The catecholamine-cytokine balance: Interaction between the brain and the immune system

Annals of the New York Academy of Sciences

Volumn 1113, Issue , 2007, Pages 311-324

  Szelényi, Judith ^a   Vizi, E S ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Catecholamine; Cytokine; Depression; Inflammation; Neuroimmunomodulation

Indexed keywords

ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; CATECHOLAMINE; CYTOKINE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; NEUROTRANSMITTER; NORADRENALIN; TUMOR NECROSIS FACTOR ALPHA;

CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DEPRESSION; DRUG MECHANISM; HIPPOCAMPUS; IMMUNE RESPONSE; IMMUNE SYSTEM; NEUROIMMUNOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM; STATISTICAL SIGNIFICANCE; STRESS;

ANIMALIA; MUS;

EID: 35548958257     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1391.026     Document Type: Conference Paper

References (65)

1. ELENKOV, I.J., R.L. WILDER, G.P. CHROUSOS & E S. VIZI. 2000. The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol. Rev. 52: 595.
2. SZELENYI, J. 2001. Cytokines and the central nervous system. Brain Res. Bull. 54: 329.
3. BEUTLER, B. 1995. TNF, immunity and inflammatory disease: lessons of the past decade. J. Investig. Med. 43: 227.
4. BENDTZEN, K. 1994. Cytokines and natural regulators of cytokines. Immunol. Lett. 43: 111.
5. DINARELLO, C.A. 1992. Anti-cytokine strategies. Eur. Cytokine Netw. 3: 7.
6. SZELENYI, J. & Z. SELMECZY. 2002. Immunomodulatory effect of antidepressants. Curr. Opin. Pharmacol. 2: 428.
7. VIZI, E.S. 1998. Receptor-mediated local fine-tuning by noradrenergic innervation of neuroendocrine and immune systems. Ann. N. Y. Acad. Sci. 851: 388.
8. BREDOW, S., N. GUHA-THAKURTA, P. TAISHI, et al. 1997. Diurnal variations of tumor necrosis factor alpha mRNA and alpha-tubulin mRNA in rat brain. Neuroimmunomodulation 4: 84.
9. VIZI, E.S. & J.P. KISS. 1998. Neurochemistry and pharmacology of the major hippocampal transmitter systems: synaptic and nonsynaptic interactions. Hippocampus 8: 566.
10. WATKINS, L.R., S.F. MAIER & L.E. GOEHLER. 1995. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 57: 1011.
11. BANKS, W.A. & A.J. KASTIN. 1997. Relative contributions of peripheral and central sources to levels of IL-1 alpha in the cerebral cortex of mice: assessment with species-specific enzyme immunoassays. J. Neuroimmunol. 79: 22.
12. BREDER, C.D., C. HAZUKA, T. GHAYUR, et al. 1994. Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl. Acad. Sci. USA 91: 11393.
13. STERNBERG, E.M. 1997. Neural-immune interactions in health and disease. J. Clin. Invest. 100: 2641.
14. WOICIECHOWSKY, C., K. ASADULLAH, D. NESTLER, et al. 1998. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nat. Med. 4: 808.
15. RAISON, C.L. & A.H. MILLER. 2003. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 160: 1554.
16. DANTZER, R. 2004. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur. J. Pharmacol. 500: 399.
17. BYLUND, D.B., D.C. EIKENBERG, J.P. HIEBLE, et al. 1994. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol. Rev. 46: 121.
18. BOURNE, H.R., L.M. LICHTENSTEIN, K.L. MELMON, et al. 1974. Modulation of inflammation and immunity by cyclic AMP. Science 184: 19.
19. KAMBAYASHI, T., C.O. JACOB, D. ZHOU, et al. 1995. Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages. J. Immunol. 155: 4909.
20. KAMINSKA, B. 2005. MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754: 253.
