Cell responses to the mechanochemical microenvironment-Implications for regenerative medicine and drug delivery

Advanced Drug Delivery Reviews

Volumn 59, Issue 13, 2007, Pages 1329-1339

  Rehfeldt, Florian ^a   Engler, Adam J ^b   Eckhardt, Adam ^c   Ahmed, Fariyal ^b   Discher, Dennis E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Atomic force microscopy (AFM); Cells; Drug delivery; Extracellular matrix; Matrix elasticity; Mesenchymal stem cell (MSC); Tissue regeneration

Indexed keywords

MATRIX ELASTICITY; MESENCHYMAL STEM CELL (MSC); TISSUE REGENERATION;

ATOMIC FORCE MICROSCOPY; CELL GROWTH; DRUG PRODUCTS; TISSUE CULTURE; TISSUE ENGINEERING;

DRUG DELIVERY;

2,3 BUTANEDIONE; ALGINIC ACID; BLEBBISTATIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CYCLOHEXIMIDE; DIMETICONE; ELASTIN; FIBRINOGEN; FIBRONECTIN; HYALURONIC ACID; KT 5926; LAMININ; MACROGOL; MATRIGEL; MITOMYCIN C; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD47; POLYACRYLAMIDE; UNCLASSIFIED DRUG; VINCULIN;

ATOMIC FORCE MICROSCOPY; CANCER CELL; CELL ADHESION; CELL DIFFERENTIATION; CYTOSKELETON; DRUG DELIVERY SYSTEM; ELASTICITY; EXTRACELLULAR MATRIX; GEL; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SCANNING PROBE MICROSCOPY; SMOOTH MUSCLE FIBER; TISSUE REGENERATION;

ANIMALS; BIOMECHANICS; CELL ADHESION; CELL DIFFERENTIATION; CELL PHYSIOLOGY; DRUG DELIVERY SYSTEMS; ELASTICITY; HUMANS; LIGANDS; REGENERATION; REGENERATIVE MEDICINE; TISSUE SCAFFOLDS;

EID: 36049045106     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2007.08.007     Document Type: Review

References (73)

