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Volumn 110, Issue 9, 2007, Pages 3136-3142

C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TRANSCRIPTION FACTOR PU 1; CCAAT ENHANCER BINDING PROTEIN ALPHA; ONCOPROTEIN; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 35348815320     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-03-080291     Document Type: Article
Times cited : (95)

References (44)
  • 1
    • 0037071397 scopus 로고    scopus 로고
    • Transcriptional regulation of granulocyte and monocyte development
    • Friedman AD. Transcriptional regulation of granulocyte and monocyte development. Oncogene. 2002;21:3377-3390.
    • (2002) Oncogene , vol.21 , pp. 3377-3390
    • Friedman, A.D.1
  • 2
    • 0026758202 scopus 로고
    • A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells
    • Scott LM, Civin CI, Rorth P, Friedman AD. A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood. 1992;80:1725-1735.
    • (1992) Blood , vol.80 , pp. 1725-1735
    • Scott, L.M.1    Civin, C.I.2    Rorth, P.3    Friedman, A.D.4
  • 3
    • 0025246676 scopus 로고
    • The macrophage and B cell-specific transcription factor PU. 1 is related to the ets oncogene
    • Klemsz MJ, McKercher SR, Celada A, Van Beveran C, Maki RA. The macrophage and B cell-specific transcription factor PU. 1 is related to the ets oncogene. Cell. 1990;61:113-124.
    • (1990) Cell , vol.61 , pp. 113-124
    • Klemsz, M.J.1    McKercher, S.R.2    Celada, A.3    Van Beveran, C.4    Maki, R.A.5
  • 5
    • 10344230611 scopus 로고    scopus 로고
    • Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα
    • Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα. Immunity. 2004;21:853-863.
    • (2004) Immunity , vol.21 , pp. 853-863
    • Zhang, P.1    Iwasaki-Arai, J.2    Iwasaki, H.3
  • 6
    • 4444233646 scopus 로고    scopus 로고
    • C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
    • Heath V, Suh HC, Holman M, et al. C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood. 2004;104:1639-1647.
    • (2004) Blood , vol.104 , pp. 1639-1647
    • Heath, V.1    Suh, H.C.2    Holman, M.3
  • 7
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU. 1 in the development of multiple hematopoietic lineages
    • Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU. 1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573-1577.
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1    Simon, M.C.2    Anastasi, J.3    Singh, H.4
  • 8
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU. 1 gene results in multiple hematopoietic abnormalities
    • McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU. 1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996;15:5647-5658.
    • (1996) EMBO J , vol.15 , pp. 5647-5658
    • McKercher, S.R.1    Torbett, B.E.2    Anderson, K.L.3
  • 9
    • 23944446085 scopus 로고    scopus 로고
    • Distinctive and indispensable roles of PU. 1 in maintenance of hematopoietic stem cells and their differentiation
    • Iwasaki H, Somoza C, Shigematsu H, et al. Distinctive and indispensable roles of PU. 1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005;106:1590-1600.
    • (2005) Blood , vol.106 , pp. 1590-1600
    • Iwasaki, H.1    Somoza, C.2    Shigematsu, H.3
  • 10
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU. 1
    • DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU. 1. Science. 2000;288:1439-1441.
    • (2000) Science , vol.288 , pp. 1439-1441
    • DeKoter, R.P.1    Singh, H.2
  • 11
    • 24944457117 scopus 로고    scopus 로고
    • + embryoid body cells derived from mouse ES cells turns cell fate determination to pro-B cells
    • + embryoid body cells derived from mouse ES cells turns cell fate determination to pro-B cells. Proc Natl Acad Sci U S A. 2005;102:13236-13241.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13236-13241
    • Zou, G.M.1    Chen, J.J.2    Yoder, M.C.3    Wu, W.4    Rowley, J.D.5
  • 12
    • 0142124320 scopus 로고    scopus 로고
    • Regulation of macrophage and neutrophil cell fates by the PU. 1:C/EBPα ratio and granulocyte colony-stimulating factor
    • Dahl R, Walsh JC, Lancki D, et al. Regulation of macrophage and neutrophil cell fates by the PU. 1:C/EBPα ratio and granulocyte colony-stimulating factor. Nat Immunol. 2003;4:1029-1036.
