Clinical and serological features of patients with autoantibodies to GW/P bodies

Clinical Immunology

Volumn 125, Issue 3, 2007, Pages 247-256

  Bhanji, Rahima A ^a   Eystathioy, Theophany ^a   Chan, Edward K L ^b   Bloch, Donald B ^c   Fritzler, Marvin J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF FLORIDA   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Ago2; Autoantibodies; Ge 1; P bodies GW182

Indexed keywords

AUTOANTIBODY; EPITOPE; GE 1 PROTEIN; GLYCINE TRYPTOPHAN REPEAT PROCESSING ANTIBODY; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; ATAXIA; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOASSAY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MALE; MOTOR NEUROPATHY; NEUROLOGIC DISEASE; NUCLEAR LOCALIZATION SIGNAL; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SENSORY NEUROPATHY; SEROLOGY; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; EUKARYOTIC INITIATION FACTOR-2; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOASSAY; IMMUNOPRECIPITATION; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES; NUCLEAR PROTEINS; SJOGREN'S SYNDROME;

EID: 36149000969     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2007.07.016     Document Type: Article

References (50)

1. Fritzler M.J., and Wiik A. Autoantibody assays, testing, and standardization. In: Rose N.R., and Mackay I.R. (Eds). The Autoimmune Diseases (2006), Elsevier Academic Press, Sydney 1011-1022
2. Lerner E.A., Lerner M.R., Janeway Jr. C.A., and Steitz J.A. Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 78 (1981) 2737-2741
3. Lerner M.R., Boyle J.A., Hardin J.A., and Steitz J.A. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science 211 (1981) 400-402
4. Padgett R.A., Mount S.M., Steitz J.A., and Sharp P.A. Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell 35 (1983) 101-107
5. Craft J. Antibodies to snRNPs in systemic lupus erythematosus. Rheum. Dis. Clin. North Am. 18 (1992) 311-335
6. Mattioli M., and Reichlin M. Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus. Arthritis Rheum. 17 (1974) 421-429
7. Maddison P.J., Mogavero H., and Reichlin M. Antibodies to nuclear ribonucleoprotein. J. Rheumatol. 5 (1978) 407-411
8. Alspaugh M.A., Talal N., and Tan E.M. Differentiation and characterization of autoantibodies and their antigens in Sjogren's syndrome. Arthritis Rheum. 19 (1976) 216-222
9. Wasicek C.A., and Reichlin M. Clinical and serological differences between systemic lupus erythematosus patients with antibodies to ro versus patients with antibodies to Ro and La. J. Clin. Invest. 69 (1982) 835-843
10. Wahren M., Tengner P., Gunnarsson I., Lundberg I., Hedfors E., Ringertz N.R., and Pettersson I. Ro/SS-A and La/SS-B antibody level variation in patients with Sjogren's syndrome and systemic lupus erythematosus. J. Autoimmun. 11 (1998) 29-38
11. Eystathioy T., Chan E.K.L., Tenenbaum S.A., Keene J.D., Griffith K.J., and Fritzler M.J. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell 13 (2002) 1338-1351
12. Eulalio A., Behm-Ansmant I., and Izaurralde E. P bodies: at the crossroads of post-transcriptional pathways. Nat. Rev., Mol. Cell Biol. 8 (2007) 9-22
13. Jakymiw A., Pauley K.M., Li S., Ikeda K., Lian S., Eystathioy T., Satoh M., Fritzler M.J., and Chan E.K.L. The role of GW/P bodies in RNA processing and silencing. J. Cell. Sci. 120 (2007) 1317-1323
14. Rana T.M. Illuminating the silence: understanding the structure and function of small RNAs. Nat. Rev., Mol. Cell Biol. 8 (2007) 23-36
15. Yang W.H., and Bloch D.B. Probing the mRNA processing body using protein macroarrays and 'autoantigenomics'. RNA 13 (2007) 704-712
16. Meister G., Landthaler M., Peters L., Chen P.Y., Urlaub H., Luhrmann R., and Tuschl T. Identification of novel argonaute-associated proteins. Curr. Biol. 15 (2005) 2149-2155
17. Eystathioy T., Chan E.K.L., Yang Z., Takeuchi K., Mahler M., Luft L.M., Zochodne D.W., and Fritzler M.J. Clinical and serological associations of autoantibodies to a novel cytoplasmic autoantigen, GW182 and GW bodies. J. Mol. Med. 81 (2003) 811-818
18. Yu J.H., Yang W.H., Gulick T., Bloch K.D., and Bloch D.B. Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. RNA 11 (2005) 1795-1802
19. Bloch D.B., Gulick T., Bloch K.D., and Yang W.H. Processing body autoantibodies reconsidered. RNA 12 (2006) 707-709
20. Yang W.H., Yu J.H., Gulick T., Bloch K.D., and Bloch D.B. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. RNA 12 (2006) 547-554
21. Jakymiw A., Ikeda K., Fritzler M.J., Reeves W.H., Satoh M., and Chan E.K. Autoimmune targeting of key components of RNA interference. Arthritis Res. Ther. 8 (2006) R87
