In vitro response to Candida albicans in cultures of whole human blood from young and aged donors

FEMS Immunology and Medical Microbiology

Volumn 51, Issue 2, 2007, Pages 327-335

  Murciano, Celia ^a   Villamón, Eva ^b   Yáñez, Alberto ^a   Murciano, José ^c   Mir, Amparo ^a   O'Connor, José E ^b   Gozalbo, Daniel ^a   Gil, M Luisa ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^c Centro de Atención Primaria Pintor Stolz   (Spain)

Author keywords

Ageing; Candida albicans; Cytokines; Innate immunity; TLRs

Indexed keywords

IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; BACTERIAL INFECTION; BLOOD; BLOOD DONOR; CANDIDA ALBICANS; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FUNGICIDAL ACTIVITY; GRANULOCYTE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; INFECTION SENSITIVITY; INNATE IMMUNITY; LYMPHOCYTE; MALE; MONOCYTE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIBODIES, FUNGAL; BLOOD; CANDIDA ALBICANS; CYTOKINES; DINOPROSTONE; FEMALE; GRANULOCYTES; HUMANS; LYMPHOCYTES; MALE; MICROBIAL VIABILITY; MONOCYTES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 6;

EID: 35148880007     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2007.00309.x     Document Type: Article

References (35)

1. Bellocchio S, Montagnoli C, Bozza S, Gaziano R, Rossi G, Mambula SS, Vecchi A, Mantovani A, Levitz SM Romani L (2004) The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172 : 3059 3069.
2. Boehmer ED, Goral J, Faunce DE Kovacs EJ (2004) Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 75 : 342 349.
3. Boehmer ED, Meehan MJ, Cutro BT Kovacs EJ (2005) Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev 126 : 1305 1313.
4. Calderone RA (2001) Candida and Candidiasis. American Society for Microbiology, New York.
5. Effros RB (2001) Ageing and the immune system. Novartis Found Symp 235 : 130 139.
6. Fradin C, De Groot P, MacCallum D, Schaller M, Klis F, Odds FC Hube B (2005) Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol 56 : 397 415.
7. Fulop T, Larbi A, Douziech N, Fortin C, Guerard KP, Lesur O, Khalil A Dupuis G (2004) Signal transduction and functional changes in neutrophils with aging. Aging Cell 3 : 217 226.
8. Gil ML Gozalbo D (2006) TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae. Microb Infect 8 : 2299 2304.
9. Gil-Navarro I, Gil ML, Casanova M, O'Connor JE, Martínez JP Gozalbo D (1997) The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is a surface antigen. J Bacteriol 179 : 4992 4999.
10. Ginaldi L, Loreto MF, Corsi MP, Modesti M De Martinis M (2001) Immunosenescence and infectious diseases. Microb Infect 3 : 851 857.
11. Gomez CR, Boehmer ED Kovacs EJ (2005) The aging innate immune system. Curr Opin Immunol 17 : 457 462.
12. Gorczynski RM, Alexander C, Bessler W et al 2007) An alteration in the levels of populations of CD4+Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract. Immunol Lett 109 : 101 112.
13. Gozalbo D, Gil-Navarro I, Azorín I, Renau-Piqueras J, Martínez JP Gil ML (1998) The cell wall-associated glyceraldehyde-3- phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infect Immun 66 : 2052 2059.
14. Hajjeh RA, Sofair AN, Harrison LH et al 2004) Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. J Clin Microbiol 42 : 1519 1527.
15. Kauffman CA (2001) Fungal infections in older adults. Clin Infect Dis 33 : 550 555.
16. Linton PJ Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5 : 133 139.
17. Murciano C, Villamón E, Gozalbo D, Roig P, O'Connor JE Gil ML (2006a) Toll-like receptor 4 defective mice carrying point or null mutations do not show increased susceptibility to Candida albicans in a model of hematogenously disseminated infection. Med Mycol 44 : 149 157.
18. Murciano C, Villamón E, Yáñez A, O'Connor JE, Gozalbo D Gil ML (2006b) Impaired immune response to Candida albicans in aged mice. J Med Microbiol 55 : 1649 1656.
19. Netea MG, Gow NAR, Munro CA et al 2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest 16 : 1642 1650.
20. Nucci M, Colombo AL, Silveira F, Richtmann R, Salomao R, Branchini ML Spector N (1998) Risk factors for death in patients with candidemia. Infect Control Hosp Epidemiol 11 : 846 850.
21. Pfaller MA Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20 : 133 163.
22. Pitarch A, Abian J, Carrascal M, Sánchez M, Nombela C Gil C (2004) Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies. Proteomics 4 : 3084 3106.
23. Plowden J, Renshaw-Hoelsche M, Engleman C, Katz J Sambhara S (2004) Innate immunity in aging: impact on macrophage function. Aging Cell 3 : 161 167.
24. Poulain D Jouault T (2004) Candida albicans cell wall glycans, host receptors and responses: elements for a decisive crosstalk. Curr Opin Microbiol 7 : 342 349.
25. Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J Sambhara S (2002) Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 169 : 4697 4701.
26. Romani L (2004) Immunity to fungal infections. Nat Rev Immunol 4 : 1 23.
27. Romani L (2005) Innate and adaptive immunity to systemic Candida albicans infection. Fungal Immunology: From an Organ Perspective (Fidel PL Huffnagle GB, eds pp. 377 401. Springer, New York.
28. van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R Shaw AC (2007) Age-associated defect in human TLR1/2 function. J Immunol 178 : 970 975.
29. Villamón E, Gozalbo D, Roig P, O'Connor JE, Fradelizi D Gil ML (2004a) Toll-like receptor 2 is essential in murine defenses against Candida albicans infections. Microb Infect 6 : 1 7.
30. Villamón E, Gozalbo D, Roig P, Murciano C, O'Connor JE, Fradelizi D Gil ML (2004b) Myeloid differentiation factor 88 (MyD88) is required for murine resistance to Candida albicans and is critically involved in Candida-induced production of cytokines. Eur Cytokine Netw 15 : 263 271.
31. Villamón E, Gozalbo D, Roig P, O'Connor JE, Ferrandiz ML, Fradelizi D Gil ML (2004c) Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasis. Microb Infect 6 : 542 548.
32. 2 production in murine peritoneal macrophages and splenocytes in response to Candida albicans. Res Microbiol 156 : 115 118.
33. West AP, Koblansky AA Ghosh S (2006) Recognition and signaling by Toll-like receptors. Annu Rev Cell Dev Biol 22 : 409 437.
34. Zelante T, Montagnoli C, Bozza S, Gaziano R, Bellocchio S, Bonifazi P, Moretti S, Fallarino F, Puccetti P Romani L (2007) Receptors and pathways in innate antifungal immunity: the implications for tolerance and immunity to fungi. Adv Exp Med Biol 590 : 209 221.
35. Zhao L, Sun L, Wang H, Ma H, Liu G Zhao Y (2007) Changes of CD4+ CD25+ Foxp3+ regulatory T cells in aged Balb/c mice. J Leukoc Biol 81 : 1386 1394.