-
1
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715.
-
(2000)
Immunity
, vol.13
, pp. 715
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
Vega, F.7
Yu, N.8
Wang, J.9
Singh, K.10
-
2
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
-
Parham, C., M Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:5699.
-
(2002)
J. Immunol.
, vol.168
, pp. 5699
-
-
Parham, C.1
Chirica, M.2
Timans, J.3
Vaisberg, E.4
Travis, M.5
Cheung, J.6
Pflanz, S.7
Zhang, R.8
Singh, K.P.9
Vega, F.10
-
3
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda, M. J., L. Luistro, R. R. Warrier, R. B. Wright, B. R. Hubbard, M. Murphy, S. F. Wolf, and M. K. Gately. 1993. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178:1223.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1223
-
-
Brunda, M.J.1
Luistro, L.2
Warrier, R.R.3
Wright, R.B.4
Hubbard, B.R.5
Murphy, M.6
Wolf, S.F.7
Gately, M.K.8
-
4
-
-
0027963161
-
Recombinant IL-12 administration induces tumor regression in association with IFN-γ production
-
Nastala, C. L., H. D. Edington, T. G. McKinney, H. Tahara, M. A. Nalesnik, M. J. Brunda, M. K. Gately, S. F. Wolf, R. D. Schreiber, W. J. Storkus, et al. 1994. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J. Immunol. 153:1697.
-
(1994)
J. Immunol.
, vol.153
, pp. 1697
-
-
Nastala, C.L.1
Edington, H.D.2
McKinney, T.G.3
Tahara, H.4
Nalesnik, M.A.5
Brunda, M.J.6
Gately, M.K.7
Wolf, S.F.8
Schreiber, R.D.9
Storkus, W.J.10
-
5
-
-
0029039610
-
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
-
Zou, J. P., N. Yamamoto, T. Fujii, H. Takenaka, M. Kobayashi, S. H. Herrmann, S. F. Wolf, H. Fujiwara, and T. Hamaoka. 1995. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells. Int. Immunol. 7:1135.
-
(1995)
Int. Immunol.
, vol.7
, pp. 1135
-
-
Zou, J.P.1
Yamamoto, N.2
Fujii, T.3
Takenaka, H.4
Kobayashi, M.5
Herrmann, S.H.6
Wolf, S.F.7
Fujiwara, H.8
Hamaoka, T.9
-
6
-
-
0032479871
-
Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
-
Boggio, K., G. Nicoletti, E. Di Carlo, F. Cavallo, L. Landuzzi, C. Melani, M. Giovarelli, I. Rossi, P. Nanni, C. De Giovanni, et al. 1998. Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med. 188:589.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 589
-
-
Boggio, K.1
Nicoletti, G.2
Di Carlo, E.3
Cavallo, F.4
Landuzzi, L.5
Melani, C.6
Giovarelli, M.7
Rossi, I.8
Nanni, P.9
De Giovanni, C.10
-
7
-
-
0034671640
-
IL-12 treatment of endogenously arising murine brain tumors
-
Roy, E. J., U. Gawlick, B. A. Orr, L. A. Rund, A. G. Webb, and D. M. Kranz. 2000. IL-12 treatment of endogenously arising murine brain tumors. J. Immunol. 165:7293.
-
(2000)
J. Immunol.
, vol.165
, pp. 7293
-
-
Roy, E.J.1
Gawlick, U.2
Orr, B.A.3
Rund, L.A.4
Webb, A.G.5
Kranz, D.M.6
-
8
-
-
0016696542
-
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure
-
Corbett, T. H., D. P. J. Griswold, B. J. Roberts, J. C. Peckham, and F. M. J. Schabel. 1975. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res. 35:2434.
-
(1975)
Cancer Res.
, vol.35
, pp. 2434
-
-
Corbett, T.H.1
Griswold, D.P.J.2
Roberts, B.J.3
Peckham, J.C.4
Schabel, F.M.J.5
-
9
-
-
0020321214
-
Cancer metastasis is selective or random depending on the parent tumor population
-
Talmadge, J. E., and I. J. Fidler. 1982. Cancer metastasis is selective or random depending on the parent tumor population. Nature 297:593.
-
(1982)
Nature
, vol.297
, pp. 593
-
-
Talmadge, J.E.1
Fidler, I.J.2
-
10
-
-
0035680992
-
Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma
-
Lee, Y. L., Y. L. Ye, C. I. Yu, Y. L. Wu, Y. L. Lai, P. H. Ku, R. L. Hong, and B. L. Chiang. 2001. Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma. Hum. Gene Ther. 12:2065.
-
(2001)
Hum. Gene Ther.