1. Discher D.E., Janmey P., and Wang Y.L. Tissue cells feel and respond to the stiffness of their substrate. Science 310 5751 (2005) 1139-1143
2. Hynes R.O. Cell adhesion: old and new questions. Trends in Biochemical Sciences 24 12 (1999) M33-M37
3. Harris A.K., Wild P., and Stopak D. Silicone-rubber substrata-new wrinkle in the study of cell locomotion. Science 208 4440 (1980) 177-179
4. Pelham R.J., and Wang Y.L. Cell locomotion and focal adhesions are regulated by substrate flexibility. Proceedings of the National Academy of Sciences of the United States of America 94 25 (1997) 13661-13665
5. Dembo M., and Wang Y.L. Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophysical Journal 76 4 (1999) 2307-2316
6. Francius G., et al. Effect of crosslinking on the elasticity of polyelectrolyte multilayer films measured by colloidal probe AFM. Microscopy Research and Technique 69 2 (2006) 84-92
7. Richert L., et al. Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules 5 5 (2004) 1908-1916
8. Engler A.J., et al. Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion. Surface Science 570 1-2 (2004) 142-154
9. Rizzi S.C., et al. Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part II: biofunctional characteristics. Biomacromolecules 7 11 (2006) 3019-3029
10. Tan J.L., et al. Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proceedings of the National Academy of Sciences of the United States of America 100 4 (2003) 1484-1489
11. Saez A., et al. Is the mechanical activity of epithelial cells controlled by deformations or forces?. Biophysical Journal 89 6 (2005) L52-L54
12. Seliktar D. Extracellular stimulation in tissue engineering. Communicative Cardiac Cell (2005) 386-394
13. Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends in Cell Biology 13 5 (2003) 264-269
14. Kleinman H.K., et al. Basement-membrane complexes with biological-activity. Biochemistry 25 2 (1986) 312-318
15. Kleinman H.K., et al. Isolation and characterization of type-Iv procollagen, laminin, and heparan-sulfate proteoglycan from the Ehs sarcoma. Biochemistry 21 24 (1982) 6188-6193
16. Stevens M.M., and George J.H. Exploring and engineering the cell surface interface. Science 310 5751 (2005) 1135-1138
17. Kong H.J., et al. FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proceedings of the National Academy of Sciences of the United States of America 102 12 (2005) 4300-4305
18. Shu X.Z., et al. Disulfide cross-linked hyaluronan hydrogels. Biomacromolecules 3 6 (2002) 1304-1311
19. Cai S.S., et al. Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials 26 30 (2005) 6054-6067
20. Liu Y.C., Shu X.Z., and Prestwich G.D. Biocompatibility and stability of disulfide-crosslinked hyaluronan films. Biomaterials 26 23 (2005) 4737-4746
21. Binnig G., Quate C.F., and Gerber C. Atomic force microscope. Physical Review Letters 56 9 (1986) 930-933
22. Binnig G., Quate C.F., and Gerber C. Atomic force microscope. Physical Review Letters 56 (1986) 930-933
23. Radmacher M. Measuring the elastic properties of living cells by the atomic force microscope. Atomic Force Microscopy in Cell Biology (2002) 67-90
24. Ludwig M., et al. AFM, a tool for single-molecule experiments. Applied Physics A, Materials Science & Processing 68 2 (1999) 173-176
25. Hertz H. Über die Berührung fester elastischer Körper. Jounal für die Reine und Angewandte Mathematik 92 (1882) 156-171
26. von Wichert G., et al. Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO Journal 22 19 (2003) 5023-5035
27. Mahaffy R.E., et al. Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells. Physical Review Letters 85 4 (2000) 880-883
28. Storm C., et al. Nonlinear elasticity in biological gels. Nature 435 7039 (2005) 191-194
29. Lu Y.B., et al. Viscoelastic properties of individual glial cells and neurons in the CNS. Proceedings of the National Academy of Sciences of the United States of America 103 47 (2006) 17759-17764
30. Georges P.C., et al. Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. Biophysical Journal 90 8 (2006) 3012-3018
31. Yoshikawa Y., et al. Transverse elasticity of myofibrils of rabbit skeletal muscle studied by atomic force microscopy. Biochemical and Biophysical Research Communications 256 1 (1999) 13-19
32. Bosboom E.M.H., et al. Passive transverse mechanical properties of skeletal muscle under in vivo compression. Journal of Biomechanics 34 10 (2001) 1365-1368
33. Engler A.J., et al. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. Journal of Cell Biology 166 6 (2004) 877-887
34. Collinsworth A.M., et al. Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. American Journal of Physiology. Cell Physiology 283 4 (2002) C1219-C1227
35. Goffin J.M., et al. Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. Journal of Cell Biology 172 2 (2006) 259-268
36. Berry M.F., et al. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. American Journal of Physiology. Heart and Circulatory Physiology 290 6 (2006) H2196-H2203
37. Polllard T.D., and Earnshaw W.C. Cell Biology. 1st ed. (2002), Saunders, Philadelphia
