메뉴 건너뛰기




Volumn 96, Issue 4, 2006, Pages 1111-1120

Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors

Author keywords

Alpha adrenergic receptor; Autoradiography; Clonidine; Norepinephrine transporter knockout; Quantitative real time polymerase chain reaction; RX821002

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; BETA ACTIN; CLONIDINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESSENGER RNA; NORADRENALIN TRANSPORTER; RAUWOLSCINE; RECEPTOR SUBTYPE; TRITIUM;

EID: 33645096730     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03598.x     Document Type: Article
Times cited : (28)

References (65)
  • 1
    • 0020081987 scopus 로고
    • Modulation of rat brain alpha 2- and beta-adrenergic receptor sensitivity following long-term treatment with antidepressants
    • Asakura M. Tsukamoto T. Hasegawa K. 1982 Modulation of rat brain alpha 2- and beta-adrenergic receptor sensitivity following long-term treatment with antidepressants Brain Res 235 192 197
    • (1982) Brain Res , vol.235 , pp. 192-197
    • Asakura, M.1    Tsukamoto, T.2    Hasegawa, K.3
  • 2
    • 0034671185 scopus 로고    scopus 로고
    • Potentiated opioid analgesia in norepinephrine transporter knock-out mice
    • Bohn LM. Xu F. Gainetdinov RR. Caron MG. 2000 Potentiated opioid analgesia in norepinephrine transporter knock-out mice JNeurosci 20 9040 9045
    • (2000) JNeurosci , vol.20 , pp. 9040-9045
    • Bohn, L.M.1    Xu, F.2    Gainetdinov, R.R.3    Caron, M.G.4
  • 3
    • 0028650309 scopus 로고
    • The noradrenaline transporter of the neuronal plasma membrane
    • Bönisch H. Brüss M. 1994 The noradrenaline transporter of the neuronal plasma membrane AnnN Y AcadSci 733 193 202
    • (1994) AnnN Y AcadSci , vol.733 , pp. 193-202
    • Bönisch, H.1    Brüss, M.2
  • 4
    • 0037154970 scopus 로고    scopus 로고
    • Two alpha (2)-adrenergic receptor subtypes, alpha (2A) and alpha (2C), inhibit transmitter release in the brain of gene-targeted mice
    • Bücheler MM. Hadamek K. Hein L. 2002 Two alpha (2)-adrenergic receptor subtypes, alpha (2A) and alpha (2C), inhibit transmitter release in the brain of gene-targeted mice Neuroscience 109 819 826
    • (2002) Neuroscience , vol.109 , pp. 819-826
    • Bücheler, M.M.1    Hadamek, K.2    Hein, L.3
  • 5
    • 0033553217 scopus 로고    scopus 로고
    • Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment
    • Callado LF. Gabilondo AM. Meana JJ. 1999 Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment Life Sci 64 2327 2339
    • (1999) Life Sci , vol.64 , pp. 2327-2339
    • Callado, L.F.1    Gabilondo, A.M.2    Meana, J.J.3
  • 6
    • 0022460850 scopus 로고
    • Clorgyline and desipramine alter the sensitivity of [3H]noradrenaline release to calcium but not to clonidine
    • Campbell IC. McKernan RM. 1986 Clorgyline and desipramine alter the sensitivity of [3H]noradrenaline release to calcium but not to clonidine Brain Res 372 253 259
    • (1986) Brain Res , vol.372 , pp. 253-259
    • Campbell, I.C.1    McKernan, R.M.2
  • 7
    • 9744277518 scopus 로고    scopus 로고
    • Dopamine reuptake by norepinephrine neurons: Exception or rule?
