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Volumn 3, Issue 3, 2002, Pages 315-327

Lopinavir/ritonavir (ABT-378/r)

Author keywords

Boosted protease inhibitor; Co formulated; Lopinavir ritonavir; Pharmacokinetic enhancement; Protease inhibitor; Ritonavir

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIFUNGAL AGENT; ANTIRETROVIRUS AGENT; ARGENERASE; ATOVAQUONE; CYCLOSPORIN; CYTOCHROME P450 3A4; DELAVIRDINE; DIDANOSINE; DISULFIRAM; EFAVIRENZ; ERGOT DERIVATIVE; FORTAVASE; HYPERICUM PERFORATUM EXTRACT; INDINAVIR; LAMIVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; METHADONE; METRONIDAZOLE; NELFINAVIR; NEVIRAPINE; ORAL CONTRACEPTIVE AGENT; PROKINETIC AGENT; PROTEINASE INHIBITOR; RIFAMPICIN; RITONAVIR; SAQUINAVIR; STAVUDINE; UNINDEXED DRUG; ZIDOVUDINE;

EID: 0036192970     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.3.3.315     Document Type: Article
Times cited : (38)

References (53)
  • 3
    • 0008660008 scopus 로고    scopus 로고
    • Single dose pharmacokinetics of ABT-378 in combination with ritonavir
    • 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada (28 September - 11 October Abstract 279.
    • (1997)
    • Lal, R.1    Hsu, A.2    Chen, P.3
  • 5
    • 0008671001 scopus 로고    scopus 로고
    • Impact of pharmacokinetics on treatment success. Redefining the art of HIV management
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October).
    • (2000)
    • Back, D.1
  • 7
    • 0008636663 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics (PK) of ABT-378/r) in HIV + subjects
    • 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, California, USA (26-29 September) Poster 0327
    • (1999)
    • Bertz, R.1    Lam, W.2    Brun, S.3
  • 9
    • 0003194577 scopus 로고    scopus 로고
    • ABT-378/ritonavir (ABT-378/r) in antiretroviral-naïve HIV + patients: 72 weeks
    • 7th Conference on Retroviruses and Opportunistic Infections. San Francisco, California, USA (30 February - 2 March) Poster 515
    • (2000)
    • Gulick, R.1    King, M.2    Brun, S.3
  • 10
    • 0008644887 scopus 로고    scopus 로고
    • Effect of human serum proteins on the antiretroviral activity of ritonavir and ABT-378, potent inhibitors of HIV protease
    • 4th Conference on Retroviruses and Opportunistic Infections. Washington DC, USA (22-26 January)
    • (1997)
    • Molla, A.1    Vasavanonda, S.2    Denissen, J.3
  • 11
    • 0003289917 scopus 로고    scopus 로고
    • Analysis of safety data from ABT-378/ritonavir (ABT-378/r) in two Phase II clinical trials. Poster presentation
    • 13th International AIDS Conference. Durban, South Africa. (9-14 July) Abstract TuPe3198.
    • (2000)
    • Kessler, H.1    Brun, S.2    King, M.3
  • 12
    • 0008643880 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between ABT-378ritonavir (ABT-378/r) and efavirenz in healthy volunteers and in HIV + subjects
    • 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada (17-20 September)
    • (2000)
    • Bertz, R.1    Lam, W.2    Hsu, A.3
  • 13
    • 0008644226 scopus 로고    scopus 로고
    • Interaction of ABT-378/ritonavir with protease inhibitors in healthy volunteers
    • 1st International Workshop on Clinical Pharmacology of HIV Therapy. Noordwijk, The Netherlands (30-31 March)
    • (2000)
    • Hsu, A.1    Bertz, R.2    Ashbrenner, E.3
  • 14
    • 0008625752 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of Kaletra (lopinavir/ritonavir 400/100mg b.i.d.) in HIV-infected subjects when taken with food
    • 2nd International Workshop on Clinical Pharmacology of HIV Therapy. Noordvijk, The Netherlands (30-31 March)
    • (2001)
    • Bertz, R.1    Renz, C.2    Foit, C.3
  • 15
    • 0003252825 scopus 로고    scopus 로고
    • Assessment of the bioequivalence and food effects for liquid and soft elastic capsule co-formulations of ABT-378/ritonavir (ABT-378/r) in healthy subjects
    • 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada (17-20 September)
    • (2000)
    • Gustavson, L.1    Lam, W.2    Bertz, R.3
  • 16
    • 17044457875 scopus 로고    scopus 로고
    • ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-naïve adults with HIV-1 infection: 48-week results
    • (15:1)
    • (2001) AIDS , vol.5
    • Murphy, R.L.1    Brun, S.2    Hicks, S.3
