-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R., Mason W.P., van den Bent M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352 (2005) 987-996
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
-
2
-
-
12144291692
-
Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
-
Hegi M.E., Diserens A.C., Godard S., et al. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 10 (2004) 1871-1874
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1871-1874
-
-
Hegi, M.E.1
Diserens, A.C.2
Godard, S.3
-
3
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi M.E., Diserens A.C., Gorlia T., et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352 (2005) 997-1003
-
(2005)
N Engl J Med
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
4
-
-
0023001905
-
Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene
-
Brennand J., and Margison G.P. Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene. Proc Natl Acad Sci U S A 83 (1986) 6292-6296
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 6292-6296
-
-
Brennand, J.1
Margison, G.P.2
-
5
-
-
0023160388
-
Antitumor imidazotetrazines-XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones
-
Tisdale M.J. Antitumor imidazotetrazines-XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones. Biochem Pharmacol 36 (1987) 457-462
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 457-462
-
-
Tisdale, M.J.1
-
6
-
-
0030022069
-
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: A comparative study in vitro
-
Wedge S.R., Porteus J.K., May B.L., et al. Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: A comparative study in vitro. Br J Cancer 73 (1996) 482-490
-
(1996)
Br J Cancer
, vol.73
, pp. 482-490
-
-
Wedge, S.R.1
Porteus, J.K.2
May, B.L.3
-
7
-
-
0027338194
-
O6-methylguanine residues elicit DNA repair synthesis by human cell extracts
-
Karran P., Macpherson P., Ceccotti S., et al. O6-methylguanine residues elicit DNA repair synthesis by human cell extracts. J Biol Chem 268 (1993) 15878-15886
-
(1993)
J Biol Chem
, vol.268
, pp. 15878-15886
-
-
Karran, P.1
Macpherson, P.2
Ceccotti, S.3
-
8
-
-
0034667383
-
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
-
Ochs K., and Kaina B. Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res 60 (2000) 5815-5824
-
(2000)
Cancer Res
, vol.60
, pp. 5815-5824
-
-
Ochs, K.1
Kaina, B.2
-
9
-
-
1942469956
-
MGMT: Its role in cancer aetiology and cancer therapeutics
-
Gerson S.L. MGMT: Its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4 (2004) 296-307
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 296-307
-
-
Gerson, S.L.1
-
10
-
-
0028171276
-
O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications
-
Hotta T., Saito Y., Fujita H., et al. O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications. J Neurooncol 21 (1994) 135-140
-
(1994)
J Neurooncol
, vol.21
, pp. 135-140
-
-
Hotta, T.1
Saito, Y.2
Fujita, H.3
-
11
-
-
13344282752
-
Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine
-
Belanich M., Pastor M., Randall T., et al. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res 56 (1996) 783-788
-
(1996)
Cancer Res
, vol.56
, pp. 783-788
-
-
Belanich, M.1
Pastor, M.2
Randall, T.3
-
12
-
-
0032588748
-
O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: Frequency and time to tumor progression after alkylating agent-based chemotherapy
-
Silber J.R., Blank A., Bobola M.S., et al. O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: Frequency and time to tumor progression after alkylating agent-based chemotherapy. Clin Cancer Res 5 (1999) 807-814
-
(1999)
Clin Cancer Res
, vol.5
, pp. 807-814
-
-
Silber, J.R.1
Blank, A.2
Bobola, M.S.3
-
13
-
-
0030823671
-
Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene
-
Qian X.C., and Brent T.P. Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. Cancer Res 57 (1997) 3672-3677
-
(1997)
Cancer Res
, vol.57
, pp. 3672-3677
-
-
Qian, X.C.1
Brent, T.P.2
-
14
-
-
0030874380
-
Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
-
Watts G.S., Pieper R.O., Costello J.F., et al. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 17 (1997) 5612-5619
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5612-5619
