2,2,5,5-Tetramethylpyrrolidin-3-one-1-sulfinyl group for 5′-hydroxyl protection of deoxyribonucleoside phosphoramidites in the solid-phase preparation of DNA oligonucleotides

Journal of the American Chemical Society

Volumn 126, Issue 31, 2004, Pages 9601-9610

  Marchán, Vicente ^a   Cieślak, Jacek ^c   Livengood, Victor ^b   Beaucage, Serge L ^a  

^a Division of Therapeutic Proteins   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ARRAYS; BACTERIA; GLASS; HYDROLYSIS; IODINE; NITROGEN COMPOUNDS; NUCLEIC ACIDS; SALTS; SULFUR COMPOUNDS; SYNTHESIS (CHEMICAL);

DEPROTECTION CONDITIONS; GLASS MICROARRAYS; OLIGONUCLEOTIDES; REAGENTS;

DNA;

2,2,5,5 TETRAMETHYLPYRROLIDIN 3 ONE 1 SULFINYL DERIVATIVE; DEOXYRIBONUCLEOSIDE; DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITE; DNA; GLASS; HYDROXYL GROUP; IODINE; NITROGEN; OLIGONUCLEOTIDE; PHOSPHODIESTERASE; PHOSPHORAMIDIC ACID DERIVATIVE; PYRROLIDINE DERIVATIVE; SNAKE VENOM; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; DEPROTECTION REACTION; DNA MICROARRAY; DRUG SYNTHESIS; GEL CHROMATOGRAPHY; HYDROLYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYRIBONUCLEOSIDES; DNA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; PYRROLIDINONES; SULFONIUM COMPOUNDS;

EID: 3543140734     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja048377i     Document Type: Article

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