Identification of interspecies concordance of mechanisms of arsenic-induced bladder cancer

Toxicology in Vitro

Volumn 21, Issue 8, 2007, Pages 1513-1529

  Sen, Banalata ^a   Wolf, Douglas C ^a   Turpaz, Yaron ^b   Bugrim, Andrej ^c   Retief, Jacques ^d   Hester, Susan D ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Thermo Fisher Scientific   (United States)

^c GeneGo bioinformatics software Inc   (United States)

^d Entelos Inc   (United States)

Author keywords

Dimethylarsinic acid; Interspecies extrapolation; Risk assessment; Toxicogenomics

Indexed keywords

ARSENIC; CACODYLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLADDER CANCER; BLADDER EPITHELIUM; CELL ADHESION; CELL CYCLE REGULATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LIPID METABOLISM; NONHUMAN; OXIDATIVE STRESS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN DEGRADATION; RAT; RISK ASSESSMENT; SPECIES COMPARISON;

ANIMALS; ARSENIC; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION PROFILING; HUMANS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED F344; URINARY BLADDER NEOPLASMS;

RATTUS;

EID: 36148999849     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.06.021     Document Type: Article

References (43)

1. Aposhian H.V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Ann. Rev. Pharmacol. Toxicol. 37 (1997) 397-419
2. Arnold L.L., Cano M., John M.St., Eldan M., van Gemert M., and Cohen S.M. Effects of dietary dimethylarsinic acid on the urine and urothelium of rats. Carcinogenesis 20 11 (1999) 2171-2179
3. Barry W.T., Nobel A.B., and Wright F.A. Significance analysis of functional categories in gene expression studies: a structured permutation approach. Bioinformatics 21 9 (2005) 1943-1949
4. Bredfeldt T.G., Kopplin M.J., and Gandolfi A.J. Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Toxicol. Appl. Pharmacol. 198 (2004) 412-418
5. Cohen S.M. Cell proliferation in the bladder and implications for cancer risk assessment. Toxicology 102 1 (1995) 149-159
6. Cohen S.M., Yamamoto S., Cano M., and Arnold L.L. Urothelial cytotoxicity and regeneration induced by dimethylarsinic acid in rats. Toxicol. Sci. 59 1 (2001) 68-74
7. Cohen S.M., Arnold L.L., Uzvolgyi E., Cano M., John M.St., Yamamoto S., Lu X., and Le X.C. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem. Res. Toxicol. 15 9 (2002) 1150-1157
8. Cohen S.M., Ohnishi T., Arnold L.L., and Le X.C. Arsenic induced bladder cancer in an animal model. Toxicol. Appl. Pharmacol. (2006) 10.1016/j.taap.2006.10.01
9. Cullen W.R., McBride B.C., and Reglinski J. The reaction of methylarsenicals with thiols: some biological implications. J. Inorg. Biochem. 21 (1984) 171-194
10. Germolec D.R., Spalding J., Yu H.S., Chen G.S., Simeonova P.P., Humble M.C., Bruccoleri A., Boorman G.A., Foley J.F., Yoshida T., and Luster M.I. Arsenic enhancement of skin Neoplasia by chronic stimulation of growth factors. Am. J. Pathol. 153 (1998) 1775-1785
11. Harris S.L., and Levine A.J. The p53 pathway: positive and negative feedback loops. Oncogene 24 (2005) 2899-2908
12. Heinloth A.N., Irwin R.D., Boorman G.A., Nettesheim P., Fannini R.D., Sieber S.O., Snell M.L., Tucker C.J., Li L., Travlos G.S., Vansant G., Blackshear P.E., Tennant R.W., Cunningham M.L., and Paules R.S. Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol. Sci. 80 1 (2004) 193-202
13. Hester S.D., Wolf D.C., Nesnow S., and Thai S.F. Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol. 34 7 (2006) 879-894
14. Huang C., Ke Q., Costa M., and Shi X. Molecular mechanisms of arsenic carcinogenesis. Mol. Cell. Biochem. 255 1-2 (2004) 57-66
15. Irizarry R.A., Bolstad B.M., Collin F., Cope L.M., Hobbs B., and Speed T.P. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31 4 (2003) e15
16. Kawamata H., Kameyama S., Nan L., Kawai K., and Oyasu R. Effect of epidermal growth factor and transforming growth factor β1 on growth and invasive potentials of newly established rat bladder carcinoma cell lines. Int. J. Cancer 55 (1993) 968-973
17. Kenyon E.M., and Hughes M.F. A concise review of the toxicity and carcinogenicity of dimethylarsinic acid. Toxicology 160 (2001) 227-236
18. Khan M.A., Fenton S.E., Swank A.E., Knapp G.W., Hester S.D., and Wolf D.C. low-level exposure effects of individual or mixtures of ammonium perchlorate and sodium chlorate on the pituitary-thyroid axis in male F-344 rats. Toxicol. Pathol. 33 (2005) 776-783
