Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis

Laboratory Investigation

Volumn 85, Issue 6, 2005, Pages 756-767

  Kumar, Pawan ^a   Benedict, Ryan ^a   Urzua, Fernando ^a   Fischbach, Claudia ^b   Mooney, David ^b   Polverini, Peter ^a  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Angiogenesis; Apoptosis; Combination therapy; Endothelial cells; PI3 K; VEGF

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CISPLATIN; MATRIGEL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BCL 2; PROTEIN KINASE B;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG TARGETING; ENDOTHELIUM CELL; GAMMA RADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LOW DRUG DOSE; MOUSE; MOUTH CARCINOMA; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION PROTECTION; RADIATION RESPONSE; RADIOSENSITIVITY; SCID MOUSE; SQUAMOUS CELL CARCINOMA; TUMOR CELL; TUMOR CELL DESTRUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CASPASES; CELL DIVISION; CELL LINE, TUMOR; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; MICE; MICE, SCID; MOUTH NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; TRANSPLANTATION, HETEROLOGOUS;

EID: 20444424979     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700272     Document Type: Article

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