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1
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4544280006
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Discovery of VX-175/GW433908, a novel, water soluble prodrug of amprenavir
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San Francisco, CA, USA, September (Abstract 916)
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TUNG RD, CHATURVEDI PR, BAKER C: Discovery of VX-175/GW433908, a novel, water soluble prodrug of amprenavir. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, September (1999) (Abstract 916).
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(1999)
39th Interscience Conference on Antimicrobial Agents and Chemotherapy
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Tung, R.D.1
Chaturvedi, P.R.2
Baker, C.3
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2
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0003281557
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Preclinical development of GW433908/VX-175 the water soluble phosphate prodrug of amprenavir
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San Francisco CA, USA, September (Abstract 917)
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FURFINE ES, BAKER C, STUDENBERG S et al.: Preclinical development of GW433908/VX-175 the water soluble phosphate prodrug of amprenavir. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco CA, USA, September (1999) (Abstract 917).
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(1999)
39th Interscience Conference on Antimicrobial Agents and Chemotherapy
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Furfine, E.S.1
Baker, C.2
Studenberg, S.3
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4
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0035997152
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Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers
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FALCOZ C, JENKINS JM, BYE C et al.: Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J. Clin. Pharmacol. (2002) 42:887-898.
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J. Clin. Pharmacol.
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Falcoz, C.1
Jenkins, J.M.2
Bye, C.3
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5
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9144240623
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Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type-1 infected patients
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WOOD R, ARASTEH K, STELLBRINK HJ et al.: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type-1 infected patients. Antimicrob. Agents Chemother. (2004) 48:116-123.
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Antimicrob. Agents Chemother.
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, pp. 116-123
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Wood, R.1
Arasteh, K.2
Stellbrink, H.J.3
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6
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0003221102
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Single dose safety and pharmacokinetics of GW433908, a prodrug of amprenavir (141W94, APV), administered as an oral liquid formulation to healthy male subjects
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San Francisco, CA, USA, September (Abstract 918)
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FALCOZ C, JENKINS JM, BYE C et al.: Single dose safety and pharmacokinetics of GW433908, a prodrug of amprenavir (141W94, APV), administered as an oral liquid formulation to healthy male subjects. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, September (1999) (Abstract 918).
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(1999)
39th Interscience Conference on Antimicrobial Agents and Chemotherapy
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Falcoz, C.1
Jenkins, J.M.2
Bye, C.3
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7
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0004834837
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Food effect on single-dose safety and pharmacokinetics of GW433908, a prodrug of amprenavir (141W94, APV) administered as a tablet to healthy male study participants
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(Abstract 329)
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FALCOZ C, JENKINS JM, BYE C et al.: Food effect on single-dose safety and pharmacokinetics of GW433908, a prodrug of amprenavir (141W94, APV) administered as a tablet to healthy male study participants. 37th Annual Meeting of the Infectious Disease Society of America (Abstract 329).
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37th Annual Meeting of the Infectious Disease Society of America
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Falcoz, C.1
Jenkins, J.M.2
Bye, C.3
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8
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4544365650
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GlaxoSmithKline: Lexiva® (fosmprenavir) package insert. GlaxoSmithKline, NC, USA
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GlaxoSmithKline: Lexiva® (fosmprenavir) package insert. GlaxoSmithKline, NC, USA (2003).
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(2003)
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9
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0008253934
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Amprenavir (APV) plasma concentrations are dramatically increased by association to ritonavir (RTV) baby-doses in HIV-infected patients: Possible combination with efavirenz
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(Abstract 2.7)
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LAMOTTE C: Amprenavir (APV) plasma concentrations are dramatically increased by association to ritonavir (RTV) baby-doses in HIV-infected patients: possible combination with efavirenz. First International Workshop on Clinical Pharmacology of HIV Therapy (2000) (Abstract 2.7).
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(2000)
First International Workshop on Clinical Pharmacology of HIV Therapy
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Lamotte, C.1
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10
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0003270087
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Pharmacokinetic (PK) drug-interaction between amprenavir (APV) and ritonavir (RTV) in HIV-seronegative subjects after multiple oral dosing
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February (Abstract 77)
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SADLER BM, PILIERO PJ, PRESTON SL, YU L, STEIN DS: Pharmacokinetic (PK) drug-interaction between amprenavir (APV) and ritonavir (RTV) in HIV-seronegative subjects after multiple oral dosing. 7th Conference on Retroviruses and Opportunistic Infections, February (2000) (Abstract 77).
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(2000)
7th Conference on Retroviruses and Opportunistic Infections
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Sadler, B.M.1
Piliero, P.J.2
Preston, S.L.3
Yu, L.4
Stein, D.S.5
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11
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0003333679
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Amprenavir (APV) plasma concentrations are dramatically decreased by association with ABT378/r in HIV-infected patients
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(Abstract P1.14)
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PEYTAVIN G, LAMOTTE C, DUVAL X et al.: Amprenavir (APV) plasma concentrations are dramatically decreased by association with ABT378/r in HIV-infected patients. 2nd International Workshop on Clinical Pharmacology of HIV Therapy (2001) (Abstract P1.14).
