Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1

Gene Therapy

Volumn 9, Issue 5, 2002, Pages 320-326

  Bainbridge, J W B ^a   Mistry, A ^b   De Alwis, M ^b   Paleolog, E ^c   Baker, A ^d   Thrasher, A J ^b   Ali, R R ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Gene therapy; Neovascularisation; Retina; Vascular endothelial growth factor

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; OXYGEN; VASCULOTROPIN INHIBITOR;

ADENO ASSOCIATED VIRUS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLINDNESS; CONTROLLED STUDY; CORNEA ENDOTHELIUM; DRUG EFFICACY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IRIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; RETINA ISCHEMIA; RETINA NEOVASCULARIZATION; RETINOPATHY; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; DEPENDOVIRUS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; RETINAL NEOVASCULARIZATION;

ADENO-ASSOCIATED VIRUS; ADENOVIRIDAE; ANIMALIA;

EID: 85047699046     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301680     Document Type: Article

References (51)

1. Childhood blindness
2. The cause-specific prevalence of visual impairment in an urban population. The Baltimore Eye Survey
3. Preventative ophthalmology. Age-related macular degeneration
4. Early photocoagulation for diabetic retinopathy. ETDRS report number 9
5. Laser photocoagulation of subfoveal recurrent neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial
6. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
7. Vascular endothelial growth factor and the eye: Biochemical mechanisms of action and implications for novel therapies
8. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
9. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
10. Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis
11. Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells
12. Time-course expression of vascular endothelial growth factor as related to the development of the retinochoroidal vasculature in rats
13. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
14. Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes
15. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model
16. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
17. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
18. Intravitreal growth factors in proliferative diabetic retinopathy: Correlation with neovascular activity and glycaemic management
19. Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity
20. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate
21. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: A new model of intraretinal and subretinal neovascularization
22. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy
23. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate
24. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
25. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
26. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
27. Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor
28. Gene transfer of a soluble receptor of VEGF inhibits the growth of experimental eyelid malignant melanoma
29. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR
30. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration
31. Complications after implantation of intraocular devices in patients with cytomegalovirus retinitis
32. Adeno-associated virus gene transfer to mouse retina
33. Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ
34. Oxygen-induced retinopathy in the mouse
35. Immune responses limit adenovirally mediated gene expression in the adult mouse eye
36. Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery
37. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse
38. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells
39. Retinal functional change caused by adenoviral vector-mediated transfection of LacZ gene
40. Adenovirus vector-mediated gene transfer into rat retinal neurons and Muller cells in vitro and in vivo
41. A vitrectomy improves the transfection efficiency of adenoviral vector-mediated gene transfer to Muller cells
42. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
43. Characterization of vascular development in the mouse retina
44. Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis
45. Clinically significant macular edema in type I diabetes. Incidence and risk factors
46. Causes and frequency of blindness in patients with intraocular inflammatory disease
47. Macular edema after cataract extraction
48. A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle
49. High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H
50. High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap
51. Evolution of neovascularization in mice with over-expression of vascular endothelial growth factor in photoreceptors