-
2
-
-
0016753182
-
Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia
-
Bilheimer D.W., Goldstein J.L., et al. Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia. J. Clin. Invest. 56 (1975) 1420-1430
-
(1975)
J. Clin. Invest.
, vol.56
, pp. 1420-1430
-
-
Bilheimer, D.W.1
Goldstein, J.L.2
-
3
-
-
84960962572
-
Coronary heart disease in the Framingham study
-
Dawber T.R., Moore F.E., et al. Coronary heart disease in the Framingham study. Am. J. Public Health Nations Health 47 4 Part 2 (1957) 4-24
-
(1957)
Am. J. Public Health Nations Health
, vol.47
, Issue.4 PART 2
, pp. 4-24
-
-
Dawber, T.R.1
Moore, F.E.2
-
4
-
-
0026091744
-
A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction
-
Stampfer M.J., Sacks F.M., et al. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N. Engl. J. Med. 325 (1991) 373-381
-
(1991)
N. Engl. J. Med.
, vol.325
, pp. 373-381
-
-
Stampfer, M.J.1
Sacks, F.M.2
-
5
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I., and Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 3 (2004) 711-715
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
6
-
-
0042322260
-
FTIR spectroscopy demonstrates biochemical differences in mammalian cell cultures at different growth stages
-
Mourant J.R., Yamada Y.R., et al. FTIR spectroscopy demonstrates biochemical differences in mammalian cell cultures at different growth stages. Biophys. J. 85 (2003) 1938-1947
-
(2003)
Biophys. J.
, vol.85
, pp. 1938-1947
-
-
Mourant, J.R.1
Yamada, Y.R.2
-
7
-
-
0023323002
-
Molecular genetics of hemophilia A in man (factor VIII deficiency)
-
Antonarakis S.E., Youssoufian H., et al. Molecular genetics of hemophilia A in man (factor VIII deficiency). Mol. Biol. Med. 4 (1987) 81-94
-
(1987)
Mol. Biol. Med.
, vol.4
, pp. 81-94
-
-
Antonarakis, S.E.1
Youssoufian, H.2
-
8
-
-
0025236339
-
Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease
-
Barton N.W., Furbish F.S., et al. Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 1913-1916
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 1913-1916
-
-
Barton, N.W.1
Furbish, F.S.2
-
9
-
-
0033614446
-
Chronic myeloid leukaemia
-
Sawyers C.L. Chronic myeloid leukaemia. N. Engl. J. Med. 340 (1999) 1330-1340
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
10
-
-
0347382285
-
Neurogenetics: single gene disorders
-
Pulst S.M. Neurogenetics: single gene disorders. J. Neurol. Neurosurg. Psychiatry 74 (2003) 1608-1614
-
(2003)
J. Neurol. Neurosurg. Psychiatry
, vol.74
, pp. 1608-1614
-
-
Pulst, S.M.1
-
11
-
-
33744493093
-
The new era in cancer research
-
Varmus H. The new era in cancer research. Science 312 (2006) 1162-1165
-
(2006)
Science
, vol.312
, pp. 1162-1165
-
-
Varmus, H.1
-
12
-
-
0037177625
-
Genetic dissection of transcriptional regulation in budding yeast
-
Brem R.B., Yvert G., et al. Genetic dissection of transcriptional regulation in budding yeast. Science 296 (2002) 752-755
-
(2002)
Science
, vol.296
, pp. 752-755
-
-
Brem, R.B.1
Yvert, G.2
-
13
-
-
0037396404
-
A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets
-
Schadt E.E., Monks S.A., et al. A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochem. Soc. Trans. 31 (2003) 437-443
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 437-443
-
-
Schadt, E.E.1
Monks, S.A.2
-
14
-
-
27844454448
-
Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits
-
Schadt E.E. Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits. Curr. Opin. Biotechnol. 16 (2005) 647-654
-
(2005)
Curr. Opin. Biotechnol.
, vol.16
, pp. 647-654
-
-
Schadt, E.E.1
-
15
-
-
33750204290
-
Genetics of global gene expression
-
Rockman M.V., and Kruglyak L. Genetics of global gene expression. Nat. Rev. Genet. 7 (2006) 862-872
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 862-872
-
-
Rockman, M.V.1
Kruglyak, L.2
-
16
-
-
22844446947
-
An integrative genomics approach to infer causal associations between gene expression and disease
-
Schadt E.E., Lamb J., et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nat. Genet. 37 (2005) 710-717
-
(2005)
Nat. Genet.
