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Volumn 14, Issue 23, 2007, Pages 1668-1673

Oral administration of doxycycline allows tight control of transgene expression: A key step towards gene therapy of retinal diseases

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; ERYTHROPOIETIN; PARVOVIRUS VECTOR; TETRACYCLINE;

EID: 35348985459     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3303034     Document Type: Article
Times cited : (34)

References (36)
  • 2
    • 0035179374 scopus 로고    scopus 로고
    • Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa
    • Liang FQ, Aleman TS, Dejneka NS, Dudus L, Fisher KJ, Maguire AM et al. Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther 2001; 4: 461-472.
    • (2001) Mol Ther , vol.4 , pp. 461-472
    • Liang, F.Q.1    Aleman, T.S.2    Dejneka, N.S.3    Dudus, L.4    Fisher, K.J.5    Maguire, A.M.6
  • 3
    • 0034980737 scopus 로고    scopus 로고
    • AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse
    • Liang FQ, Dejneka NS, Cohen DR, Krasnoperova NV, Lem J, Maguire AM et al. AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Mol Ther 2001; 3: 241-248.
    • (2001) Mol Ther , vol.3 , pp. 241-248
    • Liang, F.Q.1    Dejneka, N.S.2    Cohen, D.R.3    Krasnoperova, N.V.4    Lem, J.5    Maguire, A.M.6
  • 4
    • 0036349623 scopus 로고    scopus 로고
    • Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/ peripherin mutation
    • Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan JL, Chappelow AV et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/ peripherin mutation. Exp Eye Res 2002; 74: 719-735.
    • (2002) Exp Eye Res , vol.74 , pp. 719-735
    • Bok, D.1    Yasumura, D.2    Matthes, M.T.3    Ruiz, A.4    Duncan, J.L.5    Chappelow, A.V.6
  • 5
    • 0037352472 scopus 로고    scopus 로고
    • Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration
    • Schlichtenbrede FC, MacNeil A, Bainbridge JW, Tshernutter M, Thrasher AJ, Smith AJ et al. Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration. Gene Therapy 2003; 10: 523-527.
    • (2003) Gene Therapy , vol.10 , pp. 523-527
    • Schlichtenbrede, F.C.1    MacNeil, A.2    Bainbridge, J.W.3    Tshernutter, M.4    Thrasher, A.J.5    Smith, A.J.6
  • 6
    • 33749236815 scopus 로고    scopus 로고
    • In contrast to AAV-mediateid Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration
    • Buch PK, MacLaren RE, Duran Y, Balaggan KS, MacNeil A, Schlichtenbrede FC et al. In contrast to AAV-mediateid Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. Mol Ther 2006; 14: 700-709.
    • (2006) Mol Ther , vol.14 , pp. 700-709
    • Buch, P.K.1    MacLaren, R.E.2    Duran, Y.3    Balaggan, K.S.4    MacNeil, A.5    Schlichtenbrede, F.C.6
  • 7
    • 0036784819 scopus 로고    scopus 로고
    • Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
    • Tao W, Wen R, Goddard MB, Sherman SD, O'Rourke PJ, Stabila. PF et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002; 43: 3292-3298.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 3292-3298
    • Tao, W.1    Wen, R.2    Goddard, M.B.3    Sherman, S.D.4    O'Rourke, P.J.5    Stabila, P.F.6
  • 8
    • 33644872951 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants
    • Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJ, Fullmer KR et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci USA 2006; 103: 3896-3901.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3896-3901
    • Sieving, P.A.1    Caruso, R.C.2    Tao, W.3    Coleman, H.R.4    Thompson, D.J.5    Fullmer, K.R.6
  • 9
    • 33845897620 scopus 로고    scopus 로고
    • Regulation of rod phototransduction machinery by ciliary neurotrophic factor
    • Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y et al. Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 2006; 26: 13523-13530.
    • (2006) J Neurosci , vol.26 , pp. 13523-13530
    • Wen, R.1    Song, Y.2    Kjellstrom, S.3    Tanikawa, A.4    Liu, Y.5    Li, Y.6
  • 10
    • 0033895534 scopus 로고    scopus 로고
    • Retinal and choroidal neovascularization
