Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones

British Journal of Pharmacology

Volumn 122, Issue 1, 1997, Pages 37-42

  Uneyama, Hisayuki ^a   Takahara, Akira ^a   Dohmoto, Hideki ^a   Yoshimoto, Ryota ^a   Inoue, Kazuhide ^b   Akaike, Norio ^c  

^a AJINOMOTO CO INC   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Cilnidipine (FRC 8653); N type Ca2+ channel; Sympathetic neurones

Indexed keywords

BARIUM ION; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CILNIDIPINE; DILTIAZEM; FLUNARIZINE; NIFEDIPINE; OMEGA AGATOXIN IVA; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIC; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; ELECTRIC POTENTIAL; HYPERTENSION; ION CURRENT; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE CELL;

ANIMALS; BARIUM; CALCIUM CHANNELS; DIHYDROPYRIDINES; ELECTROPHYSIOLOGY; MALE; NEURONS; RATS; RATS, WISTAR; SYMPATHETIC NERVOUS SYSTEM;

EID: 0030766439     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701342     Document Type: Article

References (34)

1. AKAIKE, N., KOSTYUK, P.G. & OSIPCHUK, Y.V. (1989). Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones. J. Physiol., 412, 181-195.
2. BEAN, B.P. (1989). Classes of calcium channels in vertebrate cells. Ann. Rev. Physiol., 51, 367-384.
3. ELLINOR, P.T., ZHANG, J.F., HORNE, W.A. & TSEIN, R.W. (1994). Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin. Nature, 372, 272-275.
4. ++ channel in rat dorsal root ganglion neurons. J. Pharmacol. Exp. Ther., 280, 1184-1191.
5. FUJITA, Y., MYNLIEFF, M., DIRKSEN, R.T., KIM, M.S., NIIDOME, T., NAKAI, J., FRIEDRICH, T., IWABE, N., MIYATA, T., FURUICHI, T., FURUTAMA, D., MIKOSHIBA, K., MORI, Y. & BEAM, K.G. (1993). Primary structure and functional expression of the ω-conotoxin-sensitive N-type calcium channel from rat brain. Neuron, 10, 585-598.
6. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp technique for high resolution current recording from cells and cell-free membrane patch. Pflugers Arch. Eur. J. Physiol., 391, 85-100.
7. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science, 239, 57-61.
8. HOSONO, M., DOZEN, M., HIRUMA, T., FUJII, S., WATANABE, K. & HAYASHI, Y. (1995a). Changes in heart rate and plasma norepinephrine level of conscious spontaneously hypertensive rats treated with cilnidipine (FRC-8653). Jpn. Pharmacol. Ther., 23, 3029-3040.
9. HOSONO, M., FUJII, S., HIMURA, T., WATANABE, K., HAYASHI, Y., OHNISHI, H., TAKATA, Y. & KATO, H. (1995b). Inhibitory effect of cilnidipine on vascular sympathetic neurotransmission and subsequent vasoconstriction in spontaneously hypertensive rats. Jpn. J. Pharmacol., 69, 127-134.
10. HOSONO, M., HIMURA, T., WATANABE, K., HAYASHI, Y., OHNISHI, H., TAKATA, Y. & KATO, H. (1995c). Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive rats. Jpn. J. Pharmacol., 69, 119-125.
11. HOSONO, M., IIDA, H., IKEDA, K., HAYASHI, Y., DOHMOTO, H., HASHIGUCHI, Y., YAMAMOTO, H., WATANABE, N. & YOSHIMOTO, R. (1992). In vivo and ex vivo Ca-antagonistic effect of 2-methoxyethyl (E)-3-phenyl-2-propen-1-yl (±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3,5-dicarboxylate (FRC-8653), a new dihydropyridine derivative. J. Pharmacobiodyn., 15, 547-553.
12. IKEDA, S.R. & SCHOFIELD, G.G. (1989). Somatostatin blocks a calcium current in rat sympathetic ganglion neurones. J. Physiol., 409, 221-240.
13. 2+ channels in rat CNS neurones. NeuroReport, 6, 1621-1624.
