-
1
-
-
0037138370
-
Signaling through the JAK/STAT pathway, recent advances and future challenges
-
Kisseleva T., Bhattacharya S., Braunstein J., and Schindler C.W. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285 (2002) 1-24
-
(2002)
Gene
, vol.285
, pp. 1-24
-
-
Kisseleva, T.1
Bhattacharya, S.2
Braunstein, J.3
Schindler, C.W.4
-
3
-
-
18244432009
-
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer H., Cumano A., Muller M., Wu H., Huffstadt U., and Pfeffer K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 (1998) 397-409
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
Cumano, A.2
Muller, M.3
Wu, H.4
Huffstadt, U.5
Pfeffer, K.6
-
4
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
Parganas E., Wang D., Stravopodis D., et al. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93 (1998) 385-395
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
-
5
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique V., Boureux A., Valle V.D., et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278 (1997) 1309-1312
-
(1997)
Science
, vol.278
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.D.3
-
6
-
-
0030852328
-
Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
-
Peeters P., Raynaud S.D., Cools J., et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90 (1997) 2535-2540
-
(1997)
Blood
, vol.90
, pp. 2535-2540
-
-
Peeters, P.1
Raynaud, S.D.2
Cools, J.3
-
7
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter E.J., Scott L.M., Campbell P.J., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365 (2005) 1054-1061
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
8
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine R.L., Wadleigh M., Cools J., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7 (2005) 387-397
-
(2005)
Cancer Cell
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
9
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C., Ugo V., Le Couedic J.P., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434 (2005) 1144-1148
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
10
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R., Passamonti F., Buser A.S., et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352 (2005) 1779-1790
-
(2005)
N Engl J Med
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
-
11
-
-
20744460045
-
Identification of an acquired JAK2 mutation in polycythemia vera
-
Zhao R., Xing S., Li Z., et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem 280 (2005) 22788-22792
-
(2005)
J Biol Chem
, vol.280
, pp. 22788-22792
-
-
Zhao, R.1
Xing, S.2
Li, Z.3
-
12
-
-
21344440357
-
The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and the myelodysplastic syndrome
-
Steensma D.P., Dewald G.W., Lasho T.L., et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and the myelodysplastic syndrome. Blood 106 (2005) 1207-1209
-
(2005)
Blood
, vol.106
, pp. 1207-1209
-
-
Steensma, D.P.1
Dewald, G.W.2
Lasho, T.L.3
-
13
-
-
21344467318
-
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
-
Jones A.V., Kreil S., Zoi K., et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 106 (2005) 2162-2168
-
(2005)
Blood
, vol.106
, pp. 2162-2168
-
-
Jones, A.V.1
Kreil, S.2
Zoi, K.3
-
14
-
-
27144466017
-
The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders
-
Scott L.M., Campbell P.J., Baxter E.J., et al. The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood 106 (2005) 2920-2921
-
(2005)
Blood
, vol.106
, pp. 2920-2921
-
-
Scott, L.M.1
Campbell, P.J.2
Baxter, E.J.3
-
15
-
-
25844447519
-
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
-
Jelinek J., Oki Y., Gharibyan V., et al. JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 106 (2005) 3370-3373
-
(2005)
Blood
, vol.106
, pp. 3370-3373
-
-
Jelinek, J.1
Oki, Y.2
Gharibyan, V.3
-
16
-
-
25844518265
-
V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
-
V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood 106 (2005) 3377-3379
-
(2005)
Blood
, vol.106
, pp. 3377-3379
-
-
Levine, R.L.1
Loriaux, M.2
Huntly, B.J.3
-
17
-
-
33846012829
-
JAK2(V617F): prevalence in a large Chinese hospital population
-
Xu X., Zhang Q., Luo J., et al. JAK2(V617F): prevalence in a large Chinese hospital population. Blood 109 (2007) 339-342
-
(2007)
Blood
, vol.109
, pp. 339-342
-
-
Xu, X.1
Zhang, Q.2
Luo, J.3
-
18
-
-
33744490974
-
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
-
Wernig G., Mercher T., Okabe R., Levine R.L., Lee B.H., and Gilliland D.G. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 107 (2006) 4274-4281
-
(2006)
Blood
, vol.107
, pp. 4274-4281
-
-
Wernig, G.1
Mercher, T.2
Okabe, R.3
Levine, R.L.4
Lee, B.H.5
Gilliland, D.G.6
-
19
-
-
33745721197
-
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
-
Lacout C., Pisani D.F., Tulliez M., Gachelin F.M., Vainchenker W., and Villeval J.L. JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 108 (2006) 1652-1660
-
(2006)
Blood
, vol.108
, pp. 1652-1660
-
-
Lacout, C.1
Pisani, D.F.2
Tulliez, M.3
Gachelin, F.M.4
Vainchenker, W.5
Villeval, J.L.6
-
20
-
-
34447642422
-
Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F
-
Zaleskas V.M., Krause D.S., Lazarides K., et al. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS ONE 1 (2006) e18
-
(2006)
PLoS ONE
, vol.1
-
-
Zaleskas, V.M.1
Krause, D.S.2
Lazarides, K.3
-
21
-
-
33845798378
-
Characterization of murine JAK2 V617F-positive myeloproliferative disease
-
