Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 22, 2007, Pages 1888-1896

  Power, Krista A ^a   Ward, Wendy E ^a   Chen, Jian Min ^a   Saarinen, Niina M ^a   Thompson, Lilian U ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

SOYBEAN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; DIET THERAPY; FEMALE; FEMUR; HUMAN; HUMAN CELL; LINSEED; MOUSE; NONHUMAN; NUDE MOUSE; OVARIECTOMY; POSTMENOPAUSE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; UTERUS; XENOGRAFT;

ANIMALS; BONE DENSITY; CELL LINE, TUMOR; FEMALE; FEMUR; FLAX; HUMANS; LUMBAR VERTEBRAE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; ORGAN SIZE; OVARIECTOMY; PHYTOESTROGENS; SOYBEAN PROTEINS; STRESS, MECHANICAL; TRANSPLANTATION, HETEROLOGOUS; UTERUS;

MUS; MUS MUSCULUS;

EID: 35648935508     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390701549179     Document Type: Article

References (56)

1. Adlercreutz, H. 2002. Phyto-oestrogens and cancer. Lancet Oncol. 3:364-373.
2. Alekel, D. L., Germain, A. S., Peterson, C. T., Hanson, K. B., Stewart, J. W., and Toda, T. 2000. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am. J. Clin. Nutr. 72:844-852.
3. Allred, C. D., Allred, K. F., Ju, Y. H., Clausen, L. M., Doerge, D. R., Schantz, S. L., Korol, D. L., Wallig, M. A., and Helferich, W. G. 2004a. Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats. Carcinogenesis 25:211-218.
4. Allred, C. D., Allred, K. F., Ju, Y. H., Goeppinger, T. S., Doerge, D. R., and Helferich, W. G. 2004b. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 25:1649-1657.
5. Allred, C. D., Allred, K. F., Ju, Y. H., Virant, S. M., and Helferich, W. G. 2001. Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res. 61:5045-5050.
6. Arjmandi, B. H. 2001. The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. J. Am. Coll. Nutr. 20:398S-402S.
7. Arjmandi, B. H., Birnbaum, R., Goyal, N. V., Getlinger, M. J., Juma, S., Alekel, L., Hasler, C. M., Drum, M. L., Hollis, B. W., and Kukreja, S. C. 1998. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content. Am. J. Clin. Nutr. 68:1364S-1368S.
8. Breitman, P. L., Fonseca, D., and Ward, W. E. 2005. Combination of soy protein and high dietary calcium on bone biomechanics and bone mineral density in ovariectomized rats. Menopause 12:428-435.
9. Brooks, J. D., Ward, W. E., Lewis, J. E., Hilditch, J., Nickell, L., Wong, E., and Thompson, L. U. 2004. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am. J. Clin. Nutr. 79:318-325.
10. Cai, D. J., Zhao, Y., Glasier, J., Cullen, D., Barnes, S., Turner, C. H., Wastney, M., and Weaver, C. M. 2005. Comparative effect of soy protein, soy isoflavones, and 17beta-estradiol on bone metabolism in adult ovariectomized rats. J. Bone Miner. Res. 20:828-839.
11. Canadian Council on Animal Care. 1993. Guide to the care and use of experimental animals, ed. E. D. Olfert, B. M. Cross, and A. A. McWilliam, 2nd ed., Vol. 1. Ottawa: Canadian Council on Animal Care.
12. Chiechi, L. M., Secreto, G., D'Amore, M., Fanelli, M., Venturelli, E., Cantatore, F., Valerio, T., Laselva, G., and Loizzi, P. 2002. Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: The Menfis randomized trial. Maturitas 42:295-300.
13. Cohen, S. L., and Ward, W. E. 2005. Flaxseed oil and bone development in growing male and female mice. J. Toxicol. Environ. Health A 68:1861-1870.
14. Dang, Z. C., and Lowik, C. 2005. Dose-dependent effects of phytoestrogens on bone. Trends Endocrinol. Metab. 16:207-213.
15. Davis, B. C., and Kris-Etherton, P. M. 2003. Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications. Am. J. Clin. Nutr. 78:640S-646S.