19. Kitchin K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172 3 (2001) 249-261
20. Liu J., and Waalkes M. Focal adhesion kinase as a potential target in arsenic toxicity. Toxicol. Sci. 84 2 (2005) 212-213
21. Luster M.I., and Simeonova P.P. Arsenic and urinary bladder cell proliferation. Toxicol. Appl. Pharmacol. 198 (2004) 419-423
22. Marafante E., Vahter M., and Envall J. The role of methylation in the detoxification of arsenate in the rabbit. Chem. Biol. Interact. 56 (1985) 225-238
23. National Research Council. Arsenic in the Drinking Water (1999), National Academy Press, Washington, DC, USA
24. Nesnow S., Roop B.C., Lambert G., Kadiiska M., Mason R.P., Cullen W.R., and Mass M.J. DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem. Res. Toxicol. 15 12 (2002) 1627-1634
25. Nyska A., Hester S.D., Cooper R.L., Goldman J., Stoker T., House D., and Wolf D.C. Single or group housing-altered hormonal physiology and affected pituitary and interstitial cell kinetics. Toxicol. Sci. 27 (2002) 449-457
26. Rossi M.R., Masters J.R.W., Park S., Todd J.H., Garrett S.H., Sens M.A., Somji S., Nath J., and Sens D.A. The immortalized UROtsa cell line as a potential cell culture model of human urothelium. Environ. Health Perspect. 109 8 (2001) 801-808
27. Rossman T.G. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat. Res. 533 (2003) 37-65
28. Schlaepfer D.D., and Mitra S.K. Multiple connections link FAK to cell motility and invasion. Curr. Opin. Genet. Dev. 14 1 (2004) 92-101
29. Sen B., Wang A., Hester S.D., Robertson J.L., and Wolf D.C. Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urothelium. Toxicology 215 (2005) 214-226
30. Shen J., Wanibuchi H., Salime E.I., Wei M., Kinoshita A., Yoshida K., and Fukushima S. Liver tumorigenicity of trimethylarsine oxide in male Fisher 344 rats - association with oxidative DNA damage and enhanced cell proliferation. Carcinogenesis 24 (2003) 1827-1835
31. Shiobara Y., Ogra Y., and Suzuki K.T. Animal species differences in the uptake of dimethylarsinous acid (DMA(III)) by red blood cells. Chem. Res. Toxicol. 14 10 (2001) 1446-1452
32. Su P.F., Hu Y.J., Ho I.C., Cheng Y.M., and Lee T.C. Distinct gene expression profiles in immortalized human urothelial cells exposed to inorganic arsenite and its methylated trivalent metabolites. Environ. Health Perspect. 114 3 (2006) 394-403
33. Thompson D.J. A chemical hypothesis for arsenic methylation in mammals. Chem. Biol. Interact. 88 (1993) 89-114
34. US EPA, 2006. Revised Science Issue Paper: Mode of Carcinogenic Action for Cacodylic Acid (Dimethylarsinic Acid, DMAV) and Recommendations for Dose-Response Extrapolation. Available from: .
35. Vahter M., and Envall J. In vivo reduction of arsenate in mice and rabbits. Environ. Res. 32 1 (1983) 14-24
36. Ward W.O., Delker D.A., Hester S.D., Thai S.F., Wolf D.C., Allen J.W., and Nesnow S. Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol. 34 7 (2006) 863-878
37. Wei M., Wanibuchi H., Morimura K., Iwai S., Yoshida K., Endo G., Nakae D., and Fukushima S. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 23 (2002) 1387-1397
38. Wei M., Arnold L., Cano M., and Cohen S.M. Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium. Toxicol. Sci. 83 2 (2005) 237-245
39. Woo S.H., Park M.J., An S., Lee H.C., Jin H.O., Lee S.J., Gwak H.S., Park I.C., Hong S.I., and Rhee C.H. Diarsenic and tetraarsenic oxide inhibit cell cycle progression and bFGF and VEGF induced proliferation of human endothelial cells. J. Cell Biochem. 95 (2005) 120-130
40. Yamanaka K., Takabayashi F., Mizoi M., An Y., Hasegawa A., and Okada S. Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice leads to an increase in 8-oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis. Biochem. Biophys. Res. Commun. 287 1 (2001) 66-70
41. Yancy S.L., Shelden E.A., Gilmont R.R., and Welsh M.J. Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Toxicol. Sci. 84 2 (2005) 278-286
42. Yang C., and Frenkel K. Arsenic mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis. J. Environ. Pathol. Toxicol. Oncol. 21 4 (2002) 331-342
43. Yu X., William C., Griffith W.C., Hanspers K., Dillman III J.F., Ong H., Vredevoogd M.A., and Faustman E.M. A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. Toxicol. Sci. 92 2 (2006) 560-577