Bumm T.G., Elsea C., Corbin A.S., et al. Characterization of murine JAK2 V617F-positive myeloproliferative disease. Cancer Res 66 (2006) 11156-11165
-
(2006)
Cancer Res
, vol.66
, pp. 11156-11165
-
-
Bumm, T.G.1
Elsea, C.2
Corbin, A.S.3
-
22
-
-
33750534561
-
MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients
-
Pardanani A.D., Levine R.L., Lasho T., et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 108 (2006) 3472-3476
-
(2006)
Blood
, vol.108
, pp. 3472-3476
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.3
-
23
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y., Lee B.H., Mercher T., et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 3 (2006) e270
-
(2006)
PLoS Med
, vol.3
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
-
24
-
-
33846660947
-
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
-
Scott L.M., Tong W., Levine R.L., et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 356 (2007) 459-468
-
(2007)
N Engl J Med
, vol.356
, pp. 459-468
-
-
Scott, L.M.1
Tong, W.2
Levine, R.L.3
-
25
-
-
0038371050
-
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
-
Saharinen P., Vihinen M., and Silvennoinen O. Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell 14 (2003) 1448-1459
-
(2003)
Mol Biol Cell
, vol.14
, pp. 1448-1459
-
-
Saharinen, P.1
Vihinen, M.2
Silvennoinen, O.3
-
26
-
-
0030953469
-
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
-
Feng J., Witthuhn B.A., Matsuda T., Kohlhuber F., Kerr I.M., and Ihle J.N. Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol Cell Biol 17 (1997) 2497-2501
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2497-2501
-
-
Feng, J.1
Witthuhn, B.A.2
Matsuda, T.3
Kohlhuber, F.4
Kerr, I.M.5
Ihle, J.N.6
-
27
-
-
33947541141
-
Erlotinib effectively inhibits JAK2 V617F activity and polycythemia vera cell growth
-
Li Z., Xu M., Xing S., et al. Erlotinib effectively inhibits JAK2 V617F activity and polycythemia vera cell growth. J Biol Chem 282 (2007) 3428-3432
-
(2007)
J Biol Chem
, vol.282
, pp. 3428-3432
-
-
Li, Z.1
Xu, M.2
Xing, S.3
-
28
-
-
0027464656
-
Purification and characterization of a protein tyrosine phosphatase containing SH2 domains
-
Zhao Z., Bouchard P., Diltz C.D., Shen S.H., and Fischer E.H. Purification and characterization of a protein tyrosine phosphatase containing SH2 domains. J Biol Chem 268 (1993) 2816-2820
-
(1993)
J Biol Chem
, vol.268
, pp. 2816-2820
-
-
Zhao, Z.1
Bouchard, P.2
Diltz, C.D.3
Shen, S.H.4
Fischer, E.H.5
-
29
-
-
0027262361
-
Stimulation by phospholipids of a protein-tyrosine phosphatase containing two src homology 2 domains
-
Zhao Z., Shen S.H., and Fischer E.H. Stimulation by phospholipids of a protein-tyrosine phosphatase containing two src homology 2 domains. Proc Natl Acad Sci U S A 90 (1993) 4251-4255
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 4251-4255
-
-
Zhao, Z.1
Shen, S.H.2
Fischer, E.H.3
-
30
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
31
-
-
0026324171
-
Protein tyrosine phosphatases. A diverse family of intracellular and transmembrane enzymes
-
Fischer E.H., Charbonneau H., and Tonks N.K. Protein tyrosine phosphatases. A diverse family of intracellular and transmembrane enzymes. Science 253 (1991) 401-406
-
(1991)
Science
, vol.253
, pp. 401-406
-
-
Fischer, E.H.1
Charbonneau, H.2
Tonks, N.K.3
-
32
-
-
25844462316
-
Role of tyrosine kinases and phosphatases in polycythemia vera
-
Zhao Z.J., Vainchenker W., Krantz S.B., Casadevall N., and Constantinescu S.N. Role of tyrosine kinases and phosphatases in polycythemia vera. Semin Hematol 42 (2005) 221-229
-
(2005)
Semin Hematol
, vol.42
, pp. 221-229
-
-
Zhao, Z.J.1
Vainchenker, W.2
Krantz, S.B.3
Casadevall, N.4
Constantinescu, S.N.5
-
33
-
-
33845436745
-
The myeloproliferative disorders
-
Campbell P.J., and Green A.R. The myeloproliferative disorders. N Engl J Med 355 (2006) 2452-2466
-
(2006)
N Engl J Med
, vol.355
, pp. 2452-2466
-
-
Campbell, P.J.1
Green, A.R.2
-
34
-
-
33846651507
-
JAK2 Mutations in polycythemia vera-molecular mechanisms and clinical applications
-
Tefferi A. JAK2 Mutations in polycythemia vera-molecular mechanisms and clinical applications. N Engl J Med 356 (2007) 444-445
-
(2007)
N Engl J Med
, vol.356
, pp. 444-445
-
-
Tefferi, A.1
-
35
-
-
33846028528
-
Philadelphia chromosome-negative myeloproliferative disorders: biology and treatment
-
Hoffman R., Prchal J.T., Samuelson S., Ciurea S.O., and Rondelli D. Philadelphia chromosome-negative myeloproliferative disorders: biology and treatment. Biol Blood Marrow Transplant 13 (2007) 64-72
-
(2007)
Biol Blood Marrow Transplant
, vol.13
, pp. 64-72
-
-
Hoffman, R.1
Prchal, J.T.2
Samuelson, S.3
Ciurea, S.O.4
Rondelli, D.5
-
36
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P., and Hunter T. Oncogenic kinase signalling. Nature 411 (2001) 355-365
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
37
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker B.J., Talpaz M., Resta D.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344 (2001) 1031-1037
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
38
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
Paez J.G., Janne P.A., Lee J.C., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304 (2004) 1497-1500
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
39
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 (2004) 2129-2139
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
|