    • Carboni E. Silvagni A. 2004 Dopamine reuptake by norepinephrine neurons: exception or rule? CritRevNeurobiol 16 121 128
    • (2004) CritRevNeurobiol , vol.16 , pp. 121-128
    • Carboni, E.1    Silvagni, A.2
  • 9
    • 0036570222 scopus 로고    scopus 로고
    • Assessing antidepressant activity in rodents: Recent developments and future needs
    • Cryan JF. Markou A. Lucki I. 2002 Assessing antidepressant activity in rodents: recent developments and future needs Trends PharmacolSci 23 238 245
    • (2002) Trends PharmacolSci , vol.23 , pp. 238-245
    • Cryan, J.F.1    Markou, A.2    Lucki, I.3
  • 11
    • 4444356089 scopus 로고    scopus 로고
    • [ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice
    • Fagerholm V. Philipp M. Hein L. Scheinin M. 2004 [Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice EurJPharmacol 497 301 309
    • (2004) EurJPharmacol , vol.497 , pp. 301-309
    • Fagerholm, V.1    Philipp, M.2    Hein, L.3    Scheinin, M.4
  • 12
    • 0020555603 scopus 로고
    • Nucleus locus ceruleus: New evidence of anatomical and physiological specificity
    • Foote SL. Bloom FE. Aston-Jones G. 1983 Nucleus locus ceruleus: new evidence of anatomical and physiological specificity PhysiolRev 63 844 914
    • (1983) PhysiolRev , vol.63 , pp. 844-914
    • Foote, S.L.1    Bloom, F.E.2    Aston-Jones, G.3
  • 13
    • 0033930407 scopus 로고    scopus 로고
    • Norepinephrine involvement in antidepressant action
    • Frazer A. 2000 Norepinephrine involvement in antidepressant action JClinPsychiatry 61 25 30
    • (2000) JClinPsychiatry , vol.61 , pp. 25-30
    • Frazer, A.1
  • 14
    • 0031778096 scopus 로고    scopus 로고
    • Cloning and chromosomal mapping of the murine norepinephrine transporter
    • Fritz JD. Jayanthi LD. Thoreson MA. Blakely RD. 1998 Cloning and chromosomal mapping of the murine norepinephrine transporter JNeurochem 70 2241 2251
    • (1998) JNeurochem , vol.70 , pp. 2241-2251
    • Fritz, J.D.1    Jayanthi, L.D.2    Thoreson, M.A.3    Blakely, R.D.4
  • 15
    • 7244247485 scopus 로고    scopus 로고
    • Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment
    • Garcia AS. Barrera G. Burke TF. Ma S. Hensler JG. Morilak DA. 2004 Autoreceptor-mediated inhibition of norepinephrine release in rat medial prefrontal cortex is maintained after chronic desipramine treatment JNeurochem 91 683 693
    • (2004) JNeurochem , vol.91 , pp. 683-693
    • Garcia, A.S.1    Barrera, G.2    Burke, T.F.3    Ma, S.4    Hensler, J.G.5    Morilak, D.A.6
  • 16
    • 10344228794 scopus 로고    scopus 로고
    • Quantification and pharmacological characterization of dialysate levels of noradrenaline in the striatum of freely-moving rats: Release from adrenergic terminals and modulation by alpha2-autoreceptors
    • Gobert A. Billiras R. Cistarelli L. Millan MJ. 2004 Quantification and pharmacological characterization of dialysate levels of noradrenaline in the striatum of freely-moving rats: release from adrenergic terminals and modulation by alpha2-autoreceptors JNeurosciMeth 140 141 152
    • (2004) JNeurosciMeth , vol.140 , pp. 141-152
    • Gobert, A.1    Billiras, R.2    Cistarelli, L.3    Millan, M.J.4
  • 17
    • 0141446183 scopus 로고    scopus 로고
    • Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems
    • Gould GG. Pardon MC. Morilak DA. Frazer A. 2003 Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems Neuropsychopharmacology 28 1633 1641
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1633-1641
    • Gould, G.G.1    Pardon, M.C.2    Morilak, D.A.3    Frazer, A.4
  • 18
    • 0032587456 scopus 로고    scopus 로고
    • Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?
