ESR spectroscopy for analysis of hippocampal elimination of a nitroxide radical during kainic acid-induced seizure in rats

Magnetic Resonance in Medicine

Volumn 40, Issue 3, 1998, Pages 491-493

  Ueda, Yuto ^a,b   Yokoyama, Hidekatsu ^a,c   Ohya Nishiguchi, Hiroaki ^a   Kamada, Hitoshi ^a  

^a Yamagata Technopolis Foundation   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Free moving; In vivo microdialysis; Kainic acid; Nitroxide radical

Indexed keywords

BRAIN; DIALYSIS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; SODIUM CHLORIDE;

EXTRACELLULAR SPACE; FREE MOVING; FREE RADICAL PRODUCTIONS; IN-VIVO; INTRAPERITONEAL INJECTIONS; KAINIC ACID; NITROXIDE RADICALS; PHYSIOLOGICAL SALINE;

RATS;

FREE RADICAL; KAINIC ACID; NITROXIDE;

ARTICLE; CONTROLLED STUDY; DIALYSATE; ELECTRON SPIN RESONANCE; HALF LIFE TIME; HIPPOCAMPUS; MALE; NERVE CELL EXCITABILITY; NONHUMAN; RAT; SEIZURE;

EID: 0031847493     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910400321     Document Type: Article

References (16)

1. J. M. Carney, P. E. Starke-Reed, C. N. Oliver, R. W. Landum, M. S. Cheng, J. F. Wu, R. A. Floyd, Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound n-tert-butyl-a-phenylnitrone. Proc. Natl. Acad. Sci. U S A 88, 3633-3636 (1991).
2. J. T. Coyle, P. Puttfarcken. Oxidative stress, glutamate, neurodegeneration disorders. Science 262, 689-695 (1933).
3. C. P. LeBel, S. Bondy, Oxidative damage and cerebral aging. Prog. Neurobiol. 38, 601-609 (1992)
4. H, Monyer, D. M. Hartley, D.W. Choi. 21-aminosteroids attenuate excitoxic neuronal injury in cortical cultures. Neuron 5, 121-126 (1990).
5. A. J. Bruce, M. Baudry, Oxygen free radicals in rat limbic structures after kainate-induced seizures, Free Radic. Biol. Med. 18, 993-1002 (1995).
6. M. R. Cohen, C. N. Ramchand, V. Sailer, M. Fernandez, W. McAmis, N. Sridhara, C. Alson, Detoxification enzymes following intrastriatal kainic acid. Neurochem. Res. 12, 425-429 (1987).
7. M. Lafon-Cazal, S. Pietri, M. Culcasi, J. Bockaert, NMDA-dependent superoxide production and neurotoxicity. Nature 364, 535-537 (1993).
8. Y. Ueda, H. Yokoyama, R. Niwa, R. Konaka, H. Ohya-Nishiguchi, H. Kamada. Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats. Epilepsy Res. 27, 325-330 (1997).
9. G. Bacic, M. J. Nilges, R. L. Magin, T. Walczak, H. M. Swartz, In vivo localized ESR spectroscopy reflecting metabolism. Magn. Reson. Med. 10, 266-272 (1989).
10. K. Nakagawa, S. Ishida, H. Yokoyama, N. Mori, S. Niwa. N. Tsuchihashi, Rapid free radical reduction in the perfused rat liver. Free Radic. Res. 21, 169-176 (1994).
11. L. J. Pellegrino, A. S. Pellegrino, A. J. A. Cushman, "Stereotaxic Atlas of the Rat Brain." Plenum Press, New York, 1986.
12. D. Nakahara, N. Ozaki, Y. Miura, H. Miura, T. Nagatsu. Increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis. Brain Res. 495, 178-181 (1989).
13. J. T. Berliner, X. Wan, In vivo pharmacokinetics by electron spin resonance spectroscopy. Magn. Reson. Med. 9, 430-434 (1989).
14. S. Ishida, H. Kumashiro, N. Tsuchihashi, T. Ogata, M. Ono, H. Kamada, E. Yoshida, In vivo analysis of nitroxide radicals injected into small animals by L-band ESR technique. Phys. Med. Biol. 34, 1317-1323 (1989).
15. H. Yokoyama, N. Tsuchihashi, T. Ogata, M. Hiramatsu, N. Mori, An analysis of the intracerebral ability to eliminate a nitroxide radical in the rat after administration of idebenone by an in vivo electron spin resonance spectrometer. MAGMA 4, 247-250 (1996).
16. W. R. Couet. U. G. Erikson, T. N. Tozer, L. D. Tuck, G. E. Wesbey, D. Nitecki, R. C. Brasch, Pharmacokinetics and metabolic fate of two nitroxides potentially useful as constant agents for magnetic resonance imaging. Pharm. Res. 1, 203-209 (1984).