  • 17
    • 0032566902 scopus 로고    scopus 로고
    • Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus
    • (1998) Virology , vol.25 , Issue.250 , pp. 255-262
    • Molla, A.1    Vasavanonda, S.2    Kumar, G.3
  • 19
    • 0003202598 scopus 로고    scopus 로고
    • ABT-378/ritonavir (ABT-378/r) and efavirenz 24 week safety/efficacy evaluation in multiple PI experienced patients
    • 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada (17-20 September)
    • (2000)
    • Becker, S.1    Brun, S.2    Bertz, R.3
  • 20
    • 0008624250 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between Kaletra™ (lopinavir/ritonavir or ABT-378/r) and nevirapine in HIV-infected pediatric subjects
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK. (22-26 October) Poster 440.
    • (2000)
    • Hsu, A.1    Bertz, R.2    Renz, C.3
  • 22
    • 13644254254 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between Kaletra™ (lopinavir/ritonavir or ABT-378/r) and other non-HIV drugs
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October) Poster 438.
    • (2000)
    • Bertz, R.1    Hsu, A.2    Lam, W.3
  • 25
    • 0008662572 scopus 로고    scopus 로고
    • Multiple dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir
    • 5th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, USA (1-5 February) Abstract 647.
    • (1998)
    • Lal, R.1    Hsu, A.2    Granneman, G.R.3
  • 27
    • 24544445846 scopus 로고    scopus 로고
    • Lopinavir/ritonavir (Kaletra) in Antiretroviral-naïve HIV + Patients: 144 Week Follow Up
    • 1st IAS Conference on HIV Pathogenesis and Treatment. Buenos Aires, Argentina (8-11 July)
    • (2001)
    • White, C.1    Brun, S.2    King, M.3
  • 28
    • 0003248557 scopus 로고    scopus 로고
    • Kaletra™ vs. Nelfinavir in antiretroviral-naïve subjects: Week 60 comparison in a phase III, blinded randomized clinical trail
    • 1st IAS Conference on HIV Pathogenesis and Treatment. Buenos Aires, Argentina (8-11 July)
    • (2001)
    • Ruane, A.1    Mendonca, J.2    Timerman, A.3
  • 30
    • 0008648743 scopus 로고    scopus 로고
    • Durable suppression of HIV + RNA after two years of Kaletra (ABT-378/ritonavir) therapy in single protease inhibitor experienced patients
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October) Poster.
    • (2000)
    • Feinberg, J.1    Brun, S.2    Marsh, T.3
  • 31
    • 0008640820 scopus 로고    scopus 로고
    • ABT-378/ritonavir (ABT-378/r) and efavirenz: 24-week safety/efficacy evaluation in multiple PI-experienced patients
    • 13th International AIDS Conference. Durban, South Africa (9-14 July) Abstract TuPeB3196.
    • (2000)
    • Clumeck, N.1    Brun, S.2    Xu, Y.3
  • 32
    • 0008648744 scopus 로고    scopus 로고
    • Kaletra (ABT-378/ritonavir) and efavirenz: 48-week safety/efficacy evaluation in multiple PI-experienced patients
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October) Poster F150.
    • (2000)
    • Rockstroh, J.1    Brun, S.2    Bertz, R.3
  • 33
    • 0008653921 scopus 로고    scopus 로고
    • Kaletra™ (ABT-378/ritonavir) in HIV-infected children at 60 weeks
    • 8th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, USA (4-8 February) Poster.
    • (2001)
    • Saez-Llorens, X.1    Renz, C.2    Deez, C.3
  • 34
    • 0008663275 scopus 로고    scopus 로고
    • Kaletra™ (ABT-378/ritonavir) in HIV-infected children at 72 weeks
    • 1st IAS Conference on HIV Pathogenesis and Treatment. Buenos Aires, Argentina (8-11 July) Poster.
    • (2001)
    • Cahn, P.1    Renz, C.2    Saez-Llorens, X.3
  • 35
    • 0008643883 scopus 로고    scopus 로고
    • Treatment of HIV + subjects co-infected with hepatitis B or C safety and efficacy comparison of Kaletra™ (ABT-378/ritonavir) vs. nelfinavir from a Phase III blinded randomized clinical trial
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October) Poster
    • (2000)
    • Arribas, J.1    Barros, C.2    Gonzalez-Lahoz, A.3
  • 36
    • 0008653922 scopus 로고    scopus 로고
    • Results from the Kaletra™ early access program
    • 8th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, USA (4-8 February) Poster
    • (2001)
    • Reitmayer, R.1    Rode, R.2    Bernstein, B.3
  • 37
    • 0008635893 scopus 로고    scopus 로고
