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Volumn 13, Issue 10, 2007, Pages

Recent advances in tumor hypoxia: Tumor progression, molecular mechanisms, and therapeutic implications

Author keywords

Angiogenesis; Cancer; HIF 1; Hypoxia; Tumor; VEGF

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 METHOXYESTRADIOL; 2 MORPHOLINO 8 PHENYLCHROMONE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 6 (4 HYDROXYPHENYL) 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOMYCIN; CARBONATE DEHYDRATASE IX; CYTOKINE; DX 21; FUMAGILLOL CHLOROACETYLCARBAMATE; GELDANAMYCIN; GLUCOSE TRANSPORTER 1; GLYCOLYTIC ENZYME; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; KF 58333; MISONIDAZOLE; MONOCLONAL ANTIBODY DC101; OXYGEN; PACLITAXEL; PX 478; RADICICOL; SEMAXANIB; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VATALANIB; VINCRISTINE; WORTMANNIN;

EID: 35549000083     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (20)

References (48)
  • 1
    • 0030614893 scopus 로고    scopus 로고
    • 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med, 1997; 3: 177-82
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 2
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res, 1989; 49: 6449-65
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 3
    • 8544271638 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and hypoxic cell death in tumour physiology
    • Bacon AL, Harris AL: Hypoxia-inducible factors and hypoxic cell death in tumour physiology. Ann Med, 2004; 36: 530-39
    • (2004) Ann Med , vol.36 , pp. 530-539
    • Bacon, A.L.1    Harris, A.L.2
  • 4
    • 33947164399 scopus 로고    scopus 로고
    • Effect of hypoxia on the tumor phenotype: The neuroblastoma and breast cancer models
    • Holmquist L, Lofstedt T, Pahlman S: Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models. Adv Exp Med Biol, 2006; 587: 179-93
    • (2006) Adv Exp Med Biol , vol.587 , pp. 179-193
    • Holmquist, L.1    Lofstedt, T.2    Pahlman, S.3
  • 5
    • 33645331832 scopus 로고    scopus 로고
    • Oxygenated and reoxygenated tumors show better local control in radiation therapy for cervical cancer
    • Suzuki Y, Nakano T, Ohno T et al: Oxygenated and reoxygenated tumors show better local control in radiation therapy for cervical cancer. Int J Gynecol Cancer, 2006; 16: 306-11
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 306-311
    • Suzuki, Y.1    Nakano, T.2    Ohno, T.3
  • 6
    • 0036918282 scopus 로고    scopus 로고
    • Impact of tumor hypoxia and anemia on radiation therapy outcomes
    • Harrison LB, Chadha M, Hill RJ et al: Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist, 2002; 7: 492-508
    • (2002) Oncologist , vol.7 , pp. 492-508
    • Harrison, L.B.1    Chadha, M.2    Hill, R.J.3
  • 7
    • 0028632781 scopus 로고
    • Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
    • Overgaard J: Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol Res, 1994; 6: 509-18
    • (1994) Oncol Res , vol.6 , pp. 509-518
    • Overgaard, J.1
  • 8
    • 35549007324 scopus 로고    scopus 로고
    • The genomic response of tumour cells to hypoxia and reoxygenation: Differential activation of transcription factors AP-1 and NF-kB
    • Rupec RA: The genomic response of tumour cells to hypoxia and reoxygenation: differential activation of transcription factors AP-1 and NF-kB. Med Sci Monit, 1996; 2: 6-13
    • (1996) Med Sci Monit , vol.2 , pp. 6-13
    • Rupec, R.A.1
  • 9
    • 24944456241 scopus 로고    scopus 로고
    • Hyperbaric oxygen and malignancies: A potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy
    • Al-Waili NS, Butler GJ, Beale J et al: Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy. Med Sci Monit, 2005; 11(9): RA279-89
    • (2005) Med Sci Monit , vol.11 , Issue.9
    • Al-Waili, N.S.1    Butler, G.J.2    Beale, J.3
  • 10
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel M, Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst, 2001; 93: 266-76
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 11
    • 16244399521 scopus 로고    scopus 로고
    • Tumor oxygenation status as a prognostic marker
    • Menon C, Fraker DL: Tumor oxygenation status as a prognostic marker. Cancer Lett, 2005; 221: 225-35
