Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice

Journal of Lipid Research

Volumn 39, Issue 6, 1998, Pages 1141-1151

  Semenkovich, Clay F ^a   Coleman, Trey ^a   Daugherty, Alan ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cholesterol; LDL receptor knockout mice; Macrophage; Triglyceride; Vascular wall

Indexed keywords

LIPOPROTEIN LIPASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; DYSLIPIDEMIA; ENZYME ACTIVITY; HETEROZYGOSITY; HYPERLIPOPROTEINEMIA TYPE 1; HYPERTRIGLYCERIDEMIA; LIPID BLOOD LEVEL; LIPID METABOLISM; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; AORTA; ARTERIOSCLEROSIS; CHOLESTEROL; CHOLESTEROL, HDL; CROSSES, GENETIC; DIET, ATHEROGENIC; FEMALE; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; LIPOPROTEIN LIPASE; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, LDL; SEX CHARACTERISTICS; TRIGLYCERIDES;

EID: 0031810437     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Yang, W-S., D. N. Nevin, L. Iwasaki, R. Peng, R. G. Brown, J. D. Brunzell, and S. S. Deeb. 1996. Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease. J. Lipid Res. 37: 2627-2637.
2. Benlian, P., J. L. De Gennes, L. Foubert, H. Zhang, S. E. Gagne, and M. R. Hayden. 1996. Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene. N. Engl. J. Med. 335: 848-854.
3. Fisher, R. M., F. Mailly, R. E. Peacock, A. Hamsten, M. Seed, J. S. Yudkin, U. Beisiegel, G. Feussner, G. Miller, S. E. Humphries, and P. J. Talmud. 1995. Interaction of the lipoprotein lipase asparagine 291-serine mutation with body mass index determines elevated plasma triacylglycerol concentrations: a study in hyperlipidemic subjects, myocardial infarction survivors, and healthy adults. J. Lipid Res. 36: 2104-2112.
4. Reymer, P. W. A., E. Gagne, B. E. Groenmeyer, H. Zhang, I. Forsythe, H. Jansen, J. C. Seidel, D. Kromhout, K. E. Lie, J. J. Kastelein, and M. R. Hayden. 1995. A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis. Nature Genet. 10: 28-34.
5. Semenkovich, C. F., S-H. Chen, M. Wims, C-C. Luo, W-H. Li, and L. Chan. 1989. Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation and evolution. J. Lipid Res. 30: 423-431.
6. Miesenbock, G., B. Holzl, B. Foger, E. Brandstatter, B. Paulweber, F. Sandhofer, and J. R. Patsch. 1993. Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities. J. Clin. Invest. 91: 448-455.
7. Wittrup, H. H., A. Tybjaerg-Hansen, S. Abildgaard, R. Steffensen, P. Schnohr, and B. G. Nordestgaard. 1997. A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease. J. Clin. Invest. 99: 1606-1613.
8. Tsutsumi, K., Y. Inoue, A. Shima, K. Iwasaki, M. Kawamura, and T. Murase. 1993. The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. J. Clin. Invest. 92: 411-417.
9. Shimada, M., S. Ishibashi, T. Inaba, H. Yagyu, K. Harada, J. Osuga, K. Ohashi, Y. Yazaki, and N. Yamada. 1996. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc. Natl. Acad. Sci. USA. 93: 7242-7246.
10. Yla-Herttuala, S., B. A. Lipton, M. E. Rosenfeld, I.J. Goldberg, D. Steinberg, and J. L. Witztum. 1991. Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 88: 10143-10147.
11. O'Brien, K. D., D. Gordon, S. Deeb, M. Ferguson, and A. Chait. 1992. Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques. J. Clin. Invest. 89: 1544-1550.
12. Dugi, K. A., I. M. Feuerstein, S. Hill, J. Shih, S. Santamarina-Fojo, H. B. Brewer, Jr., and J. M. Hoeg. 1997. Lipoprotein lipase correlates positively and hepatic lipase inversely with calcific atherosclerosis in homozygous familial hypercholesterolemia. Arterioscl. Thromb. Vasc. Biol. 17: 354-364.
13. Saxena, U., M. G. Klein, T. M. Vanni, and I.J. Goldberg. 1992. Lipoprotein lipase increases low density lipoprotein retention by sub-endothelial matrix. J. Clin. Invest. 89: 373-380.
14. Pang, L, P. Sivaram, and I. J. Goldberg. 1996. Cell-surface expression of an amino-terminal fragment of apolipoprotein B increases lipoprotein lipase binding to cells. J. Biol. Chem. 271: 19518-19523.
15. Renier, G., E. Skamene, J. B. DeSanctis, and D. Radzioch. 1992. High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis. Arterioscler. Thromb. 13: 190-196.
16. Lucas, M., P-H. Iverius, D. K. Strickland, and T. Mazzone. 1997. Lipoprotein lipase reduces secretion of apolipoprotein E from macrophages. J. Biol. Chem. 272: 13000-13005.
17. Hendricks, W. L., F. van der Sman-de Beer, B. J. M. van Vlijmen, L. C. van Vark, M. H. Hofker, and L. M. Havekes. 1997. Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase. Arterioscler. Thromb. Vasc. Biol. 17: 498-504.
18. Wilson, D. E., A. Hata, L. K. Kwong, A. Lingam, J. Shuhua, D. Ridinger, C. Yeager, K. C. Kaltenborn, P-H. Iverius, and J. M. Lalouel. 1993. Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and noninsulin-dependent diabetes. J. Clin. Invest. 92: 203-211.
