Three-dimensional quantitative structure-activity relationships and activity predictions of human TRPV1 channel antagonists: Comparative molecular field analysis and comparative molecular similarity index analysis of cinnamides

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5608-5619

  Viswanadhan, Vellarkad N ^a   Sun, Yaxiong ^a   Norman, Mark H ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CINNAMAMIDE; CINNAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ARTICLE; ATOM; CHANNEL GATING; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; DRUG STRUCTURE; ENERGY; HUMAN; MOLECULAR MODEL; NONHUMAN; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; ANIMALS; CINNAMATES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; TRPV CATION CHANNELS;

EID: 36148932970     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070261k     Document Type: Article

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