    • Safety of Kaletra: Data from Phase II and Phase III Clinical Trials
    • 1st IAS Conference on HIV Pathogenesis and Treatment. Buenos Aires, Argentina (8-11 July)
    • (2001)
    • Bernstein, B.1    King, M.2    Brun, S.3
  • 39
    • 0008643884 scopus 로고    scopus 로고
    • Identification of clinically relevant phenotypic and genotypic breakpoints for ABT-378/r in multiple PI-experienced, NNRTI-naïve patients
    • 4th International Workshop on HIV Drug Resistance and Treatment Strategies. Sitges, Spain (12-16 June) Abstract 89
    • (2000)
    • Kempf, D.J.1    Brun, S.2    Rode, R.3
  • 40
    • 4243583668 scopus 로고    scopus 로고
    • Interpretation of phenotypic an genotypic resistance to Kaletra™ (ABT-378/ritonavir) in protease inhibitor experienced patients
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October) Poster
    • (2000)
    • Kempf, D.J.1    Isaacson, J.2    King, M.3
  • 41
    • 4243760904 scopus 로고    scopus 로고
    • Analysis of mutational patterns associated with response to lopinavir/ritonavir in multiple protease inhibitor-experienced patients
    • 5th International Workshop on HIV Drug Resistance & Treatment Strategies. Scottsdale, Arizona, USA (4-8 June)
    • (2001)
    • Kempf, D.1    King, M.2    Isaacson, J.3
  • 42
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • (2001) J. Virol. , pp. 7462-7469
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 43
    • 0008652450 scopus 로고    scopus 로고
    • trough inhibitory quotient predicts virologic response to ABT-378/ritonavir (ABT-378/r) therapy in treatment-experienced patients
    • 5th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (22-26 October)
    • (2000)
    • Hsu, A.1    Granneman, G.R.2    Kempf, D.J.3
  • 46
    • 26744460728 scopus 로고    scopus 로고
    • Patterns of resistance to lopinavir in protease inhibitor-experienced patients following viral rebound during lopinavir/ritonavir therapy
    • 5th International Workshop on HIV Drug Resistance & Treatment Strategies. Scottsdale, Arizona, USA (4-8 June)
    • (2001)
    • Molla, A.1    Brun, S.2    Garren, K.3
  • 47
    • 0141550180 scopus 로고    scopus 로고
    • Patterns of protease inhibitor cross-resistance in viral isolates with reduced susceptibility to Lopinavir
    • 8th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, USA (4-8 February)
    • (2001)
    • Brun, S.1    Kempf, D.2    Isaacson, J.3
  • 48
    • 4243429970 scopus 로고    scopus 로고
    • Lopinavir resistance still not identified in treatment-naïve patients
    • 1st IAS Conference on HIV Pathogenesis and Treatment. Conference Report: Buenos Aires, Argentina (8-11 July)
    • (2001)
    • Eron, J.E.1
  • 49
    • 0008666243 scopus 로고    scopus 로고
    • Lack of resistance to Kaletra™ (formerly known as ABT-378/r) observed through 24 weeks of therapy in antiretroviral naïve subjects
    • 5th International Congress on Drug Therapy in HIV Infection. Poster presentation, Glasgow, UK (22-26) October
    • (2000)
    • Bernstein, B.1    Kempf, D.J.2    Moseley, J.3
  • 50
    • 0008623655 scopus 로고    scopus 로고
    • Absence of resistance to Kaletra (ABT-378/r) observed through 48 weeks of therapy in antiretroviral-naïve subjects
    • 8th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, USA. (4-8 February)
    • (2001)
    • Bernstein, B.1    Moseley, J.2    Kempf, D.3
  • 51
    • 0031849665 scopus 로고    scopus 로고
    • In vitro selection and characterization of human immunodeficiency virus Type 1 variants with increased resistance to ABT-378, a novel protease inhibitor
    • (1998) J. Virol. , vol.72 , pp. 7532-7541
    • Carrillo, A.1    Strwart, K.D.2    Sham, H.L.3
  • 52
    • 0008659085 scopus 로고    scopus 로고
    • Factors Affecting Long-Term Virologic Suppression in Phase II Studies of Lopinavir/ritonavir (LPV/r) in ARV-Naïve or PI-Experienced Patients
    • 1st IAS Conference on HIV Pathogenesis and Treatment. Buenos Aires, Argentina (8-11 July)
    • (2001)
    • King, M.1    Brun, S.2    Marsh, T.3
  • 53
    • 0003667696 scopus 로고    scopus 로고
    • Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
    • Updated 23 April Department of Heath and Human Services
    • (2001)


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