Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase

Cardiovascular Research

Volumn 65, Issue 2, 2005, Pages 524-534

  Koike, Tomonari ^a   Liang, Jingyan ^a   Wang, Xiaofei ^a   Ichikawa, Tomonaga ^a   Shiomi, Masashi ^b   Sun, Huijun ^a,c   Watanabe, Teruo ^d   Liu, George ^e   Fan, Jianglin ^a  

^a Inst Basic Med Sci Univ T ^*  (Japan)

^b KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d SAGA UNIVERSITY   (Japan)

^e PEKING UNIVERSITY   (China)

Author keywords

Atherosclerosis; Hypercholesterolemia; Hypertriglyceridemia; Lipoprotein lipase; Transgenic rabbits; WHHL rabbits

Indexed keywords

BIGLYCAN; CHOLESTEROL; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; CATABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; INTERMETHOD COMPARISON; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RABBIT; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AORTA; AORTIC DISEASES; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; CHOLESTEROL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; FEMALE; HUMANS; HYPERLIPIDEMIAS; IMAGE PROCESSING, COMPUTER-ASSISTED; LIPOPROTEIN LIPASE; LIPOPROTEINS; MALE; MICROSCOPY, ELECTRON; RABBITS; TRIGLYCERIDES;

EID: 11444255417     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.10.022     Document Type: Article

References (42)