, vol.37
, pp. 710-717
-
-
Schadt, E.E.1
Lamb, J.2
-
17
-
-
34248330076
-
Recent advances in pharmacokinetic modeling
-
Ahmad A.M. Recent advances in pharmacokinetic modeling. Biopharm. Drug Dispos. 28 (2007) 135-143
-
(2007)
Biopharm. Drug Dispos.
, vol.28
, pp. 135-143
-
-
Ahmad, A.M.1
-
18
-
-
33644524918
-
Mass spectrometry-based proteomics turns quantitative
-
Ong S.E., and Mann M. Mass spectrometry-based proteomics turns quantitative. Nat. Chem. Biol. 1 (2005) 252-262
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 252-262
-
-
Ong, S.E.1
Mann, M.2
-
19
-
-
18244370796
-
How molecular profiling could revolutionize drug discovery
-
Stoughton R.B., and Friend S.H. How molecular profiling could revolutionize drug discovery. Nat. Rev. Drug Discov. 4 (2005) 345-350
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 345-350
-
-
Stoughton, R.B.1
Friend, S.H.2
-
20
-
-
33746266617
-
Highly parallel genomic assays
-
Fan J.B., Chee M.S., et al. Highly parallel genomic assays. Nat. Rev. Genet. 7 (2006) 632-644
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 632-644
-
-
Fan, J.B.1
Chee, M.S.2
-
21
-
-
20844432908
-
Can cell systems biology rescue drug discovery?
-
Butcher E.C. Can cell systems biology rescue drug discovery?. Nat. Rev. Drug Discov. 4 (2005) 461-467
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 461-467
-
-
Butcher, E.C.1
-
22
-
-
14844300115
-
An integrated approach for inference and mechanistic modeling for advancing drug development
-
Aksenov S.V., Church B., et al. An integrated approach for inference and mechanistic modeling for advancing drug development. FEBS Lett. 579 (2005) 1878-1883
-
(2005)
FEBS Lett.
, vol.579
, pp. 1878-1883
-
-
Aksenov, S.V.1
Church, B.2
-
23
-
-
0842288337
-
Inferring cellular networks using probabilistic graphical models
-
Friedman N. Inferring cellular networks using probabilistic graphical models. Science 303 (2004) 799-805
-
(2004)
Science
, vol.303
, pp. 799-805
-
-
Friedman, N.1
-
24
-
-
16844376909
-
Reverse engineering of regulatory networks in human B cells
-
Basso K., Margolin A.A., et al. Reverse engineering of regulatory networks in human B cells. Nat. Genet. 37 (2005) 382-390
-
(2005)
Nat. Genet.
, vol.37
, pp. 382-390
-
-
Basso, K.1
Margolin, A.A.2
-
25
-
-
21444452397
-
Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks
-
di Bernardo D., Thompson M.J., et al. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. Nat. Biotechnol. 23 (2005) 377-383
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 377-383
-
-
di Bernardo, D.1
Thompson, M.J.2
-
26
-
-
18144442687
-
Inferring subnetworks from perturbed expression profiles
-
Pe'er D., Regev A., et al. Inferring subnetworks from perturbed expression profiles. Bioinformatics 17 Suppl 1 (2001) S215-S224
-
(2001)
Bioinformatics
, vol.17
, Issue.SUPPL. 1
-
-
Pe'er, D.1
Regev, A.2
-
27
-
-
0000042837
-
Evaluating functional network inference using simulations of complex biological systems
-
Smith V.A., Jarvis E.D., et al. Evaluating functional network inference using simulations of complex biological systems. Bioinformatics 18 (2002) 216S-224S
-
(2002)
Bioinformatics
, vol.18
-
-
Smith, V.A.1
Jarvis, E.D.2
-
28
-
-
84960432692
-
Combining microarrays and biological knowledge for estimating gene networks via Bayesian networks
-
Imoto S., Higuchi T., et al. Combining microarrays and biological knowledge for estimating gene networks via Bayesian networks. Proc. IEEE Comput. Soc. Bioinform. Conf. 2 (2003) 104-113
-
(2003)
Proc. IEEE Comput. Soc. Bioinform. Conf.
