Roles of the novel interleukin-12-associated cytokine, interleukin-23, in the regulation of T-cell-mediated immunity

Hepatology Research

Volumn 37, Issue SUPPL. 3, 2007, Pages

  Matsui, Masanori ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

IFN ; IL 12; IL 17; IL 23; Th1; Th17

Indexed keywords

GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; PROTEIN P19; PROTEIN P40; TRANSFORMING GROWTH FACTOR BETA;

AUTOIMMUNE DISEASE; CANCER INCIDENCE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL SURVIVAL; CELLULAR IMMUNITY; CITROBACTER RODENTIUM; CONFERENCE PAPER; CRYPTOCOCCUS NEOFORMANS; CYTOKINE PRODUCTION; DRUG TARGETING; HEPATITIS C; HEPATITIS C VIRUS; HOST RESISTANCE; HUMAN; INFECTION RESISTANCE; KLEBSIELLA PNEUMONIAE; MICROBIAL IMMUNITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TOXOPLASMA GONDII; TUMOR GROWTH; TUMOR IMMUNITY;

EID: 35348922251     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2007.00249.x     Document Type: Conference Paper

References (34)

1. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133-46.
2. Leonard JP, Sherman ML, Fisher GL et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 1997; 90: 2541-8.
3. Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13: 715-25.
4. Parham C, Chirica M, Timans J et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002; 168: 5699-708.
5. Belladonna ML, Renauld J-C, Bianchi R et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol 2002; 168: 5448-54.
6. Lo C-H, Lee S-C, Wu P-Y et al. Antitumor and antimetastatic activity of IL-23. J Immunol 2003; 171: 600-7.
7. Ha S-J, Kim D-J, Baek K-H et al. IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol 2004; 172: 525-31.
8. Matsui M, Moriya O, Belladonna ML et al. Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice. J Virol 2004; 78: 9093-104.
9. Overwijk WW, de Visser KE, Tirion FH et al. Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol 2006; 176: 5213-22.
10. Matsui M, Moriya O, Yoshimoto T et al. T-bet is required for protection against vaccinia virus infection. J Virol 2005; 79: 12798-806.
11. Cua DJ, Sherlock J, Chen Y et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003; 421: 744-8.
12. Murphy CA, Langrish CL, Chen Y et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003; 198: 1951-7.
13. Uhlig HH, McKenzie BS, Hue S et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006; 25: 309-18.
14. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004; 21: 467-76.
15. Nakae S, Nambu A, Sudo K et al. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003; 171: 6173-7.
16. Komiyama Y, Nakae S, Matsuki T et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 2004; 177: 566-73.
17. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-32.
18. Park H, Li Z, Yang XO, Chang SH et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6: 1133-41.
19. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-β induces development of the TH17 lineage. Nature 2006; 441: 231-4.
20. Bettelli B, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-8.
21. Veldhoen M, Hocking RJ, Atkins CJ et al. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24: 179-89.
22. Liang SC, Tan X-Y, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006; 203: 2271-9.
23. Sutton C, Brereton C, Keogh B et al. A crucial role for interleukin (IL) -1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006; 203: 1685-91.
24. + T helper cells. Cell 2006; 126: 1121-33.
25. Pflanz S, Timans JC, Cheung J et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4 (+) T cells. Immunity 2002; 16: 779-90.
26. Hunter CA. New IL-12 family members. IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005; 5: 521-31.
27. Batten M, Li J, Yi S et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006; 7: 929-36.
28. Stumhofer JS, Laurence A, Wilson EH et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 2006; 7: 937-45.
29. Langowski JL, Zhang X, Wu L et al. IL-23 promotes tumor incidence and growth. Nature 2006; 442: 461-5.
30. Happel KI, Dubin PJ, Zheng M et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005; 202: 761-9.
31. Lieberman LA, Cardillo F, Owyang AM et al. IL-23 provides a limited mechanism of resistance to acute Toxoplasmosis in the absence of IL-12. J Immunol 2004; 173: 1887-93.
32. Khader SA, Pearl JE, Sakamoto K et al. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during Tuberculosis but is dispensable for protection and antigen-specific IFN-γ Responses if IL-12p70 is available. J Immunol 2005; 175: 788-95.
33. Kleinschek MA, Muller U, Brodie SJ et al. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J Immunol 2006; 176: 1098-106.
34. Cua DJ, Kastelein RA. TGF-β, a "double agent"in the immune pathology war. Nat Immunol 2006; 7: 557-9.