Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor

Journal of Lipid Research

Volumn 48, Issue 2, 2007, Pages 288-298

  Loeffler, Britta ^a   Heeren, Joerg ^a   Blaeser, Mareike ^a   Radner, Herbert ^b   Kayser, Daniel ^a   Aydin, Birol ^a   Merkel, Martin ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; Cholesterol; Endothelium; Lipids; Low density lipoprotein; Transport

Indexed keywords

CHYLOMICRON; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEOGLYCAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; LIPID TRANSPORT; MALE; MOUSE; MUSCLE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RECEPTOR UPREGULATION; TRANSGENICS; WILD TYPE;

ANIMALS; BIOLOGICAL TRANSPORT; BREEDING; CELLS, CULTURED; CHOLESTEROL; DIET; DIETARY FATS; ENDOTHELIAL CELLS; FEMALE; LIPIDS; LIPOPROTEIN LIPASE; LIPOPROTEINS, LDL; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PROTEOGLYCANS; RECEPTORS, LDL;

EID: 33846862687     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600292-JLR200     Document Type: Article

References (43)

1. Merkel, M., R. H. Eckel, and I. J. Goldberg. 2002. Lipoprotein lipase: genetics, lipid uptake and regulation. J. Lipid Res. 43: 1997-2006.
2. Beisiegel, U. 1995. Receptors for triglyceride-rich lipoproteins and their role in lipoprotein metabolism. Curr. Opin. Lipidol. 6: 117-122.
3. Olivecrona, G., and T. Olivecrona. 1995. Triglyceride lipases and atherosclerosis. Curr. Opin. Lipidol. 6: 291-305.
4. Mulder, M., P. Lombardi, H. Jansen, T. J. van Berkel, R. R. Frants, and L. M. Havekes. 1993. Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase. J. Biol. Chem. 268: 9369-9375.
5. Obunike, J. C., I. J. Edwards, S. C. Rumsey, L. K. Curtiss, W. D. Wagner, R. J. Deckelbaum, and I. J. Goldberg. 1994. Cellular differences in lipoprotein lipase-mediated uptake of low density lipoproteins. J. Biol. Chem. 269: 13129-13135.
6. Merkel, M., Y. Kako, H. Radner, I. S. Cho, R. Ramasamy, J. D. Brunzell, I. J. Goldberg, and J. L. Breslow. 1998. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases VLDL uptake. Direct evidence that LPL bridging occurs in vivo. Proc. Natl. Acad. Sci. USA. 95: 13841-13846.
7. Merkel, M., J. Heeren, W. Dudeck, F. Rinninger, H. Radner, J. L. Breslow, I. J. Goldberg, R. Zechner, and H. Greten. 2002. Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL also increases triglyceride hydrolysis and whole particle lipoprotein uptake. J. Biol. Chem. 277: 7405-7411.
8. Heeren, J., A. Niemeier, M. Merkel, and U. Beisiegel. 2002. Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo. J. Mol. Med. 80: 576-584.
9. Argraves, K. M., F. D. Battey, C. D. MacCalman, K. R. McCrae, M. Gafvels, K. F. Kozarsky, D. A. Chappell, J. F. Strauss, 3rd, and D. K. Strickland. 1995. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes. J. Biol. Chem. 270: 26550-26557.
10. Niemeier, A., M. Gafvels, J. Heeren, N. Meyer, B. Angelin, and U. Beisiegel. 1996. VLDL receptor mediates the uptake of human chylomicron remnants in vitro. J. Lipid Res. 37: 1733-1742.
11. Willnow, T. E., J. L. Goldstein, K. Orth, M. S. Brown, and J. Herz. 1992. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J. Biol. Chem. 267: 26172-26180.
12. Beisiegel, U., W. Weber, and G. Bengtsson-Olivecrona. 1991. Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc. Natl. Acad. Sci. USA. 88: 8342-8346.
13. Nykjaer, A., M. Nielsen, A. Lookene, N. Meyer, H. Roigaard, M. Etzerodt, U. Beisiegel, G. Olivecrona, and J. Gliemann. 1994. A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells. J. Biol. Chem. 269: 31747-31755.
14. Medh, J. D., S. L. Bowen, G. L. Fry, S. Ruben, M. Andracki, I. Inoue, J. M. Lalouel, D. K. Strickland, and D. A. Chappell. 1996. Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro. J. Biol. Chem. 271: 17073-17080.
15. Makoveichuk, E., S. Castel, S. Vilaro, and G. Olivecrona. 2004. Lipoprotein lipase-dependent binding and uptake of low density lipoproteins by THP-1 monocytes and macrophages: possible involvement of lipid rafts. Biochim. Biophys. Acta. 1686: 37-49.
16. Ishibashi, S., M. S. Brown, J. L. Goldstein, R. D. Gerard, R. E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92: 883-893.
17. Plump, A. S., J. D. Smith, T. Hayek, K. Aalto-Setala, A. Walsh, J. G. Verstuyft, E. M. Rubin, and J. L. Breslow. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 71: 343-353.
18. Dong, Q. G., S. Bernasconi, S. Lostaglio, R. W. De Calmanovici, I. Martin-Padura, F. Breviario, C. Garlanda, S. Ramponi, A. Mantovani, and A. Vecchi. 1997. A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Arterioscler. Thromb. Vasc. Biol. 17: 1599-1604.
19. Magid, R., D. Martinson, J. Hwang, H. Jo, and Z. S. Galis. 2003. Optimization of isolation and functional characterization of primary murine aortic endothelial cells. Endothelium. 10: 103-109.