    • Gray AM. Pache DM. Sewell RD. 1999 Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds? EurJPharmacol 378 161 168
    • (1999) EurJPharmacol , vol.378 , pp. 161-168
    • Gray, A.M.1    Pache, D.M.2    Sewell, R.D.3
  • 19
    • 0023189039 scopus 로고
    • Evolving concepts on the interactions between antidepressant treatments and monoamine neurotransmitters
    • Green AR. 1987 Evolving concepts on the interactions between antidepressant treatments and monoamine neurotransmitters Neuropharmacology 26 815 822
    • (1987) Neuropharmacology , vol.26 , pp. 815-822
    • Green, A.R.1
  • 20
    • 0141920354 scopus 로고    scopus 로고
    • Comparing protein abundance and mRNA expression levels on a genomic scale
    • Greenbaum D. Colangelo C. Williams K. Gerstein M. 2003 Comparing protein abundance and mRNA expression levels on a genomic scale Genome Biol 4 117
    • (2003) Genome Biol , vol.4 , pp. 117
    • Greenbaum, D.1    Colangelo, C.2    Williams, K.3    Gerstein, M.4
  • 21
    • 0038118243 scopus 로고    scopus 로고
    • A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters
    • Hahn MK. Robertson D. Blakely RD. 2003 A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters JNeurosci 23 4470 4478
    • (2003) JNeurosci , vol.23 , pp. 4470-4478
    • Hahn, M.K.1    Robertson, D.2    Blakely, R.D.3
  • 23
    • 0024454503 scopus 로고
    • Clonidine-induced hypoactivity and mydriasis in mice are respectively mediated via pre- and postsynaptic alpha 2-adrenoceptors in the brain
    • Heal DJ. Prow MR. Buckett WR. 1989 Clonidine-induced hypoactivity and mydriasis in mice are respectively mediated via pre- and postsynaptic alpha 2-adrenoceptors in the brain EurJPharmacol 170 19 28
    • (1989) EurJPharmacol , vol.170 , pp. 19-28
    • Heal, D.J.1    Prow, M.R.2    Buckett, W.R.3
  • 24
    • 0032589304 scopus 로고    scopus 로고
    • Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: Comparison of radioligand binding and immunohistochemistry
    • Holmberg M. Scheinin M. Kurose H. Miettinen R. 1999 Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry Neuroscience 93 1323 1333
    • (1999) Neuroscience , vol.93 , pp. 1323-1333
    • Holmberg, M.1    Scheinin, M.2    Kurose, H.3    Miettinen, R.4
  • 25
    • 0037430754 scopus 로고    scopus 로고
    • Regional distribution of alpha (2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha (2C)-subtype: An autoradiographic study with [(3) H]RX821002 and [(3) H]rauwolscine
    • Holmberg M. Fagerholm V. Scheinin M. 2003 Regional distribution of alpha (2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha (2C)-subtype: an autoradiographic study with [(3) H]RX821002 and [(3) H]rauwolscine Neuroscience 117 875 898
    • (2003) Neuroscience , vol.117 , pp. 875-898
    • Holmberg, M.1    Fagerholm, V.2    Scheinin, M.3
  • 26
    • 0036460779 scopus 로고    scopus 로고
    • In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex
    • Ihalainen JA. Tanila H. 2002 In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex EurJNeurosci 15 1789 1794
    • (2002) EurJNeurosci , vol.15 , pp. 1789-1794
    • Ihalainen, J.A.1    Tanila, H.2
  • 27
    • 4744376221 scopus 로고    scopus 로고
    • In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens
    • Ihalainen JA. Tanila H. 2004 In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens JNeurochem 91 49 56
    • (2004) JNeurochem , vol.91 , pp. 49-56
    • Ihalainen, J.A.1    Tanila, H.2
  • 28
    • 0037372630 scopus 로고    scopus 로고
    • Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows
    • Inderwies T. Pfaffl MW. Meyer HH. Blum JW. Bruckmaier RM. 2003 Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows DomestAnimEndocrinol 24 123 135
    • (2003) DomestAnimEndocrinol , vol.24 , pp. 123-135
    • Inderwies, T.1    Pfaffl, M.W.2    Meyer, H.H.3    Blum, J.W.4    Bruckmaier, R.M.5
