Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion

Journal of Lipid Research

Volumn 48, Issue 2, 2007, Pages 385-394

  Qiu, Guosong ^a   Ho, Alexander C ^a   Yu, Willie ^a   Hill, John S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Inflammation; Lentivirus; Microarray; Monocyte; RNA interference

Indexed keywords

CD36 ANTIGEN; CHOLESTEROL; CYTOKINE; ENDOTHELIAL LIPASE; ENZYME; GROWTH FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; LYSOPHOSPHATIDYLCHOLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER RECEPTOR; SCAVENGER RECEPTOR 1; SCAVENGER RECEPTOR BI; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; HUMAN; HUMAN CELL; LENTIVIRINAE; LIPID COMPOSITION; MACROPHAGE; METABOLISM; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

BASE SEQUENCE; CELL LINE; CYTOKINES; HUMANS; INFLAMMATION; LIPASE; LIPOPROTEIN LIPASE; LIPOPROTEINS, LDL; MACROPHAGES; MOLECULAR SEQUENCE DATA;

EID: 33846889765     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600304-JLR200     Document Type: Article

References (54)

1. Tedgui, A., and Z. Mallat. 2006. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol. Rev. 86: 515-581.
2. Ma, K., M. Cilingiroglu, J. D. Otvos, C. M. Ballantyne, A. J. Marian, and L. Chan. 2003. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc. Natl. Acad. Sci. USA. 100: 2748-2753.
3. Van Eck, M., R. Zimmermann, P. H. Groot, R. Zechner, and T. J. Van Berkel. 2000. Role of macrophage-derived lipoprotein lipase in lipoprotein metabolism and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20: E53-E62.
4. O'Brien, K. D., D. Gordon, S. Deeb, M. Ferguson, and A. Chait. 1992. Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques. J. Clin. Invest. 89: 1544-1550.
5. Azumi, H., K. Hirata, T. Ishida, Y. Kojima, Y. Rikitake, S. Takeuchi, N. Inoue, S. Kawashima, Y. Hayashi, H. Itoh, et al. 2003. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc. Res. 58: 647-654.
6. Beauchamp, M. C., E. Letendre, and G. Renier. 2002. Macrophage lipoprotein lipase expression is increased in patients with heterozygous familial hypercholesterolemia. J. Lipid Res. 43: 215-222.
7. Sartippour, M. R., and G. Renier. 2000. Upregulation of macrophage lipoprotein lipase in patients with type 2 diabetes: role of peripheral factors. Diabetes. 49: 597-602.
8. Wilson, K., G. L. Fry, D. A. Chappell, C. D. Sigmund, and J. D. Medh. 2001. Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein E knockout mice but not in C57BL/6 mice. Arterioscler. Thromb. Vasc. Biol. 21: 1809-1815.
9. Ichikawa, T., J. Liang, S. Kitajima, T. Koike, X. Wang, H. Sun, M. Morimoto, H. Shikama, T. Watanabe, N. Yamada, et al. 2005. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis. 179: 87-95.
10. Koike, T., J. Liang, X. Wang, T. Ichikawa, M. Shiomi, H. Sun, T. Watanabe, G. Liu, and J. Fan. 2005. Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovasc. Res. 65: 524-534.
11. Ishida, T., S. Y. Choi, R. K. Kundu, J. Spin, T. Yamashita, K. Hirata, Y. Kojima, M. Yokoyama, A. D. Cooper, and T. Quertermous. 2004. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J. Biol. Chem. 279: 45085-45092.
12. Badellino, K. O., M. L. Wolfe, M. P. Reilly, and D. J. Rader. 2006. Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med. 3: e22.
13. Olin, K. L., S. Potter-Perigo, P. H. Barrett, T. N. Wight, and A. Chait. 1999. Lipoprotein lipase enhances the binding of native and oxidized low density lipoproteins to versican and biglycan synthesized by cultured arterial smooth muscle cells. J. Biol. Chem. 274: 34629-34636.
14. Kaplan, M., and M. Aviram. 2001. Retention of oxidized LDL by extracellular matrix proteoglycans leads to its uptake by macrophages: an alternative approach to study lipoproteins cellular uptake. Arterioscler. Thromb. Vasc. Biol. 21: 386-393.
