Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: Effect of H-pin linkage and linker length on selectivity and affinity

Biochemistry

Volumn 46, Issue 42, 2007, Pages 11661-11670

  O'Hare, C Caroline ^a   Uthe, Peter ^b   Mackay, Hilary ^c   Blackmon, Kevin ^b   Jones, Justin ^b   Brown, Toni ^c   Nguyen, Binh ^d   Wilson, W David ^d   Lee, Moses ^b,c   Hartley, John A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FURMAN UNIVERSITY   (United States)

^c HOPE COLLEGE   (United States)

^d GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; HIGH-AFFINITY COOPERATIVE BINDING; LINKER LENGTH;

BINDING SITES; COVALENT BONDS; ETHYLENE GLYCOL; LIGANDS; POLYAMIDES;

DNA;

CARBENE; DEOXYRIBONUCLEASE I; DIMER; DNA; ETHYLENE GLYCOL; IMIDAZOLE; N FORMAMIDOIMIDAZOLE PYRROLE IMIDAZOLE; POLYAMIDE; PYRROLE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; COVALENT BOND; CROSS LINKING; DNA BINDING; DNA DENATURATION; DNA FOOTPRINTING; DNA SEQUENCE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; SOLUBILITY; SURFACE PLASMON RESONANCE;

ANTIVIRAL AGENTS; BASE SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; DEOXYRIBONUCLEASE I; DIMERIZATION; DISTAMYCINS; DNA; DNA FOOTPRINTING; IMIDAZOLES; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; PYRROLES; SENSITIVITY AND SPECIFICITY; SURFACE PLASMON RESONANCE; TEMPERATURE; TITRIMETRY;

EID: 35448948822     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701053a     Document Type: Article

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