Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay

Assay and Drug Development Technologies

Volumn 5, Issue 5, 2007, Pages 629-636

  Hamuro, Lora ^a,c   Zhang, Guangtao ^a   Tucker, Timothy J ^b   Self, Christopher ^a   Strittmatter, Warren J ^b   Burke, James R ^b  

^a Provid Pharmaceuticals Inc ^*  (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYE; GLUTATHIONE TRANSFERASE; PEPTIDE AGGREGATION INHIBITOR; POLYGLUTAMINE; PROTEIN INHIBITOR; THIOFLAVINE; UNCLASSIFIED DRUG; CONGO RED; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLUORESCENT DYE; HYBRID PROTEIN; OLIGOPEPTIDE; PEPTIDE; POLYGLUTAMINE BINDING PROTEIN 1; POLYGLUTAMINE-BINDING PROTEIN 1; THIAZOLE DERIVATIVE;

ARTICLE; DOSE RESPONSE; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN SECRETION; ULTRAVIOLET RADIATION; ALGORITHM; CHEMISTRY; FLUORESCENCE MICROSCOPY; PROTEIN CONFORMATION; SYNTHESIS;

ALGORITHMS; CONGO RED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; INDICATORS AND REAGENTS; MICROSCOPY, FLUORESCENCE; OLIGOPEPTIDES; PEPTIDES; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; THIAZOLES;

EID: 35348984636     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2007.083     Document Type: Article

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