FERRELL, JR. 2003. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 426: 460-465.
-
XIONG, W. & J.E. FERRELL, JR. 2003. A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature 426: 460-465.
-
-
-
-
49
-
-
0242541682
-
Shc-dependent pathway is redundant but dominant in MAPK cascade activation by EGF receptors: A modeling inference
-
GONG, Y. & X. ZHAO. 2003. Shc-dependent pathway is redundant but dominant in MAPK cascade activation by EGF receptors: a modeling inference. FEBS Lett. 554: 467-472.
-
(2003)
FEBS Lett
, vol.554
, pp. 467-472
-
-
GONG, Y.1
ZHAO, X.2
-
50
-
-
0842288229
-
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
-
MARKEVICH, N.I., J.B. HOEK & B.N. KHOLODENKO. 2004. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J. Cell. Biol. 164: 353-359.
-
(2004)
J. Cell. Biol
, vol.164
, pp. 353-359
-
-
MARKEVICH, N.I.1
HOEK, J.B.2
KHOLODENKO, B.N.3
-
51
-
-
25844510799
-
Alternative signaling pathways: When, where and why?
-
GONG, Y. & Z. ZHANG. 2005. Alternative signaling pathways: when, where and why? FEBS Lett. 579: 5265-5274.
-
(2005)
FEBS Lett
, vol.579
, pp. 5265-5274
-
-
GONG, Y.1
ZHANG, Z.2
-
52
-
-
0037342537
-
The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models
-
HUCKA, M. et al. 2003. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19: 524-531.
-
(2003)
Bioinformatics
, vol.19
, pp. 524-531
-
-
HUCKA, M.1
-
54
-
-
0141626866
-
E-Cell 2: Multi-platform E-Cell simulation system
-
TAKAHASHI, K. et al. 2003. E-Cell 2: multi-platform E-Cell simulation system. Bioinformatics 19: 1727-1729.
-
(2003)
Bioinformatics
, vol.19
, pp. 1727-1729
-
-
TAKAHASHI, K.1
-
55
-
-
0142219725
-
Quantitative cell biology with the Virtual Cell
-
SLEPCHENKO, B.M. et al. 2003. Quantitative cell biology with the Virtual Cell. Trends Cell. Biol. 13: 570-576.
-
(2003)
Trends Cell. Biol
, vol.13
, pp. 570-576
-
-
SLEPCHENKO, B.M.1
-
56
-
-
18844439116
-
UML as a cell and biochemistry modeling language
-
WEBB, K. & T. WHITE. 2005. UML as a cell and biochemistry modeling language. Biosystems 80: 283-302.
-
(2005)
Biosystems
, vol.80
, pp. 283-302
-
-
WEBB, K.1
WHITE, T.2
-
57
-
-
33845730788
-
Perturbations to uncover gene networks
-
TEGNER, J. & J. BJORKEGREN. 2007. Perturbations to uncover gene networks. Trends Genet 23(1): 34-41.
-
(2007)
Trends Genet
, vol.23
, Issue.1
, pp. 34-41
-
-
TEGNER, J.1
BJORKEGREN, J.2
|