    • (2003) Nat Immunol , vol.4 , pp. 1029-1036
    • Dahl, R.1    Walsh, J.C.2    Lancki, D.3
  • 13
    • 2642519463 scopus 로고    scopus 로고
    • Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU. 1
    • Rosenbauer F, Wagner K, Kutok JL, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU. 1. Nat Genet. 2004;36:624-630.
    • (2004) Nat Genet , vol.36 , pp. 624-630
    • Rosenbauer, F.1    Wagner, K.2    Kutok, J.L.3
  • 14
    • 18644373047 scopus 로고    scopus 로고
    • PU. 1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    • Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L, Nutt SL. PU. 1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med. 2005;201:1487-1502.
    • (2005) J Exp Med , vol.201 , pp. 1487-1502
    • Dakic, A.1    Metcalf, D.2    Di Rago, L.3    Mifsud, S.4    Wu, L.5    Nutt, S.L.6
  • 15
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into macrophages
    • Xie H, Graf T. Stepwise reprogramming of B cells into macrophages. Cell. 2004;117:663-676.
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.1    Graf, T.2
  • 16
    • 33747177840 scopus 로고    scopus 로고
    • C/EBPα directs monocytic commitment of primary myeloid progenitors
    • Wang D, D'Costa J, Civin CI, Friedman AD. C/EBPα directs monocytic commitment of primary myeloid progenitors. Blood. 2006;108:1223-1229.
    • (2006) Blood , vol.108 , pp. 1223-1229
    • Wang, D.1    D'Costa, J.2    Civin, C.I.3    Friedman, A.D.4
  • 17
    • 0033564978 scopus 로고    scopus 로고
    • C/EBPα by-passes G-CSF signals to rapidly induce PU. 1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32Dcl3 myeloblasts
    • Wang X, Scott E, Sawyers CL, Friedman AD. C/EBPα by-passes G-CSF signals to rapidly induce PU. 1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32Dcl3 myeloblasts. Blood. 1999;94:560-571.
    • (1999) Blood , vol.94 , pp. 560-571
    • Wang, X.1    Scott, E.2    Sawyers, C.L.3    Friedman, A.D.4
  • 18
    • 0142061500 scopus 로고    scopus 로고
    • Cross-talk between regulators of myeloid development: C/EBPα binds and activates the promoter of the PU. 1 gene
    • Kummalue T, Friedman AD. Cross-talk between regulators of myeloid development: C/EBPα binds and activates the promoter of the PU. 1 gene. J Leuk Biol. 2003;72:464-470.
    • (2003) J Leuk Biol , vol.72 , pp. 464-470
    • Kummalue, T.1    Friedman, A.D.2
  • 19
    • 20144368117 scopus 로고    scopus 로고
    • Potential autroregulation of transcription factor PU. 1 by an upstream regulatory element
    • Okuno Y, Huang G, Rosenbauer F, et al. Potential autroregulation of transcription factor PU. 1 by an upstream regulatory element. Mol Cell Biol. 2005;25:2832-2845.
    • (2005) Mol Cell Biol , vol.25 , pp. 2832-2845
    • Okuno, Y.1    Huang, G.2    Rosenbauer, F.3
  • 20
    • 0027292678 scopus 로고
    • Phorbol esterinduced myeloid differentiation is mediated by protein kinase C-α and -δ and not by protein kinase C-β II, ε, ζ, and η
    • Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinsi JF. Phorbol esterinduced myeloid differentiation is mediated by protein kinase C-α and -δ and not by protein kinase C-β II, ε, ζ, and η. J Biol Chem. 1993;268:20110-20115.
    • (1993) J Biol Chem , vol.268 , pp. 20110-20115
    • Mischak, H.1    Pierce, J.H.2    Goodnight, J.3    Kazanietz, M.G.4    Blumberg, P.M.5    Mushinsi, J.F.6
  • 21
    • 36148965304 scopus 로고    scopus 로고
    • Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced Meis expression
    • Calvo KR, Sykes DB, Pasillas M, Kamps MP. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced Meis expression. Mol Cell Biol. 2000;98:2382-2388.
