Receptors and pathways in innate antifungal immunity: The implication for tolerance and immunity to fungi

Advances in Experimental Medicine and Biology

Volumn 590, Issue , 2007, Pages 209-221

  Zelante, Teresa ^a   Montagnoli, Claudia ^a   Bozza, Silvia ^a   Gaziano, Roberta ^a   Bellocchio, Silvia ^a   Bonifazi, Pierluigi ^a   Moretti, Silvia ^a   Fallarino, Francesca ^a   Puccetti, Paolo ^a   Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; CD11B ANTIGEN; CD18 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ANTIFUNGAL ACTIVITY; ANTIGEN SPECIFICITY; ASPERGILLUS FUMIGATUS; AUTOIMMUNITY; CANDIDA ALBICANS; CANDIDIASIS; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONFERENCE PAPER; CYTOKINE PRODUCTION; DENDRITIC CELL; FUNGAL DETECTION; FUNGAL VIRULENCE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INNATE IMMUNITY; MEDIATOR; MEMORY CELL; MUCOCUTANEOUS CANDIDIASIS; MYCOSIS; NONHUMAN; OPPORTUNISTIC INFECTION; PHAGOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRYPTOPHAN METABOLISM; VAGINA CANDIDIASIS;

FUNGI;

EID: 84934440936     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-34814-8_15     Document Type: Conference Paper

References (37)