    • (2005) Cancer Lett , vol.221 , pp. 225-235
    • Menon, C.1    Fraker, D.L.2
  • 12
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response
    • Vaupel P, Harrison L: Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist, 2004; 9(Suppl.5): 4-9
    • (2004) Oncologist , vol.9 , Issue.SUPPL.5 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 13
    • 4644283094 scopus 로고    scopus 로고
    • Assessment of tumor oxygenation by electron paramagnetic resonance: Principles and applications
    • Gallez B, Baudelet C, Jordan BF: Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications. NMR Biomed, 2004; 17: 240-62
    • (2004) NMR Biomed , vol.17 , pp. 240-262
    • Gallez, B.1    Baudelet, C.2    Jordan, B.F.3
  • 15
    • 33947100334 scopus 로고    scopus 로고
    • A Quantitative review of the use of FDG-PET in the axillary staging of breast cancer
    • Sloka JS, Hollett PD, Mathews M: A Quantitative review of the use of FDG-PET in the axillary staging of breast cancer. Med Sci Monit, 2007; 13(3): RA37-46
    • (2007) Med Sci Monit , vol.13 , Issue.3
    • Sloka, J.S.1    Hollett, P.D.2    Mathews, M.3
  • 16
    • 34548155736 scopus 로고    scopus 로고
    • Determination of tumour hypoxia with the PET tracer [(18)F]EF3: Improvement of the tumour-to-background ratio in a mouse tumour model
    • Mar 3; [Epub ahead of print
    • Christian N, Bol A, De Bast M et al: Determination of tumour hypoxia with the PET tracer [(18)F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model. Eur J Nucl Med Mol Imaging, 2007 Mar 3; [Epub ahead of print]
    • (2007) Eur J Nucl Med Mol Imaging
    • Christian, N.1    Bol, A.2    De Bast, M.3
  • 17
    • 34247890108 scopus 로고    scopus 로고
    • The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography
    • Matsumoto K, Szajek L, Krishna MC et al: The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography. Int J Oncol, 2007; 30: 873-81
    • (2007) Int J Oncol , vol.30 , pp. 873-881
    • Matsumoto, K.1    Szajek, L.2    Krishna, M.C.3
  • 18
    • 33750738550 scopus 로고    scopus 로고
    • Novel noninvasive probes for measuring tumor-hypoxia by 19F-magnetic resonance spectroscopy (19F-MRS). Studies in the SCCVII/C3H murine model
    • Papadopoulou MV, Pouremad R, Bloomer WD, Wyrwicz A: Novel noninvasive probes for measuring tumor-hypoxia by 19F-magnetic resonance spectroscopy (19F-MRS). Studies in the SCCVII/C3H murine model. Anticancer Res, 2006; 26: 3259-63
    • (2006) Anticancer Res , vol.26 , pp. 3259-3263
    • Papadopoulou, M.V.1    Pouremad, R.2    Bloomer, W.D.3    Wyrwicz, A.4
  • 19
    • 3142552508 scopus 로고    scopus 로고
    • Measurement of tumor hypoxia using single-cell methods
    • Olive PL, Aquino-Parsons C: Measurement of tumor hypoxia using single-cell methods. Semin Radiat Oncol, 2004; 14: 241-48
    • (2004) Semin Radiat Oncol , vol.14 , pp. 241-248
    • Olive, P.L.1    Aquino-Parsons, C.2
  • 20
    • 0031981258 scopus 로고    scopus 로고
    • Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays
    • Chapman JD, Engelhardt EL, Stobbe CC et al: Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays. Radiother Oncol, 1998; 46: 229-37
    • (1998) Radiother Oncol , vol.46 , pp. 229-237
    • Chapman, J.D.1    Engelhardt, E.L.2    Stobbe, C.C.3
  • 21
    • 23844485492 scopus 로고    scopus 로고
    • Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
    • Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P: Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res, 2005; 65: 7259-66
    • (2005) Cancer Res , vol.65 , pp. 7259-7266
    • Sobhanifar, S.1    Aquino-Parsons, C.2    Stanbridge, E.J.3    Olive, P.4
  • 22
    • 0031656984 scopus 로고    scopus 로고
    • Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia
    • Hodgkiss RJ: Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia. Anticancer Drug Des, 1998; 13: 687-702
    • (1998) Anticancer Drug Des , vol.13 , pp. 687-702
    • Hodgkiss, R.J.1
  • 23
    • 18244431401 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX in human pancreatic cancer
    • Juhasz M, Chen J, Lendeckel U et al: Expression of carbonic anhydrase IX in human pancreatic cancer. Aliment Pharmacol Ther, 2003; 18: 837-46