    • (2000) Mol Cell Biol , vol.98 , pp. 2382-2388
    • Calvo, K.R.1    Sykes, D.B.2    Pasillas, M.3    Kamps, M.P.4
  • 22
    • 0033214311 scopus 로고    scopus 로고
    • PU. 1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
    • Anderson KL, Smith KA, Perkin H, et al. PU. 1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation. Blood. 1999;94:2310-2318.
    • (1999) Blood , vol.94 , pp. 2310-2318
    • Anderson, K.L.1    Smith, K.A.2    Perkin, H.3
  • 23
    • 0027395118 scopus 로고
    • The murine myeloperoxidase promoter contains multiple functional elements: One element binds a cell type-restricted transcription factor, myeloid nuclear factor 1(MyNF1)
    • Suzow JG, Friedman AD. The murine myeloperoxidase promoter contains multiple functional elements: one element binds a cell type-restricted transcription factor, myeloid nuclear factor 1(MyNF1). Mol Cell Biol. 1993;13:2141-2151.
    • (1993) Mol Cell Biol , vol.13 , pp. 2141-2151
    • Suzow, J.G.1    Friedman, A.D.2
  • 24
    • 0028097848 scopus 로고    scopus 로고
    • Finer MH, Dull TJ, Qin L, Farson D, Roberts MR. Kat: a high-efficiency retroviral transduction system for primary human T lymphocytes. Blood. 1994;83:43-50.
    • Finer MH, Dull TJ, Qin L, Farson D, Roberts MR. Kat: a high-efficiency retroviral transduction system for primary human T lymphocytes. Blood. 1994;83:43-50.
  • 25
    • 29444440721 scopus 로고    scopus 로고
    • Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    • Rosenbauer F, Owens BM, Yu L, et al. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nat Genet. 2006;38:27-37.
    • (2006) Nat Genet , vol.38 , pp. 27-37
    • Rosenbauer, F.1    Owens, B.M.2    Yu, L.3
  • 26
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
    • Porse BT, Pedersen TA, Xu X, et al. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell. 2001;107:247-258.
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1    Pedersen, T.A.2    Xu, X.3
  • 27
    • 0037854628 scopus 로고    scopus 로고
    • Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis
    • Wang Q, Cleaves R, Kummalue T, Nerlov C, Friedman AD. Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis. Oncogene. 2003;22:2548-2557.
    • (2003) Oncogene , vol.22 , pp. 2548-2557
    • Wang, Q.1    Cleaves, R.2    Kummalue, T.3    Nerlov, C.4    Friedman, A.D.5
  • 28
    • 0025977563 scopus 로고
    • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
    • Pevny L, Simon MC, Robertson E, et al. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991;34:257-260.
    • (1991) Nature , vol.34 , pp. 257-260
    • Pevny, L.1    Simon, M.C.2    Robertson, E.3
  • 29
    • 0030926006 scopus 로고    scopus 로고
    • A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
    • Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997;16:3965-3973.
    • (1997) EMBO J , vol.16 , pp. 3965-3973
    • Shivdasani, R.A.1    Fujiwara, Y.2    McDevitt, M.A.3    Orkin, S.H.4
  • 30
    • 0028826488 scopus 로고
    • PU. 1 (Spi-1) autoregulates its expression in myeloid cells
    • Chen H, Ray-Gallet D, Zhang P, et al. PU. 1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene. 1995;11:1549-1560.
    • (1995) Oncogene , vol.11 , pp. 1549-1560
    • Chen, H.1    Ray-Gallet, D.2    Zhang, P.3
  • 31
    • 0025876999 scopus 로고
    • Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter
    • Tsai SF, Strauss E, Orkin SH. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 1991;5:919-931.
    • (1991) Genes Dev , vol.5 , pp. 919-931
    • Tsai, S.F.1    Strauss, E.2    Orkin, S.H.3
  • 32
    • 0026029709 scopus 로고
    • CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
    • Christy RJ, Kaestner KH, Geiman DE, Lane MD. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A. 1991;88:2593-2597.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2593-2597
    • Christy, R.J.1    Kaestner, K.H.2    Geiman, D.E.3    Lane, M.D.4
  • 33
    • 0033151624 scopus 로고    scopus 로고
    • Direct interaction of hematopoietic transcription factors PU. 1 and GATA-1: Functional antagonism in erythroid cells
    • Rekhtman N, Radparvar F, Evans T, Skoultchi AI. Direct interaction of hematopoietic transcription factors PU. 1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 1999;13:1398-1411.
