Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-β1 gene

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 2, 2005, Pages 571-575

  Lai, Yu Mu ^a   Fukuda, Noboru ^a,d   Ueno, Takahiro ^a   Matsuda, Hiroyuki ^a   Saito, Satoshi ^a   Matsumoto, Koichi ^a   Ayame, Hirohito ^b   Bando, Toshikazu ^b   Sugiyama, Hiroshi ^b   Mugishima, Hideo ^a   Serie, Kazuo ^c  

^a NIHON UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Gentier Biosystems Incorporation   (Japan)

^d NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; FAT SPECIFIC ELEMENT 2; FLUORESCEIN ISOTHIOCYANATE; IMIDAZOLE DERIVATIVE; LUCIFERASE; MESSENGER RNA; OLIGONUCLEOTIDE; POLYAMIDE; PROTEIN; PYRROLE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REACTION TIME; SMOOTH MUSCLE FIBER; STATISTICAL SIGNIFICANCE; VASCULAR SMOOTH MUSCLE;

BLOTTING, WESTERN; CELLS, CULTURED; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INDICATORS AND REAGENTS; NYLONS; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); PYRROLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUBULIN;

EID: 27144555400     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.089086     Document Type: Article

References (30)

1. Ando H, Fukuda N, Kotani M, Yokoyama S, Kunimoto S, Matsumoto K, Saito S, Kanmatsuse K, and Mugishima H (2004) Chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-β1 mRNA inhibits neointima formation in rat carotid artery after balloon injury. Eur J Pharmacol 483:207-214.
2. Berger SL and Felsenfeld G (2001) Chromatin goes global. Mol Cell 8:263-268.
3. Blobe GC, Schiemann WP, and Lodish HF (2000) Role of transforming growth factor beta in human disease. N Engl J Med 342:1350-1358.
4. Border WA and Noble NA (1997) TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int 51:1388-1396.
5. Decker CJ and Parker R (1994) Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci 19:336-340.
6. Dervan PB (2001) Molecular recognition of DNA by small molecules. Bioorg Med Chem 9:2215-2235.
7. Dickinson LA, Gulizia RJ, Trauger JW, Baird EE, Mosier DE, Gottesfeld JM, and Dervan PB (1998) Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc Natl Acad Sci USA 95:12890-12895.
8. Fukuda N, Kubo A, Watanabe Y, Nakayama T, Soma M, Izumi Y, and Kanmatsuse K (1997) Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures. J Hypertens 15:1123-1136.
9. Gottesfeld JM, Belitsky JM, Melander C, Dervan PB, and Luger K (2002) Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol 321:249-263.
10. Gottesfeld JM, Melander C, Suto RK, Raviol H, Luger K, and Dervan PB (2001) Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides. J Mol Biol 309:615-629.
11. Gottesfeld JM, Neely L, Trauger JW, Baird EE, and Dervan PB (1997) Regulation of gene expression by small molecules. Nature (Lond) 387:202-205.
12. Grant MB, Wargovich TJ, Bush DM, Player DW, Caballero S, Foegh M, and Spoerri PE (1999) Expression of IGF-1, IGF-1 receptor and TGF-beta following balloon angioplasty in atherosclerotic and normal rabbit iliac arteries: an immunocytochemical study. Regul Pept 79:47-53.
13. Joki N, Kaname S, Hirakata M, Hori Y, Yamaguchi T, Fujita T, Katoh T, and Kurokawa K (2000) Tyrosine-kinase dependent TGF-beta and extracellular matrix expression by mechanical stretch in vascular smooth muscle cells. Hypertens Res 23:91-99.
14. Kim SJ, Glick A, Sporn MB, and Roberts AB (1989) Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem 264:402-408.
15. Kobayashi N, Nakano S, Mori Y, Kobayashi T, Tsubokou Y, and Matsuoka H (2001) Benidipine inhibits expression of ET-1 and TGF-beta1 in Dahl salt-sensitive hypertensive rats. Hypertens Res 24:241-250.
16. Kopka ML, Yoon C, Goodsell D, Pjura P, and Dickerson RE (1985a) Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G. J Mol Biol 183:553-563.
17. Kopka ML, Yoon C, Goodsell D, Pjura P, and Dickerson RE (1985b) The molecular origin of DNA-drug specificity in netropsin and distamycin. Proc Natl Acad Sci USA 82:1376-1380.
18. Kotani M, Fukuda N, Ando H, Hu WY, Kunimoto S, Saito S, and Kanmatsuse K (2003) Chimeric DNA-RNA hammerhead ribozyme targeting PDGF A-chain mRNA specifically inhibits neointima formation in rat carotid artery after balloon injury. Cardiovasc Res 57:265-276.
19. Kozak M (1992) Regulation of translation in eukaryotic systems. Annu Rev Cell Biol 8:197-225.
20. Lown JW, Krowicki K, Bhat UG, Skorobogaty A, Ward B, and Dabrowiak JC (1986) Molecular recognition between oligopeptides and nucleic acids: novel imidazolecontaining oligopeptides related to netropsin that exhibit altered DNA sequence specificity. Biochemistry 25:7408-7416.
21. Lyons RM and Moses HL (1990) Transforming growth factors and the regulation of cell proliferation. Eur J Biochem 187:467-473.
22. McKeown M (1992) Alternative mRNA splicing. Annu Rev Cell Biol 8:133-155.
23. Mocharla H, Mocharla R, and Hodes ME (1990) Coupled reverse transcription-polymerase chain reaction (RT-PCR) as a sensitive and rapid method for isozyme genotyping. Gene 93:271-275.
24. Romeo D, Allison RS, Kondaiah P, and Wakefield LM (1997) Recharacterization of the start sites for the major human transforming growth factor-beta 1 mRNA. Gene 189:289-295.
25. Sambrook J, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory (CSH), Cold Spring Harbor, NY.
26. Shinohara K, Narita A, Oyoshi T, Bando T, Teraoka H, and Sugiyama H (2004) Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides. J Am Chem Soc 126:5113-5118.
27. Sporn MB and Roberts AB (1992) Transforming growth factor-beta: recent progress and new challenges. J Cell Biol 119:1017-1021.
28. Trauger JW, Baird EE, and Dervan PB (1996) Recognition of DNA by designed ligands at subnanomolar concentrations. Nature (Lond) 382:559-561.
29. White S, Baird EE, and Dervan PB (1997) On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem Biol 4:569-578.
30. White S, Szewczyk JW, Turner JM, Baird EE, and Dervan PB (1998) Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature (Lond) 391:468-471.