-
-
Watts, G.S.1
Pieper, R.O.2
Costello, J.F.3
-
15
-
-
0033557903
-
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
-
Esteller M., Hamilton S.R., Burger P.C., et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59 (1999) 793-797
-
(1999)
Cancer Res
, vol.59
, pp. 793-797
-
-
Esteller, M.1
Hamilton, S.R.2
Burger, P.C.3
-
16
-
-
4143084896
-
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
-
Paz M.F., Yaya-Tur R., Rojas-Marcos I., et al. CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clin Cancer Res 10 (2004) 4933-4938
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4933-4938
-
-
Paz, M.F.1
Yaya-Tur, R.2
Rojas-Marcos, I.3
-
17
-
-
33847364433
-
MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
-
Donson A.M., Addo-Yobo S.O., Handler M.H., et al. MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr Blood Cancer 48 (2007) 403-407
-
(2007)
Pediatr Blood Cancer
, vol.48
, pp. 403-407
-
-
Donson, A.M.1
Addo-Yobo, S.O.2
Handler, M.H.3
-
18
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller M., Garcia-Foncillas J., Andion E., et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343 (2000) 1350-1354
-
(2000)
N Engl J Med
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
Garcia-Foncillas, J.2
Andion, E.3
-
19
-
-
33748043985
-
Temozolomide-mediated radiation enhancement in glioblastoma: A report on underlying mechanisms
-
Chakravarti A., Erkkinen M.G., Nestler U., et al. Temozolomide-mediated radiation enhancement in glioblastoma: A report on underlying mechanisms. Clin Cancer Res 12 (2006) 4738-4746
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4738-4746
-
-
Chakravarti, A.1
Erkkinen, M.G.2
Nestler, U.3
-
20
-
-
33645105856
-
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells
-
Hermisson M., Klumpp A., Wick W., et al. O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem 96 (2006) 766-776
-
(2006)
J Neurochem
, vol.96
, pp. 766-776
-
-
Hermisson, M.1
Klumpp, A.2
Wick, W.3
-
21
-
-
0034213118
-
Survival of human glioma cells treated with various combinations of temozolomide and X-rays
-
van Rijn J., Heimans J.J., van den Berg J., et al. Survival of human glioma cells treated with various combinations of temozolomide and X-rays. Int J Radiat Oncol Biol Phys 47 (2000) 779-784
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.47
, pp. 779-784
-
-
van Rijn, J.1
Heimans, J.J.2
van den Berg, J.3
-
22
-
-
0031052506
-
In vitro evaluation of temozolomide combined with X-irradiation
-
Wedge S.R., Porteous J.K., Glaser M.G., et al. In vitro evaluation of temozolomide combined with X-irradiation. Anticancer Drugs 8 (1997) 92-97
-
(1997)
Anticancer Drugs
, vol.8
, pp. 92-97
-
-
Wedge, S.R.1
Porteous, J.K.2
Glaser, M.G.3
-
23
-
-
0036729535
-
Radiosensitivity and TP 53, EGFR amplification and LOH10 analysis of primary glioma cell cultures
-
Gerlach B., Harder A.H., Hulsebos T.J., et al. Radiosensitivity and TP 53, EGFR amplification and LOH10 analysis of primary glioma cell cultures. Strahlenther Onkol 178 (2002) 491-496
-
(2002)
Strahlenther Onkol
, vol.178
, pp. 491-496
-
-
Gerlach, B.1
Harder, A.H.2
Hulsebos, T.J.3
-
24
-
-
0001843063
-
Glioblastoma
-
Kleihues P., and Cavanee W.K. (Eds), IARC Press, Lyon
-
Kleihues P., Burger P.C., Collins V.P., et al. Glioblastoma. In: Kleihues P., and Cavanee W.K. (Eds). Pathology and genetics, tumours of the nervous system. World Health Organization classification of tumours (2000), IARC Press, Lyon 29-39
-
(2000)
Pathology and genetics, tumours of the nervous system. World Health Organization classification of tumours
, pp. 29-39
-
-
Kleihues, P.1
Burger, P.C.2
Collins, V.P.3
-
25
-
-
0034129892
-
Comprehensive allelotype and genetic analysis of 466 human nervous system tumors
-
von Deimling A., Fimmers R., Schmidt M.C., et al. Comprehensive allelotype and genetic analysis of 466 human nervous system tumors. J Neuropathol Exp Neurol 59 (2000) 544-558
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 544-558
-
-
von Deimling, A.1
Fimmers, R.2
Schmidt, M.C.3
-
26
-
-
33750733916
-
Genetic profiling of a distant second glioblastoma multiforme after radiotherapy: Recurrence or second primary tumor?
