Immunoglobulin gene joints compensate for reduced on-rates imposed by somatic mutations in a VH gene

Molecular Immunology

Volumn 37, Issue 3-4, 2000, Pages 95-105

  Liu, Jiang ^a   Liu, Lusha ^a   Jemmerson, Ronald ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Affinity maturation; Cytochrome c; Monoclonal antibody; On rate off rate constants; Single chain variable region fragment (scFv); Somatic mutation

Indexed keywords

B LYMPHOCYTE RECEPTOR; CYTOCHROME C; EPITOPE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN; TYROSINE;

ANTIBODY AFFINITY; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL MATURATION; GERM LINE; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SOMATIC MUTATION;

ANIMALS; ANTIBODY AFFINITY; B-LYMPHOCYTES; CYTOCHROME C GROUP; GENES, IMMUNOGLOBULIN; GERM CELLS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MUTAGENESIS, SITE-DIRECTED; SELECTION (GENETICS);

EID: 0034086597     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0161-5890(00)00041-9     Document Type: Article

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