    • Campochiaro PA. Retinal and choroidal neovascularization. J Cell Physiol 2000; 184: 301-310.
    • (2000) J Cell Physiol , vol.184 , pp. 301-310
    • Campochiaro, P.A.1
  • 11
    • 23944480405 scopus 로고    scopus 로고
    • Angiogenic pathways in diabetic retinopathy
    • Aiello LP. Angiogenic pathways in diabetic retinopathy. N Engl J Med 2005; 353: 839-841.
    • (2005) N Engl J Med , vol.353 , pp. 839-841
    • Aiello, L.P.1
  • 12
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438: 967-974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 13
    • 33646948521 scopus 로고    scopus 로고
    • Pegaptanib sodium for neovascular age-related macular degeneration: Two-year safety results of the two prospective, multicenter, controlled clinical trials
    • D'Amico DJ, Masonson HN, Patel M, Adamis AP, Cunningham Jr ET, Guyer DR et al. Pegaptanib sodium for neovascular age-related macular degeneration: Two-year safety results of the two prospective, multicenter, controlled clinical trials. Ophthalmology 2006; 113: 992-1001.
    • (2006) Ophthalmology , vol.113 , pp. 992-1001
    • D'Amico, D.J.1    Masonson, H.N.2    Patel, M.3    Adamis, A.P.4    Cunningham Jr, E.T.5    Guyer, D.R.6
  • 14
    • 25844513658 scopus 로고    scopus 로고
    • A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Cunningham Jr ET, Adamis AP, Altaweel M, Aiello LP, Bressler NM, D'Amico DJ et al. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005; 112: 1747-1757.
    • (2005) Ophthalmology , vol.112 , pp. 1747-1757
    • Cunningham Jr, E.T.1    Adamis, A.P.2    Altaweel, M.3    Aiello, L.P.4    Bressler, N.M.5    D'Amico, D.J.6
  • 16
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1432-1444.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3    Soubrane, G.4    Heier, J.S.5    Kim, R.Y.6
  • 17
  • 19
    • 0037173042 scopus 로고    scopus 로고
    • Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization
    • Raisler BJ, Berns KI, Grant MB, Beliaev D, Hauswirth WW. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci USA 2002; 99: 8909-8914.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8909-8914
    • Raisler, B.J.1    Berns, K.I.2    Grant, M.B.3    Beliaev, D.4    Hauswirth, W.W.5
  • 20
    • 0036798747 scopus 로고    scopus 로고
    • Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents
    • Auricchio A, Behling KC, Maguire AM, O'Connor EM, Bennett J, Wilson JM et al. Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents. Mol Ther 2002; 6: 490-494.
    • (2002) Mol Ther , vol.6 , pp. 490-494
    • Auricchio, A.1    Behling, K.C.2    Maguire, A.M.3    O'Connor, E.M.4    Bennett, J.5    Wilson, J.M.6
  • 21
    • 0036271989 scopus 로고    scopus 로고
    • AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization
    • Mori K, Gehlbach P. Yamamoto S, Duh E, Zack DJ, Li Q et al. AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 2002; 43: 1994-2000.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 1994-2000
    • Mori, K.1    Gehlbach, P.2    Yamamoto, S.3    Duh, E.4    Zack, D.J.5    Li, Q.6
  • 23
    • 0036083592 scopus 로고    scopus 로고
    • Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy
    • Lai YK, Shen WY, Brankov M, Lai CM, Constable IJ, Rakoczy PE. Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy. Gene Therapy 2002; 9: 804-813.
    • (2002) Gene Therapy , vol.9 , pp. 804-813
    • Lai, Y.K.1    Shen, W.Y.2    Brankov, M.3    Lai, C.M.4    Constable, I.J.5    Rakoczy, P.E.6
  • 24
    • 34447253623 scopus 로고    scopus 로고
    • Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model
    • Ideno J, Mizukami H, Kakehashi A, Saito Y, Okada T, Urabe M et al. Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model. Int J Mol Med 2007; 19: 75-79.
    • (2007) Int J Mol Med , vol.19 , pp. 75-79
    • Ideno, J.1    Mizukami, H.2    Kakehashi, A.3    Saito, Y.4    Okada, T.5    Urabe, M.6
  • 25
    • 27744567638 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