14. LIPSCOMBE, D., KONGSAMUT, S. & TSEIN, R.W. (1989). α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium channel. Nature, 340, 639.
15. MATSZAWA, Y., OIKAWA, I., GONSHO, A., YAMAMOTO, K. & OZAKI, M. (1992). Absorption, distribution and excretion of (±)-2-methoxyethyl-3-phenyl-2(E)-propenyl-1,4-dihydro-2,6-dimethyl-4-(3- nitrophenyl) 3,5-pyridine dicarboxylate (FRC-8653) after single administration to rats. Jpn. Pharmacol. Ther., 20, 111-129.
16. 2+ channels. J. Biol. Chem., 267, 1403-1406.
17. NAKAGAWA, T., KOMUNE, S., VEMURA, T. & AKAIKE, N. (1991). Excitatory amino acid response in isolated spinal ganglion cells of guinea pig cochlea. J. Neurophysiol., 65, 715-723.
18. NAKASHIMA, M., KOU, M., HASHITANI, H., CHEN, G., ONO, H., KURIYAMA, H. & SUZUKI, H. (1991). Action of FRC-8653 on smooth muscle cells of the rabbit mesenteric artery. Jpn. J. Pharmacol., 57, 51-61.
19. PLUMMER, M.R., LOGOTHETIS, D.E. & HESS, P. (1989). Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron, 2, 1453-1463.
20. PRUNEAU, D. & ANGUS, J.A. (1990). ω-Conotoxin GVIA, the N-type calcium channel inhibitor, is sympatholytic but not vagolytic: Consequences for hemodynamics and autonomic reflexes in conscious rabbits. J. Cardiovasc. Pharmacol., 16, 675-680.
21. PRUNEAU, D. & BELICHARD, P. (1992). Haemodynamic and humoral effects of ω-conotoxin GVIA in normotensive and spontaneously hypertensive rats. Eur. J. Pharmacol., 211, 329-335.
22. 2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and ω-conotoxin. Neuron, 6, 269-280.
23. ++ channels. J. Pharmacol. Exp. Ther., 271, 1348-1352.
24. SAH, D.W. & BEAN, B.P. (1994). Inhibition of P-type and N-type calcium channels by dopamine receptor antagonists. Mol. Pharmacol., 45, 84-92.
25. SAIHARA, S., SUMIO, M., HOSONO, N., HAYASHI, Y., KITAMURA, Y. & HASHIMOTO, S. (1993). Effect of FRC-8653 (Cilnidipine) on blood pressure changes during the cold pressor test. Jpn. Pharmacol. Ther., 21, 271-276.
26. TAKAHASHI, K. & AKAIKE, N. (1991). Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons. J. Pharmacol. Exp. Ther., 256, 169-175.
27. TOUW, K.B. HAYWOOD, J.R., SCHAFFER, R.A. & BRODY, M.J. (1980). Contribution of the sympathetic nervous system to vascular resistance in conscious young and adult spontaneously hypertensive rats. Hypertension, 2, 408-418.
28. 2+ channels. Trends Pharmacol. Sci., 12, 349-354.
29. TSEIN, R.W., LIPSCOMBE, D., MADISON, D.V., BLEY, K.R. & FOX, A.P. (1988). Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci., 11, 431-438.
30. TYTGAT, J., VEREECKE, J. & CARMELIET, E. (1990). A combined study of sodium current and T-type calcium current in isolated cardiac cells. Pflugers Archiv. Eur. J. Physiol., 417, 142-148.
31. UNEYAMA, H., MUNAKATA, M. & AKAIKE, N. (1993a). Caffeine response of freshly dissociated rat hippocampal pyramidal neurons. Brain Res., 604, 24-31.
32. 2+ oscillation in rat megakaryocyte. J. Biol. Chem., 268, 168-174.
33. VALENTINO, K., NEWCOMB, R., GADBOIS, T., SINGH, T., BOWERSOX, S., BITNER, S., JUSTICE, A., YAMASHIRO, D., HOFFMAN, B.B., CIARANELLO, R., MILJANICH, G. & RAMACHANDRAN, J. (1993). A selective calcium channel agonist protects against neuronal loss after global cerebral ischemia. Proc. Natl. Acad. Sci. U.S.A., 90, 7894-7897.
34. YOSHIMOTO, R., DOHMOTO, H., YAMADA, K. & GOTO, A. (1991). Prolonged inhibition of vascular contraction and calcium influx by the novel 1,4-dihydropyridine calcium antagonist cinaldipine. Jpn. J. Pharmacol., 56, 225-229.