38. Lauffenburger D.A., and Lindermann J.J. Receptors: Models for Binding, Trafficking, and Signaling. 2nd ed. (1996), Oxford University Press, London 365
39. Peyton S.R., and Putnam A.J. Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion. Journal of Cellular Physiol 204 1 (2005) 198-209
40. Engler A., et al. Substrate compliance versus ligand density in cell on gel responses. Biophysical Journal 86 1 (2004) 617-628
41. Gaudet C., et al. Influence of type I collagen surface density on fibroblast spreading, motility, and contractility. Biophysical Journal 85 5 (2003) 3329-3335
42. Engler A.J., et al. Matrix elasticity directs stem cell lineage specification. Cell 126 (2006) 677-689
43. Paszek M.J., et al. Tensional homeostasis and the malignant phenotype. Cancer Cells 8 3 (2005) 241-254
44. Wang N., et al. Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. American Journal of Physiology. Cell Physiology 282 3 (2002) C606-C616
45. Lo C.M., et al. Cell movement is guided by the rigidity of the substrate. Biophysical Journal 79 1 (2000) 144-152
46. Beningo K.A., Dembo M., and Wang Y.I. Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors. Proceedings of the National Academy of Sciences of the United States of America 101 52 (2004) 18024-18029
47. Cukierman E., et al. Taking cell-matrix adhesions to the third dimension. Science 294 5547 (2001) 1708-1712
48. Mao Y., and Schwarzbauer J.E. Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. Journal of Cell Science 118 Pt 19 (2005) 4427-4436
49. Lutolf M.P., and Hubbell J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nature Biotechnology 23 1 (2005) 47-55
50. Stegemann J.P., and Nerem R.M. Altered response of vascular smooth muscle cells to exogenous biochemical stimulation in two-and three-dimensional culture. Experimental Cell Research 283 2 (2003) 146-155
51. Zaman M.H., et al. Computational model for cell migration in three-dimensional matrices. Biophysical Journal 89 2 (2005) 1389-1397
52. Reneker D.H., and Chun I. Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 7 3 (1996) 216-223
53. Matthews J.A., et al. Electrospinning of collagen nanofibers. Biomacromolecules 3 2 (2002) 232-238
54. Lauffenburger D.A., and Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 84 3 (1996) 359-369
55. Mitchison T.J., and Cramer L.P. Actin-based cell motility and cell locomotion. Cell 84 3 (1996) 371-379
56. Riveline D., et al. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. Journal of Cell Biology 153 6 (2001) 1175-1186
57. Schoenwaelder S.M., and Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Current Opinion in Cell Biology 11 2 (1999) 274-286
58. Balaban N.Q., et al. Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nature Cell Biology 3 5 (2001) 466-472
59. Rottner K., Hall A., and Small J.V. Interplay between Rac and Rho in the control of substrate contact dynamics. Current Biology 9 12 (1999) 640-648
60. Hinz B. Masters and servants of the force: The role of matrix adhesions in myofibroblast force perception and transmission. European Journal of Cell Biology 85 3-4 (2006) 175-181
61. Cai Y., et al. Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. Biophysical Journal 91 10 (2006) 3907-3920
62. Straight A.F., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 5613 (2003) 1743-1747
63. Rief M., et al. The mechanical stability of immunoglobulin and fibronectin III domains in the muscle protein titin measured by atomic force microscopy. Biophysical Journal 75 6 (1998) 3008-3014
64. Evans E., and Ritchie K. Dynamic strength of molecular adhesion bonds. Biophysical Journal 72 4 (1997) 1541-1555
65. Marshall B.T., et al. Direct observation of catch bonds involving cell-adhesion molecules. Nature 423 6936 (2003) 190-193
66. Thomas W.E., et al. Bacterial adhesion to target cells enhanced by shear force. Cell 109 7 (2002) 913-923
67. Evans E.A., and Parsegian V.A. Thermal-mechanical fluctuations enhance repulsion between biomolecular layers. Proceedings of the National Academy of Sciences of the United States of America 83 19 (1986) 7132-7136
68. Jana S.S., Kawamoto S., and Adelstein R.S. A specific isoform of nonmuscle myosin II-C is required for cytokinesis in a tumor cell line. Journal of Biological Chemistry 281 34 (2006) 24662-24670
69. Mateo V., et al. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nature Medicine 5 11 (1999) 1277-1284
70. Eckhardt A., Engler A.J., and Discher D.E. Influence of protein synthesis on smooth muscle cells spreading. Molecular Biology of the Cell 15 (2004) 150A
71. Griffin M.A., et al. Adhesion-contractile balance in myocyte differentiation. Journal of Cell Science 117 24 (2004) 5855-5863
72. Gratzer P.F., Santerre J.P., and Lee J.M. Modulation of collagen proteolysis by chemical modification of amino acid side-chains in acellularized arteries. Biomaterials 25 11 (2004) 2081-2094
73. El-Kassaby A.W., et al. Urethral stricture repair with an off-the-shelf collagen matrix. Journal of Urology 169 1 (2003) 170-173