    • Deng WT, Yan Z, Dinculescu A, Pang J, Teusner JT, Cortez NG et al. Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy. Hum Gene Ther 2005; 16: 1247-1254.
    • (2005) Hum Gene Ther , vol.16 , pp. 1247-1254
    • Deng, W.T.1    Yan, Z.2    Dinculescu, A.3    Pang, J.4    Teusner, J.T.5    Cortez, N.G.6
  • 26
    • 33847305368 scopus 로고    scopus 로고
    • Gene therapy for ocular neovascularization
    • Campochiaro PA. Gene therapy for ocular neovascularization. Curr Gene Ther 2007; 7: 25-33.
    • (2007) Curr Gene Ther , vol.7 , pp. 25-33
    • Campochiaro, P.A.1
  • 27
    • 85047694286 scopus 로고    scopus 로고
    • VEGF: A critical player in neurodegeneration
    • Storkebaum E, Carmeliet P. VEGF: A critical player in neurodegeneration. J Clin Invest 2004; 113: 14-18.
    • (2004) J Clin Invest , vol.113 , pp. 14-18
    • Storkebaum, E.1    Carmeliet, P.2
  • 28
    • 33645840126 scopus 로고    scopus 로고
    • Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors
    • Stieger K, Le Meur G, Lasne F, Weber M, Deschamps JY, Nivard D et al. Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors. Mol Ther 2006; 13: 967-975.
    • (2006) Mol Ther , vol.13 , pp. 967-975
    • Stieger, K.1    Le Meur, G.2    Lasne, F.3    Weber, M.4    Deschamps, J.Y.5    Nivard, D.6
  • 29
    • 1642525149 scopus 로고    scopus 로고
    • Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieye more tightly regulated transgene-expression from nonhuman primate muscle
    • Chenuaud P, Larcher T, Rabinowitz JE, Provost N, Joussemet B, Bujard H et al. Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieye more tightly regulated transgene-expression from nonhuman primate muscle. Mol Ther 2004; 9: 410-418.
    • (2004) Mol Ther , vol.9 , pp. 410-418
    • Chenuaud, P.1    Larcher, T.2    Rabinowitz, J.E.3    Provost, N.4    Joussemet, B.5    Bujard, H.6
  • 31
    • 10744229842 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subrefinal delivery
    • Weber M, Rabinowitz J, Provost N, Conrath H, Folliot S, Briot D et al. Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subrefinal delivery. Mol Ther 2003; 7: 774-781.
    • (2003) Mol Ther , vol.7 , pp. 774-781
    • Weber, M.1    Rabinowitz, J.2    Provost, N.3    Conrath, H.4    Folliot, S.5    Briot, D.6
  • 33
    • 0036827724 scopus 로고    scopus 로고
    • Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycydine-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant-adeno-associated virus
    • Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D et al. Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycydine-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant-adeno-associated virus. J Virol 2002; 76: 11605-11611.
    • (2002) J Virol , vol.76 , pp. 11605-11611
    • Favre, D.1    Blouin, V.2    Provost, N.3    Spisek, R.4    Porrot, F.5    Bohl, D.6
  • 34
    • 0035160030 scopus 로고    scopus 로고
    • New uses of older antibiotics
    • Klein NC, Cunha BA. New uses of older antibiotics. Med Clin North Am 2001; 85: 125-132.
    • (2001) Med Clin North Am , vol.85 , pp. 125-132
    • Klein, N.C.1    Cunha, B.A.2
  • 35
    • 0026722298 scopus 로고
    • Serum concentrations of penicillin, doxycycline, and ciprofloxacin during prolonged therapy in rhesus monkeys
    • Kelly DJ, Chulay JD, Mikesell P, Friedlander AM. Serum concentrations of penicillin, doxycycline, and ciprofloxacin during prolonged therapy in rhesus monkeys. J Infect Dis 1992; 166: 1184-1187.
    • (1992) J Infect Dis , vol.166 , pp. 1184-1187
    • Kelly, D.J.1    Chulay, J.D.2    Mikesell, P.3    Friedlander, A.M.4
  • 36
    • 13544262341 scopus 로고    scopus 로고
    • Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer
    • Rivera VM, Gao GP, Grant RL, Schnell MA, Zoltick PW, Rozamus LW et al. Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer. Blood 2005; 105: 1424-1430.
    • (2005) Blood , vol.105 , pp. 1424-1430
    • Rivera, V.M.1    Gao, G.P.2    Grant, R.L.3    Schnell, M.A.4    Zoltick, P.W.5    Rozamus, L.W.6


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