15. Makoveichuk, E., S. Castel, S. Vilaro, and G. Olivecrona. 2004. Lipoprotein lipase-dependent binding and uptake of low density lipoproteins by THP-1 monocytes and macrophages: possible involvement of lipid rafts. Biochim. Biophys. Acta. 1686: 37-49.
16. Fuki, I. V., N. Blanchard, W. Jin, D. H. Marchadier, J. S. Millar, J. M. Glick, and D. J. Rader. 2003. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway. J. Biol. Chem. 278: 34331-34338.
17. Mamputu, J. C., A. C. Desfaits, and G. Renier. 1997. Lipoprotein lipase enhances human monocyte adhesion to aortic endothelial cells. J. Lipid Res. 38: 1722-1729.
18. Obunike, J. C., S. Paka, S. Pillarisetti, and I. J. Goldberg. 1997. Lipoprotein lipase can function as a monocyte adhesion protein. Arterioscler. Thromb. Vasc. Biol. 17: 1414-1420.
19. Kojma, Y., K. Hirata, T. Ishida, Y. Shimokawa, N. Inoue, S. Kawashima, T. Quertermous, and M. Yokoyama. 2004. Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation. J. Biol. Chem. 279: 54032-54038.
20. Muhammad, T. S., T. R. Hughes, A. Cryer, and D. P. Ramji. 1998. The suppression of lipoprotein lipase expression in J774.2 macrophages by IFN-gamma and TNF-alpha is mediated at the transcriptional level. Biochem. Soc. Trans. 26 (Suppl.): 12.
21. Tengku-Muhammad, T. S., T. R. Hughes, A. Cryer, and D. P. Ramji. 1996. Differential regulation of lipoprotein lipase in the macrophage J774.2 cell line by cytokines. Cytokine. 8: 525-533.
22. Greenberg, A. S., R. P. Nordan, J. McIntosh, J. C. Calvo, R. O. Scow, and D. Jablons. 1992. Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. Cancer Res. 52: 4113-4116.
23. Jin, W., G. S. Sun, D. Marchadier, E. Octtaviani, J. M. Glick, and D. J. Rader. 2003. Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ. Res. 92: 644-650.
24. Reiner, G., M. Oliver, E. Skamene, and D. Radzioch. 1994. Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation. J. Lipid Res. 35: 1413-1421.
25. Renier, G., E. Skamene, J. B. DeSanctis, and D. Radzioch. 1994. Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase. J. Lipid Res. 35: 271-278.
26. Hill, J. S., D. Yang, J. Nikazy, L. K. Curtiss, J. T. Sparrow, and H. Wong. 1998. Subdomain chimeras of hepatic lipase and lipoprotein lipase. Localization of heparin and cofactor binding. J. Biol. Chem. 273: 30979-30984.
27. Innis, S. M., and R. A. Dyer. 2002. Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. J. Lipid Res. 43: 1529-1536.
28. Gauster, M., G. Rechberger, A. Sovic, G. Horl, E. Steyrer, W. Sattler, and S. Frank. 2005. Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine. J. Lipid Res. 46: 1517-1525.
29. Fugman, D. A., K. Shirai, R. L. Jackson, and J. D. Johnson. 1984. Lipoprotein lipase- and phospholipase A2-catalyzed hydrolysis of phospholipid vesicles with an encapsulated fluorescent dye. Effects of apolipoproteins. Biochim. Biophys. Acta. 795: 191-195.
30. Cantin, B., L. D. Brun, C. Gagne, M. R. Murthy, P. J. Lupien, and P. Julien. 1992. Alterations in erythrocyte membrane lipid composition and fluidity in primary lipoprotein lipase deficiency. Biochim. Biophys. Acta. 1139: 25-31.
31. Murugesan, G., M. R. Sandhya Rani, C. E. Gerber, C. Mukhopadhyay, R. M. Ransohoff, G. M. Chisolm, and K. Kottke-Marchant. 2003. Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines. J. Mol. Cell. Cardiol. 35: 1375-1384.
32. Rong, J. X., J. W. Berman, M. B. Taubman, and E. A. Fisher. 2002. Lysophosphatidylcholine stimulates monocyte chemoattractant protein-1 gene expression in rat aortic smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 22: 1617-1623.
33. Yan, L., M. Velikanov, P. Flook, W. Zheng, S. Szalma, and S. Kahn. 2003. Assessment of putative protein targets derived from the SARS genome. FEBS Lett. 554: 257-263.
34. Liu-Wu, Y., E. Hurt-Camejo, and O. Wiklund. 1998. Lysophosphatidylcholine induces the production of IL-1beta by human monocytes. Atherosclerosis. 137: 351-357.