22. Laurino C.F.C., Fritzler M.J., Mortara R.A., Silva N.P., Almeida I.C., and Andrade L.E.C. Human autoantibodies to diacyl-phosphatidylethanolamine recognize a specific set of discrete cytoplasmic domains. Clin. Exp. Immunol. 143 (2006) 572-584
23. Ikeda K., Satoh M., Pauley K.M., Fritzler M.J., Reeves W.H., and Chan E.K. Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody. J. Immunol. Methods 317 (2006) 38-44
24. Eystathioy T., Chan E.K.L., Mahler M., Luft L.M., Fritzler M.L., and Fritzler M.J. A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182. Hybridoma Hybridomics 22 (2003) 79-86
25. Selak S., Mahler M., Miyachi K., Fritzler M.L., and Fritzler M.J. Identification of the B-cell epitopes of the early endosome antigen 1 (EEA1). Clin. Immunol. 109 (2003) 154-164
26. Stinton L.M., Eystathioy T., Selak S., Chan E.K.L., and Fritzler M.J. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes and GW bodies. Clin. Immunol. 110 (2004) 30-44
27. Fritzler M.J., Behmanesh F., and Fritzler M.L. Analysis of human sera that are polyreactive in an addressable laser bead immunoassay. Clin. Immunol. 120 (2006) 349-356
28. Reveille J.D., Fischbach M., McNearney T., Friedman A.W., Aguilar M.B., Lisse J., Fritzler M.J., Ahn C., and Arnett F.C. Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants. Semin. Arthritis Rheum. 30 (2001) 332-346
29. Reveille J.D. The genetic basis of autoantibody production. Autoimmun. Rev. 5 (2006) 389-398
30. van Dijk E., Cougot N., Meyer S., Babajko S., Wahle E., and Séraphin B. Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J. 21 (2002) 6915-6924
31. Wang Z.R., Jiao X.F., Carr-Schmid A., and Kiledjian M. The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12663-12668
32. Lykke-Andersen J. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol. Cell. Biol. 22 (2002) 8114-8121
33. Fenger-Gron M., Fillman C., Norrild B., and Lykke-Andersen J. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol. Cell 20 (2005) 905-915
34. Simon E., Camier S., and Seraphin B. New insights into the control of mRNA decapping. Trends Biochem. Sci. 31 (2006) 241-243
35. Arbuckle M.R., McClain M.T., Rubertone M.V., Scofield R.H., Dennis G.J., James J.A., and Harley J.B. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349 (2003) 1526-1533
36. Liu J., Rivas F.V., Wohlschlegel J., Yates III J.R., Parker R., and Hannon G.J. A role for the P-body component GW182 in microRNA function. Nat. Cell Biol. 7 (2005) 1161-1166
37. Jakymiw A., Eystathioy T., Satoh M., Hamel J.C., Fritzler M.J., and Chan E.K.L. Disruption of GW bodies impairs mammalian mRNA interference. Nat. Cell Biol. 7 (2005) 1167-1174
38. Pourmand N., Blange I., Ringertz N., and Pettersson I. Intracellular localisation of the Ro 52 kD auto-antigen in HeLa cells visualised with green fluorescent protein chimeras. Autoimmunity 28 (1998) 225-233
39. Espinosa A., Zhou W., Ek M., Hedlund M., Brauner S., Popovic K., Horvath L., Wallerskog T., Oukka M., Nyberg F., Kuchroo V.K., and Wahren-Herlenius M. The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. J. Immunol. 176 (2006) 6277-6285
40. Behm-Ansmant I., Rehwinkel J., Doerks T., Stark A., Bork P., and Izaurralde E. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev. 20 (2006) 1885-1898
41. Rivett A.J., and Hearn A.R. Proteasome function in antigen presentation: immunoproteasome complexes, peptide production, and interactions with viral proteins. Curr. Protein Pept. Sci. 5 (2004) 153-161
42. Song J.J., Smith S.K., Hannon G.J., and Joshua-Tor L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305 (2004) 1434-1437
43. Pruijn G.J.M. The RNA interference pathway: a new target for autoimmunity. Arthritis Res. Ther. 8 (2006) 110-112
44. Sarnow P., Jopling C.L., Norman K.L., Schutz S., and Wehner K.A. MicroRNAs: expression, avoidance and subversion by vertebrate viruses. Nat. Rev., Microbiol. 4 (2006) 651-659
45. Waterhouse P.M., Wang M.B., and Lough T. Gene silencing as an adaptive defence against viruses. Nature 411 (2001) 834-842
46. Schutz S., and Sarnow P. Interaction of viruses with the mammalian RNA interference pathway. Virology 344 (2006) 151-157
47. Fujinami R.S., von Herrath M.G., Christen U., and Whitton J.L. Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin. Microbiol. Rev. 19 (2006) 80-94
48. Bloch D.B., Rabkina D., Quertermous T., and Bloch K.D. The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. Clin. Immunol. Immunopathol. 72 (1994) 380-389
49. Fritzler M.J., and Manns M.P. Anti-mitochondrial antibodies. Clin. Appl. Immunol. Rev. 3 (2002) 87-113
50. Fritzler M.J., and Miller B.J. Detection of autoantibodies to SS-A/Ro by indirect immunofluorescence using a transfected and overexpressed human 60 kD Ro autoantigen in HEp-2 cells. J. Clin. Lab. Anal. 9 (1995) 218-224