21. SZELENYI, J., J.P. KISS & E.S. VIZI. 2000. Differential involvement of sympathetic nervous system and immune system in the modulation of TNF-alpha production by alpha2- and beta-adrenoceptors in mice. J. Neuroimmunol. 103: 34.
22. SZELENYI, J., J.P. KISS, E. PUSKAS, et al. 2000. Contribution of differently localized alpha 2- and beta-adrenoceptors in the modulation of TNF-alpha and IL-10 production in endotoxemic mice. Ann. N. Y. Acad. Sci. 917: 145.
23. SZELENYI, J., J.P. KISS, E. PUSKAS, et al. 2000. Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice. Neuroreport 11: 3565.
24. ELENKOV, I.J. & E.S. VIZI. 1991. Presynaptic modulation of release of noradrenaline from the sympathetic nerve terminals in the rat spleen. Neuropharmacology 30: 1319.
25. VIZI, E.S. 1979. Presynaptic modulation of neurochemical transmission. Prog. Neurobiol. 12: 181.
26. KISS, J.P., G. ZSILLA, A. MIKE, et al. 1995. Subtype-specificity of the presynaptic alpha 2-adrenoceptors modulating hippocampal norepinephrine release in rat. Brain Res. 674: 238.
27. PERRY, V.H., M.D. BELL, H.C. BROWN & M.K. MATYSZAK. 1995. Inflammation in the nervous system. Curr. Opin. Neurobiol. 5: 636.
28. ZHU, Y., S. ROTH-EICHHORN, N. BRAUN, et al. 2000. The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat. Brain Res. 866: 286.
29. ROTHWELL, N.J. 1999. Annual review prize lecture cytokines killers in the brain? J. Physiol. 514(Pt 1): 3.
30. FEUERSTEIN, G.Z., X. WANG & F.C. BARONE. 1998. The role of cytokines in the neuropathology of stroke and neurotrauma. Neuroimmunomodulation 5: 143.
31. ALLAN, S.M. & N.J. ROTHWELL. 2001. Cytokines and acute neurodegeneration. Nat. Rev. Neurosci. 2: 734.
32. MATSUOKA, Y., Y. KITAMURA, H. TAKAHASHI, et al. 1999. Interferon-gamma plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus. Neurochem. Int. 34: 91.
33. ROTHWELL, N., S. ALLAN4 & S. TOULMOND. 1997. The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. J. Clin. Invest. 100: 2648.
34. JEOHN, G.H., L.Y. KONG, B. WILSON, et al. 1998. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures. J. Neuroimmunol. 85: 1.
35. VENTERS, H.D., R. DANTZER & K.W. KELLEY. 2000. A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Trends Neurosci. 23: 175.
36. SPENGLER, R.N., R.M. ALLEN, D.G. REMICK, et al. 1990. Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J. Immunol. 145: 1430.
37. ABRASS, C.K., S.W. O'CONNOR, P.J. SCARPACE & I.B. ABRASS. 1985. Characterization of the beta-adrenergic receptor of the rat peritoneal macrophage. J. Immunol. 135: 1338.
38. CHONG, Y.H., Y.J. SHIN & Y.H. SUH. 2003. Cyclic AMP inhibition of tumor necrosis factor alpha production induced by amyloidogenic C-terminal peptide of Alzheimer's amyloid precursor protein in macrophages: involvement of multiple intracellular pathways and cyclic AMP response element binding protein. Mol. Pharmacol. 63: 690.
39. VAN DER POLL, T., J. JANSEN, E. ENDERT, et al. 1994. Noradrenaline inhibits lipopolysaccharide- induced tumor necrosis factor and interleukin 6 production in human whole blood. Infect. Immun. 62: 2046.
40. SZELENYI, J., Z. SELMECZY, A. BROZIK, et al. 2006. Dual beta-adrenergic modulation in the immune system: stimulus-dependent effect of isoproterenol on MAPK activation and inflammatory mediator production in macrophages. Neurochem. Int. 49: 94.