  • 30
    • 0030610424 scopus 로고    scopus 로고
    • Substitution of a mutant alpha2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
    • Lakhlani PP. MacMillan LB. Guo TZ. McCool BA. Lovinger DM. Maze M. Limbird LE. 1997 Substitution of a mutant alpha2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo ProcNatl AcadSciUSA 94 9950 9955
    • (1997) ProcNatl AcadSciUSA , vol.94 , pp. 9950-9955
    • Lakhlani, P.P.1    MacMillan, L.B.2    Guo, T.Z.3    McCool, B.A.4    Lovinger, D.M.5    Maze, M.6    Limbird, L.E.7
  • 32
    • 11844287713 scopus 로고    scopus 로고
    • Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys
    • Ma CL. Arnsten AF. Li BM. 2005 Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys BiolPsychiatry 57 192 195
    • (2005) BiolPsychiatry , vol.57 , pp. 192-195
    • Ma, C.L.1    Arnsten, A.F.2    Li, B.M.3
  • 33
    • 0028328482 scopus 로고
    • Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration
    • Mongeau R. de Montigny C. Blier P. 1994 Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration Neuropsychopharmacology 10 41 51
    • (1994) Neuropsychopharmacology , vol.10 , pp. 41-51
    • Mongeau, R.1    De Montigny, C.2    Blier, P.3
  • 34
    • 0030993317 scopus 로고    scopus 로고
    • The serotonergic and noradrenergic systems of the hippocampus: Their interactions and the effects of antidepressant treatments
    • Mongeau R. Blier P. de Montigny C. 1997 The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments Brain ResBrain ResRev 23 145 195
    • (1997) Brain ResBrain ResRev , vol.23 , pp. 145-195
    • Mongeau, R.1    Blier, P.2    De Montigny, C.3
  • 35
    • 0037080158 scopus 로고    scopus 로고
    • Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: Evidence from knock-out mouse lines
    • Moron JA. Brockington A. Wise RA. Rocha BA. Hope BT. 2002 Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines JNeurosci 22 389 395
    • (2002) JNeurosci , vol.22 , pp. 389-395
    • Moron, J.A.1    Brockington, A.2    Wise, R.A.3    Rocha, B.A.4    Hope, B.T.5
  • 36
    • 0028183038 scopus 로고
    • Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes
    • O'Rourke MF. Blaxall HS. Iversen LJ. Bylund DB. 1994 Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes JPharmacolExpTher 268 1362 1367
    • (1994) JPharmacolExpTher , vol.268 , pp. 1362-1367
    • O'Rourke, M.F.1    Blaxall, H.S.2    Iversen, L.J.3    Bylund, D.B.4
  • 37
    • 0036220528 scopus 로고    scopus 로고
    • Pharmacological properties of the naturally occurring Ala (457) Pro variant of the human norepinephrine transporter
    • Paczkowski FA. Bönisch H. Bryan-Lluka LJ. 2002 Pharmacological properties of the naturally occurring Ala (457) Pro variant of the human norepinephrine transporter Pharmacogenetics 12 165 173
    • (2002) Pharmacogenetics , vol.12 , pp. 165-173
    • Paczkowski, F.A.1    Bönisch, H.2    Bryan-Lluka, L.J.3
  • 40
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. 2001 A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 e45
    • (2001) Nucleic Acids Res , vol.29 , pp. 45
    • Pfaffl, M.W.1
  • 41
    • 0036337129 scopus 로고    scopus 로고
    • Physiological significance of alpha (2)-adrenergic receptor subtype diversity: One receptor is not enough
    • Philipp M. Brede M. Hein L. 2002 Physiological significance of alpha (2)-adrenergic receptor subtype diversity: one receptor is not enough AmJPhysiolRegulIntegrCompPhysiol 283 R287 R295
    • (2002) AmJPhysiolRegulIntegrCompPhysiol , vol.283
    • Philipp, M.1    Brede, M.2    Hein, L.3
  • 42
    • 0033988574 scopus 로고    scopus 로고
    • Animal models of depression: Utility for transgenic research
    • Porsolt RD. 2000 Animal models of depression: utility for transgenic research RevNeurosci 11 53 58
    • (2000) RevNeurosci , vol.11 , pp. 53-58
    • Porsolt, R.D.1
