Aging alters acute apoptotic response to azoxymethane in the colon of rats

Experimental Gerontology

Volumn 42, Issue 12, 2007, Pages 1154-1161

  Kwon, Youngjoo ^a   Magnuson, Bernadene A ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Age; Aging; Apoptosis; Azoxymethane; Colon; Crypt morphology

Indexed keywords

AZOXYMETHANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 2; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53;

AGING; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; COLON; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION;

AGING; ALKALINE PHOSPHATASE; ANIMALS; APOPTOSIS; AZOXYMETHANE; BCL-X PROTEIN; CARCINOGENS; COLON; GENE EXPRESSION; GENES, BCL-2; GENES, P53; INTESTINAL MUCOSA; ISOENZYMES; MALE; NF-KAPPA B; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA; RATTUS;

EID: 35848956551     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2007.09.011     Document Type: Article

References (39)

1. Aizu W., Guda K., Nambiar P., Xin T., Thibodeau M., Rosenberg D.W., and Giardina C. p53 and its co-activator p300 are inversely regulated in the mouse colon in response to carcinogen. Toxicol. Lett. 144 (2003) 213-224
2. Bissell M.J., Radisky D.C., Rizki A., Weaver V.M., and Petersen O.W. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 70 (2002) 537-546
3. Bissell M.J., Rizki A., and Mian I.S. Tissue architecture: the ultimate regulator of breast epithelial function. Curr. Opin. Cell Biol. 15 (2003) 753-762
4. Bitar K.N. Aging and neural control of the GI tract V aging and gastrointestinal smooth muscle: from signal transduction to contractile proteins. Am. J. Physiol. Gastrointest. Liver Physiol. 284 (2003) G1-G7
5. Boland M.P. DNA damage signalling and NF-kappaB: implications for survival and death in mammalian cells. Biochem. Soc. Trans. 29 (2001) 674-678
6. Breckenridge D.G., and Xue D. Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases. Curr. Opin. Cell Biol. 16 (2004) 647-652
7. Campisi J. Cancer and ageing: rival demons?. Nat. Rev. Cancer 3 (2003) 339-349
8. Chen W., Cooper T.K., Zahnow C.A., Overholtzer M., Zhao Z., Ladanyi M., Karp J.E., Gokgoz N., Wunder J.S., Andrulis I.L., Levine A.J., Mankowski J.L., and Baylin S.B. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell 6 (2004) 387-398
9. Chen W.Y., Wang D.H., Yen R.C., Luo J., Gu W., and Baylin S.B. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 (2005) 437-448
10. Chen W.Y., Zeng X., Carter M.G., Morrell C.N., Chiu Yen R.W., Esteller M., Watkins D.N., Herman J.G., Mankowski J.L., and Baylin S.B. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat. Genet. 33 (2003) 197-202
11. Craven P.A., Pfanstiel J., Saito R., and DeRubertis F.R. Relationship between loss of rat colonic surface epithelium induced by deoxycholate and initiation of the subsequent proliferative response. Cancer Res. 46 (1986) 5754-5759
12. Dupont-Versteegden E.E. Apoptosis in muscle atrophy: relevance to sarcopenia. Exp. Gerontol. 40 (2005) 473-481
13. Gerschenson L.E., and Rotello R.J. Apoptosis: a different type of cell death. FASEB J. 6 (1992) 2450-2455
14. Heiser D., Labi V., Erlacher M., and Villunger A. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Gerontol. 39 (2004) 1125-1135
15. Herndon L.A., Schmeissner P.J., Dudaronek J.M., Brown P.A., Listner K.M., Sakano Y., Paupard M.C., Hall D.H., and Driscoll M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419 (2002) 808-814
16. Hickman J.A. Apoptosis and tumourigenesis. Curr. Opin. Genet. Dev. 12 (2002) 67-72
17. Hirose Y., Yoshimi N., Makita H., Hara A., Tanaka T., and Mori H. Early alterations of apoptosis and cell proliferation in azoxymethane-initiated rat colonic epithelium. Jpn. J. Cancer Res. 87 (1996) 575-582
18. Hong M.Y., Chapkin R.S., Wild C.P., Morris J.S., Wang N., Carroll R.J., Turner N.D., and Lupton J.R. Relationship between DNA adduct levels, repair enzyme, and apoptosis as a function of DNA methylation by azoxymethane. Cell Growth Differ. 10 (1999) 749-758
19. Hu Y., Le Leu R.K., and Young G.P. Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours. Int. J. Cancer 115 (2005) 561-567
20. Karin M., and Lin A. NF-kappaB at the crossroads of life and death. Nat. Immunol. 3 (2002) 221-227
21. Kwon Y., and Magnuson B.A. Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. Scand. J. Gastroenterol. 42 (2007) 72-80
22. Kwon Y., Malik M., and Magnuson B.A. Inhibition of colonic aberrant crypt foci by curcumin in rats is affected by age. Nutr. Cancer 48 (2004) 37-43
23. Lee H.M., Greeley Jr. G.H., and Englander E.W. Effects of aging on expression of genes involved in regulation of proliferation and apoptosis in the colonic epithelium. Mech. Ageing Dev. 115 (2000) 139-155
24. Martin K., Kirkwood T.B., and Potten C.S. Age changes in stem cells of murine small intestinal crypts. Exp. Cell Res. 241 (1998) 316-323
25. McDougal J.N., Miller M.S., Burks T.F., and Kreulen D.L. Age-related changes in colonic function in rats. Am. J. Physiol. 247 (1984) G542-G546
26. Medina C., Santana A., Paz M.C., Diaz-Gonzalez F., Farre E., Salas A., Radomski M.W., and Quintero E. Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis. J. Leukoc. Biol. 79 (2006) 954-962
27. Meier P., Finch A., and Evan G. Apoptosis in development. Nature 407 (2000) 796-801
28. Murphy M.E., Leu J.I., and George D.L. p53 moves to mitochondria: a turn on the path to apoptosis. Cell Cycle 3 (2004) 836-839
29. Parrinello S., Coppe J.P., Krtolica A., and Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci. 118 (2005) 485-496
30. Pollack M., Phaneuf S., Dirks A., and Leeuwenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann. NY Acad. Sci. 959 (2002) 93-107
31. Reed J.C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 17 (1999) 2941-2953
32. Roberts D., Gelperin D., and Wiley J.W. Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon. Am. J. Physiol. 267 (1994) G515-G522
33. Schoemaker M.H., Ros J.E., Homan M., Trautwein C., Liston P., Poelstra K., van Goor H., Jansen P.L., and Moshage H. Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis. J. Hepatol. 36 (2002) 742-750
34. Sohn O.S., Ishizaki H., Yang C.S., and Fiala E.S. Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 12 (1991) 127-131
35. Valks D.M., Kemp T.J., and Clerk A. Regulation of Bcl-xL expression by H2O2 in cardiac myocytes. J. Biol. Chem. 278 (2003) 25542-25547
36. Wang Q., Wang X., and Evers B.M. Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. J. Biol. Chem. 278 (2003) 51091-51099
37. Warner H.R. Apoptosis: a two-edged sword in aging. Ann. NY Acad. Sci. 887 (1999) 1-11
38. Xiao Z.Q., Moragoda L., Jaszewski R., Hatfield J.A., Fligiel S.E., and Majumdar A.P. Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. Mech. Ageing Dev. 122 (2001) 1849-1864
39. Zahir N., and Weaver V.M. Death in the third dimension: apoptosis regulation and tissue architecture. Curr. Opin. Genet. Dev. 14 (2004) 71-80