-
van Nifterik K.A., Elkhuizen P.H., van Andel R.J., et al. Genetic profiling of a distant second glioblastoma multiforme after radiotherapy: Recurrence or second primary tumor?. J Neurosurg 105 (2006) 739-744
-
(2006)
J Neurosurg
, vol.105
, pp. 739-744
-
-
van Nifterik, K.A.1
Elkhuizen, P.H.2
van Andel, R.J.3
-
27
-
-
24044464247
-
Methylation-specific MLPA (MS-MLPA): Simultaneous detection of CpG methylation and copy number changes of up to 40 sequences
-
Nygren A.O., Ameziane N., Duarte H.M., et al. Methylation-specific MLPA (MS-MLPA): Simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res 33 (2005) e128
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Nygren, A.O.1
Ameziane, N.2
Duarte, H.M.3
-
28
-
-
0022485676
-
D-1 dopaminergic and beta-adrenergic stimulation of adenylate cyclase in a clone derived from the human astrocytoma cell line G-CCM
-
Balmforth A.J., Ball S.G., Freshney R.I., et al. D-1 dopaminergic and beta-adrenergic stimulation of adenylate cyclase in a clone derived from the human astrocytoma cell line G-CCM. J Neurochem 47 (1986) 715-719
-
(1986)
J Neurochem
, vol.47
, pp. 715-719
-
-
Balmforth, A.J.1
Ball, S.G.2
Freshney, R.I.3
-
30
-
-
0028859434
-
Proliferation and clonal survival of human lung cancer cells treated with fractionated irradiation in combination with paclitaxel
-
van Rijn J., van den Berg J., and Meijer O.W. Proliferation and clonal survival of human lung cancer cells treated with fractionated irradiation in combination with paclitaxel. Int J Radiat Oncol Biol Phys 33 (1995) 635-639
-
(1995)
Int J Radiat Oncol Biol Phys
, vol.33
, pp. 635-639
-
-
van Rijn, J.1
van den Berg, J.2
Meijer, O.W.3
-
31
-
-
0025686126
-
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts
-
Bigner S.H., Humphrey P.A., Wong A.J., et al. Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res 50 (1990) 8017-8022
-
(1990)
Cancer Res
, vol.50
, pp. 8017-8022
-
-
Bigner, S.H.1
Humphrey, P.A.2
Wong, A.J.3
-
32
-
-
0344420263
-
Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR
-
Pandita A., Aldape K.D., Zadeh G., et al. Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes Chromosomes Cancer 39 (2004) 29-36
-
(2004)
Genes Chromosomes Cancer
, vol.39
, pp. 29-36
-
-
Pandita, A.1
Aldape, K.D.2
Zadeh, G.3
-
33
-
-
0031920406
-
Genetic sub-types of human malignant astrocytoma correlate with survival
-
Leenstra S., Oskam N.T., Bijleveld E.H., et al. Genetic sub-types of human malignant astrocytoma correlate with survival. Int J Cancer 79 (1998) 159-165
-
(1998)
Int J Cancer
, vol.79
, pp. 159-165
-
-
Leenstra, S.1
Oskam, N.T.2
Bijleveld, E.H.3
-
34
-
-
0035880788
-
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
-
Smith J.S., Tachibana I., Passe S.M., et al. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J Natl Cancer Inst 93 (2001) 1246-1256
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1246-1256
-
-
Smith, J.S.1
Tachibana, I.2
Passe, S.M.3
-
35
-
-
0034761379
-
Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: Correlation with patient age and survival
-
Tada K., Shiraishi S., Kamiryo T., et al. Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: Correlation with patient age and survival. J Neurosurg 95 (2001) 651-659
-
(2001)
J Neurosurg
, vol.95
, pp. 651-659
-
-
Tada, K.1
Shiraishi, S.2
Kamiryo, T.3
-
36
-
-
0036069508
-
Prognostic value of loss of heterozygosity around three candidate tumor suppressor genes on chromosome 10q in astrocytomas
-
Terada K., Tamiya T., Daido S., et al. Prognostic value of loss of heterozygosity around three candidate tumor suppressor genes on chromosome 10q in astrocytomas. J Neurooncol 58 (2002) 107-114
-
(2002)
J Neurooncol
, vol.58
, pp. 107-114
-
-
Terada, K.1
Tamiya, T.2
Daido, S.3
-
37
-
-
33644874646
-
Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment
-
Wemmert S., Ketter R., Rahnenfuhrer J., et al. Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment. Neoplasia 7 (2005) 883-893
-
(2005)
Neoplasia
, vol.7
, pp. 883-893
-
-
Wemmert, S.1
Ketter, R.2
Rahnenfuhrer, J.3
-
38
-
-
33846252663
-
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
-
Roos W.P., Batista L.F., Naumann S.C., et al. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene 26 (2007) 186-197
-
(2007)
Oncogene
, vol.26
, pp. 186-197
-
-
Roos, W.P.1
Batista, L.F.2
Naumann, S.C.3
-
39
-
-
0034901404
-
Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents
-
Srivenugopal K.S., Shou J., Mullapudi S.R., et al. Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. Clin Cancer Res 7 (2001) 1398-1409
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1398-1409
-
-
Srivenugopal, K.S.1
Shou, J.2
Mullapudi, S.R.3
-
40
-
-
0037317521
-
The role of p53 in determining sensitivity to radiotherapy
-
Gudkov A.V., and Komarova E.A. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 3 (2003) 117-129
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 117-129
-
-
Gudkov, A.V.1
Komarova, E.A.2
-
41
-
-
0033556646
-
p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors
-
Haas-Kogan D.A., Kogan S.S., Yount G., et al. p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors. Int J Radiat Oncol Biol Phys 43 (1999) 399-403
-
(1999)
Int J Radiat Oncol Biol Phys
, vol.43
, pp. 399-403
-
-
Haas-Kogan, D.A.1
Kogan, S.S.2
Yount, G.3
|