Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats

Carcinogenesis

Volumn 25, Issue 2, 2004, Pages 211-218

  Allred, Clinton ^a   Allred, Kimberly F ^a   Ju, Young H ^a   Clausen, Laura M ^a   Doerge, Daniel R ^b   Schantz, Susan L ^a   Korol, Donna L ^a   Wallig, Mattew A ^a   William, G Helferich ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Natl Ctr Toxicological Res F   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; GENISTEIN; ISOFLAVONE; METHYLNITROSOUREA; PROGESTERONE RECEPTOR;

ADENOCARCINOMA; AGE DISTRIBUTION; ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BENIGN TUMOR; BLOOD LEVEL; BREAST ADENOCARCINOMA; BREAST CANCER; BREAST TUMOR; CANCER GROWTH; CANCER PREVENTION; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DIET; DIETARY INTAKE; DRUG EFFECT; DRUG POTENTIATION; ESTRADIOL BLOOD LEVEL; ESTROGEN ACTIVITY; EXPERIMENTAL NEOPLASM; FEMALE; GROWTH, DEVELOPMENT AND AGING; HISTOPATHOLOGY; HORMONE SUBSTITUTION; IATROGENIC DISEASE; IMMUNOHISTOCHEMISTRY; MALIGNANT NEOPLASTIC DISEASE; METABOLISM; NEOPLASM; NONHUMAN; ORGAN WEIGHT; OVARIECTOMY; PATHOLOGY; POSTMENOPAUSE; PRIORITY JOURNAL; RAT; RAT STRAIN; UTERUS; UTERUS WEIGHT;

ADENOCARCINOMA; ALKYLATING AGENTS; ANIMAL FEED; ANIMALS; ANTICARCINOGENIC AGENTS; CELL DIVISION; DIET; DRUG SYNERGISM; ESTROGENS; FEMALE; GENISTEIN; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; NEOPLASMS, HORMONE-DEPENDENT; ORGAN SIZE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; UTERUS;

EID: 1242330446     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg198     Document Type: Article

References (39)