16. Devareddy, L., Khalil, D. A., Korlagunta, K., Hooshmand, S., Bellmer, D. D., and Arjmandi, B. H. 2006. The effects of fructo-oligosaccharides in combination with soy protein on bone in osteopenic ovariectomized rats. Menopause 13:692-699.
17. Dodin, S., Lemay, A., Jacques, H., Legare, F., Forest, J. C., and Masse, B. 2005. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J. Clin. Endocrinol. Metab. 90:1390-1397.
18. Fernandes, G., Lawrence, R., and Sun, D. 2003. Protective role of n-3 lipids and soy protein in osteoporosis. Prostaglandins Leukotrienes Essential Fatty Acids 68:361-372.
19. Fonseca, D., and Ward, W. E. 2004. Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice. Bone 35:489-497.
20. Gao, Y. H., and Yamaguchi, M. 2000. Suppressive effect of genistein on rat bone osteoclasts: Involvement of protein kinase inhibition and protein tyrosine phosphatase activation. Int. J. Mol. Med. 5:261-267.
21. Genazzani, A. R., Gadducci, A., and Gambacciani, M. 2001. Hormone replacement therapy and cancer. Gynecol. Endocrinol. 15:453-465.
22. Gerber, B., Scholz, C., Reimer, T., Briese, V., and Janni, W. 2006. Complementary and alternative therapeutic approaches in patients with early breast cancer: A systematic review. Breast Cancer Res. Treat. 95:199-209.
23. Greendale, G. A., FitzGerald, G., Huang, M. H., Sternfeld, B., Gold, E., Seeman, T., Sherman, S., and Sowers, M. 2002. Dietary soy isoflavones and bone mineral density: Results from the study of women's health across the nation. Am. J. Epidemiol. 155:746-754.
24. Harkness, L. S., Fiedler, K., Sehgal, A. R., Oravec, D., and Lerner, E. 2004. Decreased bone resorption with soy isoflavone supplementation in postmenopausal women. J. Women's Health (Larchmt.) 13:1000-1007.
25. Ho, S. C., Chan, S. G., Yi, Q., Wong, E., and Leung, P. C. 2001. Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. J. Bone Miner. Res.16:1363-1369.
26. Horiuchi, T., Onouchi, T., Takahashi, M., Ito, H., and Orimo, H. 2000. Effect of soy protein on bone metabolism in postmenopausal Japanese women. Osteoporosis Int. 11:721-724.
27. Ishimi, Y., Arai, N., Wang, X., Wu, J., Umegaki, K., Miyaura, C., Takeda, A., and Ikegami, S. 2000. Difference in effective dosage of genistein on bone and uterus in ovariectomized mice. Biochem. Biophys. Res. Commun. 274:697-701.
28. Kardinaal, A. F., Morton, M. S., Bruggemann-Rotgans, I. E., and van Beresteijn, E. C. 1998. Phyto-oestrogen excretion and rate of bone loss in postmenopausal women. Eur. J. Clin. Nutr. 52:850-855.
29. Kreijkamp-Kaspers, S., Kok, L., Grobbee, D. E., de Haan, E. H., Aleman, A., Lampe, J. W., and van der Schouw, Y. T. 2004. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: A randomized controlled trial. .J Am. Med. Assoc. 292:65-74.
30. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252-4263.
31. Kurzer, M. S. 2003. Phytoestrogen supplementation use by women. J. Nutr. 133:1983S-1986S.
32. Lee, S. K., Kadono, Y., Okada, F., Jacquin, C., Koczon-Jaremko, B., Gronowicz, G., Adams, D. J., Aguila, H. L., Choi, Y., and Lorenzo, J. A. 2006. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J. Bone Miner. Res. 21:1704-1712.
33. Li, B., and Yu, S. 2003. Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation. Biol. Pharm. Bull. 26:780-786.
34. Lindberg, M. K., Weihua, Z., Andersson, N., Moverare, S., Gao, H., Vidal, O., Erlandsson, M., Windahl, S., Andersson, G., Lubahn, D. B., Carlsten, H., Dahlman-Wright, K., Gustafsson, J. A., and Ohlsson, C. 2002. Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J. Endocrinol. 174:167-178.
35. Lucas, E. A., Wild, R. D., Hammond, L. J., Khalil, D. A., Juma, S., Daggy, B. P., Stoecker, B. J., and Arjmandi, B. H. 2002. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J. Clin. Endocrinol. Metab. 87:1527-1532.