  • 43
    • 0028798930 scopus 로고
    • Molecular cloning and organization of the coding region of the human norepinephrine transporter gene
    • Pörzgen P. Bönisch H. Brüss M. 1995 Molecular cloning and organization of the coding region of the human norepinephrine transporter gene BiochemBiophysResCommun 215 1145 1150
    • (1995) BiochemBiophysResCommun , vol.215 , pp. 1145-1150
    • Pörzgen, P.1    Bönisch, H.2    Brüss, M.3
  • 44
    • 0033232510 scopus 로고    scopus 로고
    • Role of norepinephrine in the pathophysiology and treatment of mood disorders
    • Ressler KJ. Nemeroff CB. 1999 Role of norepinephrine in the pathophysiology and treatment of mood disorders BiolPsychiatry 46 1219 1233
    • (1999) BiolPsychiatry , vol.46 , pp. 1219-1233
    • Ressler, K.J.1    Nemeroff, C.B.2
  • 45
    • 0035166942 scopus 로고    scopus 로고
    • Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: Studies on the role of presynaptic alpha2-adrenoceptors
    • Sacchetti G. Bernini M. Gobbi M. Parini S. Pirona L. Mennini T. Samanin R. 2001 Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors Naunyn Schmiedebergs ArchPharmacol 363 66 72
    • (2001) Naunyn Schmiedebergs ArchPharmacol , vol.363 , pp. 66-72
    • Sacchetti, G.1    Bernini, M.2    Gobbi, M.3    Parini, S.4    Pirona, L.5    Mennini, T.6    Samanin, R.7
  • 46
    • 0031015266 scopus 로고    scopus 로고
    • Genetic alteration of alpha 2C-adrenoceptor expression in mice: Influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist
    • Sallinen J. Link RE. Haapalinna A. et al. 1997 Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist MolPharmacol 51 36 46
    • (1997) MolPharmacol , vol.51 , pp. 36-46
    • Sallinen, J.1    Link, R.E.2    Haapalinna, A.3
  • 47
    • 0032589476 scopus 로고    scopus 로고
    • Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
    • Sallinen J. Haapalinna A. MacDonald E. Viitamaa T. Lahdesmaki J. Rybnikova E. Pelto-Huikko M. Kobilka BK. Scheinin M. 1999 Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels MolPsychiatry 4 443 452
    • (1999) MolPsychiatry , vol.4 , pp. 443-452
    • Sallinen, J.1    Haapalinna, A.2    MacDonald, E.3    Viitamaa, T.4    Lahdesmaki, J.5    Rybnikova, E.6    Pelto-Huikko, M.7    Kobilka, B.K.8    Scheinin, M.9
  • 49
    • 0034745987 scopus 로고    scopus 로고
    • Alpha2-adrenoceptors modulating neuronal serotonin release: A study in alpha2-adrenoceptor subtype-deficient mice
    • Scheibner J. Trendelenburg AU. Hein L. Starke K. 2001 Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice BrJPharmacol 132 925 933
    • (2001) BrJPharmacol , vol.132 , pp. 925-933
    • Scheibner, J.1    Trendelenburg, A.U.2    Hein, L.3    Starke, K.4
  • 50
    • 0035815077 scopus 로고    scopus 로고
    • Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models
    • Scheinin M. Sallinen J. Haapalinna A. 2001 Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models Life Sci 68 2277 2285
    • (2001) Life Sci , vol.68 , pp. 2277-2285
    • Scheinin, M.1    Sallinen, J.2    Haapalinna, A.3
  • 51
    • 0020003939 scopus 로고
    • 3H-Noradrenaline and 3H-5-hydroxytryptamine release from rat brain slices and its presynaptic alpha-adrenergic modulation after long-term desipramine pretreatment
    • Schoffelmeer AN. Mulder AH. 1982 3H-Noradrenaline and 3H-5-hydroxytryptamine release from rat brain slices and its presynaptic alpha-adrenergic modulation after long-term desipramine pretreatment Naunyn Schmiedebergs ArchPharmacol 318 173 180
    • (1982) Naunyn Schmiedebergs ArchPharmacol , vol.318 , pp. 173-180
    • Schoffelmeer, A.N.1    Mulder, A.H.2
  • 52
    • 0035399969 scopus 로고    scopus 로고
    • The alpha (2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety
    • Schramm NL. McDonald MP. Limbird LE. 2001 The alpha (2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety JNeurosci 21 4875 4882
