Delivery of molecular and cellular medicine to solid tumors

Advanced Drug Delivery Reviews

Volumn 26, Issue 2-3, 1997, Pages 71-90

  Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Angiogenesis; Binding; Blood flow; Cancer detection and treatment; Cell adhesion and deformation; Diffusion and convection; Interstitial pressure; Lymphatics; Receptor ligand; Tumor microcirculation; Vascular permeability

Indexed keywords

ADHESION; BLOOD VESSELS; CELLS; DIFFUSION IN LIQUIDS; MECHANICAL PERMEABILITY; MICROCIRCULATION; MOLECULES; ONCOLOGY;

ANGIOGENESIS;

DRUG THERAPY;

ANTINEOPLASTIC AGENT;

ANGIOGENESIS; BLOOD VESSEL PERMEABILITY; CANCER DIAGNOSIS; CANCER IMMUNOTHERAPY; CANCER THERAPY; DRUG TARGETING; DRUG TRANSPORT; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOLID TUMOR; TISSUE PRESSURE; TUMOR VASCULARIZATION;

EID: 0031558243     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00027-6     Document Type: Review

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135. Y. Boucher, M. Leunig, R.K. Jain, Tumor angiogenesis and interstitial hypertension, Cancer Res. 56 (1996) 4264-4266.
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137. D. Fukumura, F. Yuan, M. Endo, R.K. Jain, Role of nitric oxide in tumor microcirculation: blood flow, vascular permeability, and leukocyte-endothelial interactions, Am. J. Pathol. 150 (1997) 713-725.
138. L.E. Gerlowski, R.K. Jain, Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues, Int. J. Microcir. Clin. Exp. 4 (1985) 363-372.
139. C.A. Kristensen, M. Nozue, Y. Boucher, R.K. Jain, Reduction of interstitial fluid pressure after TNF-a treatment of human melanoma xenografts, Br. J. Cancer 74 (1996) 533-536.
140. C.A. Kristensen, S. Roberge, R.K. Jain, Effect of tumor necrosis factor-alpha on vascular resistance, nitric oxide production, glucose and oxygen consumption in perfused, tissue-isolated human melanoma xenografts, Clin. Cancer Res. 3 (1997) 319-324.
141. L.T. Baxter, R.K. Jain, Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data, Br. J. Cancer 73 (1996) 447-456.
142. L.T. Baxter, F. Yuan, R.K. Jain, Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data, Cancer Res. 52 (1992) 5838-5844.
143. P.E. Kristjansen, Y. Boucher, R.K. Jain, Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft, Cancer Res. 53 (1993) 4764-4766.
144. I. Lee, Y. Boucher, R.K. Jain, Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications, Cancer Res. 52 (1992) 3237-3240.
145. I. Lee, Y. Boucher, T.J. Demhartner, R.K. Jain, Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline, Br. J. Cancer 69 (1994) 492-496.
146. I. Lee, T.J. Demhartner, Y. Boucher, R.K. Jain, M. Intaglietta, Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation, Microvasc. Res. 48 (1994) 1-12.
147. M. Leunig, A.E. Goetz, M. Dellian, G. Zetterer, F. Gamarra, R.K. Jain, K. Messmer, Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response, Cancer Res. 52 (1992) 487-490.
148. M. Leunig, A.E. Goetz, F. Gamarra, G. Zetterer, K. Messmer, R.K. Jain, Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster, Br. J. Cancer 69 (1994) 101-103.
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150. R.A. Zlotecki, Y. Boucher, I. Lee, L.T. Baxter, R.K. Jain, Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure, Cancer Res. 53 (1993) 2466-2468.
151. R.K. Jain, Delivery of molecular medicine to solid tumors, Science 271 (1996) 1079-1080.