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(2001)
2nd International Workshop on Clinical Pharmacology of HIV Therapy
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Peytavin, G.1
Lamotte, C.2
Duval, X.3
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12
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0036740266
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Pharmacokinetic interactions between lopinavir/r and amprenavir in salvage therapy
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BASSO C, SOLAS C, QUINSON AM et al.: Pharmacokinetic interactions between lopinavir/r and amprenavir in salvage therapy. J. Acquir. Immune Defic. Syndr. (2002) 31(1):115-117.
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J. Acquir. Immune Defic. Syndr.
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, pp. 115-117
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Basso, C.1
Solas, C.2
Quinson, A.M.3
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13
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4544334155
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Unexpected complexity in nuclear receptor activation by HIV protease inhibitors and induction of CYP enzymes and transporters (135)
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Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11
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MARZOLINI C, TIRONA RG, LEE W et al.: Unexpected complexity in nuclear receptor activation by HIV protease inhibitors and induction of CYP enzymes and transporters (135). Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11 (2004).
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(2004)
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Marzolini, C.1
Tirona, R.G.2
Lee, W.3
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14
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0142138993
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A prospective study of deep salvage therapy with lopinavir/r, amprenavir, and NRTIs: Final 24- week data, pharmacokinetics, and association of drug levels/drug susceptibility with virologic response (423-W)
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Paper presented at 9th Conference on Retroviruses and Opportunistic Infections, Seattle, USA, February 24-28
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BALDINI F, RIZZO MG, HOETELMANS R et al.: A prospective study of deep salvage therapy with lopinavir/r, amprenavir, and NRTIs: final 24- week data, pharmacokinetics, and association of drug levels/drug susceptibility with virologic response (423-W). Paper presented at 9th Conference on Retroviruses and Opportunistic Infections, Seattle, USA, February 24-28 (2002).
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(2002)
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Baldini, F.1
Rizzo, M.G.2
Hoetelmans, R.3
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15
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4544322999
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Efficacy and tolerability of the combination of lopinavir/ritonavir (LPV/RTV) and amprenavir (APV) in patients with multiple protease inhibitors resistant HIV strains: Results at week 24
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Program and Abstracts of the 8th European Conference on Clinical Aspects and Treatment of HIV Infection, Athens, Greece, October 28-31 (Abstract p63)
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DE WIT S, WAND H, LAW M et al.: Efficacy and tolerability of the combination of lopinavir/ritonavir (LPV/RTV) and amprenavir (APV) in patients with multiple protease inhibitors resistant HIV strains: results at week 24. Program and Abstracts of the 8th European Conference on Clinical Aspects and Treatment of HIV Infection, Athens, Greece, October 28-31 (2001) (Abstract p63).
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(2001)
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De Wit, S.1
Wand, H.2
Law, M.3
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16
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4544344187
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Combining GW433908 (fosamprenavir; fosamprenavir) with lopinavir/ritonavir (LPV/R) in HIV-1 infected adults results in substantial reductions in amprenavir (APV and LPV concentrations: Pharmacokinetic (PK) results from Adult ACTG Protocol A5143
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Program and Abstracts of the 43rd Annual ICAAC Meeting, Chicago Illinois, USA, September 14-17 (Abstract H-855a)
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KASHUBA ADM, TIERNEY C, DOWNEY GF, VERGIS EN et al.: Combining GW433908 (fosamprenavir; fosamprenavir) with lopinavir/ritonavir (LPV/R) in HIV-1 infected adults results in substantial reductions in amprenavir (APV and LPV concentrations: pharmacokinetic (PK) results from Adult ACTG Protocol A5143. Program and Abstracts of the 43rd Annual ICAAC Meeting, Chicago, Illinois, USA, September 14-17 (2003) (Abstract H-855a).
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(2003)
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Kashuba, A.D.M.1
Tierney, C.2
Downey, G.F.3
Vergis, E.N.4
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17
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19444362024
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Dose separation strategies to overcome the pharmacokinetic interaction of a triple protease inhibitor regimen containing fosamprenavir, lopinavir and ritonavir (611)
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Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11
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CORBETT AH, DAVIDSON L, PARK JJ et al.: Dose separation strategies to overcome the pharmacokinetic interaction of a triple protease inhibitor regimen containing fosamprenavir, lopinavir and ritonavir (611). Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11 (2004).
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(2004)
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Corbett, A.H.1
Davidson, L.2
Park, J.J.3
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18
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3242708452
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The pharmacokinetic (PK) interaction between GW433908 (908) with lopinavir (LPV)/ritonavir (RTV) (APV10011 and APV10012)
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February (Abstract 612)
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WIRE MB, NADERER OJ, MASTERMAN AL et al.: The pharmacokinetic (PK) interaction between GW433908 (908) with lopinavir (LPV)/ritonavir (RTV) (APV10011 and APV10012). 11th Conference on Retroviruses and Opportunistic Infections, February (2004) (Abstract 612).
