In vivo activation of N-methyl-d-aspartate receptors generates free radicals and reduces antioxidant ability in the rat hippocampus: Experimental protocol of in vivo ESR spectroscopy and microdialysis for redox status evaluation

Brain Research

Volumn 1178, Issue 1, 2007, Pages 20-27

  Ueda, Yuto ^a   Doi, Taku ^a   Nagatomo, Keiko ^a   Nakajima, Akira ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Antioxidant ability; Excitotoxicity; Free radical; Glutamate; NMDA R; Redox

Indexed keywords

ANTIOXIDANT; FREE RADICAL; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE SYNTHASE; NITROXIDE; PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; EXCITOTOXICITY; HIPPOCAMPUS; HOMEOSTASIS; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTIOXIDANTS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; GLUTAMIC ACID; HALF-LIFE; HIPPOCAMPUS; LIPID METABOLISM; MALE; MICRODIALYSIS; OXIDATION-REDUCTION; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

RATTUS;

EID: 35448933112     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.08.022     Document Type: Article

References (40)

1. Barnes G.N., and Slevin J.T. Ionotropic glutamate receptor biology: effect on synaptic connectivity and function in neurological disease. Curr. Med. Chem. 10 (2003) 2059-2072
2. Beckman J.S. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Dev. Physiol. 15 (1991) 53-59
3. Bruce A.J., and Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic. Biol. Med. 18 (1995) 993-1002
4. Bruce A., Najm I., Malfroy B., and Baudry M. Effects of desferrioxamine/manganese complex, a superoxide dismutase-mimic, on kainate-induced pathology in rat brain. Neuroscience 13 (1992) 265-271
5. Chen H.S., and Lipton S.A. The chemical biology of clinically tolerated NMDA receptor antagonists. J. Neurochem. 97 (2006) 1611-1626
6. Cohen M.R., Ramchand C.N., Sailer V., Fernandez M., McAmis W., Sridhara N., and Alston C. Detoxification enzymes following intrastriatal kainic acid. Neurochem. Res. 12 (1987) 425-429
7. During M.J., and Spencer D.D. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. [see comments]. Lancet 341 (1993) 1607-1610
8. Lafon-Cazal M., Culcasi M., Gaven F., Pietri S., and Bockaert J. Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells. Neuropharmacology 32 (1993) 1259-1266
9. Lafon-Cazal M., Pietri S., Culcasi M., and Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature 364 (1993) 535-537
10. Lancelot E., Revaud M.L., Boulu R.G., Plotkine M., and Callebert J. A microdialysis study investigating the mechanisms of hydroxyl radical formation in rat striatum exposed to glutamate. Brain Res. 809 (1998) 294-296
11. Lewerenz J., Klein M., and Methner A. Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity. J. Neurochem. 98 (2006) 916-925
12. Mathern G.W., Mendoza D., Lozada A., Pretorius J.K., Dehnes Y., Danbolt N.C., Nelson N., Leite J.P., Chimelli L., Born D.E., Sakamoto A.C., Assirati J.A., Fried I., Peacock W.J., Ojemann G.A., and Adelson P.D. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. [see comments]. Neurology 52 (1999) 453-472
13. Michiels C., Raes M., Toussaint O., and Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic. Biol. Med. 17 (1994) 235-248
14. Miller H.P., Levey A.I., Rothstein J.D., Tzingounis A.V., and Conn P.J. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. J. Neurochem. 68 (1997) 1564-1570
15. Minamoto Y., Itano T., Tokuda M., Matsui H., Janjua N.A., Hosokawa K., Okada Y., Murakami T.H., Negi T., and Hatase O. In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat. Brain Res. 573 (1992) 345-348
16. Oja S.S., and Saransaari P. Modulation of taurine release by glutamate receptors and nitric oxide. Prog. Neurobiol. 62 (2000) 407-425
17. Peghini P., Janzen J., and Stoffel W. Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. Embo J. 16 (1997) 3822-3832
18. Pellegrino J.L., Pellegrino A.S., and Cushman A.J.A. Stereotaxic Atlas of the Rat Brain (1986), Plenum Press, New York and London
19. Pepicelli O., Fedele E., Bonanno G., Raiteri M., Ajmone-Cat M.A., Greco A., Levi G., and Minghetti L. In vivo activation of N-methyl-d-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms. J. Neurochem. 81 (2002) 1028-1034