, vol.2
, pp. 104-113
-
-
Imoto, S.1
Higuchi, T.2
-
29
-
-
3042698613
-
Bayesian network and nonparametric heteroscedastic regression for nonlinear modeling of genetic network
-
Imoto S., Kim S., et al. Bayesian network and nonparametric heteroscedastic regression for nonlinear modeling of genetic network. J. Bioinform. Comput. Biol. 1 (2003) 231-252
-
(2003)
J. Bioinform. Comput. Biol.
, vol.1
, pp. 231-252
-
-
Imoto, S.1
Kim, S.2
-
31
-
-
0002370418
-
A tutorial on learning with Bayesian networks
-
Jordan M.I. (Ed), MIT Press, Cambridge, Massachusetts
-
Heckerman D. A tutorial on learning with Bayesian networks. In: Jordan M.I. (Ed). Learning in Graphical Models (1999), MIT Press, Cambridge, Massachusetts 301-354
-
(1999)
Learning in Graphical Models
, pp. 301-354
-
-
Heckerman, D.1
-
32
-
-
0001341735
-
Introduction to Monte Carlo methods
-
Jordan M.I. (Ed), MIT Press
-
Mackay D.J.C. Introduction to Monte Carlo methods. In: Jordan M.I. (Ed). Learning in Graphical Models (1999), MIT Press 175-204
-
(1999)
Learning in Graphical Models
, pp. 175-204
-
-
Mackay, D.J.C.1
-
33
-
-
17644427718
-
Causal protein-signaling networks derived from multiparameter single-cell data
-
Sachs K., Perez O., et al. Causal protein-signaling networks derived from multiparameter single-cell data. Science 308 (2005) 523-529
-
(2005)
Science
, vol.308
, pp. 523-529
-
-
Sachs, K.1
Perez, O.2
-
34
-
-
33745585792
-
Phosphoproteomic analysis of Her2/neu signaling and inhibition
-
Bose R., Molina H., et al. Phosphoproteomic analysis of Her2/neu signaling and inhibition. PNAS 103 (2006) 9773-9778
-
(2006)
PNAS
, vol.103
, pp. 9773-9778
-
-
Bose, R.1
Molina, H.2
-
35
-
-
20044388557
-
From signatures to models: understanding cancer using microarrays
-
Segal E., Friedman N., et al. From signatures to models: understanding cancer using microarrays. Nat. Genet. 37 Suppl (2005) S38-S45
-
(2005)
Nat. Genet.
, vol.37
, Issue.SUPPL
-
-
Segal, E.1
Friedman, N.2
-
36
-
-
33747891871
-
Predicting the prognosis of breast cancer by integrating clinical and microarray data with Bayesian networks
-
Gevaert O., Smet F.D., et al. Predicting the prognosis of breast cancer by integrating clinical and microarray data with Bayesian networks. Bioinformatics 22 (2006) e184-e190
-
(2006)
Bioinformatics
, vol.22
-
-
Gevaert, O.1
Smet, F.D.2
-
37
-
-
33646198860
-
Pharmaco-metabonomic phenotyping and personalized drug treatment
-
Clayton T.A., Lindon J.C., et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440 (2006) 1073-1077
-
(2006)
Nature
, vol.440
, pp. 1073-1077
-
-
Clayton, T.A.1
Lindon, J.C.2
-
38
-
-
0031003468
-
Learning versus confirming in clinical drug development
-
Sheiner L.B. Learning versus confirming in clinical drug development. Clin. Pharmacol. Ther. 61 (1997) 275-291
-
(1997)
Clin. Pharmacol. Ther.
, vol.61
, pp. 275-291
-
-
Sheiner, L.B.1
-
39
-
-
0036441845
-
Returns on research and development for 1990s new drug introductions
-
Grabowski H., Vernon J., et al. Returns on research and development for 1990s new drug introductions. Pharmacoeconomics 20 Suppl 3 (2002) 11-29
-
(2002)
Pharmacoeconomics
, vol.20
, Issue.SUPPL. 3
, pp. 11-29
-
-
Grabowski, H.1
Vernon, J.2
-
40
-
-
35748957547
-
-
PHRMA (2006-2007). Annual Report
-
-
-
-
41
-
-
33748991736
-
Molecular biology. Little molecules with big goals
-
O'Malley B.W. Molecular biology. Little molecules with big goals. Science 313 (2006) 1749-1750
-
(2006)
Science
, vol.313
, pp. 1749-1750
-
-
O'Malley, B.W.1
-
42
-
-
15944426084
-
Bayesian analysis of signaling networks governing embryonic stem cell fate decisions
-
Woolf P.J., Prudhomme W., et al. Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinformatics 21 6 (2005) 741-753
-
(2005)
Bioinformatics
, vol.21
, Issue.6
, pp. 741-753
-
-
Woolf, P.J.1
Prudhomme, W.2
|