Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q)

Biochemical Journal

Volumn 339, Issue 1, 1999, Pages 21-32

  Vickers, Mark F ^a,d,e   Mani, Rajam S ^a,d,e   Sundaram, Manickavasagam ^a   Hogue, Douglas L ^b   Young, James D ^a   Baldwin, Stephen A ^c   Cass, Carol E ^a,d,e  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d Molec Biology for Membranes Group   (Canada)

^e Membrane Transport Research Group   (Canada)

Author keywords

Nitrobenzylmercaptopurine ribonucleoside; Nucleoside transport

Indexed keywords

DILAZEP; DIPYRIDAMOLE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE; THYMIDINE; TRITIUM;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION KINETICS; GLYCOSYLATION; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DILAZEP; DIPYRIDAMOLE; DNA PRIMERS; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; GENETIC COMPLEMENTATION TEST; GLYCOSYLATION; HUMANS; KINETICS; MEMBRANE PROTEINS; PROTEOLIPIDS; RECOMBINANT PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; THIOINOSINE; THYMIDINE;

EID: 0033118410     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3390021     Document Type: Article

References (49)

1. Cass, C. E., Young, J. D., Baldwin, S. A., Cabrita, M. A., Graham, K. A., Griffiths, M., Jennings, L. L., Mackey, J. R., Ng, A. M. L., Ritzel, M. W. L. et al. (1999) in Membrane Transporters as Drug Targets (Amidon, G. and Sadee, W., eds.), Plenum Publishing Corporation, New York, in the press
2. Mackey, J. R., Baldwin, S. A., Young, J. D. and Cass, C. E. (1998) Drug Resistance Updates 1, 310-324
3. Cass, C. E. (1995) in Drug Transport in Antimicrobial and Anticancer Chemotherapy (Georgopapadakou, N. H., ed.), pp. 403-451, Marcel Dekker, New York
4. Griffith, D. A. and Jarvis, S. M. (1996) Biochim. Biophys. Acta Rev. Biomembr. 1286, 153-181
5. Huang, Q. Q., Yao, S. Y., Ritzel, M. W., Paterson, A. R., Cass, C. E. and Young, J. D. (1994) J. Biol. Chem. 269, 17757-17760
6. Yao, S. Y., Ng, A. M., Ritzel, M. W., Gati, W. P., Cass, C. E. and Young, J. D. (1996) Mol. Pharmacol. 50, 1529-1535
7. Che, M., Ortiz, D. F. and Arias, I. M. (1995) J. Biol. Chem. 270, 13596-13599
8. Ritzel, M. W. L., Yao, S. Y. M., Huang, M. Y., Elliott, J. F., Cass, C. E. and Young, J. D. (1997) Am. J. Physiol. 272, C707-C714
9. Yao, S. Y., Ng, A. M., Muzyka, W. R., Griffiths, M., Cass, C. E., Baldwin, S. A. and Young, J. D. (1997) J. Biol. Chem. 272, 28423-28430
10. Ritzel, M. W. L., Yao, S. Y. M., Ng, A. M. L., Mackey, J. R., Cass, C. E. and Young, J. D. (1998) Mol. Membr. Biol. 15, 203-211
11. Griffiths, M., Yao, S. Y. M., Abidi, F., Phillips, S. E. V., Cass, C. E., Young, J. D. and Baldwin, S. A. (1997) Biochem. J. 328, 739-743
12. Griffiths, M., Beaumont, N., Yao, S. Y., Sundaram, M., Boumah, C. E., Davies, A., Kwong, F. Y., Coe, I., Cass, C. E., Young, J. D. and Baldwin, S. A. (1997) Nat. Med. (N. Y.) 3, 89-93
13. Wang, J., Su, S.-F., Dresser, M. J., Schnaner, M. E., Washington, C. B. and Giacomini, K. M. (1997) Am. J. Physiol. 273, F1058-F1065
14. Crawford, C. R., Patel, D. H., Naeve, C. and Belt, J. A. (1998) J. Biol. Chem. 273, 5288-5293