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(2004)
11th Conference on Retroviruses and Opportunistic Infections
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Wire, M.B.1
Naderer, O.J.2
Masterman, A.L.3
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19
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0008577205
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An assessment of plasma amprenavir (APV) pharmacokinetics (PK) following administration of two GW433908 (908) and ritonavir (RTV) QD regimens in combination with efavirenz (EFV) in healthy adult subjects (APV10009)
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September (Abstract 1737)
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WIRE MB, PRESTON SL, BALLOW C et al.: An assessment of plasma amprenavir (APV) pharmacokinetics (PK) following administration of two GW433908 (908) and ritonavir (RTV) QD regimens in combination with efavirenz (EFV) in healthy adult subjects (APV10009). 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, September (2002) (Abstract 1737).
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(2002)
41st Interscience Conference on Antimicrobial Agents and Chemotherapy
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Wire, M.B.1
Preston, S.L.2
Ballow, C.3
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20
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4544325434
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Steady state pharmacokinetics of saquinavir hard gel/fosamprenavir 1000/700 plus 100 mg and 200 mg of ritonavir twice daily in HIV+ patients (608)
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Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11
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BOFFITO M, DICKINSON L, HILL A et al.: Steady state pharmacokinetics of saquinavir hard gel/fosamprenavir 1000/700 plus 100 mg and 200 mg of ritonavir twice daily in HIV+ patients (608). Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11 (2004).
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(2004)
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Boffito, M.1
Dickinson, L.2
Hill, A.3
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21
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1642546599
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Pharmacokinetics of amprenavir given once or twice a day when combined with atazanavir in heavily pre-treated HI- positive patients
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GUFFANTI M, DE PASCALIS CR, SEMINARI E et al.: Pharmacokinetics of amprenavir given once or twice a day when combined with atazanavir in heavily pre-treated HI- positive patients. AIDS (2003) 17(18):2669-2671.
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AIDS
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Guffanti, M.1
De Pascalis, C.R.2
Seminari, E.3
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22
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0033766373
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Resistance to the HIV protease inhibitor amprenavir in vitro and in clinical studies: A review
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TISDALE M, MYERS R, RANDAL F et al.: Resistance to the HIV protease inhibitor amprenavir in vitro and in clinical studies: a review. Clinical Drug Investigation (2000) 20:267-285.
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Tisdale, M.1
Myers, R.2
Randal, F.3
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23
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4544314746
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HIV clinical isolates containing mutations representative of those selected after first line failure with unboosted GW433908 remain sensitive to other protease inhibitors
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(Abstract 19)
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ROSS L, PARKIN N, CHAPPEY C, TISDALE M, ELSTON R: HIV clinical isolates containing mutations representative of those selected after first line failure with unboosted GW433908 remain sensitive to other protease inhibitors. XII International HIV Drug Resistance Workshop (2003) (Abstract 19).
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(2003)
XII International HIV Drug Resistance Workshop
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Ross, L.1
Parkin, N.2
Chappey, C.3
Tisdale, M.4
Elston, R.5
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25
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0347990584
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The NEAT study: A 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naïve HIV-1-Infected patients
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RODRIGUEZ-FRENCH A, BOGHOSSIAN J, GRAY GE et al.: The NEAT study: A 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naïve HIV-1-Infected patients. J. AIDS (2004) 35:22-32.
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J. AIDS
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Rodriguez-French, A.1
Boghossian, J.2
Gray, G.E.3
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26
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3843151487
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SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients
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GATHE JC Jr, IVE P, WOOD R: SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS (2004) 18(11):1529-1537.
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AIDS
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Gathe Jr., J.C.1
Ive, P.2
Wood, R.3
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27
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4544326387
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Efficacy and safety of atazanavir with ritonavir or saquinavir versus lopinavir/ritonavir in patients who have experienced virologic failure on multiple HAART regimens: 48 week results from BMS A124-045 (547)
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Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11
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DEJESUS E, GRINSZTEJN B, RODRIGUEZ C et al.: Efficacy and safety of atazanavir with ritonavir or saquinavir versus lopinavir/ritonavir in patients who have experienced virologic failure on multiple HAART regimens: 48 week results from BMS A124-045 (547). Paper presented at 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11 (2004).
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(2004)
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Dejesus, E.1
Grinsztejn, B.2
Rodriguez, C.3
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28
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4544235925
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The use of observational databases to compare anti-retroviral effectiveness (559)
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Paper presented at 11th Conference on retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11
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KEISER P, NASSAR N, YAZDANI B, ARMAS L, MORENO S: The use of observational databases to compare anti-retroviral effectiveness (559). Paper presented at 11th Conference on retroviruses and Opportunistic Infections, San Francisco, USA, February 8-11 (2004).
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Keiser, P.1
Nassar, N.2
Yazdani, B.3
Armas, L.4
Moreno, S.5
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