20. Obermeyer, N., N. Janson, J. Bergmann, F. Buck, and W. D. Ito. 2003. Proteome analysis of migrating versus nonmigrating rat heart endothelial cells reveals distinct expression patterns. Endothelium. 10: 167-178.
21. Heeren, J., T. Grewal, A. Laatsch, D. Rottke, F. Rinninger, C. Enrich, and U. Beisiegel. 2003. Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization. J. Biol. Chem. 278: 14370-14378.
22. Goldstein, J. L., S. K. Basu, and M. S. Brown. 1983. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98: 241-260.
23. Jokinen, E. V., K. T. Landschulz, K. L. Wyne, Y. K. Ho, P. K. Frykman, and H. H. Hobbs. 1994. Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle. J. Biol. Chem. 269: 26411-26418.
24. Havel, R. J., H. A. Eder, and J. H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1345-1353.
25. Pittman, R. C., and C. A. Taylor, Jr. 1986. Methods for assessment of tissue sites of lipoprotein degradation. Methods Enzymol. 129: 612-628.
26. Dole, V. P. 1956. A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. Clin. Invest. 35: 150-154.
27. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and T. D. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
28. Ishibashi, S., J. L. Goldstein, M. S. Brown, J. Herz, and D. K. Burns. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93: 1885-1893.
29. Rumsey, S. C., J. C. Obunike, Y. Arad, R. J. Deckelbaum, and I. J. Goldberg. 1992. Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages. J. Clin. Invest. 90: 1504-1512.
30. Hussain, M. M., J. C. Obunike, A. Shaheen, M. J. Hussain, G. S. Shelness, and I. J. Goldberg. 2000. High affinity binding between lipoprotein lipase and lipoproteins involves multiple ionic and hydrophobic interactions, does not require enzyme activity, and is modulated by glycosaminoglycans. J. Biol. Chem. 275: 29324-29330.
31. Boren, J., A. Lookene, E. Makoveichuk, S. Xiang, M. Gustafsson, H. Liu, P. Talmud, and G. Olivecrona. 2001. Binding of low density lipoproteins to lipoprotein lipase is dependent on lipids but not on apolipoprotein B. J. Biol. Chem. 276: 26916-26922.
32. Sivaram, P., S. Y. Choi, L. K. Curtiss, and I. J. Goldberg. 1994. An amino-terminal fragment of apolipoprotein B binds to lipoprotein lipase and may facilitate its binding to endothelial cells. J. Biol. Chem. 269: 9409-9412.
33. Choi, S. Y., L. Pang, P. A. Kern, H. J. Kayden, L. K. Curtiss, T. M. Vanni-Reyes, and I. J. Goldberg. 1997. Dissociation of LPL and LDL: effects of lipoproteins and anti-apoB antibodies. J. Lipid Res. 38: 77-85.
34. Lookene, A., R. Savonen, and G. Olivecrona. 1997. Interaction of lipoproteins with heparan sulfate proteoglycans and with lipoprotein lipase. Studies by surface plasmon resonance technique. Biochemistry. 36: 5267-5275.
35. Takahashi, S., J. Sakai, T. Fujino, I. Miyamori, and T. T. Yamamoto. 2003. The very low density lipoprotein (VLDL) receptor - a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues. Mol. Cell. Biochem. 248: 121-127.
36. Rutledge, J. C., A. E. Mullick, G. Gardner, and I. J. Goldberg. 2000. Direct visualization of lipid deposition and reverse lipid transport in a perfused artery: roles of VLDL and HDL. Circ. Res. 86: 768-773.
37. Schonherr, E., B. Zhao, H. Hausser, M. Muller, C. Langer, W. D. Wagner, I. J. Goldberg, and H. Kresse. 2000. Lipoprotein lipase-mediated interactions of small proteoglycans and low-density lipoproteins. Eur. J. Cell Biol. 79: 689-696.
38. van Dijk, K. W., B. J. van Vlijmen. H. B. van't Hof, A. van der Zee, S. Santamarina-Fojo, T. J. van Berkel, L. M. Havekes, and M. H. Hofker. 1999. In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE. J. Lipid Res. 40: 336-344.
39. Nordestgaard, B. G. 1996. The vascular endothelial barrier - selective retention of lipoproteins. Curr. Opin. Lipidol. 7: 269-273.
40. Levak-Frank, S., H. Radner, A. Walsh, R. Stollberger, G. Knipping, G. Hoefler, W. Sattler, P. H. Weinstock, J. L. Breslow, and R. Zechner. 1995. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J. Clin. Invest. 96: 976-986.
41. Lutz, E. P., M. Merkel, Y. Kako, K. Melford, H. Radner, J. L. Breslow, A. Bensadoun, and I. J. Goldberg. 2001. Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues. J. Clin. Invest. 107: 1183-1192.
42. Rinninger, F., M. Brundert, I. Brosch, N. Donarski, R. M. Budzinski, and H. Greten. 2001. Lipoprotein lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent of scavenger receptor BI. J. Lipid Res. 42: 1740-1751.
43. Seo, T., M. Al-Haideri, E. Treskova, T. S. Worgall, Y. Kako, I. J. Goldberg, and R. J. Deckelbaum. 2000. Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1. J. Biol. Chem. 275: 30355-30362.