41. GUHA, M. & N. MACKMAN. 2001. LPS induction of gene expression in human monocytes. Cell Signal. 13: 85.
42. MAGOCSI, M., E.S. VIZI, Z.S. SELMECZY & A.J.S. BROZIK. 2007. Multiple G protein coupling specificity of beta-adrenoceptor in macrophages. Immunology. In press.
43. CAPURON, L. & A.H. MILLER. 2004. Cytokines and psychopathology: lessons from interferon-alpha. Biol. Psychiatry 56: 819.
44. BESEDOVSKY, H.O. & A. DEL REY. 1996. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 17: 64.
45. DUNN, A.J., J. WANG & T. ANDO. 1999. Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress. Adv. Exp. Med. Biol. 461: 117.
46. GAO, H.M., J. JIANG, B. WILSON, et al. 2002. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J. Neurochem. 81: 1285.
47. SILVERMAN, M.N., B.D. PEARCE, C.A. BIRON & A.H. MILLER. 2005. Immune modulation of the hypothalamic-pituitary- adrenal (HPA) axis during viral infection. Viral Immunol. 18: 41.
48. DUNN, A.J. 1988. Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone. Life Sci. 43: 429.
49. ELENKOV, I.J., K. KOVACS, E. DUDA, et al. 1992. Presynaptic inhibitory effect of TNF-alpha on the release of noradrenaline in isolated median eminence. J. Neuroimmunol. 41: 117.
50. AKIYOSHI, M., Y. SHIMIZU & M. SAITO. 1990. Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats. Biochem. Biophys. Res. Commun. 173: 1266.
51. BESEDOVSKY, H., E. SORKIN, M. KELLER & J. MULLER. 1975. Changes in blood hormone levels during the immune response. Proc. Soc. Exp. Biol. Med. 150: 466.
52. DUNN, A.J. 1992. Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1. J. Pharmacol. Exp. Ther. 261: 964.
53. SHIMIZU, N., T. HORI & H. NAKANE. 1994. An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats. Brain Behav. Immun. 8: 14.
54. RAISON, C.L., L. CAPURON & A.H. MILLER. 2006. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 27: 24.
55. BIERHAUS, A., J. WOLF, M. ANDRASSY, et al. 2003. A mechanism converting psychosocial stress into mononuclear cell activation. Proc. Natl. Acad. Sci. USA 100: 1920.
56. XU, F., R.R. GAINETDINOV, W.C. WETSEL, et al. 2000. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat. Neurosci. 3: 465.
57. SELMECZY, Z., J. SZELENYI & E.S. VIZI. 2003. Intact noradrenaline transporter is needed for the sympathetic fine-tuning of cytokine balance. Eur. J. Pharmacol. 469: 175.
58. MORON, J.A., A. BROCKINGTON, R.A. WISE, et al. 2002. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J. Neurosci. 22: 389.
59. ALEXANDRE, C., D. POPA, V. FABRE, et al. 2006. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. J. Neurosci. 26: 5554.
60. GILSBACH, R., A. FARON-GORECKA, Z. ROGOZ, et al. 2006. Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors. J. Neurochem. 96: 1111.
61. VIZI, E.S., G. ZSILLA, M.G. CARON & J.P. KISS. 2004. Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. J. Neurosci. 24: 7888.
62. SZELENYI, J., Z. SELMECZY & E.S. VIZI. 2004. Effect of monoamine transporter inhibitors on the LPS-induced cytokine production. 18: 95.
63. SZELENYI, J. & E.S. V. 2007. Neuroimmune correlates of sleep in depression: role of cytokines. In Neuroimmunology of Sleep, S.R.C. Pandi-Perumal & P. Daniel; Ed.: Dr Chrousos, Georgios), 295. Springer. New York, NY.
64. ZHU, J., E. MIX & B. WINBLAD. 2001. The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev. 7: 387.
65. CHEN, A.C., Y. SHIRAYAMA, K.H. SHIN, et al. 2001. Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect. Biol. Psychiatry 49: 753.