19. Wilson, D. E., M. Emi, P-H. Iverius, A. Hata, L. L. Wu, E. Hillas, R. R. Williams, and J. M. Lalouel. 1990. Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation. J. Clin. Invest. 86: 735-750.
20. Coleman, T., R. L. Seip, J. M. Gimble, D. Lee, N. Maeda, and C. F. Semenkovich. 1995. COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity. J. Biol. Chem. 270: 12518-12525.
21. Weinstock, P. H., C. L. Bisgaier, K. Aalto-Setala, H. Radner, R. Ramakrishnan, S. Levak-Frank, A. D. Essenburg, R. Zechner, and J. L. Breslow. 1995. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. J. Clin. Invest. 96: 2555-2568.
22. Ashbourne-Excoffon, K. J. D. A., G. Liu, L. Miao, J. E. Wilson, B. M. McManus, C. F. Semenkovich, T. Coleman, P. Benoit, N. Duverger, D. Branellec, P. Denefle, M. R. Hayden, and M. E. S. Lewis. 1997. Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arterioscler. Thromb. Vasc. Biol. 17: 2532-2539.
23. Zsigmond, E., E. Scheffler, T. M. Forte, R. Potenz, W. Wu, and L. Chan. 1994. Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter, a phenotype associated with increased perinatal mortality and reduced plasma very low density lipoprotein of normal size. J. Biol. Chem. 269: 18757-18766.
24. Gaw, A., F. P. Mancini, and S. Ishibashi. 1995. Rapid genotyping of low density lipoprotein receptor knockout mice using a polymerase chain reaction technique. Lab. Animals. 29: 447-449.
25. Seip, R. L., T. J. Angelopoulos, and C. F. Semenkovich. 1995. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. Am. J. Physiol. 268: E229-E236.
26. Paigen, B., A. Morrow, C. Brandon, D. Mitchell, and P. Holmes. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Athemsclerosis. 57: 65-73.
27. Tangirala, R. K., E. M. Rubin, and W. Palinski. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid Res. 36: 2320-2328.
28. Daugherty, A., E. Pure, D. Delfel-Butteiger, S. Chen, J. Leferovich, S. E. Roselaar, and D. J. Rader. 1997. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/-mice. J. Clin. Invest. 100: 1575-1580.
29. Ishibashi, S., J. L. Goldstein, M. S. Brown, J. Herz, and D. K. Burns. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93: 1885-1893.
30. LeBoeuf, R. C., M. Caldwell, and E. Kirk. 1994. Regulation by nutritional status of lipids and apolipoproteins A-I, A-II, and A-IV in inbred mice. J. Lipid Res. 35: 121-133.
31. Veniant, M. M., V. Pierotti, D. Newland, C. M. Cham, D. A. Sanan, R. L. Walzem, and S. G. Young. 1997. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B-48 or apolipoprotein B-100. J. Clin. Invest. 100: 180-188.
32. Zilversmit, D. B. 1979. Atherogenesis: a postprandial phenomenon. Circulation. 60: 473-485.
33. Werba, J. P., L. A. Cuniberti, R. P. Laguens, L. D. Masnatta, R. H. Rey, R. Levy, and R. H. Pichel. 1996. Injury produces early rise in lipoprotein lipase activity in rabbit aorta. Atherosclerosis. 125: 257-266.
34. Goldberg, I. J. 1996. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 37: 693-707.
35. Rutledge, J. C., M. M. Woo, A. A. Rezai, L. K. Curtiss, and I. J. Goldberg. 1997. Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products. Circ. Res. 80: 819-828.
36. Obunike, J. C., S. Paka, S. Pillarisetti, and I. J. Goldberg. 1997. Lipoprotein lipase can function as a monocyte adhesion protein. Arterioscler. Thromb. Vasc. Biol. 17: 1414-1420.
37. Mattson, L., H. Johansson, M. Ottosson, G. Bondjers, and O. Wiklund. 1993. Expression of lipoprotein lipase mRNA and secretion in macrophages isolated from human atherosclerotic aorta. J. Clin. Invest. 92: 1759-1765.
38. Hulten, L. M., H. Lindmark, U. Diczfalusy, I. Bjorkhem, M. Ottosson, Y. Liu, G. Bondjers, and O. Wiklund. 1996. Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. J. Clin. Invest. 97: 461-468.
39. Ross, R. 1995. Cell biology of atherosclerosis. Annu. Rev. Physiol. 57: 791-804.
40. von Hodenberg, E., J. C. Khoo, D. Jensen, J. L. Witztum, and D. Steinberg. 1984. Mobilization of stored triglycerides from macrophages as free fatty acids. Arteriosclerosis. 4: 630-635.
41. Brown, M. S., Y. K. Ho, and J. L. Goldstein. 1980. The cholesterol ester cycle in macrophage foam cells. J. Biol. Chem. 255: 9344-9352.
42. Paigen, B., P. A. Holmes, D. Mitchell, and D. Albee. 1986. Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c and C3H. Atherosclerosis. 64: 215-221.
43. Rubanyi, G. M., A. D. Freay, K. Kauser, D. Sukovich, G. Burton, D. B. Lubahn, J. F. Couse, S. W. Curtis, and K. S. Korach. 1997. Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. J. Clin. Invest. 99: 2429-2437.