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 837-846
    • Juhasz, M.1    Chen, J.2    Lendeckel, U.3
  • 24
    • 33751162608 scopus 로고    scopus 로고
    • Immunohistochemical detection of osteopontin in advanced head-and-neck cancer: Prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1alpha-related markers, and hemoglobin levels
    • Bache M, Reddemann R, Said HM et al: Immunohistochemical detection of osteopontin in advanced head-and-neck cancer: prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1alpha-related markers, and hemoglobin levels. Int J Radiat Oncol Biol Phys, 2006; 66: 1481-87
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 1481-1487
    • Bache, M.1    Reddemann, R.2    Said, H.M.3
  • 25
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE: Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood, 2004; 104: 2224-34
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 26
    • 0038827528 scopus 로고    scopus 로고
    • Inhibitory effect of high molecular weight water-soluble chitosan on hypoxia-induced inflammatory cytokine production
    • Seo SB, Jeong HJ, Chung HS et al: Inhibitory effect of high molecular weight water-soluble chitosan on hypoxia-induced inflammatory cytokine production. Biol Pharm Bull, 2003; 26: 717-21
    • (2003) Biol Pharm Bull , vol.26 , pp. 717-721
    • Seo, S.B.1    Jeong, H.J.2    Chung, H.S.3
  • 27
    • 17744366566 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis
    • Garayoa M, Martinez A, Lee S et al: Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol, 2000; 14: 848-62
    • (2000) Mol Endocrinol , vol.14 , pp. 848-862
    • Garayoa, M.1    Martinez, A.2    Lee, S.3
  • 28
    • 1842868935 scopus 로고    scopus 로고
    • Molecular responses to hypoxia in tumor cells
    • Kunz M, Ibrahim SM: Molecular responses to hypoxia in tumor cells. Mol Cancer, 2003; 2: 23-35
    • (2003) Mol Cancer , vol.2 , pp. 23-35
    • Kunz, M.1    Ibrahim, S.M.2
  • 29
    • 0032749463 scopus 로고    scopus 로고
    • Hypoxia-induced activation of HIF-1: Role of HIF-1alpha-Hsp90 interaction
    • Minet E, Mottet D, Michel G et al: Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett, 1999; 460: 251-56
    • (1999) FEBS Lett , vol.460 , pp. 251-256
    • Minet, E.1    Mottet, D.2    Michel, G.3
  • 30
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza GL: Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda), 2004; 19: 176-82
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 31
    • 33645730274 scopus 로고    scopus 로고
    • Regulation of BNIP3 in normal and cancer cells
    • Lee H, Paik SG: Regulation of BNIP3 in normal and cancer cells. Mol Cells, 2006; 21: 1-6
    • (2006) Mol Cells , vol.21 , pp. 1-6
    • Lee, H.1    Paik, S.G.2
  • 32
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel W, Schindler C, Haas-Kogan D et al: Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev, 2000; 14: 391-96
    • (2000) Genes Dev , vol.14 , pp. 391-396
    • Zundel, W.1    Schindler, C.2    Haas-Kogan, D.3
  • 33
    • 0037404443 scopus 로고    scopus 로고
    • Genetic models in applied physiology: Invited review: effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest
    • Douglas RM, Haddad GG: Genetic models in applied physiology: invited review: effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest. J Appl Physiol, 2003; 94: 2068-83
    • (2003) J Appl Physiol , vol.94 , pp. 2068-2083
    • Douglas, R.M.1    Haddad, G.G.2
  • 34
    • 0036206130 scopus 로고    scopus 로고
    • Protean PTEN: Form and function
    • Waite KA, Eng C: Protean PTEN: form and function. Am J Hum Genet, 2002; 70: 829-44
    • (2002) Am J Hum Genet , vol.70 , pp. 829-844
    • Waite, K.A.1    Eng, C.2
  • 35
    • 16644363476 scopus 로고    scopus 로고
    • HIF-1 and p53: Communication of transcription factors under hypoxia
    • Schmid T, Zhou J, Brune B: HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med, 2004; 8: 423-31
    • (2004) J Cell Mol Med , vol.8 , pp. 423-431
    • Schmid, T.1    Zhou, J.2    Brune, B.3
  • 36
    • 4444311880 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha as a cancer drug target