    • (1999) Genes Dev , vol.13 , pp. 1398-1411
    • Rekhtman, N.1    Radparvar, F.2    Evans, T.3    Skoultchi, A.I.4
  • 34
    • 0033587755 scopus 로고    scopus 로고
    • Negative cross-talk between hematopoietic regulators: GATA proteins repress PU. 1
    • Zhang P, Behre G, Pan J, et al. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU. 1. Proc Natl Acad Sci U S A. 1999;96:8705-8710.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8705-8710
    • Zhang, P.1    Behre, G.2    Pan, J.3
  • 35
    • 0034667672 scopus 로고    scopus 로고
    • PU. 1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
    • Zhang P, Zhang X, Iwama A, et al. PU. 1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 2000;96:2641-2648.
    • (2000) Blood , vol.96 , pp. 2641-2648
    • Zhang, P.1    Zhang, X.2    Iwama, A.3
  • 36
    • 31444431706 scopus 로고    scopus 로고
    • Antagonstic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    • Hsu CL, King-Fleischman AG, Lai AY, Matsumoto Y, Weissman IL, Kondo M. Antagonstic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc Natl Acad Sci U S A. 2006;103:672-677.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 672-677
    • Hsu, C.L.1    King-Fleischman, A.G.2    Lai, A.Y.3    Matsumoto, Y.4    Weissman, I.L.5    Kondo, M.6
  • 37
    • 79960555619 scopus 로고    scopus 로고
    • PU. 1 is a major downstream target of AML1/RUNX1 in adult hematopoiesis
    • in press
    • Huang G, Zhang P, Hirai H, et al. PU. 1 is a major downstream target of AML1/RUNX1 in adult hematopoiesis. Nature Genet. 2007; in press.
    • (2007) Nature Genet
    • Huang, G.1    Zhang, P.2    Hirai, H.3
  • 38
    • 0036682473 scopus 로고    scopus 로고
    • Heterozygous PU. 1 mutations are associated with acute myeloid leukemia
    • Mueller BU, Pabst T, Osato M, et al. Heterozygous PU. 1 mutations are associated with acute myeloid leukemia. Blood. 2002;100:998-1007.
    • (2002) Blood , vol.100 , pp. 998-1007
    • Mueller, B.U.1    Pabst, T.2    Osato, M.3
  • 39
    • 0035093813 scopus 로고    scopus 로고
    • Dominantnegative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, et al. Dominantnegative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nat Genet. 2001;27:263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3
  • 40
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
    • Pabst T, Mueller BU, Harakawa N, et al. AML1-ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nat Med. 2001;7:444-451.
    • (2001) Nat Med , vol.7 , pp. 444-451
    • Pabst, T.1    Mueller, B.U.2    Harakawa, N.3
  • 41
    • 0036893435 scopus 로고    scopus 로고
    • Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    • Zheng R, Friedman AD, Small D. Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood. 2002;100:4154-4161.
    • (2002) Blood , vol.100 , pp. 4154-4161
    • Zheng, R.1    Friedman, A.D.2    Small, D.3
  • 42
    • 0036340784 scopus 로고    scopus 로고
    • BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2
    • Perrotti D, Cesi V, Trotta R, et al. BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2. Nat Genet. 2002;30:48-58.
    • (2002) Nat Genet , vol.30 , pp. 48-58
    • Perrotti, D.1    Cesi, V.2    Trotta, R.3
  • 43
    • 33344455424 scopus 로고    scopus 로고
    • Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
    • Radomska HS, Basseres DS, Zheng R, et al. Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med. 2006;203:371-381.
    • (2006) J Exp Med , vol.203 , pp. 371-381
    • Radomska, H.S.1    Basseres, D.S.2    Zheng, R.3
  • 44
    • 33645734361 scopus 로고    scopus 로고
    • ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU. 1 expression
    • Mueller BU, Pabst T, Fos J, et al. ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU. 1 expression. Blood. 2006;107:3330-3338.
    • (2006) Blood , vol.107 , pp. 3330-3338
    • Mueller, B.U.1    Pabst, T.2    Fos, J.3


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