1. S. Santamarina-Fojo, and K.A. Dugi Structure, function and role of lipoprotein lipase in lipoprotein metabolism Curr. Opin. Lipidol. 5 1994 117 125
2. G. Olivecrona, and T. Olivecrona Triglyceride lipases and atherosclerosis Curr. Opin. Lipidol. 6 1995 291 305
3. I.J. Goldberg Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis J. Lipid Res. 37 1996 693 707
4. R.H. Eckel Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic disease New Engl. J. Med. 320 1989 1060 1068
5. M. Shimada, S. Ishibashi, T. Inaba, H. Yagyu, K. Harada, and J.I. Osuga Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase Proc. Natl. Acad. Sci. U. S. A. 93 1996 7242 7246
6. H. Yagyu, S. Ishibashi, Z. Chen, J. Osuga, M. Okazaki, and S. Perrey Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice J. Lipid Res. 40 1999 1677 1685
7. P. Benlian, J.L. De Gennes, L. Foubert, H. Zhang, S.E. Gagne, and M. Hayden Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene N. Engl. J. Med. 335 1996 848 854
8. J.J. Kastelein, J.W. Jukema, A.H. Zwinderman, S. Clee, A.J. van Boven, and H. Jansen Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS study group Circulation 102 2000 1629 1633
9. K. Tsutsumi, Y. Inoue, A. Shima, K. Iwasaki, M. Kawamura, and T. Murase The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis J. Clin. Invest. 92 1993 411 417
10. T. Chiba, S. Miura, F. Sawamura, R. Uetsuka, I. Tomita, and Y. Inoue Antiatherogenic effects of a novel lipoprotein lipase-enhancing agent in cholesterol-fed New Zealand white rabbits Arterioscler. Thromb. Vasc. Biol. 17 1997 2601 2608
11. J. Fan, H. Unoki, N. Kojima, H. Sun, H. Shimoyamada, and H. Deng Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis J. Biol. Chem. 276 2001 40071 40079
12. J.R. Mead, A. Cryer, and D.P. Ramji Lipoprotein lipase, a key role in atherosclerosis? FEBS Lett. 462 1999 1 6
13. S. Yla-Herttuala, B. Lipton, M. Rosenfeld, I. Goldberg, D. Steinberg, and J. Witztum Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions Proc. Natl. Acad. Sci. U. S. A. 88 1991 10143 10147
14. K. O'Brien, D. Gordon, S. Deeb, M. Ferguson, and A. Chait Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques J. Clin. Invest. 89 1992 1544 1550
15. G. Renier, E. Skamene, J.B. DeSanctis, and D. Radzioch High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis Arterioscler. Thromb. 13 1993 190 196
16. V.R. Babaev, S. Fazio, L.A. Gleaves, K.J. Carter, C.F. Semenkovich, and M.F. Linton Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo J. Clin. Invest. 103 1999 1697 1705
17. V.R. Babaev, M.B. Patel, C.F. Semenkovich, S. Fazio, and M.F. Linton Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice J. Biol. Chem. 275 2000 26293 26299
18. K. Wilson, G.L. Fry, D.A. Chappell, C.D. Sigmund, and J.D. Medh Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice Arterioscler. Thromb. Vasc. Biol. 21 2001 1809 1815
19. T. Ichikawa, J. Liang, S. Kitajima, T. Koike, X. Wang, and H. Sun Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits Atherosclerosis 2004 [in press]
20. J.C. Mamputu, A.C. Desfaits, and G. Renier Lipoprotein lipase enhances human monocyte adhesion to aortic endothelial cells J. Lipid Res. 38 1997 1722 1729
21. J.C. Obunike, S. Paka, S. Pillarisetti, and I.J. Goldberg Lipoprotein lipase can function as a monocyte adhesion protein Arterioscler. Thromb. Vasc. Biol. 17 1997 1414 1420
22. U. Beisiegel, W. Weber, and G. Bengtsson-Olivecrona Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein Proc. Natl. Acad. Sci. U. S. A. 88 1991 8342 8346
23. F. de Beer, W.L. Hendriks, L.C. van Vark, S.W. Kamerling, K.W. van Dijk, and M.H. Hofker Binding of beta-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas ApoE only modulates binding affinity Arterioscler. Thromb. Vasc. Biol. 19 1999 633 637
24. J. Boren, A. Lookene, E. Makoveichuk, S. Xiang, M. Gustafsson, and H. Liu Binding of low density lipoproteins to lipoprotein lipase is dependent on lipids but not on apolipoprotein B J. Biol. Chem. 276 2001 26916 26922
25. M. Aviram, E.L. Bierman, and A. Chait Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells J. Biol. Chem. 263 1988 15416 15422
26. K.A. Dugi, I.M. Feuerstein, S. Hill, J. Shih, S. Santamarina-Fojo, and H.B. Brewer Jr. Lipoprotein lipase correlates positively and hepatic lipase inversely with calcific atherosclerosis in homozygous familial hypercholesterolemia Arterioscler. Thromb. Vasc. Biol. 17 1997 354 364
27. T. Koike, J. Liang, X. Wang, T. Ichikawa, M. Shiomi, and G. Liu Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity J. Biol. Chem. 279 2004 7521 7529
28. J. Fan, Z.S. Ji, Y. Huang, H. de Silva, D. Sanan, and R.W. Mahley Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma J. Clin. Invest. 101 1998 2151 2164
29. H. Sun, H. Unoki, X. Wang, J. Liang, T. Ichikawa, and Y. Arai Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a) J. Biol. Chem. 277 2002 47486 47492
30. T. Ichikawa, S. Kitajima, J. Liang, T. Koike, X. Wang, and H. Sun Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis Lab. Invest. 84 2004 715 726
31. J. Fan, H. Shimoyamada, H. Sun, S. Marcovina, K. Honda, and T. Watanabe Transgenic rabbits expressing human apolipoprotein(a) develop more extensive atherosclerotic lesions in response to a cholesterol-rich diet Arterioscler. Thromb. Vasc. Biol. 21 2001 88 94
32. H. Itabe, E. Takeshima, H. Iwasaki, J. Kimura, Y. Yoshida, and T. Imanaka A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides J. Biol. Chem. 269 1994 15274 15279
33. T. Ichikawa, H. Unoki, H. Sun, H. Shimoyamada, S. Marcovina, and H. Shikama Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits Am. J. Pathol. 160 2002 227 236
34. K. Skalen, M. Gustafsson, E.K. Rydberg, L.M. Hulten, O. Wiklund, and T.L. Innerarity Subendothelial retention of atherogenic lipoproteins in early atherosclerosis Nature 417 2002 750 754
35. P.T. Kovanen, M.S. Brown, S.K. Basu, D.W. Bilheimer, and J.L. Goldstein Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits Proc. Natl. Acad. Sci. U. S. A. 78 1981 1396 1400
36. M.M. Hussain, T.L. Innerarity, W.J. Brecht, and R.W. Mahley Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits. Saturation of the sequestration step of the remnant clearance pathway J. Biol. Chem. 270 1995 8578 8587
37. G. Camejo, E. Hurt-Camejo, O. Wiklund, and G. Bondjers Association of apoB lipoproteins with arterial proteoglycans: pathological significance and molecular basis Atherosclerosis 139 1998 205 222
38. P. Lindqvist, A. Ostlund-Lindqvist, J. Witztum, D. Steinberg, and J. Little The role of lipoprotein lipase in the metabolism of triglyceride-rich lipoproteins by macrophages J. Biol. Chem. 258 1983 9086 9092
39. U. Saxena, M. Klein, T. Vanni, and I. Goldberg Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix J. Clin. Invest. 89 1992 373 380
40. K. Tsutsumi, Y. Inoue, and T. Murase Effects of NO-1886, a lipoprotein lipase promoting agent, on homozygous and heterozygous Watanabe heritable hyperlipidaemic rabbits Arzneimittelforschung 50 2000 118 121
41. S. Ishibashi, J.L. Goldstein, M.S. Brown, J. Herz, and D.K. Burns Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice J. Clin. Invest. 93 1994 1885 1893
42. J. Fan, and T. Watanabe Transgenic rabbits as therapeutic protein bioreactors and human disease models Pharmacol. Ther. 99 2003 261 282