    • Powis G, Kirkpatrick L: Hypoxia inducible factor-1alpha as a cancer drug target. Mol Cancer Ther, 2004; 3: 647-54
    • (2004) Mol Cancer Ther , vol.3 , pp. 647-654
    • Powis, G.1    Kirkpatrick, L.2
  • 37
    • 0030512608 scopus 로고    scopus 로고
    • Transgenic mouse models of tumour angiogenesis: The angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models
    • Hanahan D, Christofori G, Naik P, Arbeit J: Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. Eur J Cancer, 1996; 32A: 2386-93
    • (1996) Eur J Cancer , vol.32 A , pp. 2386-2393
    • Hanahan, D.1    Christofori, G.2    Naik, P.3    Arbeit, J.4
  • 38
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn HF, Poyton RO: Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev, 1996; 76: 839-85
    • (1996) Physiol Rev , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 39
    • 24044437159 scopus 로고    scopus 로고
    • Dual role of VEGF family members in the pathogenesis of head and neck cancer (HNSCC): Possible link between angiogenesis and immune tolerance
    • Strauss L, Volland D, Kunkel M, Reichert TE: Dual role of VEGF family members in the pathogenesis of head and neck cancer (HNSCC): possible link between angiogenesis and immune tolerance. Med Sci Monit, 2005; 11(8): BR280-92
    • (2005) Med Sci Monit , vol.11 , Issue.8
    • Strauss, L.1    Volland, D.2    Kunkel, M.3    Reichert, T.E.4
  • 40
    • 3042855669 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor-A and vascular endothelial growth factor-C as prognostic factors for non-small cell lung cancer
    • Nakashima T, Huang CL, Liu D et al: Expression of vascular endothelial growth factor-A and vascular endothelial growth factor-C as prognostic factors for non-small cell lung cancer. Med Sci Monit, 2004; 10(6): BR157-65
    • (2004) Med Sci Monit , vol.10 , Issue.6
    • Nakashima, T.1    Huang, C.L.2    Liu, D.3
  • 41
    • 0032568448 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    • An WG, Kanekal M, Simon MC et al: Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature, 1998; 392: 405-8
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1    Kanekal, M.2    Simon, M.C.3
  • 42
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors. Faseb J, 1999; 13: 9-22
    • (1999) Faseb J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 43
    • 0037872699 scopus 로고    scopus 로고
    • Angiogenesis in ischemic and neoplastic disorders
    • Semenza GL: Angiogenesis in ischemic and neoplastic disorders. Annu Rev Med, 2003; 54: 17-28
    • (2003) Annu Rev Med , vol.54 , pp. 17-28
    • Semenza, G.L.1
  • 44
    • 0029849637 scopus 로고    scopus 로고
    • In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor
    • Cao Y, Linden P, Shima D et al: In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J Clin Invest, 1996; 98: 2507-11
    • (1996) J Clin Invest , vol.98 , pp. 2507-2511
    • Cao, Y.1    Linden, P.2    Shima, D.3
  • 45
    • 0028843411 scopus 로고
    • Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
    • Gleadle JM, Ebert BL, Firth JD, Ratcliffe PJ: Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol, 1995; 268: C1362-68
    • (1995) Am J Physiol , vol.268
    • Gleadle, J.M.1    Ebert, B.L.2    Firth, J.D.3    Ratcliffe, P.J.4
  • 46
    • 2942615346 scopus 로고    scopus 로고
    • Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
    • Duffy JP, Eibl G, Reber HA, Hines OJ: Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer. Mol Cancer, 2003; 2: 12-21
    • (2003) Mol Cancer , vol.2 , pp. 12-21
    • Duffy, J.P.1    Eibl, G.2    Reber, H.A.3    Hines, O.J.4
  • 47
    • 33747128652 scopus 로고    scopus 로고
    • Hypoxia and angiogenesis in pancreatic cancer
    • Garcea G, Doucas H, Steward WP et al: Hypoxia and angiogenesis in pancreatic cancer. ANZ J Surg, 2006; 76: 830-42
    • (2006) ANZ J Surg , vol.76 , pp. 830-842
    • Garcea, G.1    Doucas, H.2    Steward, W.P.3
  • 48
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • Lewis C, Murdoch C: Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol, 2005; 167: 627-35
    • (2005) Am J Pathol , vol.167 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2


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