    • (2001) JNeurosci , vol.21 , pp. 4875-4882
    • Schramm, N.L.1    McDonald, M.P.2    Limbird, L.E.3
  • 55
    • 0022571923 scopus 로고
    • Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus coeruleus
    • Simson PG. Weiss JM. Hoffman LJ. Ambrose MJ. 1986 Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus coeruleus Neuropharmacology 25 385 389
    • (1986) Neuropharmacology , vol.25 , pp. 385-389
    • Simson, P.G.1    Weiss, J.M.2    Hoffman, L.J.3    Ambrose, M.J.4
  • 56
    • 0035672752 scopus 로고    scopus 로고
    • Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus
    • Szabo ST. Blier P. 2001 Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus Neuropsychopharmacology 25 845 857
    • (2001) Neuropsychopharmacology , vol.25 , pp. 845-857
    • Szabo, S.T.1    Blier, P.2
  • 57
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele J. De Preter K. Pattyn F. Poppe B. Van Roy N. De Paepe A. Speleman F. 2002 Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 3, RESEARCH0034q3.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 58
    • 4544230526 scopus 로고    scopus 로고
    • Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: Implications for the action of selective serotonin reuptake inhibitors
    • Vizi ES. Zsilla G. Caron MG. Kiss JP. 2004 Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors JNeurosci 24 7888 7894
    • (2004) JNeurosci , vol.24 , pp. 7888-7894
    • Vizi, E.S.1    Zsilla, G.2    Caron, M.G.3    Kiss, J.P.4
  • 59
    • 0029761930 scopus 로고    scopus 로고
    • Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: Evaluation of spatial and temporal information imparted by 3 kb of 5′ regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals
    • Wang R. MacMillan LB. Fremeau RT. Jr. Magnuson MA. Lindner J. Limbird LE. 1996 Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5′ regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals Neuroscience 74 199 218
    • (1996) Neuroscience , vol.74 , pp. 199-218
    • Wang, R.1    MacMillan, L.B.2    Fremeau Jr., R.T.3    Magnuson, M.A.4    Lindner, J.5    Limbird, L.E.6
  • 61
    • 0033232476 scopus 로고    scopus 로고
    • Genetic approaches to studying norepinephrine function: Knockout of the mouse norepinephrine transporter gene
    • Wang YM. Xu F. Gainetdinov RR. Caron MG. 1999 Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene BiolPsychiatry 46 1124 1130
    • (1999) BiolPsychiatry , vol.46 , pp. 1124-1130
    • Wang, Y.M.1    Xu, F.2    Gainetdinov, R.R.3    Caron, M.G.4
  • 62
    • 0022585502 scopus 로고
    • Infusion of adrenergic receptor agonists and antagonists into the locus coeruleus and ventricular system of the brain. Effects on swim-motivated and spontaneous motor activity
    • Weiss JM. Simson PG. Hoffman LJ. Ambrose MJ. Cooper S. Webster A. 1986 Infusion of adrenergic receptor agonists and antagonists into the locus coeruleus and ventricular system of the brain. Effects on swim-motivated and spontaneous motor activity Neuropharmacology 25 367 384
    • (1986) Neuropharmacology , vol.25 , pp. 367-384
    • Weiss, J.M.1    Simson, P.G.2    Hoffman, L.J.3    Ambrose, M.J.4    Cooper, S.5    Webster, A.6
  • 64
  • 65
    • 0029583328 scopus 로고
    • Changes in the regulation of 5-hydroxytryptamine release by alpha2-adrenoceptors in the rat hippocampus after long-term desipramine treatment
    • Yoshioka M. Matsumoto M. Numazawa R. Togashi H. Smith CB. Saito H. 1995 Changes in the regulation of 5-hydroxytryptamine release by alpha2-adrenoceptors in the rat hippocampus after long-term desipramine treatment EurJPharmacol 294 565 570
    • (1995) EurJPharmacol , vol.294 , pp. 565-570
    • Yoshioka, M.1    Matsumoto, M.2    Numazawa, R.3    Togashi, H.4    Smith, C.B.5    Saito, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.