The TSH receptor is linked with AP1 and NFκB signaling in COS7 cells

Experimental and Clinical Endocrinology and Diabetes

Volumn 115, Issue 9, 2007, Pages 590-593

  Voigt, C ^a   Prodinger, C ^a   Paschke, R ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Luciferase; Reporter gene; Signaling pathway; TSH receptor

Indexed keywords

CRE RECOMBINASE; CYCLIC AMP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; THYROTROPIN RECEPTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; DNA RESPONSIVE ELEMENT; GENE VECTOR; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; GENES, REPORTER; LUCIFERASES; LUMINESCENT MEASUREMENTS; NF-KAPPA B; PEPTIDES; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; THYROTROPIN; TRANSFECTION;

EID: 35948948313     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-981453     Document Type: Article

References (34)

1. Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE. The human thyrotropin receptor activates G-proteins Gs and Gq/11. J Biol Chem 1994; 269: 13733-13735
2. Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci USA 2003; 100: 940-945
3. Cetani F, Tonacchera M, Vassart G. Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors. FEBS Lett 1996; 378: 27-31
4. Corvilain B, Laurent E, Lecomte M, Vansande J, Dumont JE. Role of the cyclic adenosine 3′, 5′-monophosphate and the phosphatidylinositol-Ca2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. J Clin Endocrinol Metab 1994; 79: 152-159
5. Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997; 390: 88-91
6. Gudermann T, Grosse R, Schultz G. Contribution of receptor/G protein signaling to cell growth and transformation. Naunyn Schmiedebergs Arch Pharmacol 2000; 361: 345-362
7. Gudermann T, Nurnberg B, Schultz G. Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function. J Mol Med 1995; 73: 51-63
8. Gurevich EV, Gurevich VV. Arrestins: ubiquitous regulators of cellular signaling pathways. Genome Biol 2006; 7: 236
9. Iacovelli L, Capobianco L, Salvatore L, Sallese M, D'Ancona GM, De Blasi A. Thyrotropin activates mitogen-activated protein kinase pathway in FRTL-5 by a cAMP-dependent protein kinase A-independent mechanism. Mol Pharmacol 2001; 60: 924-933
10. Ji TH, Grossmann M, Ji I. G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J Biol Chem 1998; 273: 17299-17302
11. Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G. The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. Proc Natl Acad Sci USA 1996; 93: 116-120
12. Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science 2005; 308: 512-517
13. Liebmann C. Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity. Cell Signal 2001; 13: 777-785
14. Lopez-Ilasaca M. Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. Biochem Pharmacol 1998; 56: 269-277
15. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della RG, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 1999; 283: 655-661
16. Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, lefkowitz RJ. Activation and targeting of extracellular signal-regulated kinases by beta -arrestin scaffolds. Proc Natl Acad Sci USA 2001; 98: 2449-2454
17. Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 2001; 22: 368-376
18. McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science 2000; 290: 1574-1577
19. Nagayama Y, Rapoport B. The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning. Mol Endocrinol 1992; 6: 145-156
20. Pacifico F, Mauro C, Barone C, Crescenzi E, Mellone S, Monaco M, Chiappetta G, Terrazzano G, Liguoro D, Vito P, Consiglio E, Formisano S, Leonardi A. Oncogenic and anti-apoptotic activity of NF-kappa B in human thyroid carcinomas. J Biol Chem 2004; 279: 54610-54619
21. Reddy SA, Huang JH, Liao WS. Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. J Biol Chem 1997; 272: 29167-29173
22. Saunier B, Tournier C, Jacquemin C, Pierre M. Stimulation of mitogen-activated protein kinase by thyrotropin in primary cultured human thyroid follicles. J Biol Chem 1995; 270: 3693-3697
23. Schaaf L, Leiprecht A, Saji M, Hubner U, Usadel KH, Kohn LD. Glycosylation variants of human TSH selectively activate signal transduction pathways. Mol Cell Endocrinol 1997; 132: 185-194
24. Segaloff DL, Ascoli M. The lutropin/choriogonadotropin receptor ... 4 years later. Endocr Rev 1993; 14: 324-347
25. Sprengel R, Braun T, Nikolics K, Segaloff DL, Seeburg PH. The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA. Mol Endocrinol 1990; 4: 525-530
26. Sun Y, Huang J, Xiang Y, Bastepe M, Juppner H, Kobilka BK, Zhang JJ, Huang XY. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J 2007; 26: 53-64
27. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiol Rev 2002; 82: 473-502
28. Taniguchi SI, Shong M, Giuliani C, Napolitano G, Saji M, Montani V, Suzuki K, Singer DS, Kohn LD. Iodide suppression of major histocompatibility class I gene expression in thyroid cells involves enhancer A and the transcription factor NF-kappa B. Mol Endocrinol 1998; 12: 19-33
29. Van Sande J, Raspe E, Perret J, Lejeune C, Maenhaut C, Vassart G, Dumont JE. Thyrotropin activates both the cyclic AMP and the PIP2 cascades in CHO cells expressing the human cDNA of TSH receptor. Mol Cell Endocrinol 1990; 74: R1-R6
30. Vassart G, Dumont JE. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 1992; 13: 596-611
31. Visconti R, Cerutti J, Battista S, Fedele M, Trapasso F, Zeki K, Miano MP, de Nigris F, Casalino L, Curcio F, Santoro M, Fusco A. Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression. Oncogene 1997; 15: 1987-1994
32. Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 1996; 74: 589-607
33. Wonerow P, Schoneberg T, Schultz G, Gudermann T, Paschke R. Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation. J Biol Chem 1998; 273: 7900-7905
34. Ye RD. Regulation of nuclear factor kappaB activation by G-protein-coupled receptors. J Leukoc Biol 2001; 70: 839-848