20. Petrovic M., Horak M., Sedlacek M., and Vyklicky Jr. L. Physiology and pathology of NMDA receptors. Prague Med. Rep. 106 (2005) 113-136
21. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., and Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16 (1996) 675-686
22. Samanta S., Perkinton M.S., Morgan M., and Williams R.J. Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons: role of mitogen-activated protein kinase. J. Neurochem. 70 (1998) 2082-2090
23. Schulz J.B., Matthews R.T., Jenkins B.G., Ferrante R.J., Siwek D., Henshaw D.R., Cipolloni P.B., Mecocci P., Kowall N.W., Rosen B.R., et al. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J. Neurosci. 15 (1995) 8419-8429
24. Tanaka K. Functions of glutamate transporters in the brain. Neurosci. Res. 37 (2000) 15-19
25. Tanaka T., Tanaka S., Fujita T., Takano K., Fukuda H., Sako K., and Yonemasu Y. Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures. Prog. Neurobiol. 38 (1992) 317-334
26. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Kikuchi T., Okuyama S., Kawashima N., Hori S., Takimoto M., and Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 (1997) 1699-1702
27. Tessler S., Danbolt N.C., Faull R.L., Storm-Mathisen J., and Emson P.C. Expression of the glutamate transporters in human temporal lobe epilepsy. Neuroscience 88 (1999) 1083-1091
28. Tokumaru J., Ueda Y., Yokoyama H., Nakajima A., Doi T., Mitsuyama Y., Ohya-Nishiguchi H., and Kamada H. In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. [in process citation]. Neurochem. Res. 25 (2000) 1107-1111
29. Trotti D., Nussberger S., Volterra A., and Hediger M.A. Differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1. Eur. J. Neurosci. 9 (1997) 2207-2212
30. Ueda Y., and Tsuru N. Bilateral seizure-related changes of extracellular glutamate concentration in hippocampi during development of amygdaloid kindling. Epilepsy Res. 18 (1994) 85-88
31. Ueda Y., Yokoyama H., Niwa R., Konaka R., Ohya-Nishiguchi H., and Kamada H. Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats. Epilepsy Res. 26 (1997) 329-333
32. Ueda Y., Yokoyama H., Ohya-Nishiguchi H., and Kamada H. ESR spectroscopy for analysis of hippocampal elimination of a nitroxide radical during kainic acid-induced seizure in rats. Magn. Reson. Med. 40 (1998) 491-493
33. Ueda Y., Yokoyama H., Nakajima A., Tokumaru J., Doi T., and Mitsuyama Y. Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Exp. Brain Res. 147 (2002) 219-226
34. Ueda Y., Yokoyama H., Tokumaru J., Doi T., and Nakajima A. Kinetics of extracellular nitroxide radical and glutamate levels in the hippocampus of conscious rats: cautionary note to the application of nitroxide radical on clinical arena. Neurochem. Res. 29 (2004) 1695-1701
35. Ueda Y., Doi T., Tokumaru J., Nakajima A., and Nagatomo K. In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-Induced seizure status in rats. Neurochem. Res. 30 (2005) 1117-1121
36. Ueda Y., Noor J.I., Nagatomo K., Doi T., Ikeda T., Nakajima A., and Ikenoue T. Generation of lipid radicals in the hippocampus of neonatal rats after acute hypoxic-ischemic brain damage. Exp. Brain Res. (2005) 1-5
37. Waterfall A.H., Singh G., Fry J.R., and Marsden C.A. Detection of the lipid peroxidation product malonaldehyde in rat brain in vivo. Neurosci. Lett. 2000 (1995) 69-72ISSN :0304-3940 (Nov 10)
38. Yokoyama H., Lin Y., Itoh O., Ueda Y., Nakajima A., Ogata T., Sato T., Ohya-Nishiguchi H., and Kamada H. EPR imaging for in vivo analysis of the half-life of a nitroxide radical in the hippocampus and cerebral cortex of rats after epileptic seizures. Free Radic. Biol. Med. 27 (1999) 442-448
39. Yokoyama H., Tada M., Itoh O., and Fukui K. Reaction kinetics analysis to estimate in vivo decay rate of EPR signals of a nitroxide radical in the brain and the inferior vena cava of rats. Appl. Magn. Reson. 25 (2003) 217-225
40. Yu X.M. The role of intracellular sodium in the regulation of NMDA-receptor-mediated channel activity and toxicity. Mol. Neurobiol. 33 (2006) 63-80