36. Messina, M. J. 1999. Legumes and soybeans: Overview of their nutritional profiles and health effects. Am. J. Clin. Nutr. 70: 439S-450S.
37. Morabito, N., Crisafulli, A., Vergara, C., Gaudio, A., Lasco, A., Frisina, N., D'Anna, R., Corrado, F., Pizzoleo, M. A., Cincotta, M., Altavilla, D., Ientile, R., Squadrito, F. 2002. Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: A randomized double-blind placebo-controlled study. J. Bone Miner. Res. 17:1904-1912.
38. Nagata, C., Shimizu, H., Takami, R., Hayashi, M., Takeda, N., and Yasuda, K. 2002. Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women. Osteoporosis Int.13:200-204.
39. Nakajima, D., Kim, C. S., Oh, T. W., Yang, C. Y., Naka, T., Igawa, S., and Ohta, F. 2001. Suppressive effects of genistein dosage and resistance exercise on bone loss in ovariectomized rats. J. Physiol. Anthropol. Appl. Hum. Sci. 20:285-291.
40. Picherit, C., Coxam, V., Bennetau-Pelissero, C., Kati-Coulibaly, S., Davicco, M. J., Lebecque, P., and Barlet, J. P. 2000. Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J. Nutr. 130:1675-1681.
41. Potter, S. M., Baum, J. A., Teng, H., Stillman, R. J., Shay, N. F., and Erdman, J. W., Jr. 1998. Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 68:1375S-1379S.
42. Power, K. A., Ward, W. E., Chen, J. M., Saarinen, N. M., and Thompson, L. U. 2006. Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone 39:117-124.
43. Reeves, P. G., Nielsen, F. H., and Fahey, G. C. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123:1939-1951.
44. Rickard, D. J., Monroe, D. G., Ruesink, T. J., Khosla, S., Riggs, B. L., and Spelsberg, T. C. 2003. Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta. J. Cell. Biochem. 89:633-646.
45. Saarinen, N. M., Power, K., Chen, J., and Thompson, L. U. 2006. Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Int. J. Cancer 119:925-931.
46. Scheiber, M. D., Liu, J. H., Subbiah, M. T., Rebar, R. W., and Setchell, K. D. 2001. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 8:384-392.
47. Setchell, K. D., Brown, N. M., and Lydeking-Olsen, E. 2002. The clinical importance of the metabolite equol - A clue to the effectiveness of soy and its isoflavones. J. Nutr. 132:3577-3584.
48. Somekawa, Y., Chiguchi, M., Ishibashi, T., and Aso, T. 2001. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet. Gynecol. 97:109-115.
49. Syed, F. A., Modder, U. I., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L., and Khosla, S. 2005. Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. J. Bone Miner. Res. 20:1992-2001.
50. Watkins, B. A., Li, Y., and Seifert, M. F. 2006. Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: Actions on bone mineral and serum biomarkers in ovariectomized rats. J. Nutr. Biochem. 17:282-289.
51. Watkins, B. A., Reinwald, S., Li, Y., and Seifert, M. F. 2005. Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats. J. Nutr. Biochem. 16:479-488.
52. Weitzmann, M. N., and Pacifici, R. 2006. Estrogen regulation of immune cell bone interactions. Ann. NY Acad. Sci. 1068:256-274.
53. Weitzmann, M. N., and Pacifici, R. 2005. The role of T lymphocytes in bone metabolism. Immunol. Rev. 208:154-168.
54. Windahl, S. H., Hollberg, K., Vidal, O., Gustafsson, J. A., Ohlsson, C., and Andersson, G. 2001. Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss. J. Bone Miner. Res. 16:1388-1398.
55. Wu, J., Wang, X., Chiba, H., Higuchi, M., Nakatani, T., Ezaki, O., Cui, H., Yamada, K., and Ishimi, Y. 2004. Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53:942-948.
56. Yamaguchi, M., and Sugimoto, E. 2000. Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: Activation of aminoacyl-t-RNA synthetase. Mol. Cell. Biochem. 214:97-102.