, vol.12
, pp. 2065
-
-
Lee, Y.L.1
Ye, Y.L.2
Yu, C.I.3
Wu, Y.L.4
Lai, Y.L.5
Ku, P.H.6
Hong, R.L.7
Chiang, B.L.8
-
11
-
-
0031953116
-
Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by code-livery of various cytokine genes
-
Chow, Y. H., B. L. Chiang, Y. L. Lee, W. K. Chi, W. C. Lin, Y. T. Chen, and M. H. Tao. 1998. Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by code-livery of various cytokine genes. J. Immunol. 160:1320.
-
(1998)
J. Immunol.
, vol.160
, pp. 1320
-
-
Chow, Y.H.1
Chiang, B.L.2
Lee, Y.L.3
Chi, W.K.4
Lin, W.C.5
Chen, Y.T.6
Tao, M.H.7
-
12
-
-
0034554842
-
Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen
-
Huang, T. H., P. Y. Wu, C. N. Lee, H. I. Huang, S. L. Hsieh, J. Kung, and M. H. Tao. 2000. Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen. Blood 96:3663.
-
(2000)
Blood
, vol.96
, pp. 3663
-
-
Huang, T.H.1
Wu, P.Y.2
Lee, C.N.3
Huang, H.I.4
Hsieh, S.L.5
Kung, J.6
Tao, M.H.7
-
13
-
-
9544221745
-
The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product
-
Huang, A. Y., P. H. Gulden, A. S. Woods, M. C. Thomas, C. D. Tong, W. Wang, V. H. Engelhard, G. Pasternack, R. Cotter, D. Hunt, et al. 1996. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc. Natl. Acad. Sci. USA 93:9730.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9730
-
-
Huang, A.Y.1
Gulden, P.H.2
Woods, A.S.3
Thomas, M.C.4
Tong, C.D.5
Wang, W.6
Engelhard, V.H.7
Pasternack, G.8
Cotter, R.9
Hunt, D.10
-
14
-
-
0028104782
-
High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins
-
Sykulev, Y., A. Brunmark, T. J. Tsomides, S. Kageyama, M. Jackson, P. A. Peterson, and H. N. Eisen. 1994. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 91:11487.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11487
-
-
Sykulev, Y.1
Brunmark, A.2
Tsomides, T.J.3
Kageyama, S.4
Jackson, M.5
Peterson, P.A.6
Eisen, H.N.7
-
15
-
-
0030068953
-
Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA
-
Wilkinson, V. L., R. R. Warrier, T. P. Truitt, P. Nunes, M. K. Gately, and D. H. Presky. 1996. Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA. J. Immunol. Methods 189:15.
-
(1996)
J. Immunol. Methods
, vol.189
, pp. 15
-
-
Wilkinson, V.L.1
Warrier, R.R.2
Truitt, T.P.3
Nunes, P.4
Gately, M.K.5
Presky, D.H.6
-
16
-
-
0029898839
-
Amount of interleukin 12 available at the tumor site is critical for tumor regression
-
Colombo, M. P., M. Vagliani, F. Spreafioo, M. Parenza, C. Chiodoni, C. Melani, and A. Stoppacciaro. 1996. Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res. 56:2531.
-
(1996)
Cancer Res.
, vol.56
, pp. 2531
-
-
Colombo, M.P.1
Vagliani, M.2
Spreafioo, F.3
Parenza, M.4
Chiodoni, C.5
Melani, C.6
Stoppacciaro, A.7
-
17
-
-
0036005890
-
Interleukin-12 in anti-tumor immunity and immunotherapy
-
Colombo, M. P., and G. Trinchieri. 2002. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 13:155.
-
(2002)
Cytokine Growth Factor Rev.
, vol.13
, pp. 155
-
-
Colombo, M.P.1
Trinchieri, G.2
-
18
-
-
0030766971
-
Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-γ production
-
Leonard, J. P., M. L. Sherman, G. L. Fisher, L. J. Buchanan, G. Larsen, M. B. Atkins, J. A. Sosman, J. P. Dutcher, N. J. Vogelzang, and J. L. Ryan. 1997. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-γ production. Blood 90:2541.
-
(1997)
Blood
, vol.90
, pp. 2541
-
-
Leonard, J.P.1
Sherman, M.L.2
Fisher, G.L.3
Buchanan, L.J.4
Larsen, G.5
Atkins, M.B.6
Sosman, J.A.7
Dutcher, J.P.8
Vogelzang, N.J.9
Ryan, J.L.10
-
19
-
-
0030066799
-
Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells
-
Vagliani, M., M. Rodolfo, F. Cavallo, M. Parenza, C. Melani, G. Parmiani, G. Forni, and M. P. Colombo. 1996. Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells. Cancer Res. 56:467.
-
(1996)
Cancer Res.