1. L. Romani. Overview of fungal pathogens. In Immunology of infectious diseases, pp. 25-37. Ed. S.H. Kaufmann, A. Sher and R. Ahmed. Washington, DC: ASM Press (2001).
2. N.A. Gow, A.J. Brown and F.C. Odds. Fungal morphogenesis and host invasion. Curr Opin Microbiol 5:366-371 (2002).
3. M.C. Lorenz and G.R. Fink. The glyoxylate cycle is required for fungal virulence. Nature 412:83-86 (2001).
4. L. Romani, F. Bistoni and P. Puccetti. Fungi, dendritic cells and receptors: a host perspective of fungal virulence. Trends Microbiol 10:508-514 (2002).
5. R.A. Calderone. Candida and candidiasis. Washington, DC: ASM Press (2002).
6. K.A. Marr, T. Patterson and D. Denning. Aspergillosis: pathogenesis, clinical manifestations, and therapy. Infect Dis Clin North Am 16:875-894 (2002).
7. L. Romani. Immunity to fungal infections. Nat Rev Immunol 4:1-23 (2004).
8. S. Akira and K. Takeda. Toll-like receptor signalling. Nat Rev Immunol 4:499-511 (2004).
9. L. Romani. The T cell response against fungal infections. Curr Opin Immunol 9:484-490 (1997).
10. L. Romani. Innate immunity to fungi: the art of speed and specificity. In Pathogenic fungi: host interactions and emerging strategies for control, pp. 167-214. Ed. G. San-Blas and R.A. Calderone. Norfolk: Caister Academic Press (2004).
11. S.L. Newman. Histoplasma capsulatum: diary of an intracellular survivor. In Fungal pathogenesis, principles and clinical applications, pp. 81-96. Ed. R.A. Calderone and R.L. Cihlar. New York: Marcel Dekker (2002).
12. L.A. Gildea, R.E. Morris and S.L. Newman. Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells. J Immunol 166:1049-1056 (2001).
13. S. Akira, K. Takeda and T. Kaisho. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675-680 (2001).
14. S. Bellocchio, C. Montagnoli, S. Bozza, R. Gaziano, G. Rossi, S.S. Mambula, A. Vecchi, A. Mantovani, S.M. Levitz and L. Romani. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172:3059-3069 (2004).
15. S. Bellocchio, S. Moretti, K. Perruccio, F. Fallarino, S. Bozza, C. Montagnoli, P. Mosci, G.B. Lipford, L. Pitzurra and L. Romani. TLRs govern neutrophil activity in aspergillosis. J Immunol 173:7406-7415 (2004).
16. M.G. Netea, J.W. Van der Meer and B.J. Kullberg. Toll-like receptors as an escape mechanism from the host defense. Trends Microbiol 12:484-488 (2004).
17. S.M. Levitz. Interactions of Toll-like receptors with fungi. Microbes Infect 6:1351-1355 (2004).
18. K. Shortman and Y.J. Liu. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2:151-161 (2002).
19. A. Bacci, C. Montagnoli, K. Perruccio, S. Bozza, R. Gaziano, L. Pitzurra, A. Velardi, C.F. d'Ostiani, J.E. Cutler and L. Romani. Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation. J Immunol 168:2904-2913 (2002).
20. S. Bozza, R. Gaziano, A. Spreca, A. Bacci, C. Montagnoli, P. di Francesco and L. Romani. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol 168:1362-1371 (2002).
21. S. Bozza, K. Perruccio, C. Montagnoli, R. Gaziano, S. Bellocchio, E. Burchielli, G. Nkwanyuo, L. Pitzurra, A. Velardi and L. Romani. A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 102:3807-3814 (2003).
22. U. Grohmann, F. Fallarino and P. Puccetti. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 24:242-248 (2003).
23. U. Grohmann, C. Orabona, F. Fallarino, C. Vacca, F. Calcinaro, A. Falorni, P. Candeloro, M.L. Belladonna, R. Bianchi, M.C. Fioretti and P. Puccetti. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3:1097-1101 (2002).
24. F. Fallarino, U. Grohmann, K.W. Hwang, C. Orabona, C. Vacca, R. Bianchi, M.L. Belladonna, M.C. Fioretti, M.L. Alegre and P. Puccetti. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol 4:1206-1212 (2003).
25. C. Orabona, U. Grohmann, M.L. Belladonna, F. Fallarino, C. Vacca, R. Bianchi, S. Bozza, C. Volpi, B.L. Salomon, M.C. Fioretti, L. Romani and P.C. Puccetti. CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. Nat Immunol 5:1134-1142 (2004).
26. C. Montagnoli, A. Bacci, S. Bozza, R. Gaziano, P. Mosci, A.H. Sharpe and L. Romani. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol 169:6298-6308 (2002).
27. S. Bozza, F. Fallarino, L. Pitzurra, T. Zelante, C. Montagnoli, S. Bellocchio, P. Mosci, C. Vacca, P. Puccetti and L. Romani. A crucial role for tryptophan catabolism at the host/Candida albicans interface. J Immunol 174:2910-2918 (2005).
28. G.J. Gurtner, R.D. Newberry, S.R. Schloemann, K.G. McDonald and W.F. Stenson. Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice. Gastroenterology 125:1762-1773 (2003).
29. Y. Belkaid and B.T. Rouse. Natural regulatory T cells in infectious disease. Nat Immunol 6:353-360 (2005).
30. S. Hori, T.L. Carvalho and J. Demengeot. CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur J Immunol 32:1282-1291 (2002).
31. C. Montagnoli, F. Fallarino, R. Gaziano, S. Bozza, S. Bellocchio, T. Zelante, W.P. Kurup, L. Pitzurra, P. Puccetti and L. Romani. The plasticity of dendritic cells at the host/fungal interface. J Immunol 204:582-589 (2001).
32. P.L. Fidel Jr. The protective immune response against vaginal candidiasis: lessons learned from clinical studies and animal models. Int Rev Immunol 21:515-548 (2002).
33. L.P. Carvalho, O. Bacellar, N. Neves, A.R. de Jesus and E.M. Carvalho. Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis. J Allergy Clin Immunol 109:102-105 (2002).
34. D. Lilic. New perspectives on the immunology of chronic mucocutaneous candidiasis. Curr Opin Infect Dis 15:143-147 (2002).
35. A. Liston, S. Lesage, J. Wilson, L. Peltonen and C.C. Goodnow. Aire regulates negative selection of organ-specific T cells. Nat Immunol 4:350-354 (2003).
36. M. Ostroukhova, C. Seguin-Devaux, T.B. Oriss, B. Dixon-McCarthy, L. Yang, B.T. Ameredes, T.E. Corcoran and A. Ray. Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest 114:28-38 (2004).
37. L. Romani. Host immune reactivity and antifungal chemotherapy: the power of being together. J Chemother 13:347-353 (2001).