Structure and function in rhodopsin: Kinetic studies of retinal binding to purified opsin mutants in defined phospholipid-detergent mixtures serve as probes of the retinal binding pocket

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 5, 1999, Pages 1927-1931

  Reeves, Philip J ^a   Hwa, John ^a   Khorana, H Gobind ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

11 cis retinal; Binding pocket; G protein coupled receptors; Retinitis pigmentosa; Signal transduction

Indexed keywords

11 CIS RETINAL; DETERGENT; OPSIN; PHOSPHOLIPID; RETINAL; RHODOPSIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN COS1; CONCENTRATION RESPONSE; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RETINITIS PIGMENTOSA; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATTLE; COS CELLS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OPSIN; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RETINALDEHYDE; RHODOPSIN; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0033514949     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.5.1927     Document Type: Article

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