15. Kwong, F. Y., Wu, J. S., Shi, M. M., Fincham, H. E., Davies, A., Henderson, P. J., Baldwin, S. A. and Young, J. D. (1993) J. Biol. Chem. 268, 22127-22134
16. Hogue, D. L., Hodgson, K. C. and Cass, C. E. (1990) Biochem. Cell Biol. 68, 199-209
17. Hogue, D. L., Ellison, M. J., Young, J. D. and Cass, C. E. (1996) J. Biol. Chem. 271, 9801-9808
18. Kozak, M. (1986) Cell 44, 283-292
19. Kozak, M. (1991) J. Cell Biol. 115, 887-903
20. Ito, H., Fukuda, Y., Murata, K. and Kimura, A. (1983) J. Bacteriol. 153, 163-168
21. Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
22. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. D., Smith, J. A. and Stuuhl, K. (1994) Current Protocols in Molecular Biology, John Wiley, New York
23. Laemmli, U.K. (1970) Nature (London) 227, 680-685
24. Harley, E. R., Paterson, A. R. and Cass, C. E. (1982) Cancer Res. 42, 1289-1295
25. Agbanyo, F. R., Cass, C. E. and Paterson, A. R. (1988) Mol. Pharmacol. 33, 332-337
26. Cheng, Y.-C. and Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108
27. Hammond, J. R. (1994) J. Pharmacol. Exp.Ther. 271, 906-917
28. Hammond, J. R. and Zarenda, M. (1996) Arch. Biochem. Biophys. 332, 313-322
29. Tse, C. M., Belt, J. A., Jarvis, S. M., Paterson, A. R., Wu, J. S. and Young, J. D. (1985) J. Biol. Chem. 260, 3506-3511
30. Hogue, D. L., Ellison, M. J., Vickers, M. and Cass, C. E. (1997) Biochem. Biophys. Res. Commun. 238, 811-816
31. Kwong, F. Y., Davies, A., Tse, C. M., Young, J. D., Henderson, P. J. and Baldwin, S. A. (1988) Biochem. J. 255, 243-249
32. Koren, R., Cass, C. E. and Paterson, A. R. (1983) Biochem. J. 216, 299-308
33. Hammond, J. R. (1991) Mol. Pharmacol. 39, 771-779
34. Jarvis, S. M. (1986) Mol. Pharmacol. 30, 659-665
35. Boleti, H., Coe, I. R., Baldwin, S. A., Young, J. D. and Cass, C. E. (1997) Neuropharmacology 36, 1167-1179
36. Boumah, C. E., Hogue, D. L. and Cass, C. E. (1992) Biochem. J. 288, 987-996
37. Mahanty, S. K., Rao, U. S., Nicholas, R. A. and Scarborough, G. A. (1994) J. Biol. Chem. 269, 17705-17712
38. Ruetz, S. and Gros, P. (1994) J. Biol. Chem. 269, 12277-12284
39. Kaiser, B. N., Finnegan, P. M., Tyerman, S. D., Whitehead, L. F., Bergersen, F. J., Day, D. A. and Udrardi, M. K. (1998) Science 281, 1202-1206
40. Sekler, I., Kopito, R. and Casey, J. R. (1995) J. Biol. Chem. 270, 21028-21034
41. Zinser, E. and Daum, G. (1995) Yeast 11, 493-536
42. Kwong, F. Y. P., Baldwin, S. A., Scudder, P. R., Jarvis, S. J., Choy, M. Y. M. and Young, J. D. (1986) Biochem. J. 240, 349-356
43. Cass, C. E. and Paterson, A. R. (1976) Biochim. Biophys. Acta 419, 285-294
44. Jarvis, S. M., McBride, D. and Young, J. D. (1982) J. Physiol. (London) 324, 31-46
45. Jarvis, S. M. and Young, J. D. (1980) Biochem. J. 190, 377-383
46. Sundaram, M., Yao, S. Y. M., Ng, A. M. L., Griffiths, M., Cass, C. E., Baldwin, S. A. and Young, J. D. (1998) J. Biol. Chem. 273, 21519-21525
47. Jarvis, S. M., Janmohamed, S. N. and Young, J. D. (1983) Biochem. J. 216, 661-667
48. Mani, R. S., Hammond, J. R., Marjan, J. M. J., Graham, K. A., Young, J. D., Baldwin, S. A. and Cass, C. E. (1998) J. Biol. Chem. 273, 30818-30825
49. Crawford, C. R., Ng, C. Y., Ullman, B. and Belt, J. A. (1990) Biochim. Biophys. Acta 1024, 289-297