1. Garton, M., Reid, D. and Rennie, E. (1995) The climacteric, osteoporosis and hormone replacement therapy; views of women aged 45-49. Maturitas, 21, 7-15.
2. Vihtamaki, T., Savilahti, R. and Tuimala, R. (1999) Why do postmenopausal women discontinue hormone replacement therapy? Maturitas, 33, 99-105.
3. MacLennan ,A., Lester, S. and Moore, V. (2001) Oral estrogen replacement therapy versus placebo for hot flushes: a systematic review. Climacteric, 4, 58-74.
4. American Cancer Society (2001) Breast Cancer Cancer Facts and Figures, 2001-2002.
5. Brett, K.M. and Madans, J.H. (1997) Use of postmenopausal hormone replacement therapy: estimates from a nationally representative cohort study. Am. J. Epidemiol., 145, 536-545.
6. Keating, N.L., Cleary, P.D., Rossi, A.S., Zaslavsky, A.M. and Ayanian, J.Z. (1999) Use of hormone replacement therapy by postmenopausal women in the United States. Annal. Intern. Med., 130, 545-553.
7. Writing Group for the Women's Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. J. Am. Med. Assoc., 288, 321-333.
8. Martin, P.M., Horwitz ,K.B., Ryan, D.S. and McGuire, W.L. (1978) hytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology, 103, 1860-1867.
9. Hsieh, C.Y., Santell, R.C. and Helferich ,W.G. (1998) Genistein enhances estrogen-dependent breast cancer cell growth in vitro and in vivo. Cancer Res., 58, 3833-3838.
10. Allred, C.D., Ju, Y.H., Allred, K.F., Chang, J. and Helferich, W.G. (2001) Dietary genistin stimulates growth of estrogen-dependent breast cancer similar to that observed with genistein. Carcinogenesis, 22, 1667-1673.
11. Allred ,C.D., Allred, K.F., Ju, Y.H., Virant, S.M. and Helferich, W.G. (2001) Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent tumors in a dose dependent manner. Cancer Res., 61, 5045-5050.
12. Huggins ,C. and Yang, N.C. (1962) Induction and extinction of mammary cancer. Science, 137, 257-262.
13. Gullino, P.M., Pettigrew, H.M. and Grantham, F.H. (1975) N-Nitrosomethylurea as a mammary gland carcinogen in rats. J. Natl Cancer Inst., 54, 401-414.
14. Rivera ,E.S., Andrade, N., Martin, G., Melito, G., Cricco, G., Mohamad, N., Davio, C., Caro ,R. and Bergoc, R. M. (1994) Induction of mammary tumors in rat by intraperitoneal injection of NMU: histopathology and estral cycle influence. Cancer Lett., 86, 223-228.
15. Russo, J., Gusterson ,B.A., Rogers, A.E., Russo, I.H., Wellings, S.R. and Zwieten, V. (1990) Comparative study of human and rat mammary tumoigenesis. Lab. Invest., 62, 244-278.
16. Fritz, W.A., Coward, L., Wang, J. and Lamartiniere, C.A. (1998) Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis, 19, 2151-2158.
17. Cohen, L.A., Zhao, Z., Pittman, B. and Scimeca, J.A. (2000) Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis. Carcinogenesis, 21, 929-935.
18. Thompson, H.J., Adlukha, H. and Singh ,M. (1992) Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea. Carcinogenesis, 13, 1535-1539.
19. Reeves, P.G., Nielsen, F.H. and Fahey, Jr. G.C. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of AIN-76A rodent diet. J. Nutr., 123, 1939-1951.
20. Clinton, S.K., Li, P.S., Mulloy, A.L., Imrey, P.B., Handkumar ,S. and Visek ,W.J. (1995) The combined effects of dietary fat and estrogen on survival, 7,12-dimethylbenz(a)anthracene-induced breast cancer and prolactin metabolism in rats. J. Nutr., 125, 1192-1204.
21. Legan, S.J., Coon, G.A. and Karsch, F.J. (1975) Role of estrogen as initiator of daily LH surges in the ovariectomized rat. Endocrinology, 96, 50-56.
22. Kao, K.J. and Ramirez, V.D. (1979) Induction of pituitary and mammary tumors in male, 'fale' and female rats by either DMBA, estradiol implant or combined treatment. Proc. Soc. Exp. Bio. Med., 160, 296-301.
23. Santell, R.C., Kieu, N. and Helferich, W.G. (2000) Genistein inhibits growth of estrogen-independent human breast cancer cell in culture but not in athymic mice. J. Nutr., 130, 1665-1669.
24. Xu, X., Wang, H.J., Murphy, P.A. and Hendrich, S. (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J. Nutr., 124, 825-832.
25. Rose, D.P., Pruitt, B., Stauber, P., Erturk, E. and Bryan, G.T. (1980) Influence of dosage schedule on the biological characteristics of N-nitrosomethylurea-induced rat mammary tumors. Cancer Res., 40, 235-239.
26. Chou, Y., Guzman, R.C., Swanson, S.M., Yang, J., Lui, H.M., Wu, V. and Nandi, S. (1999) Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor. Carcinogenesis, 20, 677-684.
27. Twaddle ,N.C., Churchwell, M.I. and Doerge, D.R. (2002) High throughput quantification of soy isoflavones in human and mouse plasma using LC with electrospray-MS and MS/MS detection. J. Chromatogr. B, 777, 137-143.
28. Ju, Y.H., Allred, C.D., Allred, K.F., Karko, K.L., Doerge, D.R. and Helferich, W.G. (2001) Physiological concentrations of dietary genistein stimulate dose-dependently growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted into athymic nude mice. J. Nutr., 131, 2957-2962.
29. Gallo, D., Giacomelli, S., Cantelmo, F., Zannoni, G.F., Ferrendina, G., Fruscella ,E., Riva, A., Morazzoni, P., Bombardelli, E., Mancuso, S. and Scambia, G. (2001) Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy. Breast Cancer Res. Treat., 69, 153-164.
30. Lamartiniere, C.A., Moore, J.B., Brown, N.M., Thompson ,R., Hardin, M.J. and Barnes ,S. (1995) Genistein suppresses mammary cancer in rats. Carcinogenesis, 16, 2833-2840.
31. Murrill, W.B., Brown, N.M., Zhang, J.-X., Manzolillo, P.A. and Lamartiniere, C.A. (1996) Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis, 17, 1451-1457.
32. Cotroneo, M.S., Wang ,J., Fritz, W.A., Eltoum, E. and Lamartiniere ,C.A. (2002) Genistein action in the prepubertal mammary gland in a chemoprevention model. Carcinogenesis, 23, 1467-1474.
33. Grubbs, C.J., Farnell, D.R., Hill, D.L. and McDonough, K.C. (1985) Chempoprevention of N-nitroso-N-methylurea-induced mammary cancers by pretreatment with 17 β-estradiol and pregesterone. J. Natl Cancer Inst., 74, 927-931.
34. Shellabarger ,C.J. and Soo, V.A. (1973) Effects of neonatally administered sex steroids on 7,12-dimethylbenz(a)anthrecene-induced mammary neoplasia in rats. Cancer Res., 33, 1567-1569.
35. Lamartiniere, C.A. and Holland, M.B. (1992) Neonatal diethylstilbestrol prevents spontaneously developing mammary tumors. In Li,J.J., Nandi,S.A. and Li,S.A. (eds), Hormonal Carcinogensis. Springer Verlag, Berlin, pp. 305-308.
36. Hilakivi-Clarke, L., Cho, E., Onojafe, I., Raygada, M. and Clarke, R. (1999) Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol. Rep., 6, 1095-1099.
37. Constantinou, A.I., Lantvit, D., Hawthorne , M., Xu, X., van Breemen, R.B. and Pezzuto, J.M. (2001) Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr. Cancer, 41, 75-81.
38. Lonning, P.E., Geisler, J., Johannessen, D.C. and Ekse, D. (1997) Plasma estrogen suppression with aromatase inhibitors evaluated by a novel, sensitive assay for estrone sulphate. J. Steroid Biochem. Mol. Biol., 61, 255-260.
39. Li, S., Martel, C., Dauvois, S., Belanger, A. and Labrie, F. (1994) Effect of estrone on the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in the rat: a model of postmenopausal breast cancer. Endocrinology, 134, 1352-1357.