, vol.56
, pp. 467
-
-
Vagliani, M.1
Rodolfo, M.2
Cavallo, F.3
Parenza, M.4
Melani, C.5
Parmiani, G.6
Forni, G.7
Colombo, M.P.8
-
20
-
-
0031893260
-
Immune response against large tumors eradicated by treatment with cyclophosphamide and IL-12
-
Tsung, K., J. B. Meko, Y. L. Tsung, G. R. Peplinski, and J. A. Norton. 1998. Immune response against large tumors eradicated by treatment with cyclophosphamide and IL-12. J. Immunol. 160:1369.
-
(1998)
J. Immunol.
, vol.160
, pp. 1369
-
-
Tsung, K.1
Meko, J.B.2
Tsung, Y.L.3
Peplinski, G.R.4
Norton, J.A.5
-
21
-
-
0037102374
-
The role of IFN-γ rejection of established tumors by IL-12: Source of production and target
-
Segal, J. G., N. C. Lee, Y. L. Tsung, J. A. Norton, and K. Tsung. 2002. The role of IFN-γ rejection of established tumors by IL-12: source of production and target. Cancer Res. 62:4696.
-
(2002)
Cancer Res.
, vol.62
, pp. 4696
-
-
Segal, J.G.1
Lee, N.C.2
Tsung, Y.L.3
Norton, J.A.4
Tsung, K.5
-
22
-
-
17344383269
-
Tumor cell responses to IFN-γ affect tumorigenicity and response to IL-12 therapy and antiangiogenesis
-
Coughlin, C. M., K. E. Salhany, M. S. Gee, D. C. LaTemple, S. Kotenko, X. Ma, G. Gri, M. Wysocka, J. E. Kim, L. Liu, et al. 1998. Tumor cell responses to IFN-γ affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity 9:25.
-
(1998)
Immunity
, vol.9
, pp. 25
-
-
Coughlin, C.M.1
Salhany, K.E.2
Gee, M.S.3
LaTemple, D.C.4
Kotenko, S.5
Ma, X.6
Gri, G.7
Wysocka, M.8
Kim, J.E.9
Liu, L.10
-
23
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski, M. T., M. W. Leach, E. W. Evans, L. Sullivan, S. C. Chen, G. Vassileva, J. F. Bazan, D. M. Gorman, R. A. Kastelein, S. Narula, and S. A. Lira. 2001. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166:7563.
-
(2001)
J. Immunol.
, vol.166
, pp. 7563
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
Sullivan, L.4
Chen, S.C.5
Vassileva, G.6
Bazan, J.F.7
Gorman, D.M.8
Kastelein, R.A.9
Narula, S.10
Lira, S.A.11
-
24
-
-
0028928622
-
CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes
-
Martinotti, A., A. Stoppacciaro, M. Vagliani, C. Melani, F. Spreafico, M. Wysocka, G. Parmiani, G. Trinchieri, and M. P. Colombo. 1995. CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes. Eur. J. Immunol. 25:137.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 137
-
-
Martinotti, A.1
Stoppacciaro, A.2
Vagliani, M.3
Melani, C.4
Spreafico, F.5
Wysocka, M.6
Parmiani, G.7
Trinchieri, G.8
Colombo, M.P.9
-
25
-
-
0028978033
-
Cytokine gene therapy with interleukin-2-transduced fibroblasts: Effects of IL-2 dose on anti-tumor immunity
-
Fakhrai, H., D. L. Shawler, R. Gjerset, R. K. Naviaux, J. Koziol, I. Royston, and R. E. Sobol. 1995. Cytokine gene therapy with interleukin-2-transduced fibroblasts: effects of IL-2 dose on anti-tumor immunity. Hum. Gene Ther. 6:591.
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 591
-
-
Fakhrai, H.1
Shawler, D.L.2
Gjerset, R.3
Naviaux, R.K.4
Koziol, J.5
Royston, I.6
Sobol, R.E.7
-
26
-
-
0036308936
-
Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor
-
Wang, X. Y., Y. Li, M. H. Manjili, E. A. Repasky, D. M. Pardoll, and J. R. Subjeck. 2002. Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor. Cancer Immunol. Immunother. 51:311.
-
(2002)
Cancer Immunol. Immunother.
, vol.51
, pp. 311
-
-
Wang, X.Y.1
Li, Y.2
Manjili, M.H.3
Repasky, E.A.4
Pardoll, D.M.5
Subjeck, J.R.6
-
27
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744.
-
(2003)
Nature
, vol.421
, pp. 744
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
-
28
-
-
0036604062
-
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
-
Belladonna, M. L., J. C. Renauld, R. Bianchi, C. Vacca, F. Fallarino, C. Orabona, M. C. Fioretti, U. Grohmann, and P. Puccetti. 2002. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J. Immunol. 168:5448.
-
(2002)
J. Immunol.
, vol.168
, pp. 5448
-
-
Belladonna, M.L.1
Renauld, J.C.2
Bianchi, R.3
Vacca, C.4
Fallarino, F.5
Orabona, C.6
Fioretti, M.C.7
Grohmann, U.8
Puccetti, P.9
|