35. Rikitake, Y., K. Hirata, T. Yamashita, K. Iwai, S. Kobayashi, H. Itoh, M. Ozaki, J. Ejiri, M. Shiomi, N. Inoue, et al. 2002. Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 22: 2049-2053.
36. Milosavljevic, D., A. Kontush, S. Griglio, G. Le Naour, J. Thillet, and M. J. Chapman. 2003. VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass. Biochim. Biophys. Acta. 1631: 51-60.
37. Hung, Y. C., M. Y. Hong, and G. S. Huang. 2006. Cholesterol loading augments oxidative stress in macrophages. FEBS Lett. 580: 849-861.
38. Li, Y., R. F. Schwabe, T. DeVries-Seimon, P. M. Yao, M. C. Gerbod-Giannone, A. R. Tall, R. J. Davis, R. Flavell, D. A. Brenner, and I. Tabas. 2005. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and MAP kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 280: 21763-21772.
39. Wang, N., I. Tabas, R. Winchester, S. Ravalli, L. E. Rabbani, and A. Tall. 1996. Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J. Biol. Chem. 271: 8837-8842.
40. Ziouzenkova, O., S. Perrey, L. Asatryan, J. Hwang, K. L. MacNaul, D. E. Moller, D. J. Rader, A. Sevanian, R. Zechner, G. Hoefler, et al. 2003. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc. Natl. Acad. Sci. USA. 100: 2730-2735.
41. Kratky, D., R. Zimmermann, E. M. Wagner, J. G. Strauss, W. Jin, G. M. Kostner, G. Haemmerle, D. J. Rader, and R. Zechner. 2005. Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue. J. Clin. Invest. 115: 161-167.
42. Ahmed, W., G. Orasanu, V. Nehra, L. Asatryan, D. J. Rader, O. Ziouzenkova, and J. Plutzky. 2006. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ. Res. 98: 490-498.
43. Alaoui-El-Azher, M., Y. Wu, N. Havet, A. Israel, A. Lilienbaum, and L. Touqui. 2002. Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways. Mol. Pharmacol. 61: 786-794.
44. Bocher, V., L. J. Millatt, J. C. Fruchart, and B. Staels. 2003. Liver X receptors: new players in atherogenesis? Curr. Opin. Lipidol. 14: 137-143.
45. Murakami, A., T. Nishizawa, K. Egawa, T. Kawada, Y. Nishikawa, K. Uenakai, and H. Ohigashi. 2005. New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages. Biochem. Pharmacol. 70: 1330-1342.
46. Fruchart, J. C., P. Duriez, and B. Staels. 1999. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr. Opin. Lipidol. 10: 245-257.
47. Matsunaga, T., S. Hokari, I. Koyama, T. Harada, and T. Komoda. 2003. NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein. Biochem. Biophys. Res. Commun. 303: 313-319.
48. Cominacini, L., A. F. Pasini, U. Garbin, A. Davoli, M. L. Tosetti, M. Campagnola, A. Rigoni, A. M. Pastorino, V. Lo Cascio, and T. Sawamura. 2000. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J. Biol. Chem. 275: 12633-12638.
49. Janabi, M., S. Yamashita, K. Hirano, N. Sakai, H. Hiraoka, K. Matsumoto, Z. Zhang, S. Nozaki, and Y. Matsuzawa. 2000. Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients. Arterioscler. Thromb. Vasc. Biol. 20: 1953-1960.
50. Varadhachary, A. S., M. Monestier, and P. Salgame. 2001. Reciprocal induction of IL-10 and IL-12 from macrophages by low-density lipoprotein and its oxidized forms. Cell. Immunol. 213: 45-51.
51. Kim, O. S., C. S. Lee, E. H. Joe, and I. Jou. 2006. Oxidized low density lipoprotein suppresses lipopolysaccharide-induced inflammatory responses in microglia: oxidative stress acts through control of inflammation. Biochem. Biophys. Res. Commun. 342: 9-18.
52. Marson, A., R. M. Lawn, and T. Mikita. 2004. Oxidized low density lipoprotein blocks lipopolysaccharide-induced interferon beta synthesis in human macrophages by interfering with IRF3 activation. J. Biol. Chem. 279: 28781-28788.
53. Chung, S. W., B. Y. Kang, S. H. Kim, Y. K. Pak, D. Cho, G. Trinchieri, and T. S. Kim. 2000. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. J. Biol. Chem. 275: 32681-32687.
54. Fong, L. G., T. A. Fong, and A. D. Cooper. 1991. Inhibition of lipopolysaccharide-induced interleukin-1 beta mRNA expression in mouse macrophages by oxidized low density lipoprotein. J. Lipid Res. 32: 1899-1910.